{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:48:23Z","timestamp":1790534903409,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s00262-008-0621-3","type":"journal-article","created":{"date-parts":[[2008,11,18]],"date-time":"2008-11-18T08:34:56Z","timestamp":1226997296000},"page":"1047-1055","source":"Crossref","is-referenced-by-count":28,"title":["Reduced levels of recent thymic emigrants in acute myeloid leukemia patients"],"prefix":"10.1007","volume":"58","author":[{"given":"Yangqiu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz K.","family":"Przybylski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,19]]},"reference":[{"key":"621_CR1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/cncr.22233","volume":"107","author":"B Deschler","year":"2006","unstructured":"Deschler B, L\u00fcbbert M (2006) Acute myeloid leukemia: epidemiology and etiology. Cancer 107:2099\u20132107","journal-title":"Cancer"},{"key":"621_CR2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1182\/asheducation-2007.1.420","volume":"2007","author":"HP Erba","year":"2007","unstructured":"Erba HP (2007) Prognostic factor in elderly patients with AML and the implications for treatment. Hematology Am Soc Hematol Educ Program 2007:420\u2013428","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"621_CR3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1567-5769(03)00060-2","volume":"3","author":"JW Hadden","year":"2003","unstructured":"Hadden JW (2003) Immunodeficiency and cancer: prospects for correction. Int Immunopharmacol 3:1061\u20131071","journal-title":"Int Immunopharmacol"},{"key":"621_CR4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0609.2003.00065.x","volume":"70","author":"RT Costello","year":"2003","unstructured":"Costello RT, Rey J, Fauriat C, Gastaut JA, Olive D (2003) New approaches in the immunotherapy of haematological malignancies. Eur J Haematol 70:333\u2013345","journal-title":"Eur J Haematol"},{"key":"621_CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/10245330400026196","volume":"10","author":"Y Li","year":"2005","unstructured":"Li Y, Chen S, Yang L, Zhou Y, Wu X, Huang M, Geng S (2005) Clonal expanded TCR V\u03b2 T cells in patients with APL. Hematology 10:135\u2013139","journal-title":"Hematology"},{"key":"621_CR6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/10245330500093591","volume":"10","author":"Y Li","year":"2005","unstructured":"Li Y (2005) Recent thymic output function in patients with hematological malignancy. Hematology 10:297\u2013305","journal-title":"Hematology"},{"key":"621_CR7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/335170a0","volume":"335","author":"JP Villartay De","year":"1998","unstructured":"De Villartay JP, Hockett R, Coran D, Korsmeyer SJ, Cohen DI (1998) Deletion of the human T-cell receptor \u03b4-gene by a site specific recombination. Nature 335:170\u2013174","journal-title":"Nature"},{"key":"621_CR8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/25374","volume":"396","author":"DC Douek","year":"1998","unstructured":"Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA (1998) Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690\u2013695","journal-title":"Nature"},{"key":"621_CR9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s001090100271","volume":"79","author":"MD Hazenberg","year":"2001","unstructured":"Hazenberg MD, Verschuren MC, Hamann D, Miedema F, van Dongen JJ (2001) T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med 79:631\u2013640","journal-title":"J Mol Med"},{"key":"621_CR10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1760305","volume":"176","author":"V Geenen","year":"2003","unstructured":"Geenen V, Poulin JF, Dion ML, Martens H, Castermans E, Hansenne I, Moutschen M, Sekaly RP, Cheynier R (2003) Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J Endocrinol 176:305\u2013311","journal-title":"J Endocrinol"},{"key":"621_CR11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-1759(00)00136-8","volume":"237","author":"L Al-Harthi","year":"2000","unstructured":"Al-Harthi L, Marchett G, Steffens CM, Poulin J, Sekaly R, Landay A (2000) Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J Immunol Methods 237:187\u2013197","journal-title":"J Immunol Methods"},{"key":"621_CR12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.190.4.479","volume":"190","author":"JF Poulin","year":"1999","unstructured":"Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, S\u00e9kaly RP (1999) Direct evidence for thymic function in adult humans. J Exp Med 190:479\u2013486","journal-title":"J Exp Med"},{"key":"621_CR13","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1182\/blood-2003-05-1428","volume":"102","author":"JF Poulin","year":"2003","unstructured":"Poulin JF, Sylvestre M, Champagne P, Dion ML, Kettaf N, Dumont A, Lainesse M, Fontaine P, Roy DC, Perreault C, S\u00e9kaly RP, Cheynier R (2003) Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease. Blood 102:4600\u20134607","journal-title":"Blood"},{"key":"621_CR14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ijc.10568","volume":"101","author":"E Petridou","year":"2002","unstructured":"Petridou E, Klimentopoulou AE, Moustaki M, Kostrikis LG, Hatzakis A, Trichopoulos D (2002) Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies. Int J Cancer 101:74\u201377","journal-title":"Int J Cancer"},{"issue":"11","key":"621_CR15","doi-asserted-by":"crossref","first-page":"614a","DOI":"10.1182\/blood.V104.11.614.614","volume":"104","author":"WN Haining","year":"2004","unstructured":"Haining WN, Evans J, Seth N, Callaway G, Wucherpfennig K, Nadler L, Guinan E (2004) Rapid T cell response to vaccination can occur without antibody response in children post HSCT. Blood 104(11):614a","journal-title":"Blood"},{"issue":"11","key":"621_CR16","first-page":"608a","volume":"102","author":"Y Li","year":"2003","unstructured":"Li Y, Yang L, Chen S, Wang Z, Wu X, Przybylski GK, Schmidt CA (2003) Recent thymic output function in patients with acute myelogenous leukemia. Blood 102(11):608a","journal-title":"Blood"},{"key":"621_CR17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20011756","volume":"195","author":"S Kimmig","year":"2002","unstructured":"Kimmig S, Przybylski GK, Schmidt CA, Laurisch K, Mowes B, Radbruch A, Thiel A (2002) Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med 195:789\u2013794","journal-title":"J Exp Med"},{"key":"621_CR18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.trim.2007.05.011","volume":"18","author":"Y Li","year":"2007","unstructured":"Li Y, Chen S, Yang L, Yin Q, Geng S, Wu X, Schmidt CA, Przybylski GK (2007) TRAV and TRBV repertoire, clonality and the proliferative history of umbilical cord blood T cells. Transplant Immunol 18:151\u2013158","journal-title":"Transplant Immunol"},{"key":"621_CR19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10245330310001621288","volume":"8","author":"Y Li","year":"2003","unstructured":"Li Y (2003) Leukemia associated clonal expansion TCR V\u03b2 subfamily T cells. Hematology 8:375\u2013384","journal-title":"Hematology"},{"key":"621_CR20","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.4049\/jimmunol.153.9.4281","volume":"153","author":"F Farace","year":"1994","unstructured":"Farace F, Orlanducci F, Dietrich PY, Gaudin C, Angevin E, Courtier MH, Bayle C, Hercend T, Triebel F (1994) T cell repertoire in patients with B chronic lymphocytic leukemia evidence for multiple in vivo T cell clonal expansions. J Immunol 153:4281\u20134290","journal-title":"J Immunol"},{"key":"621_CR21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00002371-199809000-00004","volume":"21","author":"N Alatrakchi","year":"1998","unstructured":"Alatrakchi N, Farace F, Frau E, Carde P, Munck JN, Triebel F (1998) T-cell clonal expansion in patients with B-cell lymphoproliferative disorders. J Immunother 21:363\u2013370","journal-title":"J Immunother"},{"key":"621_CR22","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.4049\/jimmunol.158.3.1482","volume":"158","author":"D Serrano","year":"1997","unstructured":"Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, Buchbinder A, Vinciguerra VP, Chiorazzi N, Gregersen PK (1997) Clonal expansion within the CD4+CD57+ and CD8+CD57+T cell subsets in chronic lymphocytic leukemia. J Immunol 158:1482\u20131489","journal-title":"J Immunol"},{"key":"621_CR23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ni0203-97","volume":"4","author":"MD Hazenberg","year":"2003","unstructured":"Hazenberg MD, Borghans JAM, de Boer RJ, Miedema F (2003) Thynic output: a bad TREC record. Nat Immunol 4:97\u201399","journal-title":"Nat Immunol"},{"key":"621_CR24","first-page":"477","volume":"22","author":"QS Yin","year":"2006","unstructured":"Yin QS, Li YQ, Chen SH, Yang LJ, Lu YH, Zhang XL (2006) Detection of TCR Vbeta subfamily sjTRECs in normal peripheral blood and cord blood. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (J Cell Mol Immunol) 22:477\u2013479","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (J Cell Mol Immunol)"},{"key":"621_CR25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2249.2001.01640.x","volume":"125","author":"J Pido-Lopez","year":"2001","unstructured":"Pido-Lopez J, Imami N, Aspinall R (2001) Both age and gender affect thymic output: more recent thymic migrants in females than males as they age. Clin Exp Immunol 125:409\u2013413","journal-title":"Clin Exp Immunol"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-008-0621-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-008-0621-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-008-0621-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T03:58:08Z","timestamp":1684641488000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-008-0621-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,19]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["621"],"URL":"https:\/\/doi.org\/10.1007\/s00262-008-0621-3","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,19]]}}}