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Discordant findings are common because these modalities evaluate different biological and anatomical aspects of the disease. MRI is best suited for intraprostatic lesion detection and local staging, whereas PSMA PET\/CT is superior for assessing nodal and distant metastases and may also contribute to selected diagnostic pathways. This review explains the reasons for these discrepancies, discusses their clinical implications, and provides practical guidance for interpreting and managing discordant findings.<\/jats:p>","DOI":"10.1007\/s00261-026-05699-4","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:27:35Z","timestamp":1784899655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Not always a perfect match: discrepancies between PSMA PET\/CT and MRI in prostate cancer diagnosis and staging"],"prefix":"10.1007","author":[{"given":"Ana","family":"Lemos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungmin","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lucano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadson","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Fukumori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gouvea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdair","family":"Muglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"5699_CR1","unstructured":"World Health Organization \u2013 International Agency for Research on Cancer. 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