{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:30:53Z","timestamp":1792265453582,"version":"4.4.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,4,12]],"date-time":"2008-04-12T00:00:00Z","timestamp":1207958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00262-008-0515-4","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T08:23:17Z","timestamp":1207902197000},"page":"1719-1726","source":"Crossref","is-referenced-by-count":139,"title":["Molecular mechanisms of MHC class I abnormalities and APM components in human tumors"],"prefix":"10.1007","volume":"57","author":[{"given":"Barbara","family":"Seliger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,4,12]]},"reference":[{"key":"515_CR1","first-page":"4358","volume":"56","author":"RS Alpan","year":"1996","unstructured":"Alpan RS, Zhang M, Pardee AB (1996) Cell cycle-dependent expression of TAP1, TAP2, and HLA-B27 messenger RNAs in a human breast cancer cell line. Cancer Res 56:4358\u20134361","journal-title":"Cancer Res"},{"key":"515_CR2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-0-387-72005-0_13","volume":"601","author":"N Aptsiauri","year":"2007","unstructured":"Aptsiauri N, Cabrera T, Mendez R, Garcia-Lora A, Ruiz-Cabello F, Garrido F (2007) Role of altered expression of HLA class I molecules in cancer progression. Adv Exp Med Biol 601:123\u2013131","journal-title":"Adv Exp Med Biol"},{"key":"515_CR3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/01.ju.0000094807.95420.fe","volume":"171","author":"D Atkins","year":"2004","unstructured":"Atkins D, Ferrone S, Schmahl GE, Storkel S, Seliger B (2004) Down-regulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma? J Urol 171:885\u2013889","journal-title":"J Urol"},{"key":"515_CR4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4049\/jimmunol.176.2.905","volume":"176","author":"JD Bui","year":"2006","unstructured":"Bui JD, Carayannopoulos LN, Lanier LL, Yokoyama WM, Schreiber RD (2006) IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. J Immunol 176:905\u2013913","journal-title":"J Immunol"},{"key":"515_CR5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-3083.2007.01934.x","volume":"65","author":"CM Cabrera","year":"2007","unstructured":"Cabrera CM (2007) The double role of the endoplasmic reticulum chaperone tapasin in peptide optimization of HLA class I molecules. Scand J Immunol 65:487\u2013493","journal-title":"Scand J Immunol"},{"key":"515_CR6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1399-0039.2006.00777.x","volume":"69","author":"T Cabrera","year":"2007","unstructured":"Cabrera T, Maleno I, Collado A, Lopez Nevot MA, Tait BD, Garrido F (2007) Analysis of HLA class I alterations in tumors: choosing a strategy based on known patterns of underlying mechanisms. Tissue Antigens 69(Suppl 1):264\u2013268","journal-title":"Tissue Antigens"},{"issue":"4","key":"515_CR7","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1074\/jbc.M708196200","volume":"283","author":"JE Chambers","year":"2007","unstructured":"Chambers JE, Jessop CE, Bulleid NJ (2007) Formation of a MHC Class I-tapasin mixed disulfide indicates a change in spatial organization of the peptide loading complex during assembly. J Biol Chem 283(4):1862\u20131869","journal-title":"J Biol Chem"},{"key":"515_CR8","doi-asserted-by":"crossref","first-page":"18763","DOI":"10.1074\/jbc.M511525200","volume":"281","author":"CC Chang","year":"2006","unstructured":"Chang CC, Ogino T, Mullins DW, Oliver JL, Yamshchikov GV, Bandoh N, Slingluff CL Jr, Ferrone S (2006) Defective human leukocyte antigen class I-associated antigen presentation caused by a novel beta2-microglobulin loss-of-function in melanoma cells. J Biol Chem 281:18763\u201318773","journal-title":"J Biol Chem"},{"key":"515_CR9","doi-asserted-by":"crossref","first-page":"17107","DOI":"10.1073\/pnas.0500721102","volume":"102","author":"SC Chang","year":"2005","unstructured":"Chang SC, Momburg F, Bhutani N, Goldberg AL (2005) The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a \u201cmolecular ruler\u201d mechanism. Proc Natl Acad Sci USA 102:17107\u201317112","journal-title":"Proc Natl Acad Sci USA"},{"key":"515_CR10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00262-006-0183-1","volume":"56","author":"CC Chang","year":"2007","unstructured":"Chang CC, Ferrone S (2007) Immune selective pressure and HLA class I antigen defects in malignant lesions. Cancer Immunol Immunother 56:227\u2013236","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ng0696-210","volume":"13","author":"HL Chen","year":"1996","unstructured":"Chen HL, Gabrilovich D, Tampe R, Girgis KR, Nadaf S, Carbone DP (1996) A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer. Nat Genet 13:210\u2013213","journal-title":"Nat Genet"},{"key":"515_CR12","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3748\/wjg.v9.i8.1853","volume":"9","author":"XL Deng","year":"2003","unstructured":"Deng XL, Chen W, Cai MY, Wei DP (2003) Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma. World J Gastroenterol 9:1853\u20131855","journal-title":"World J Gastroenterol"},{"key":"515_CR13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","volume":"21","author":"GP Dunn","year":"2004","unstructured":"Dunn GP, Old LJ, Schreiber RD (2004) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21:137\u2013148","journal-title":"Immunity"},{"key":"515_CR14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","volume":"6","author":"GP Dunn","year":"2006","unstructured":"Dunn GP, Koebel CM, Schreiber RD (2006) Interferons, immunity and cancer immunoediting. Nat Rev Immunol 6:836\u2013848","journal-title":"Nat Rev Immunol"},{"key":"515_CR15","first-page":"87","volume":"30","author":"MA Fern\u00e1ndez","year":"2000","unstructured":"Fern\u00e1ndez MA, Ruiz-Cabello F, Oliva MR, Cabrera T, Jimenez P, L\u00f3pez Nevot MA, Garrido F (2000) Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors. Int J Clin Lab Res 30:87\u201392","journal-title":"Int J Clin Lab Res"},{"key":"515_CR16","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.4049\/jimmunol.176.8.4869","volume":"176","author":"D Fruci","year":"2006","unstructured":"Fruci D, Ferracuti S, Limongi MZ, Cunsolo V, Giorda E, Fraioli R, Sibilio L, Carroll O, Hattori A, van Endert PM et al (2006) Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia\/lymphoma, carcinoma, and melanoma cell lines. J Immunol 176:4869\u20134879","journal-title":"J Immunol"},{"key":"515_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0161-5890(02)00098-6","volume":"39","author":"AL Goldberg","year":"2002","unstructured":"Goldberg AL, Cascio P, Saric T, Rock KL (2002) The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. Mol Immunol 39:147\u2013164","journal-title":"Mol Immunol"},{"key":"515_CR18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0161-5890(98)00059-5","volume":"35","author":"B Gubler","year":"1998","unstructured":"Gubler B, Daniel S, Armandola EA, Hammer J, Caillat-Zucman S, van Endert PM (1998) Substrate selection by transporters associated with antigen processing occurs during peptide binding to TAP. Mol Immunol 35:427\u2013433","journal-title":"Mol Immunol"},{"key":"515_CR19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/intimm\/14.2.189","volume":"14","author":"Y Guo","year":"2002","unstructured":"Guo Y, Yang T, Liu X, Lu S, Wen J, Durbin JE, Liu Y, Zheng P (2002) Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator. Int Immunol 14:189\u2013200","journal-title":"Int Immunol"},{"key":"515_CR20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1182\/blood.V98.4.1108","volume":"98","author":"K Hallermalm","year":"2001","unstructured":"Hallermalm K, Seki K, Wei C, Castelli C, Rivoltini L, Kiessling R, Levitskaya J (2001) Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface. Blood 98:1108\u20131115","journal-title":"Blood"},{"key":"515_CR21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ni1286","volume":"7","author":"GE Hammer","year":"2006","unstructured":"Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N (2006) The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol 7:103\u2013112","journal-title":"Nat Immunol"},{"key":"515_CR22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni1409","volume":"8","author":"GE Hammer","year":"2007","unstructured":"Hammer GE, Gonzalez F, James E, Nolla H, Shastri N (2007) In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol 8:101\u2013108","journal-title":"Nat Immunol"},{"key":"515_CR23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.immuni.2007.04.003","volume":"26","author":"GE Hammer","year":"2007","unstructured":"Hammer GE, Kanaseki T, Shastri N (2007) The final touches make perfect the peptide-MHC class I repertoire. Immunity 26:397\u2013406","journal-title":"Immunity"},{"key":"515_CR24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-0039.1996.tb02603.x","volume":"48","author":"DJ Hicklin","year":"1996","unstructured":"Hicklin DJ, Kageshita T, Ferrone S (1996) Development and characterization of rabbit antisera to human MHC-linked transporters associated with antigen processing. Tissue Antigens 48:38\u201346","journal-title":"Tissue Antigens"},{"key":"515_CR25","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/path.2142","volume":"211","author":"T Hirata","year":"2007","unstructured":"Hirata T, Yamamoto H, Taniguchi H, Horiuchi S, Oki M, Adachi Y, Imai K, Shinomura Y (2007) Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability. J Pathol 211:516\u2013523","journal-title":"J Pathol"},{"key":"515_CR26","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/ni1516","volume":"8","author":"PE Jensen","year":"2007","unstructured":"Jensen PE (2007) Recent advances in antigen processing and presentation. Nat Immunol 8:1041\u20131048","journal-title":"Nat Immunol"},{"key":"515_CR27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<91::AID-IJC17>3.0.CO;2-4","volume":"83","author":"P Jimenez","year":"1999","unstructured":"Jimenez P, Canton J, Collado A, Cabrera T, Serrano A, Real LM, Garcia A, Ruiz-Cabello F, Garrido F (1999) Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors. Int J Cancer 83:91\u201397","journal-title":"Int J Cancer"},{"key":"515_CR28","first-page":"36","volume":"54","author":"J Kawamura","year":"2007","unstructured":"Kawamura J, Shimada Y, Kitaichi H, Komoto I, Hashimoto Y, Kaganoi J, Miyake M, Yamasaki S, Kondo K, Imamura M (2007) Clinicopathological significance of aminopeptidase N\/CD13 expression in human gastric carcinoma. Hepatogastroenterology 54:36\u201340","journal-title":"Hepatogastroenterology"},{"key":"515_CR29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1365-2249.1998.00513.x","volume":"111","author":"A Kehlen","year":"1998","unstructured":"Kehlen A, Gohring B, Langner J, Riemann D (1998) Regulation of the expression of aminopeptidase A, aminopeptidase N\/CD13 and dipeptidylpeptidase IV\/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators. Clin Exp Immunol 111:435\u2013441","journal-title":"Clin Exp Immunol"},{"key":"515_CR30","first-page":"8500","volume":"63","author":"A Kehlen","year":"2003","unstructured":"Kehlen A, Lendeckel U, Dralle H, Langner J, Hoang-Vu C (2003) Biological significance of aminopeptidase N\/CD13 in thyroid carcinomas. Cancer Res 63:8500\u20138506","journal-title":"Cancer Res"},{"issue":"5","key":"515_CR31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00262-007-0402-4","volume":"57","author":"AN Khan","year":"2007","unstructured":"Khan AN, Gregorie CJ, Tomasi TB (2007) Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. Cancer Immunol Immunother 57(5):647\u2013654","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR32","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni1483","volume":"8","author":"A Kienast","year":"2007","unstructured":"Kienast A, Preuss M, Winkler M, Dick TP (2007) Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nat Immunol 8:864\u2013872","journal-title":"Nat Immunol"},{"key":"515_CR33","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nature06309","volume":"450","author":"CM Koebel","year":"2007","unstructured":"Koebel CM, Vermi W, Swann JB, Zerafa N, Rodig SJ, Old LJ, Smyth MJ, Schreiber RD (2007) Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450:903\u2013907","journal-title":"Nature"},{"key":"515_CR34","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/intimm\/13.12.1515","volume":"13","author":"J Li","year":"2001","unstructured":"Li J, Schuler-Thurner B, Schuler G, Huber C, Seliger B (2001) Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation. Int Immunol 13:1515\u20131523","journal-title":"Int Immunol"},{"key":"515_CR35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.iy.13.040195.003103","volume":"13","author":"DR Madden","year":"1995","unstructured":"Madden DR (1995) The three-dimensional structure of peptide-MHC complexes. Annu Rev Immunol 13:587\u2013622","journal-title":"Annu Rev Immunol"},{"key":"515_CR36","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ijc.20000","volume":"109","author":"I Maleno","year":"2004","unstructured":"Maleno I, Lopez Nevot MA, Seliger B, Garrido F (2004) Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas. Int J Cancer 109:636\u2013638","journal-title":"Int J Cancer"},{"key":"515_CR37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2567.2007.02689.x","volume":"123","author":"J Manning","year":"2008","unstructured":"Manning J, Indrova M, Lubyova B, Pribylova H, Bieblova J, Hejnar J, Simova J, Jandlova T, Bubenik J, Reinis M (2008) Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. Immunology 123:218\u2013227","journal-title":"Immunology"},{"key":"515_CR38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00262-007-0362-8","volume":"57","author":"AM Mehta","year":"2008","unstructured":"Mehta AM, Jordanova ES, Kenter GG, Ferrone S, Fleuren GJ (2008) Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma. Cancer Immunol Immunother 57:197\u2013206","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR39","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1158\/1078-0432.CCR-04-2146","volume":"11","author":"M Meissner","year":"2005","unstructured":"Meissner M, Reichert TE, Kunkel M, Gooding W, Whiteside TL, Ferrone S, Seliger B (2005) Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. Clin Cancer Res 11:2552\u20132560","journal-title":"Clin Cancer Res"},{"issue":"5","key":"515_CR40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00262-007-0411-3","volume":"57","author":"R Mendez","year":"2008","unstructured":"Mendez R, Rodriguez T, Del Campo A, Monge E, Maleno I, Aptsiauri N, Jimenez P, Pedrinaci S, Pawelec G, Ruiz-Cabello F, Garrido F (2008) Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines. Cancer Immunol Immunother 57(5):719\u2013729","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR41","first-page":"1450","volume":"53","author":"A Menrad","year":"1993","unstructured":"Menrad A, Speicher D, Wacker J, Herlyn M (1993) Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells. Cancer Res 53:1450\u20131455","journal-title":"Cancer Res"},{"key":"515_CR42","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/carcin\/22.10.1615","volume":"22","author":"Y Nie","year":"2001","unstructured":"Nie Y, Yang G, Song Y, Zhao X, So C, Liao J, Wang LD, Yang CS (2001) DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas. Carcinogen 22:1615\u20131623","journal-title":"Carcinogen"},{"key":"515_CR43","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.10906","volume":"103","author":"A Paschen","year":"2003","unstructured":"Paschen A, M\u00e9ndez RM, Jimenez P, Sucker A, Ruiz-Cabello F, Song M, Garrido F, Schadendorf D (2003) Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events. Int J Cancer 103:759\u2013767","journal-title":"Int J Cancer"},{"key":"515_CR44","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.161.5.2099","volume":"161","author":"M Petersson","year":"1998","unstructured":"Petersson M, Charo J, Salazar-Onfray F, Noffz G, Mohaupt M, Qin Z, Klein G, Blankenstein T, Kiessling R (1998) Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1\/2 function in the prototype NK target YAC-1. J Immunol 161:2099\u20132105","journal-title":"J Immunol"},{"key":"515_CR45","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0198-8859(00)00171-3","volume":"61","author":"LM Ramal","year":"2000","unstructured":"Ramal LM, Maleno I, Cabrera T, Collado A, Ferron A, Lopez-Nevot MA, Garrido F (2000) Molecular strategies to define HLA haplotype loss in microdissected tumor cells. Hum Immunol 61:1001\u201312","journal-title":"Hum Immunol"},{"key":"515_CR46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF00172063","volume":"41","author":"HG Rammensee","year":"1995","unstructured":"Rammensee HG, Friede T, Stevanoviic S (1995) MHC ligands and peptide motifs: first listing. Immunogenetics 41:178\u2013228","journal-title":"Immunogenetics"},{"key":"515_CR47","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00262-005-0085-7","volume":"55","author":"N Ramnath","year":"2006","unstructured":"Ramnath N, Tan D, Li Q, Hylander BL, Bogner P, Ryes L, Ferrone S (2006) Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival? Cancer Immunol Immunother 55:891\u2013899","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR48","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20052494","volume":"203","author":"EA Reits","year":"2006","unstructured":"Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, Camphausen K, Luiten RM, de Ru AH, Neijssen J, Griekspoor A, Mesman E, Verreck FA, Spits H, Schlom J, van Veelen P, Neefjes JJ (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203:1259\u20131271","journal-title":"J Exp Med"},{"key":"515_CR49","first-page":"1211","volume":"19","author":"U Ritz","year":"2001","unstructured":"Ritz U, Momburg F, Pilch H, Huber C, Maeurer MJ, Seliger B (2001) Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma. Int J Oncol 19:1211\u20131220","journal-title":"Int J Oncol"},{"key":"515_CR50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2407-7-34","volume":"7","author":"T Rodriguez","year":"2007","unstructured":"Rodriguez T, Mendez R, Del Campo A, Jimenez P, Aptsiauri N, Garrido F, Ruiz-Cabello F (2007) Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines. BMC Cancer 7:34","journal-title":"BMC Cancer"},{"key":"515_CR51","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ijc.20499","volume":"113","author":"JM Romero","year":"2005","unstructured":"Romero JM, Jim\u00e9nez P, Cabrera T, C\u00f3zar JM, Pedrinaci S, Tallada M, Garrido F, Ruiz-Cabello F (2005) Coordinated downregulation of the antigen presentation machinery and HLA class I\/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer. Int J Cancer 113:605\u2013610","journal-title":"Int J Cancer"},{"key":"515_CR52","doi-asserted-by":"crossref","first-page":"17587","DOI":"10.1074\/jbc.M702212200","volume":"282","author":"SG Santos","year":"2007","unstructured":"Santos SG, Campbell EC, Lynch S, Wong V, Antoniou AN, Powis SJ (2007) Major histocompatibility complex class I-ERp57-tapasin interactions within the peptide-loading complex. J Biol Chem 282:17587\u201317593","journal-title":"J Biol Chem"},{"key":"515_CR53","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni1208","volume":"6","author":"L Saveanu","year":"2005","unstructured":"Saveanu L, Carroll O, Lindo V, Del Val M, Lopez D, Lepelletier Y, Greer F, Schomburg L, Fruci D, Niedermann G, van Endert PM (2005) Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol 6:689\u2013697","journal-title":"Nat Immunol"},{"key":"515_CR54","first-page":"1427","volume":"2","author":"B Seliger","year":"1996","unstructured":"Seliger B, Hohne A, Knuth A, Bernhard H, Ehring B, Tampe R, Huber C (1996) Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. Clin Cancer Res 2:1427\u20131433","journal-title":"Clin Cancer Res"},{"key":"515_CR55","first-page":"1756","volume":"56","author":"B Seliger","year":"1996","unstructured":"Seliger B, Hohne A, Knuth A, Bernhard H, Meyer T, Tampe R, Momburg F, Huber C (1996) Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression. Cancer Res 56:1756\u20131760","journal-title":"Cancer Res"},{"key":"515_CR56","first-page":"8647","volume":"61","author":"B Seliger","year":"2001","unstructured":"Seliger B, Ritz U, Abele R, Bock M, Tampe R, Sutter G, Drexler I, Huber C, Ferrone S (2001) Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway. Cancer Res 61:8647\u20138650","journal-title":"Cancer Res"},{"key":"515_CR57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2165\/00063030-200519060-00002","volume":"19","author":"B Seliger","year":"2005","unstructured":"Seliger B (2005) Strategies of tumor immune evasion. BioDrugs 19:347\u2013354","journal-title":"BioDrugs"},{"key":"515_CR58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ijc.21312","volume":"118","author":"B Seliger","year":"2006","unstructured":"Seliger B, Ritz U, Ferrone S (2006) Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. Int J Cancer 118:129\u2013138","journal-title":"Int J Cancer"},{"key":"515_CR59","doi-asserted-by":"crossref","first-page":"9167","DOI":"10.1158\/0008-5472.CAN-04-1442","volume":"64","author":"L Sigalotti","year":"2004","unstructured":"Sigalotti L, Fratta E, Coral S, Tanzarella S, Danielli R, Colizzi F, Fonsatti E, Traversari C, Altomonte M, Maio M (2004) Intratumor heterogeneity of cancer\/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2\u00b4-deoxycytidine. Cancer Res 64:9167\u20139171","journal-title":"Cancer Res"},{"key":"515_CR60","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1074-7613(02)00480-6","volume":"17","author":"MT Spiotto","year":"2002","unstructured":"Spiotto MT, Yu P, Rowley DA, Nishimura MI, Meredith SC, Gajewski TF, Fu YX, Schreiber H (2002) Increasing tumor antigen expression overcomes \u201cignorance\u201d to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17:737\u2013747","journal-title":"Immunity"},{"key":"515_CR61","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0968-0004(02)02090-X","volume":"27","author":"PM Endert van","year":"2002","unstructured":"van Endert PM, Saveanu L, Hewitt EW, Lehner P (2002) Powering the peptide pump: TAP crosstalk with energetic nucleotides. Trends Biochem Sci 27:454\u2013461","journal-title":"Trends Biochem Sci"},{"key":"515_CR62","doi-asserted-by":"crossref","first-page":"F780","DOI":"10.1152\/ajprenal.00148.2006","volume":"292","author":"A Varona","year":"2007","unstructured":"Varona A, Blanco L, Lopez JI, Gil J, Agirregoitia E, Irazusta J, Larrinaga G (2007) Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. Am J Physiol Renal Physiol 292:F780\u2013F788","journal-title":"Am J Physiol Renal Physiol"},{"key":"515_CR63","first-page":"8006","volume":"63","author":"S Vertuani","year":"2003","unstructured":"Vertuani S, De Geer A, Levitsky V, Kogner P, Kiessling R, Levitskaya J (2003) Retinoids act as multistep modulators of the major histocompatibility class I presentation pathway and sensitize neuroblastomas to cytotoxic lymphocytes. Cancer Res 63:8006\u20138013","journal-title":"Cancer Res"},{"key":"515_CR64","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00262-006-0185-z","volume":"56","author":"S Vertuani","year":"2007","unstructured":"Vertuani S, Dubrovska E, Levitsky V, Jager MJ, Kiessling R, Levitskaya J (2007) Retinoic acid elicits cytostatic, cytotoxic and immunomodulatory effects on uveal melanoma cells. Cancer Immunol Immunother 56:193\u2013204","journal-title":"Cancer Immunol Immunother"},{"key":"515_CR65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1158\/1078-0432.67.11.1","volume":"11","author":"M Vitale","year":"2005","unstructured":"Vitale M, Pelusi G, Taroni B, Gobbi G, Micheloni C, Rezzani R, Donato F, Wang X, Ferrone S (2005) HLA class I antigen down-regulation in primary ovary carcinoma lesions: association with disease stage. Clin Cancer Res 11:67\u201372","journal-title":"Clin Cancer Res"},{"key":"515_CR66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2005.00309.x","volume":"207","author":"JW Yewdell","year":"2005","unstructured":"Yewdell JW (2005) The seven dirty little secrets of major histocompatibility complex class I antigen processing. Immunol Rev 207:8\u201318","journal-title":"Immunol Rev"},{"key":"515_CR67","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1182\/blood.V90.6.2390","volume":"90","author":"R Zeidler","year":"1997","unstructured":"Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, Hammerschmidt W (1997) Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin\u201310. Blood 90:2390\u20132397","journal-title":"Blood"},{"key":"515_CR68","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1038\/sj.onc.1203235","volume":"18","author":"K Zhu","year":"1999","unstructured":"Zhu K, Wang J, Zhu J, Jiang J, Shou J, Chen X (1999) p53 induces TAP1 and enhances the transport of MHC class I peptides. Oncogene 18:7740\u20137747","journal-title":"Oncogene"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-008-0515-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-008-0515-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-008-0515-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T20:43:27Z","timestamp":1708807407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-008-0515-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,12]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["515"],"URL":"https:\/\/doi.org\/10.1007\/s00262-008-0515-4","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,12]]}}}