{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:06:15Z","timestamp":1793307975258,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2025QNB021"],"award-info":[{"award-number":["2025QNB021"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024ZD01004"],"award-info":[{"award-number":["2024ZD01004"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2413500"],"award-info":[{"award-number":["2023YFC2413500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian ProvinceJoint Funds for the Innovation of Science and Technology, Fujian Province","award":["2024Y9601"],"award-info":[{"award-number":["2024Y9601"]}]},{"name":"Joint Funds for the Innovation of Science and Technology, Fujian Province","award":["2023Y9320"],"award-info":[{"award-number":["2023Y9320"]}]},{"name":"Fujian Province Natural Science Foundation of China","award":["2024J011105"],"award-info":[{"award-number":["2024J011105"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-026-05681-0","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:11:35Z","timestamp":1785222695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic factors and treatment response in previously treated hepatocellular carcinoma patients receiving Y-90 radioembolization combined with targeted-immunotherapy: an exploratory analysis"],"prefix":"10.1007","author":[{"given":"Jianwei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6297-3067","authenticated-orcid":false,"given":"Zhuting","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"5681_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Ferlay Sung","year":"2021","unstructured":"Sung, Ferlay, Siegel, Laversanne, Soerjomataram, Jemal, Bray. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2021;71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"Journal for Clinicians"},{"key":"5681_CR2","doi-asserted-by":"publisher","unstructured":"Singal, Llovet, Yarchoan, Mehta, Heimbach, Dawson, Jou, Kulik, Agopian, Marrero, Mendiratta-Lala, Brown, Rilling, Goyal, Wei, Taddei. AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78:1922\u20131965. https:\/\/doi.org\/10.1097\/HEP.0000000000000466","DOI":"10.1097\/HEP.0000000000000466"},{"key":"5681_CR3","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/liv.12637","volume":"35","author":"El Fouly","year":"2015","unstructured":"El Fouly, Ertle, El Dorry, Shaker, Dech\u00eane, Abdella, Mueller, Barakat, Lauenstein, Bockisch, Gerken, Schlaak. In intermediate stage hepatocellular carcinoma: Radioembolization with yttrium 90 or chemoembolization? Liver International. 2015;35:627\u2013635. https:\/\/doi.org\/10.1111\/liv.12637","journal-title":"Liver International"},{"key":"5681_CR4","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.jvir.2022.11.036","volume":"34","author":"Gabr Ranganathan","year":"2023","unstructured":"Ranganathan, Gabr, Entezari, Gordon, Riaz, Desai, Thornburg, Kulik, Kalyan, Salem, Lewandowski. Radioembolization for intermediate-stage hepatocellular carcinoma maintains liver function and permits systemic therapy at progression. Journal of Vascular and Interventional Radiology. 2023;34:968\u2013975. https:\/\/doi.org\/10.1016\/j.jvir.2022.11.036","journal-title":"Journal of Vascular and Interventional Radiology"},{"key":"5681_CR5","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/hep.29691","volume":"68","author":"Gabr Salem","year":"2018","unstructured":"Salem, Gabr, Riaz, Mora, Ali, Abecassis, Hickey, Kulik, Ganger, Flamm, Atassi, Atassi, Sato, Benson, Mulcahy, Abouchaleh, Asadi, Desai, Thornburg, Vouche, Habib, Caicedo, Miller, Yaghmai, Kallini, Mouli, Lewandowski. Institutional decision to adopt Y90 as primary treatment for hepatocellular carcinoma informed by a 1,000-patient 15-year experience. Hepatology. 2018;68:1429\u20131440. https:\/\/doi.org\/10.1002\/hep.29691","journal-title":"Hepatology"},{"key":"5681_CR6","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"Qin Finn","year":"2020","unstructured":"Finn, Qin, Ikeda, Galle, Ducreux, Kim, Kudo, Breder, Merle, Kaseb, Li, Verret, Xu, Hernandez, Liu, Huang, Mulla, Wang, Lim, Zhu, Cheng. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. New England Journal of Medicine. 2020;382:1894\u20131905. https:\/\/doi.org\/10.1056\/NEJMoa1915745","journal-title":"New England Journal of Medicine"},{"key":"5681_CR7","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1158\/1078-0432.CCR-23-0581","volume":"29","author":"Nam Lee","year":"2023","unstructured":"Lee, Nam, Cho, Lee, Yu, Kim, Paeng, Yoon, Kim. A phase I\/IIa trial of yttrium-90 radioembolization in combination with durvalumab for locally advanced unresectable hepatocellular carcinoma. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research. 2023;29:3651\u20133658. https:\/\/doi.org\/10.1158\/1078-0432.CCR-23-0581","journal-title":"Clinical Cancer Research: an Official Journal of the American Association for Cancer Research"},{"key":"5681_CR8","doi-asserted-by":"publisher","unstructured":"Yu, Yu, Keane, Mauro, Helft, Harris, Sanoff, Johnson, O\u2019Neil, McRee, Somasundaram. A pilot study of pembrolizumab in combination with Y90 radioembolization in subjects with poor prognosis hepatocellular carcinoma. Oncologist. 2024;29. https:\/\/doi.org\/10.1093\/oncolo\/oyad331","DOI":"10.1093\/oncolo\/oyad331"},{"key":"5681_CR9","doi-asserted-by":"publisher","first-page":"7349","DOI":"10.1007\/s00330-025-11659-1","volume":"35","author":"Jiang Wei","year":"2025","unstructured":"Wei, Jiang, Yoo, Kim, Kang, Wu, Liu, Kim, Lee. Temporal evolution of the LI-RADS radiation treatment response assessment on multiphase CT\/MRI in patients undergoing selective internal radiation therapy for hepatocellular carcinoma. European Radiology. 2025;35:7349\u20137362. https:\/\/doi.org\/10.1007\/s00330-025-11659-1","journal-title":"European Radiology"},{"key":"5681_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.diii.2020.09.004","volume":"102","author":"Derbel Ghosn","year":"2021","unstructured":"Ghosn, Derbel, Kharrat, Oubaya, Mul\u00e9, Chalaye, Regnault, Amaddeo, Itti, Luciani, Kobeiter, Tacher. Prediction of overall survival in patients with hepatocellular carcinoma treated with Y-90 radioembolization by imaging response criteria. Diagnostic and Interventional Imaging. 2021;102:35\u201344. https:\/\/doi.org\/10.1016\/j.diii.2020.09.004","journal-title":"Diagnostic and Interventional Imaging"},{"key":"5681_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3348\/kjr.2018.0469","volume":"20","author":"Kim Kim","year":"2019","unstructured":"Kim, Kim, An, Han, Won, Kim, Kim, Choi. Evaluation of early response to treatment of hepatocellular carcinoma with yttrium-90 radioembolization using quantitative computed tomography analysis. Korean Journal of Radiology. 2019;20:449. https:\/\/doi.org\/10.3348\/kjr.2018.0469","journal-title":"Korean Journal of Radiology"},{"key":"5681_CR12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jhep.2025.10.020","volume":"84","author":"Sanduzzi-Zamparelli Reig","year":"2025","unstructured":"Reig, Sanduzzi-Zamparelli, Forner, Rimola, Ferrer-F\u00e0brega, Burrel, Garcia-Criado, D\u00edaz, Llarch, Iserte, Moll\u00e0, Kelley, Galle, Mazzaferro, Salem, Sangro, Singal, Vogel, Yanagihara, Ayuso, Torres, Bruix. BCLC strategy for prognosis prediction and treatment recommendations: the 2026 update. Journal of Hepatology. 2025;84:631\u2013654. https:\/\/doi.org\/10.1016\/j.jhep.2025.10.020","journal-title":"Journal of Hepatology"},{"key":"5681_CR13","doi-asserted-by":"publisher","first-page":"100100","DOI":"10.1016\/j.jhepr.2020.100100","volume":"2","author":"Dioguardi Gregory","year":"2020","unstructured":"Gregory, Dioguardi Burgio, Corrias, Vilgrain, Ronot. Evaluation of liver tumour response by imaging. JHEP Reports. 2020;2:100100. https:\/\/doi.org\/10.1016\/j.jhepr.2020.100100","journal-title":"JHEP Reports"},{"key":"5681_CR14","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1148\/radiol.2018181494","volume":"289","author":"Fowler Chernyak","year":"2018","unstructured":"Chernyak, Fowler, Kamaya, Kielar, Elsayes, Bashir, Kono, Do, Mitchell, Singal, Tang, Sirlin. Liver imaging reporting and data system (LI-RADS) version 2018: Imaging of hepatocellular carcinoma in at-risk patients. Radiology. 2018;289:816\u2013830. https:\/\/doi.org\/10.1148\/radiol.2018181494","journal-title":"Radiology"},{"key":"5681_CR15","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00330-023-10045-z","volume":"34","author":"King Stocker","year":"2023","unstructured":"Stocker, King, Homsi, Gnerre, Marinelli, Wurnig, Schwartz, Kim, Taouli. Early post-treatment MRI predicts long-term hepatocellular carcinoma response to radiation segmentectomy. European Radiology. 2023;34:475\u2013484. https:\/\/doi.org\/10.1007\/s00330-023-10045-z","journal-title":"European Radiology"},{"key":"5681_CR16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1102\/1470-7330.2013.0057","volume":"13","author":"Anil Singh","year":"2014","unstructured":"Singh, Anil. Yttrium-90 radioembolization of liver tumors: What do the images tell us? Cancer Imaging: the Official Publication of the International Cancer Imaging Society. 2014;13:645\u2013657. https:\/\/doi.org\/10.1102\/1470-7330.2013.0057","journal-title":"the International Cancer Imaging Society"},{"key":"5681_CR17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/HP.0000000000001601","volume":"123","author":"Liu Jiao, Cao","year":"2022","unstructured":"Jiao, Cao, Liu. Radiation-induced cell death and its mechanisms. Health Physics. 2022;123:376\u2013386. https:\/\/doi.org\/10.1097\/HP.0000000000001601","journal-title":"Health Physics"},{"key":"5681_CR18","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1007\/s00330-025-12040-y","volume":"36","author":"Goh Park","year":"2025","unstructured":"Park, Goh, Sinn, Shin, Rhee. Predicting early progression to atezolizumab\u2013bevacizumab in hepatocellular carcinoma: a clinical and imaging-based scoring system. European Radiology. 2025;36:2892\u20132902. https:\/\/doi.org\/10.1007\/s00330-025-12040-y","journal-title":"European Radiology"},{"key":"5681_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pharmthera.2014.11.001","volume":"147","author":"Tijeras-Raballand Neuzillet","year":"2014","unstructured":"Neuzillet, Tijeras-Raballand, Cohen, Cros, Faivre, Raymond, de Gramont. Targeting the TGF\u03b2 pathway for cancer therapy. Pharmacology & Therapeutics. 2014;147:22\u201331. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.001","journal-title":"Pharmacology & Therapeutics"},{"key":"5681_CR20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1245\/s10434-009-0330-y","volume":"16","author":"Poon","year":"2009","unstructured":"Poon. Differentiating early and late recurrences after resection of HCC in cirrhotic patients: Implications on surveillance, prevention, and treatment strategies. Annals of Surgical Oncology. 2009;16:792\u2013794. https:\/\/doi.org\/10.1245\/s10434-009-0330-y","journal-title":"Annals of Surgical Oncology"},{"key":"5681_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40425-018-0398-7","volume":"6","author":"Lawson Bakos","year":"2018","unstructured":"Bakos, Lawson, Rouleau, Tai. Combining surgery and immunotherapy: Turning an immunosuppressive effect into a therapeutic opportunity. Journal for ImmunoTherapy of Cancer. 2018;6:86\u201396. https:\/\/doi.org\/10.1186\/s40425-018-0398-7","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"5681_CR22","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00259-022-05956-w","volume":"50","author":"Padia Salem","year":"2022","unstructured":"Salem, Padia, Lam, Chiesa, Haste, Sangro, Toskich, Fowers, Herman, Kappadath, Leung, Sze, Kim, Garin. Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: Updated 2022 recommendations from an international multidisciplinary working group. European Journal of Nuclear Medicine and Molecular Imaging. 2022;50:328\u2013343. https:\/\/doi.org\/10.1007\/s00259-022-05956-w","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"5681_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.jhep.2024.08.028","volume":"82","author":"Argemi Sangro","year":"2025","unstructured":"Sangro, Argemi, Ronot, Paradis, Meyer, Mazzaferro, Jepsen, Golfieri, Galle, Dawson, Reig. EASL clinical practice guidelines on the management of hepatocellular carcinoma. Journal of Hepatology. 2025;82:315\u2013374. https:\/\/doi.org\/10.1016\/j.jhep.2024.08.028","journal-title":"Journal of Hepatology"},{"key":"5681_CR24","doi-asserted-by":"publisher","unstructured":"Meyer, Pieper, Ahmadzadehfar, Lampe, Matuschek, Maschke, Enkirch, Essler, Spengler,Schild. Yttrium-90 radioembolization of unresectable hepatocellular carcinoma \u2013a single center experience. OncoTargets and Therapy. 2017;10:4773\u20134785. https:\/\/doi.org\/10.2147\/OTT.S137519","DOI":"10.2147\/OTT.S137519"},{"key":"5681_CR25","doi-asserted-by":"publisher","unstructured":"Liu, Liang, Yang, Lin, Hsu, Wu. Comparison of dosimetry models to predict outcome for radioembolization in patients with intermediate to advanced hepatocellular carcinoma. Journal of the Formosan Medical Association. 2025;S0929664625002980. https:\/\/doi.org\/10.1016\/j.jfma.2025.06.024","DOI":"10.1016\/j.jfma.2025.06.024"},{"key":"5681_CR26","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"Meyer Vogel","year":"2022","unstructured":"Vogel, Meyer, Sapisochin, Salem, Saborowski. Hepatocellular carcinoma. Lancet (London, England). 2022;400:1345\u20131362. https:\/\/doi.org\/10.1016\/S0140-6736(22)01200-4","journal-title":"England)"},{"key":"5681_CR27","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","volume":"33","author":"Berhane Johnson","year":"2015","unstructured":"Johnson, Berhane, Kagebayashi, Satomura, Teng, Reeves, O\u2019Beirne, Fox, Skowronska, Palmer, Yeo, Mo, Lai, I\u00f1arrairaegui, Chan, Sangro, Miksad, Tada, Kumada, Toyoda. Assessment of liver function in patients with hepatocellular carcinoma: A new evidence-based approach\u2014the ALBI grade. Journal of Clinical Oncology. 2015;33:550\u2013558. https:\/\/doi.org\/10.1200\/JCO.2014.57.9151","journal-title":"Journal of Clinical Oncology"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-026-05681-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-026-05681-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-026-05681-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:28:33Z","timestamp":1785518913000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-026-05681-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":27,"alternative-id":["5681"],"URL":"https:\/\/doi.org\/10.1007\/s00261-026-05681-0","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"12 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from Fujian Cancer Hospital Medical Ethics Committee (No. K2026-153-01). Written informed consent was waived due to the retrospective nature of the study.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has received funding by Fujian Provincial Health Technology Project (Grant Number: 2025QNB021), National Key Research and Development Program of China (Grant Number: 2023YFC2413500), Joint Funds for the Innovation of Science and Technology, Fujian Province (Grant Number: 2024Y9601), Joint Funds for the Innovation of Science and Technology, Fujian Province (Grant number: 2023Y9320), Fujian Province Natural Science Foundation of China (Grant Number: 2024J011105), and Fujian Provincial Health Technology Project (Grant Number: 2024ZD01004).","order":3,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Declarations"}}]}}