{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T17:11:10Z","timestamp":1719767470852},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,4,10]],"date-time":"2009-04-10T00:00:00Z","timestamp":1239321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00262-009-0703-x","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T11:46:46Z","timestamp":1239277606000},"page":"1449-1457","source":"Crossref","is-referenced-by-count":11,"title":["BCR\/ABL-specific CD8+ T cells can be detected from CML patients, but are only expanded from healthy donors"],"prefix":"10.1007","volume":"58","author":[{"given":"Sylvie","family":"Rusakiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Madrigal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Travers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony I.","family":"Dodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,4,10]]},"reference":[{"issue":"5284","key":"703_CR1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","volume":"274","author":"JD Altman","year":"1996","unstructured":"Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274(5284):94\u201396","journal-title":"Science"},{"issue":"5","key":"703_CR2","first-page":"1931","volume":"6","author":"C Bertazzoli","year":"2000","unstructured":"Bertazzoli C, Marchesi E, Passoni L, Barni R, Ravagnani F, Lombardo C, Corneo GM, Pioltelli P, Pogliani E, Gambacorti-Passerini C (2000) Differential recognition of a BCR\/ABL peptide by lymphocytes from normal donors and chronic myeloid leukemia patients. Clin Cancer Res 6(5):1931\u20131935","journal-title":"Clin Cancer Res"},{"issue":"10","key":"703_CR3","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1182\/blood.V85.10.2680.bloodjournal85102680","volume":"85","author":"M Bocchia","year":"1995","unstructured":"Bocchia M, Wentworth PA, Southwood S, Sidney J, McGraw K, Scheinberg DA, Sette A (1995) Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules. Blood 85(10):2680\u20132684","journal-title":"Blood"},{"issue":"9460","key":"703_CR4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(05)17945-8","volume":"365","author":"M Bocchia","year":"2005","unstructured":"Bocchia M, Gentili S, Abruzzese E, Fanelli A, Iuliano F, Tabilio A, Amabile M, Forconi F, Gozzetti A, Raspadori D, Amadori S, Lauria F (2005) Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365(9460):657\u2013662","journal-title":"Lancet"},{"issue":"9","key":"703_CR5","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1182\/blood.V88.9.3522.bloodjournal8893522","volume":"88","author":"GJ Bosch","year":"1996","unstructured":"Bosch GJ, Joosten AM, Kessler JH, Melief CJ, Leeksma OC (1996) Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide. Blood 88(9):3522\u20133527","journal-title":"Blood"},{"issue":"8","key":"703_CR6","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood-2003-11-4086","volume":"103","author":"NM Butt","year":"2004","unstructured":"Butt NM, Wang L, Abu-Eisha HM, Christmas SE, Clark RE (2004) BCR-ABL-specific T cells can be detected in healthy donors and in chronic myeloid leukemia patients following allogeneic stem cell transplantation. Blood 103(8):3245","journal-title":"Blood"},{"issue":"10","key":"703_CR7","first-page":"1315","volume":"90","author":"NM Butt","year":"2005","unstructured":"Butt NM, Rojas JM, Wang L, Christmas SE, Abu-Eisha HM, Clark RE (2005) Circulating bcr-abl-specific CD8+ T cells in chronic myeloid leukemia patients and healthy subjects. Haematologica 90(10):1315\u20131323","journal-title":"Haematologica"},{"issue":"8","key":"703_CR8","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/eji.1830270834","volume":"27","author":"A Buzyn","year":"1997","unstructured":"Buzyn A, Ostankovitch M, Zerbib A, Kemula M, Connan F, Varet B, Guillet JG, Choppin J (1997) Peptides derived from the whole sequence of BCR-ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytes. Eur J Immunol 27(8):2066\u20132072","journal-title":"Eur J Immunol"},{"issue":"3","key":"703_CR9","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1182\/blood-2003-03-0954","volume":"103","author":"K Cathcart","year":"2004","unstructured":"Cathcart K, Pinilla-Ibarz J, Korontsvit T, Schwartz J, Zakhaleva V, Papadopoulos EB, Scheinberg DA (2004) A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia. Blood 103(3):1037\u20131042","journal-title":"Blood"},{"issue":"4","key":"703_CR10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1182\/blood.V89.4.1133","volume":"89","author":"A Choudhury","year":"1997","unstructured":"Choudhury A, Gajewski JL, Liang JC, Popat U, Claxton DF, Kliche KO, Andreeff M, Champlin RE (1997) Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 89(4):1133\u20131142","journal-title":"Blood"},{"issue":"10","key":"703_CR11","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1182\/blood.V98.10.2887","volume":"98","author":"RE Clark","year":"2001","unstructured":"Clark RE, Dodi IA, Hill SC, Lill JR, Aubert G, Macintyre AR, Rojas J, Bourdon A, Bonner PL, Wang L, Christmas SE, Travers PJ, Creaser CS, Rees RC, Madrigal JA (2001) Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood 98(10):2887\u20132893","journal-title":"Blood"},{"issue":"10","key":"703_CR12","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Goldman JM, Melo JV (2000) The molecular biology of chronic myeloid leukemia. Blood 96(10):3343\u20133356","journal-title":"Blood"},{"issue":"9","key":"703_CR13","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1182\/blood-2002-06-1841","volume":"101","author":"R Dong","year":"2003","unstructured":"Dong R, Cwynarski K, Entwistle A, Marelli-Berg F, Dazzi F, Simpson E, Goldman JM, Melo JV, Lechler RI, Bellantuono I, Ridley A, Lombardi G (2003) Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration. Blood 101(9):3560\u20133567","journal-title":"Blood"},{"issue":"12","key":"703_CR14","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.4049\/jimmunol.174.12.8210","volume":"174","author":"M Gannage","year":"2005","unstructured":"Gannage M, Abel M, Michallet AS, Delluc S, Lambert M, Giraudier S, Kratzer R, Niedermann G, Saveanu L, Guilhot F, Camoin L, Varet B, Buzyn A, Caillat-Zucman S (2005) Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy. J Immunol 174(12):8210\u20138218","journal-title":"J Immunol"},{"issue":"4","key":"703_CR15","first-page":"693","volume":"10","author":"G Greco","year":"1996","unstructured":"Greco G, Fruci D, Accapezzato D, Barnaba V, Nisini R, Alimena G, Montefusco E, Vigneti E, Butler R, Tanigaki N, Tosi R (1996) Two brc-abl junction peptides bind HLA-A3 molecules and allow specific induction of human cytotoxic T lymphocytes. Leukemia 10(4):693\u2013699","journal-title":"Leukemia"},{"issue":"11","key":"703_CR16","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1158\/0008-5472.CAN-05-2868","volume":"66","author":"F Grunebach","year":"2006","unstructured":"Grunebach F, Mirakaj V, Muller MR, Brummendorf T, Brossart P (2006) BCR-ABL is not an immunodominant antigen in chronic myelogenous leukemia. Cancer Res 66(11):5892\u20135900","journal-title":"Cancer Res"},{"issue":"10","key":"703_CR17","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/sj.leu.2404354","volume":"20","author":"JH Kessler","year":"2006","unstructured":"Kessler JH, Bres-Vloemans SA, van Veelen PA, de Ru A, Huijbers IJ, Camps M, Mulder A, Offringa R, Drijfhout JW, Leeksma OC, Ossendorp F, Melief CJ (2006) BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes. Leukemia 20(10):1738\u20131750","journal-title":"Leukemia"},{"issue":"1","key":"703_CR18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1182\/blood.V90.1.290","volume":"90","author":"SI Mannering","year":"1997","unstructured":"Mannering SI, McKenzie JL, Fearnley DB, Hart DN (1997) HLA-DR1-restricted bcr-abl (b3a2)-specific CD4+ T lymphocytes respond to dendritic cells pulsed with b3a2 peptide and antigen-presenting cells exposed to b3a2 containing cell lysates. Blood 90(1):290\u2013297","journal-title":"Blood"},{"issue":"3","key":"703_CR19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1182\/blood.V91.3.977","volume":"91","author":"M Nieda","year":"1998","unstructured":"Nieda M, Nicol A, Kikuchi A, Kashiwase K, Taylor K, Suzuki K, Tadokoro K, Juji T (1998) Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia. Blood 91(3):977\u2013983","journal-title":"Blood"},{"issue":"3","key":"703_CR20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1046\/j.1365-2141.2000.02090.x","volume":"109","author":"LC Norbury","year":"2000","unstructured":"Norbury LC, Clark RE, Christmas SE (2000) b3a2 BCR-ABL fusion peptides as targets for cytotoxic T cells in chronic myeloid leukaemia. Br J Haematol 109(3):616\u2013621","journal-title":"Br J Haematol"},{"issue":"2","key":"703_CR21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.leu.2401311","volume":"13","author":"Y Osman","year":"1999","unstructured":"Osman Y, Takahashi M, Zheng Z, Koike T, Toba K, Liu A, Furukawa T, Aoki S, Aizawa Y (1999) Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients. Leukemia 13(2):166\u2013174","journal-title":"Leukemia"},{"issue":"6","key":"703_CR22","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood.V88.6.2118.bloodjournal8862118","volume":"88","author":"G Pawelec","year":"1996","unstructured":"Pawelec G, Max H, Halder T, Bruserud O, Merl A, da Silva P, Kalbacher H (1996) BCR\/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors. Blood 88(6):2118\u20132124","journal-title":"Blood"},{"issue":"10","key":"703_CR23","first-page":"1324","volume":"90","author":"J Pinilla-Ibarz","year":"2005","unstructured":"Pinilla-Ibarz J, Korontsvit T, Zakhaleva V, Roberts W, Scheinberg DA (2005) Synthetic peptide analogs derived from bcr\/abl fusion proteins and the induction of heteroclitic human T-cell responses. Haematologica 90(10):1324\u20131332","journal-title":"Haematologica"},{"issue":"5","key":"703_CR24","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V95.5.1781.005k46_1781_1787","volume":"95","author":"J Pinilla-Ibarz","year":"2000","unstructured":"Pinilla-Ibarz J, Cathcart K, Korontsvit T, Soignet S, Bocchia M, Caggiano J, Lai L, Jimenez J, Kolitz J, Scheinberg DA (2000) Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 95(5):1781\u20131787","journal-title":"Blood"},{"issue":"9","key":"703_CR25","first-page":"1062","volume":"89","author":"EF Posthuma","year":"2004","unstructured":"Posthuma EF, van Bergen CA, Kester MG, de Paus RA, van Veelen PA, de Ru AH, Drijfhout JW, Lurvink EG, Willemze R, Falkenburg JH (2004) Proteosomal degradation of BCR\/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated. Haematologica 89(9):1062\u20131071","journal-title":"Haematologica"},{"issue":"11","key":"703_CR26","first-page":"3863","volume":"93","author":"EF Posthuma","year":"1999","unstructured":"Posthuma EF, Falkenburg JH, Apperley JF, Gratwohl A, Roosnek E, Hertenstein B, Schipper RF, Schreuder GM, D\u2019Amaro J, Oudshoorn M, van Biezen JH, Hermans J, Willemze R, Niederwieser D (1999) HLA-B8 and HLA-A3 coexpressed with HLA-B8 are associated with a reduced risk of the development of chronic myeloid leukemia. The Chronic Leukemia Working Party of the EBMT. Blood 93(11):3863\u20133865","journal-title":"Blood"},{"issue":"11","key":"703_CR27","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/sj.leu.2404858","volume":"21","author":"JM Rojas","year":"2007","unstructured":"Rojas JM, Knight K, Wang L, Clark RE (2007) Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study. Leukemia 21(11):2287\u20132295","journal-title":"Leukemia"},{"issue":"5405","key":"703_CR28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"JD Rowley","year":"1973","unstructured":"Rowley JD (1973) Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243(5405):290\u2013293","journal-title":"Nature"},{"issue":"8","key":"703_CR29","first-page":"1344","volume":"9","author":"GJ ten Bosch","year":"1995","unstructured":"ten Bosch GJ, Toornvliet AC, Friede T, Melief CJ, Leeksma OC (1995) Recognition of peptides corresponding to the joining region of p210BCR-ABL protein by human T cells. Leukemia 9(8):1344\u20131348","journal-title":"Leukemia"},{"issue":"11","key":"703_CR30","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1158\/0008-5472.CAN-06-3737","volume":"67","author":"G Volpe","year":"2007","unstructured":"Volpe G, Cignetti A, Panuzzo C, Kuka M, Vitaggio K, Brancaccio M, Perrone G, Rinaldi M, Prato G, Fava M, Geuna M, Pautasso M, Casnici C, Signori E, Tonon G, Tarone G, Marelli O, Fazio VM, Saglio G (2007) Alternative BCR\/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67(11):5300\u20135307","journal-title":"Cancer Res"},{"issue":"2","key":"703_CR31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2141.2004.04873.x","volume":"125","author":"J Westermann","year":"2004","unstructured":"Westermann J, Schlimper C, Richter G, Mohm J, Dorken B, Pezzutto A (2004) T cell recognition of bcr\/abl in healthy donors and in patients with chronic myeloid leukaemia. Br J Haematol 125(2):213\u2013216","journal-title":"Br J Haematol"},{"issue":"5","key":"703_CR32","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1182\/blood.V98.5.1498","volume":"98","author":"M Yasukawa","year":"2001","unstructured":"Yasukawa M, Ohminami H, Kojima K, Hato T, Hasegawa A, Takahashi T, Hirai H, Fujita S (2001) HLA class II-restricted antigen presentation of endogenous bcr-abl fusion protein by chronic myelogenous leukemia-derived dendritic cells to CD4(+) T lymphocytes. Blood 98(5):1498\u20131505","journal-title":"Blood"},{"issue":"9","key":"703_CR33","first-page":"3355","volume":"92","author":"M Yasukawa","year":"1998","unstructured":"Yasukawa M, Ohminami H, Kaneko S, Yakushijin Y, Nishimura Y, Inokuchi K, Miyakuni T, Nakao S, Kishi K, Kubonishi I, Dan K, Fujita S (1998) CD4(+) cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner. Blood 92(9):3355\u20133361","journal-title":"Blood"},{"issue":"10","key":"703_CR34","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1172\/JCI488","volume":"101","author":"P Yotnda","year":"1998","unstructured":"Yotnda P, Firat H, Garcia-Pons F, Garcia Z, Gourru G, Vernant JP, Lemonnier FA, Leblond V, Langlade-Demoyen P (1998) Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia. J Clin Invest 101(10):2290\u20132296","journal-title":"J Clin Invest"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-009-0703-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-009-0703-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-009-0703-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T11:40:24Z","timestamp":1589715624000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-009-0703-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,10]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["703"],"URL":"https:\/\/doi.org\/10.1007\/s00262-009-0703-x","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,10]]}}}