{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:27:54Z","timestamp":1789698474758,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,8,13]],"date-time":"2005-08-13T00:00:00Z","timestamp":1123891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1007\/s00262-005-0042-5","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T10:08:29Z","timestamp":1123841309000},"page":"246-253","source":"Crossref","is-referenced-by-count":56,"title":["Effective induction of anti-melanoma immunity following genetic vaccination with synthetic mRNA coding for the fusion protein EGFP.TRP2"],"prefix":"10.1007","volume":"55","author":[{"given":"Julia","family":"Steitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedrik M.","family":"Britten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"W\u00f6lfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"T\u00fcting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,8,13]]},"reference":[{"key":"42_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-5699(97)80020-5","volume":"18","author":"T Boon","year":"1997","unstructured":"Boon T, Coulie PG, Van den EB (1997) Tumor antigens recognized by T cells. Immunol Today 18:267","journal-title":"Immunol Today"},{"issue":"Suppl 3","key":"42_CR2","first-page":"200","volume":"6","author":"SA Rosenberg","year":"2000","unstructured":"Rosenberg SA (2000) Identification of cancer antigens: impact on development of cancer immunotherapies. Cancer J 6(Suppl 3):200","journal-title":"Cancer J"},{"key":"42_CR3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/eji.1830240340","volume":"24","author":"T W\u00f6lfel","year":"1994","unstructured":"W\u00f6lfel T, Van Pel A, Brichard V, Schneider J, Seliger B, Meyer zum B\u00fcschenfelde KH, Boon T (1994) Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur J Immunol 24:759","journal-title":"Eur J Immunol"},{"key":"42_CR4","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.7652577","volume":"269","author":"T W\u00f6lfel","year":"1995","unstructured":"W\u00f6lfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D (1995) A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269:1281","journal-title":"Science"},{"key":"42_CR5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.185.3.453","volume":"185","author":"MB Bloom","year":"1997","unstructured":"Bloom MB, Perry-Lalley D, Robbins PF, Li Y, el-Gamil M, Rosenberg SA, Yang JC (1997) Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med 185:453","journal-title":"J Exp Med"},{"key":"42_CR6","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/(SICI)1521-2254(199911\/12)1:6<400::AID-JGM68>3.0.CO;2-D","volume":"1","author":"T Tuting","year":"1999","unstructured":"Tuting T, Steitz J, Bruck J, Gambotto A, Steinbrink K, Deleo AB, Robbins P, Knop J, Enk AH (1999) Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity. J Gene Med 1:400","journal-title":"J Gene Med"},{"key":"42_CR7","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.190.11.1717","volume":"190","author":"WB Bowne","year":"1999","unstructured":"Bowne WB, Srinivasan R, Wolchok JD, Hawkins WG, Blachere NE, Dyall R, Lewis JJ, Houghton AN (1999) Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190:1717","journal-title":"J Exp Med"},{"key":"42_CR8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<89::AID-IJC14>3.0.CO;2-I","volume":"86","author":"J Steitz","year":"2000","unstructured":"Steitz J, Bruck J, Steinbrink K, Enk A, Knop J, Tuting T (2000) Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma. Int J Cancer 86:89","journal-title":"Int J Cancer"},{"key":"42_CR9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.gt.3301634","volume":"9","author":"J Steitz","year":"2002","unstructured":"Steitz J, Bruck J, Gambotto A, Knop J, Tuting T (2002) Genetic immunization with a melanocytic self-antigen linked to foreign helper sequences breaks tolerance and induces autoimmunity and tumor immunity. Gene Ther 9:208","journal-title":"Gene Ther"},{"key":"42_CR10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jim.2004.01.026","volume":"287","author":"CM Britten","year":"2004","unstructured":"Britten CM, Meyer RG, Frankenberg N, Huber C, W\u00f6lfel T (2004) The use of clonal mRNA as an antigenic format for the detection of antigen-specific T lymphocytes in IFN-\u03b3 ELISPOT assays. J Immunol Methods 287:125","journal-title":"J Immunol Methods"},{"key":"42_CR11","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/sj.gt.3301521","volume":"8","author":"J Steitz","year":"2001","unstructured":"Steitz J, Bruck J, Knop J, Tuting T (2001) Adenovirus-transduced dendritic cells stimulate cellular immunity to melanoma via a CD4(+) T cell-dependent mechanism. Gene Ther 8:1255","journal-title":"Gene Ther"},{"key":"42_CR12","first-page":"253","volume":"60","author":"V Bronte","year":"2000","unstructured":"Bronte V, Apolloni E, Ronca R, Zamboni P, Overwijk WW, Surman DR, Restifo NP, Zanovello P (2000) Genetic vaccination with and quot;self and quot; tyrosinase-related protein 2 causes melanoma eradication but not vitiligo. Cancer Res 60:253","journal-title":"Cancer Res"},{"key":"42_CR13","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1158\/0008-5472.CAN-03-3227","volume":"64","author":"C Lane","year":"2004","unstructured":"Lane C, Leitch J, Tan X, Hadjati J, Bramson JL, Wan Y (2004) Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin. Cancer Res 64:1509","journal-title":"Cancer Res"},{"key":"42_CR14","first-page":"6995","volume":"60","author":"MW Schreurs","year":"2000","unstructured":"Schreurs MW, Eggert AA, de Boer AJ, Vissers JL, van HT, Offringa R, Figdor CG, Adema GJ (2000) Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model. Cancer Res 60:6995","journal-title":"Cancer Res"},{"key":"42_CR15","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.168.5.2393","volume":"168","author":"N Shibagaki","year":"2002","unstructured":"Shibagaki N, Udey MC (2002) Dendritic cells transduced with protein antigens induce cytotoxic lymphocytes and elicit antitumor immunity. J Immunol 168:2393","journal-title":"J Immunol"},{"key":"42_CR16","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI200215399","volume":"109","author":"HY Wang","year":"2002","unstructured":"Wang HY, Fu T, Wang G, Zeng G, Perry-Lalley DM, Yang JC, Restifo NP, Hwu P, Wang RF (2002) Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells. J Clin Invest 109:1463","journal-title":"J Clin Invest"},{"key":"42_CR17","first-page":"2618","volume":"61","author":"K Shimizu","year":"2001","unstructured":"Shimizu K, Thomas EK, Giedlin M, Mule JJ (2001) Enhancement of tumor lysate-pulsed and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein. Cancer Res 61:2618","journal-title":"Cancer Res"},{"key":"42_CR18","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nm1096-1122","volume":"2","author":"C Condon","year":"1996","unstructured":"Condon C, Watkins SC, Celluzzi CM, Thompson K, Falo LD Jr (1996) DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 2:1122","journal-title":"Nat Med"},{"key":"42_CR19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1084\/jem.188.6.1075","volume":"188","author":"A Porgador","year":"1998","unstructured":"Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN (1998) Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med 188:1075","journal-title":"J Exp Med"},{"key":"42_CR20","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.1690918","volume":"247","author":"JA Wolff","year":"1990","unstructured":"Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL (1990) Direct gene transfer into mouse muscle in vivo. Science 247:1465","journal-title":"Science"},{"key":"42_CR21","first-page":"262","volume":"3","author":"P Qiu","year":"1996","unstructured":"Qiu P, Ziegelhoffer P, Sun J, Yang NS (1996) Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization. Gene Ther 3:262","journal-title":"Gene Ther"},{"key":"42_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1521-4141(200001)30:1<1::AID-IMMU1>3.0.CO;2-#","volume":"30","author":"I Hoerr","year":"2000","unstructured":"Hoerr I, Obst R, Rammensee HG, Jung G (2000) In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol 30:1","journal-title":"Eur J Immunol"},{"key":"42_CR23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.184.2.465","volume":"184","author":"D Boczkowski","year":"1996","unstructured":"Boczkowski D, Nair SK, Snyder D, Gilboa E (1996) Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med 184:465","journal-title":"J Exp Med"},{"key":"42_CR24","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1084\/jem.186.7.1177","volume":"186","author":"DM Ashley","year":"1997","unstructured":"Ashley DM, Faiola B, Nair S, Hale LP, Bigner DD, Gilboa E (1997) Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J Exp Med 186:1177","journal-title":"J Exp Med"},{"key":"42_CR25","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1089\/10430349950018148","volume":"10","author":"W Zhang","year":"1999","unstructured":"Zhang W, He L, Yuan Z, Xie Z, Wang J, Hamada H, Cao X (1999) Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin. Hum Gene Ther 10:1151","journal-title":"Hum Gene Ther"},{"key":"42_CR26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/79519","volume":"6","author":"SK Nair","year":"2000","unstructured":"Nair SK, Heiser A, Boczkowski D, Majumdar A, Naoe M, Lebkowski JS, Vieweg J, Gilboa E (2000) Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. Nat Med 6:1011","journal-title":"Nat Med"},{"key":"42_CR27","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1046\/j.1523-1747.2000.00929.x","volume":"114","author":"RD Granstein","year":"2000","unstructured":"Granstein RD, Ding W, Ozawa H (2000) Induction of anti-tumor immunity with epidermal cells pulsed with tumor-derived RNA or intradermal administration of RNA. J Invest Dermatol 114:632","journal-title":"J Invest Dermatol"},{"key":"42_CR28","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1038\/sj.gt.3301326","volume":"7","author":"I Strobel","year":"2000","unstructured":"Strobel I, Berchtold S, Gotze A, Schulze U, Schuler G, Steinkasserer A (2000) Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes. Gene Ther 7:2028","journal-title":"Gene Ther"},{"key":"42_CR29","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00002371-200007000-00004","volume":"23","author":"C Thornburg","year":"2000","unstructured":"Thornburg C, Boczkowski D, Gilboa E, Nair SK (2000) Induction of cytotoxic T lymphocytes with dendritic cells transfected with human papillomavirus E6 and E7 RNA: implications for cervical cancer immunotherapy. J Immunother 23:412","journal-title":"J Immunother"},{"key":"42_CR30","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1080\/1042819021000002992","volume":"43","author":"Z Su","year":"2002","unstructured":"Su Z, Peluso MV, Raffegerst SH, Schendel DJ, Roskrow MA (2002) Antigen presenting cells transfected with LMP2a RNA induce CD4+ LMP2a-specific cytotoxic T lymphocytes, which kill via a Fas-independent mechanism. Leuk Lymphoma 43:1651","journal-title":"Leuk Lymphoma"},{"key":"42_CR31","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.4049\/jimmunol.165.8.4710","volume":"165","author":"D Weissman","year":"2000","unstructured":"Weissman D, Ni H, Scales D, Dude A, Capodici J, McGibney K, Abdool A, Isaacs SN, Cannon G, Kariko K (2000) HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response. J Immunol 165:4710","journal-title":"J Immunol"},{"key":"42_CR32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nbt0498-364","volume":"16","author":"SK Nair","year":"1998","unstructured":"Nair SK, Boczkowski D, Morse M, Cumming RI, Lyerly HK, Gilboa E (1998) Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat Biotechnol 16:364","journal-title":"Nat Biotechnol"},{"key":"42_CR33","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.4049\/jimmunol.164.10.5508","volume":"164","author":"A Heiser","year":"2000","unstructured":"Heiser A, Dahm P, Yancey DR, Maurice MA, Boczkowski D, Nair SK, Gilboa E, Vieweg J (2000) Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. J Immunol 164:5508","journal-title":"J Immunol"},{"key":"42_CR34","first-page":"5041","volume":"62","author":"Z Su","year":"2002","unstructured":"Su Z, Vieweg J, Weizer AZ, Dahm P, Yancey D, Turaga V, Higgins J, Boczkowski D, Gilboa E, Dannull J (2002) Enhanced induction of telomerase-specific CD4(+) T cells using dendritic cells transfected with RNA encoding a chimeric gene product. Cancer Res 62:5041","journal-title":"Cancer Res"},{"key":"42_CR35","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.4049\/jimmunol.170.11.5391","volume":"170","author":"M Zeis","year":"2003","unstructured":"Zeis M, Siegel S, Wagner A, Schmitz M, Marget M, Kuhl-Burmeister R, Adamzik I, Kabelitz D, Dreger P, Schmitz N, Heiser A (2003) Generation of cytotoxic responses in mice and human individuals against hematological malignancies using survivin-RNA-transfected dendritic cells. J Immunol 170:5391","journal-title":"J Immunol"},{"key":"42_CR36","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1182\/blood-2003-01-0198","volume":"102","author":"S Siegel","year":"2003","unstructured":"Siegel S, Wagner A, Kabelitz D, Marget M, Coggin J Jr, Barsoum A, Rohrer J, Schmitz N, Zeis M (2003) Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies. Blood 102:4416","journal-title":"Blood"},{"key":"42_CR37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ymthe.2004.02.011","volume":"9","author":"X Liao","year":"2004","unstructured":"Liao X, Li Y, Bonini C, Nair S, Gilboa E, Greenberg PD, Yee C (2004) Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. Mol Ther 9:757","journal-title":"Mol Ther"},{"key":"42_CR38","first-page":"1028","volume":"60","author":"D Boczkowski","year":"2000","unstructured":"Boczkowski D, Nair SK, Nam JH, Lyerly HK, Gilboa E (2000) Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Res 60:1028","journal-title":"Cancer Res"},{"key":"42_CR39","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4049\/jimmunol.166.5.2953","volume":"166","author":"A Heiser","year":"2001","unstructured":"Heiser A, Maurice MA, Yancey DR, Wu NZ, Dahm P, Pruitt SK, Boczkowski D, Nair SK, Ballo MS, Gilboa E, Vieweg J (2001) Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. J Immunol 166:2953","journal-title":"J Immunol"},{"key":"42_CR40","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1182\/blood-2002-04-1273","volume":"101","author":"C Milazzo","year":"2003","unstructured":"Milazzo C, Reichardt VL, Muller MR, Grunebach F, Brossart P (2003) Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA. Blood 101:977","journal-title":"Blood"},{"key":"42_CR41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.cgt.7700557","volume":"10","author":"A Nencioni","year":"2003","unstructured":"Nencioni A, Muller MR, Grunebach F, Garuti A, Mingari MC, Patrone F, Ballestrero A, Brossart P (2003) Dendritic cells transfected with tumor RNA for the induction of antitumor CTL in colorectal cancer. Cancer Gene Ther 10:209","journal-title":"Cancer Gene Ther"},{"key":"42_CR42","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1182\/blood-2003-06-2097","volume":"103","author":"MR Muller","year":"2004","unstructured":"Muller MR, Tsakou G, Grunebach F, Schmidt SM, Brossart P (2004) Induction of chronic lymphocytic leukemia (CLL)-specific CD4-mediated and CD8-mediated T-cell responses using RNA-transfected dendritic cells. Blood 103:1763","journal-title":"Blood"},{"key":"42_CR43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI0214364","volume":"109","author":"A Heiser","year":"2002","unstructured":"Heiser A, Coleman D, Dannull J, Yancey D, Maurice MA, Lallas CD, Dahm P, Niedzwiecki D, Gilboa E, Vieweg J (2002) Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest 109:409","journal-title":"J Clin Invest"},{"key":"42_CR44","first-page":"2127","volume":"63","author":"Z Su","year":"2003","unstructured":"Su Z, Dannull J, Heiser A, Yancey D, Pruitt S, Madden J, Coleman D, Niedzwiecki D, Gilboa E, Vieweg J (2003) Immunological and linical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. Cancer Res 63:2127","journal-title":"Cancer Res"},{"key":"42_CR45","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/00000658-200204000-00013","volume":"235","author":"SK Nair","year":"2002","unstructured":"Nair SK, Morse M, Boczkowski D, Cumming RI, Vasovic L, Gilboa E, Lyerly HK (2002) Induction of tumor-specific cytotoxic T lymphocytes in cancer patients by autologous tumor RNA-transfected dendritic cells. Ann Surg 235:540","journal-title":"Ann Surg"},{"key":"42_CR46","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00262-003-0408-5","volume":"52","author":"T Kobayashi","year":"2003","unstructured":"Kobayashi T, Yamanaka R, Homma J, Tsuchiya N, Yajima N, Yoshida S, Tanaka R (2003) Tumor mRNA-loaded dendritic cells elicit tumor-specific CD8(+) cytotoxic T cells in patients with malignant glioma. Cancer Immunol Immunother 52:632","journal-title":"Cancer Immunol Immunother"},{"key":"42_CR47","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","volume":"408","author":"H Hemmi","year":"2000","unstructured":"Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408:740","journal-title":"Nature"},{"key":"42_CR48","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","volume":"303","author":"F Heil","year":"2004","unstructured":"Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526","journal-title":"Science"},{"key":"42_CR49","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","volume":"303","author":"SS Diebold","year":"2004","unstructured":"Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529","journal-title":"Science"},{"key":"42_CR50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.0022-202X.2004.23538.x","volume":"124","author":"J Steitz","year":"2005","unstructured":"Steitz J, Bruck J, Lenz J, Buchs S, Tuting T (2005) Peripheral CD8+ T cell tolerance against melanocytic in the skin is regulated in two steps by CD4+ T cells and local inflammation: implications for the pathophysiology of vitiligo. J Invest Dermatol 124:144\u2013155","journal-title":"J Invest Dermatol"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-005-0042-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-005-0042-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-005-0042-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:32:58Z","timestamp":1558701178000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-005-0042-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,13]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["42"],"URL":"https:\/\/doi.org\/10.1007\/s00262-005-0042-5","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,13]]}}}