{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:11:13Z","timestamp":1791155473229,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s00262-012-1246-0","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T07:02:20Z","timestamp":1334646140000},"page":"1511-1520","source":"Crossref","is-referenced-by-count":81,"title":["The roles of mast cells in anticancer immunity"],"prefix":"10.1007","volume":"61","author":[{"given":"Dyana K.","family":"Dalton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph J.","family":"Noelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"issue":"6024","key":"1246_CR1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"RD Schreiber","year":"2011","unstructured":"Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion. Science 331(6024):1565\u20131570. doi: 10.1126\/science.1203486","journal-title":"Science"},{"issue":"1","key":"1246_CR2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0952-7915(99)80010-7","volume":"11","author":"SJ Galli","year":"1999","unstructured":"Galli SJ, Maurer M, Lantz CS (1999) Mast cells as sentinels of innate immunity. Curr Opin Immunol 11(1):53\u201359. doi: 10.1016\/S0952-7915(99)80010-7","journal-title":"Curr Opin Immunol"},{"issue":"6","key":"1246_CR3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","volume":"8","author":"SJ Galli","year":"2008","unstructured":"Galli SJ, Grimbaldeston M, Tsai M (2008) Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 8(6):478\u2013486. doi: 10.1038\/nri2327","journal-title":"Nat Rev Immunol"},{"key":"1246_CR4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature05010","volume":"442","author":"LF Lu","year":"2006","unstructured":"Lu LF, Lind EF, Gondek DC et al (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442:997\u20131002. doi: 10.1038\/nature05010","journal-title":"Nature"},{"issue":"1","key":"1246_CR5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/DAD.0b013e31815c932a","volume":"30","author":"TW Beer","year":"2008","unstructured":"Beer TW, Ng LB, Murray K (2008) Mast cells have prognostic value in Merkel cell carcinoma. Am J Dermatopathol 30(1):27\u201330. doi: 10.1097\/DAD.0b013e31815c932a","journal-title":"Am J Dermatopathol"},{"issue":"5","key":"1246_CR6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1046\/j.1365-2362.2003.01152.x","volume":"33","author":"D Ribatti","year":"2003","unstructured":"Ribatti D, Ennas MG, Vacca A, Ferreli F, Nico B, Orru S, Sirigu P (2003) Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest 33(5):420\u2013425","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"1246_CR7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0560.1998.tb01683.x","volume":"25","author":"LM Duncan","year":"1998","unstructured":"Duncan LM, Richards LA, Mihm MC Jr (1998) Increased mast cell density in invasive melanoma. J Cutan Pathol 25(1):11\u201315","journal-title":"J Cutan Pathol"},{"issue":"1","key":"1246_CR8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2141.2002.03768.x","volume":"119","author":"D Molin","year":"2002","unstructured":"Molin D, Edstrom A, Glimelius I, Glimelius B, Nilsson G, Sundstrom C, Enblad G (2002) Mast cell infiltration correlates with poor prognosis in Hodgkin\u2019s lymphoma. Br J Haematol 119(1):122\u2013124. doi: 10.1111\/j.1600-0560","journal-title":"Br J Haematol"},{"issue":"50","key":"1246_CR9","doi-asserted-by":"crossref","first-page":"19977","DOI":"10.1073\/pnas.0704620104","volume":"104","author":"E Gounaris","year":"2007","unstructured":"Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K (2007) Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci USA 104(50):19977\u201319982. doi: 10.1073\/pnas.0704620104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1246_CR10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.dld.2004.09.028","volume":"37","author":"MF Acikalin","year":"2005","unstructured":"Acikalin MF, Oner U, Topcu I, Yasar B, Kiper H, Colak E (2005) Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. Dig Liver Dis 37(3):162\u2013169. doi: 10.1016\/j.dld.2004.09.028","journal-title":"Dig Liver Dis"},{"issue":"7","key":"1246_CR11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1440-1746.2007.05009.x","volume":"24","author":"M Gulubova","year":"2009","unstructured":"Gulubova M, Vlaykova T (2009) Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol 24(7):1265\u20131275. doi: 10.1111\/j.1440-1746.2007.05009.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"1246_CR12","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/jcp.2003.014498","volume":"57","author":"I Esposito","year":"2004","unstructured":"Esposito I, Menicagli M, Funel N, Bergmann F, Boggi U, Mosca F, Bevilacqua G, Campani D (2004) Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol 57(6):630\u2013636","journal-title":"J Clin Pathol"},{"issue":"4","key":"1246_CR13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.surg.2010.10.009","volume":"149","author":"SW Cai","year":"2011","unstructured":"Cai SW, Yang SZ, Gao J, Pan K, Chen JY, Wang YL, Wei LX, Dong JH (2011) Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma. Surgery 149(4):576\u2013584. doi: 10.1016\/j.surg.2010.10.009","journal-title":"Surgery"},{"issue":"8","key":"1246_CR14","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/1078-0432.CCR-09-1230","volume":"16","author":"MJ Strouch","year":"2010","unstructured":"Strouch MJ, Cheon EC, Salabat MR, Krantz SB, Gounaris E, Melstrom LG, Dangi-Garimella S, Wang E, Munshi HG, Khazaie K, Bentrem DJ (2010) Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res 16(8):2257\u20132265. doi: 10.1158\/1078-0432.CCR-09-1230","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1246_CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10549-007-9546-3","volume":"107","author":"ABTD Rajput","year":"2008","unstructured":"Rajput ABTD, Cheang MC, Voduc DK, Leung S, Gelmon KA, Gilks CB, Huntsman DG (2008) Stromal mast cells in invasive breast cancer are a marker of favorable prognosis: a study of 4,444 cases. Breast Cancer Res Treat 107(2):249\u2013257","journal-title":"Breast Cancer Res Treat"},{"issue":"4B","key":"1246_CR16","first-page":"2465","volume":"27","author":"F Rovere della","year":"2007","unstructured":"della Rovere F, Granata A, Familiari D, D\u2019Arrigo G, Mondello B, Basile G (2007) Mast cells in invasive ductal breast cancer: different behavior in high and minimum hormone-receptive cancers. Anticancer Res 27(4B):2465\u20132471","journal-title":"Anticancer Res"},{"issue":"18","key":"1246_CR17","first-page":"4199","volume":"58","author":"JL Gooch","year":"1998","unstructured":"Gooch JL, Lee AV, Yee D (1998) Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. Cancer Res 58(18):4199\u20134205","journal-title":"Cancer Res"},{"issue":"2","key":"1246_CR18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2353\/ajpath.2010.100070","volume":"177","author":"A Johansson","year":"2010","unstructured":"Johansson A, Rudolfsson S, Hammarsten P, Halin S, Pietras K, Jones J, Stattin P, Egevad L, Granfors T, Wikstrom P, Bergh A (2010) Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy. Am J Pathol 177(2):1031\u20131041. doi: 10.2353\/ajpath.2010.100070","journal-title":"Am J Pathol"},{"issue":"35","key":"1246_CR19","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1200\/JCO.2005.01.4910","volume":"23","author":"TJ Welsh","year":"2005","unstructured":"Welsh TJ, Green RH, Richardson D, Waller DA, O\u2019Byrne KJ, Bradding P (2005) Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 23(35):8959\u20138967. doi: 10.1200\/JCO.2005.01.4910","journal-title":"J Clin Oncol"},{"issue":"4","key":"1246_CR20","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1182\/blood-2008-03-147033","volume":"112","author":"B Huang","year":"2008","unstructured":"Huang B, Lei Z, Zhang GM et al (2008) SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood 112(4):1269\u20131279","journal-title":"Blood"},{"issue":"3","key":"1246_CR21","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0002-9440(10)62055-X","volume":"167","author":"MA Grimbaldeston","year":"2005","unstructured":"Grimbaldeston MA, Chen CC, Piliponsky AM et al (2005) Mast cell-deficient W-sash c-kit mutant KitW-sh\/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167(3):835\u2013848","journal-title":"Am J Pathol"},{"issue":"1","key":"1246_CR22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2222.2005.02136.x","volume":"35","author":"PJ Wolters","year":"2005","unstructured":"Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH (2005) Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)\/Kit(W-sh) sash mice. Clin Exp Allergy 35(1):82\u201388. doi: 10.1111\/j.1365-2222.2005.02136.x","journal-title":"Clin Exp Allergy"},{"key":"1246_CR23","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1101\/gad.13.11.1382","volume":"13","author":"LM Coussens","year":"1999","unstructured":"Coussens LM, Raymond WW, Bergers G et al (1999) Inflammatory cells up-regualate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 13:1382\u20131397","journal-title":"Genes Dev"},{"issue":"10","key":"1246_CR24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nm1649","volume":"13","author":"L Soucek","year":"2007","unstructured":"Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI (2007) Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13(10):1211\u20131218. doi: 10.1038\/nm1649","journal-title":"Nat Med"},{"key":"1246_CR25","doi-asserted-by":"crossref","first-page":"19977","DOI":"10.1073\/pnas.0704620104","volume":"104","author":"E Gounaris","year":"2007","unstructured":"Gounaris E, Erdman S, Restaino C et al (2007) Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A 104:19977\u201319982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1246_CR26","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1111\/j.1600-6143.2009.02755.x","volume":"9","author":"VC Vries de","year":"2009","unstructured":"de Vries VC, Wasiuk A, Bennett KA, Benson MJ, Elgueta R, Waldschmidt TJ, Noelle RJ (2009) Mast cell degranulation breaks peripheral tolerance. Am J Transplant 9(10):2270\u20132280. doi: 10.1111\/j.1600-6143.2009.02755.x","journal-title":"Am J Transplant"},{"issue":"4","key":"1246_CR27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.immuni.2011.09.012","volume":"35","author":"VC Vries de","year":"2011","unstructured":"de Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C, Noelle RJ (2011) Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35(4):550\u2013561. doi: 10.1016\/j.immuni.2011.09.012","journal-title":"Immunity"},{"issue":"11","key":"1246_CR28","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.4049\/jimmunol.1001137","volume":"185","author":"SA Oldford","year":"2010","unstructured":"Oldford SA, Haidl ID, Howatt MA, Leiva CA, Johnston B, Marshall JS (2010) A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth. J Immunol 185(11):7067\u20137076. doi: 10.4049\/jimmunol.1001137","journal-title":"J Immunol"},{"issue":"10","key":"1246_CR29","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1398-9995.2008.01768.x","volume":"63","author":"E Jensen-Jarolim","year":"2008","unstructured":"Jensen-Jarolim E, Achatz G, Turner MC, Karagiannis S, Legrand F, Capron M, Penichet ML, Rodriguez JA, Siccardi AG, Vangelista L, Riemer AB, Gould H (2008) AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy 63(10):1255\u20131266. doi: 10.1111\/j.1398-9995.2008.01768.x","journal-title":"Allergy"},{"issue":"14","key":"1246_CR30","first-page":"5517","volume":"61","author":"E Reali","year":"2001","unstructured":"Reali E, Greiner JW, Corti A, Gould HJ, Bottazzoli F, Paganelli G, Schlom J, Siccardi AG (2001) IgEs targeted on tumor cells: therapeutic activity and potential in the design of tumor vaccines. Cancer Res 61(14):5517\u20135522","journal-title":"Cancer Res"},{"issue":"11","key":"1246_CR31","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3527::AID-IMMU3527>3.0.CO;2-5","volume":"29","author":"HJ Gould","year":"1999","unstructured":"Gould HJ, Mackay GA, Karagiannis SN, O\u2019Toole CM, Marsh PJ, Daniel BE, Coney LR, Zurawski VR Jr, Joseph M, Capron M, Gilbert M, Murphy GF, Korngold R (1999) Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol 29(11):3527\u20133537. doi: 10.1002\/(SICI)1521-4141(199911)29:11<3527:AID-IMMU3527>3.0.CO;2-5","journal-title":"Eur J Immunol"},{"issue":"21","key":"1246_CR32","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1158\/1078-0432.CCR-07-0692","volume":"13","author":"KH Bramswig","year":"2007","unstructured":"Bramswig KH, Knittelfelder R, Gruber S, Untersmayr E, Riemer AB, Szalai K, Horvat R, Kammerer R, Zimmermann W, Zielinski CC, Scheiner O, Jensen-Jarolim E (2007) Immunization with mimotopes prevents growth of carcinoembryonic antigen positive tumors in BALB\/c mice. Clin Cancer Res 13(21):6501\u20136508. doi: 10.1158\/1078-0432.CCR-07-0692","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1246_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2007.07.008","volume":"113","author":"AB Riemer","year":"2007","unstructured":"Riemer AB, Jensen-Jarolim E (2007) Mimotope vaccines: epitope mimics induce anti-cancer antibodies. Immunol Lett 113(1):1\u20135. doi: 10.1016\/j.imlet.2007.07.008","journal-title":"Immunol Lett"},{"issue":"7","key":"1246_CR34","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1158\/0008-5472.CAN-06-3758","volume":"67","author":"AB Riemer","year":"2007","unstructured":"Riemer AB, Untersmayr E, Knittelfelder R, Duschl A, Pehamberger H, Zielinski CC, Scheiner O, Jensen-Jarolim E (2007) Active induction of tumor-specific IgE antibodies by oral mimotope vaccination. Cancer Res 67(7):3406\u20133411. doi: 10.1158\/0008-5472.CAN-06-3758","journal-title":"Cancer Res"},{"issue":"6","key":"1246_CR35","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1158\/0008-5472.CAN-08-2654","volume":"69","author":"M Camus","year":"2009","unstructured":"Camus M, Tosolini M, Mlecnik B, Pages F, Kirilovsky A, Berger A, Costes A, Bindea G, Charoentong P, Bruneval P, Trajanoski Z, Fridman WH, Galon J (2009) Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res 69(6):2685\u20132693. doi: 10.1158\/0008-5472.CAN-08-2654","journal-title":"Cancer Res"},{"issue":"7","key":"1246_CR36","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5","volume":"77","author":"CG Clemente","year":"1996","unstructured":"Clemente CG, Mihm MC Jr, Bufalino R, Zurrida S, Collini P, Cascinelli N (1996) Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 77(7):1303\u20131310. doi: 10.1002\/(SICI)1097-0142(19960401)77:7<1303:AID-CNCR12>3.0.CO;2-5","journal-title":"Cancer"},{"issue":"27","key":"1246_CR37","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1200\/JCO.2007.15.0284","volume":"26","author":"MC Dieu-Nosjean","year":"2008","unstructured":"Dieu-Nosjean MC, Antoine M, Danel C, Heudes D, Wislez M, Poulot V, Rabbe N, Laurans L, Tartour E, de Chaisemartin L, Lebecque S, Fridman WH, Cadranel J (2008) Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 26(27):4410\u20134417. doi: 10.1200\/JCO.2007.15.0284","journal-title":"J Clin Oncol"},{"issue":"5795","key":"1246_CR38","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","volume":"313","author":"J Galon","year":"2006","unstructured":"Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoue F, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Pages F (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795):1960\u20131964. doi: 10.1126\/science.1129139","journal-title":"Science"},{"issue":"16","key":"1246_CR39","first-page":"3491","volume":"58","author":"Y Naito","year":"1998","unstructured":"Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H (1998) CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58(16):3491\u20133494","journal-title":"Cancer Res"},{"issue":"2 Pt 1","key":"1246_CR40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1158\/1078-0432.498.11.2","volume":"11","author":"E Ryschich","year":"2005","unstructured":"Ryschich E, Notzel T, Hinz U, Autschbach F, Ferguson J, Simon I, Weitz J, Frohlich B, Klar E, Buchler MW, Schmidt J (2005) Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma. Clin Cancer Res 11(2 Pt 1):498\u2013504. doi: 10.1034\/j.1399-0039.2003","journal-title":"Clin Cancer Res"},{"issue":"51","key":"1246_CR41","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1073\/pnas.0509182102","volume":"102","author":"E Sato","year":"2005","unstructured":"Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, Jungbluth AA, Frosina D, Gnjatic S, Ambrosone C, Kepner J, Odunsi T, Ritter G, Lele S, Chen YT, Ohtani H, Old LJ, Odunsi K (2005) Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102(51):18538\u201318543. doi: 10.1073\/pnas.0509182102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1246_CR42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa020177","volume":"348","author":"L Zhang","year":"2003","unstructured":"Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348(3):203\u2013213. doi: 10.1056\/NEJMoa020177","journal-title":"N Engl J Med"},{"issue":"10","key":"1246_CR43","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00262-008-0524-3","volume":"57","author":"AW Griffioen","year":"2008","unstructured":"Griffioen AW (2008) Anti-angiogenesis: making the tumor vulnerable to the immune system. Cancer Immunol Immunother 57(10):1553\u20131558. doi: 10.1007\/s00262-008-0524-3","journal-title":"Cancer Immunol Immunother"},{"issue":"10","key":"1246_CR44","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nri3064","volume":"11","author":"GT Motz","year":"2011","unstructured":"Motz GT, Coukos G (2011) The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat Rev Immunol 11(10):702\u2013711. doi: 10.1038\/nri3064","journal-title":"Nat Rev Immunol"},{"key":"1246_CR45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-pathol-011110-130224","volume":"6","author":"WA Muller","year":"2011","unstructured":"Muller WA (2011) Mechanisms of leukocyte transendothelial migration. Annu Rev Pathol 6:323\u2013344. doi: 10.1146\/annurev-pathol-011110-130224","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"1246_CR46","first-page":"2322","volume":"63","author":"AE Dirkx","year":"2003","unstructured":"Dirkx AE, Oude Egbrink MG, Kuijpers MJ, van der Niet ST, Heijnen VV, Bouma-ter Steege JC, Wagstaff J, Griffioen AW (2003) Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer Res 63(9):2322\u20132329","journal-title":"Cancer Res"},{"issue":"6","key":"1246_CR47","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1096\/fj.05-4493com","volume":"20","author":"AE Dirkx","year":"2006","unstructured":"Dirkx AE, oude Egbrink MG, Castermans K, van der Schaft DW, Thijssen VL, Dings RP, Kwee L, Mayo KH, Wagstaff J, Bouma-ter Steege JC, Griffioen AW (2006) Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J 20(6):621\u2013630. doi: 10.1096\/fj.05-4493com","journal-title":"FASEB J"},{"issue":"13","key":"1246_CR48","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1158\/1078-0432.CCR-07-0374","volume":"13","author":"EA Manning","year":"2007","unstructured":"Manning EA, Ullman JG, Leatherman JM, Asquith JM, Hansen TR, Armstrong TD, Hicklin DJ, Jaffee EM, Emens LA (2007) A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism. Clin Cancer Res 13(13):3951\u20133959. doi: 10.1158\/1078-0432.CCR-07-0374","journal-title":"Clin Cancer Res"},{"issue":"15","key":"1246_CR49","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1158\/0008-5472.CAN-10-0153","volume":"70","author":"RK Shrimali","year":"2010","unstructured":"Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA (2010) Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 70(15):6171\u20136180. doi: 10.1158\/0008-5472.CAN-10-0153","journal-title":"Cancer Res"},{"issue":"5A","key":"1246_CR50","first-page":"2679","volume":"28","author":"D Patel","year":"2008","unstructured":"Patel D, Bassi R, Hooper AT, Sun H, Huber J, Hicklin DJ, Kang X (2008) Enhanced suppression of melanoma tumor growth and metastasis by combined therapy with anti-VEGF receptor and anti-TYRP-1\/gp75 monoclonal antibodies. Anticancer Res 28(5A):2679\u20132686","journal-title":"Anticancer Res"},{"key":"1246_CR51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","volume":"6","author":"SJ Galli","year":"2005","unstructured":"Galli SJ, Nakae S, Tsai M (2005) Mast cells in the development of adaptive immune responses. Nat Immunol 6:135\u2013142","journal-title":"Nat Immunol"},{"key":"1246_CR52","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.4049\/jimmunol.170.10.4943","volume":"170","author":"P Gosset","year":"2003","unstructured":"Gosset P, Bureau F, Angeli V et al (2003) Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. J Immunol 170:4943\u20134952","journal-title":"J Immunol"},{"key":"1246_CR53","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/ni1503","volume":"8","author":"MA Grimbaldeston","year":"2007","unstructured":"Grimbaldeston MA, Nakae S, Kalesnikoff J et al (2007) Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8:1095\u20131104","journal-title":"Nat Immunol"},{"key":"1246_CR54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4049\/jimmunol.159.1.28","volume":"159","author":"PHC Kalinski","year":"1997","unstructured":"Kalinski PHC, Snijders A et al (1997) IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2 promote type 2 cytokine production in maturing human naive Th cells. J Immunol 159:28","journal-title":"J Immunol"},{"issue":"12","key":"1246_CR55","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/intimm\/dxl113","volume":"18","author":"T Kitawaki","year":"2006","unstructured":"Kitawaki T, Kadowaki N, Sugimoto N, Kambe N, Hori T, Miyachi Y, Nakahata T, Uchiyama T (2006) IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells. Int Immunol 18(12):1789\u20131799. doi: 10.1093\/intimm\/dxl113","journal-title":"Int Immunol"},{"issue":"4","key":"1246_CR56","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2567.2006.02326.x","volume":"117","author":"A McIlroy","year":"2006","unstructured":"McIlroy A, Caron G, Blanchard S, Fremaux I, Duluc D, Delneste Y, Chevailler A, Jeannin P (2006) Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Immunology 117(4):507\u2013516. doi: 10.1111\/j.1365-2567.2006.02326.x","journal-title":"Immunology"},{"issue":"3","key":"1246_CR57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000069515","volume":"130","author":"M Aoki","year":"2003","unstructured":"Aoki M, Pawankar R, Niimi Y, Kawana S (2003) Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol 130(3):216\u2013223. doi: 10.1159\/000069515","journal-title":"Int Arch Allergy Immunol"},{"key":"1246_CR58","author":"JJ Wei","year":"2011","unstructured":"Wei JJ, Song CW, Sun LC, Yuan Y, Li D, Yan B, Liao SJ, Zhu JH, Wang Q, Zhang GM, Feng ZH (2011) SCF and TLR4 ligand cooperate to augment the tumor-promoting potential of mast cells. Cancer Immunol Immunother. doi: 10.1007\/s00262-011-1098-z","journal-title":"Cancer Immunol Immunother"},{"issue":"11","key":"1246_CR59","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1182\/blood.V92.11.4150","volume":"92","author":"D Gabrilovich","year":"1998","unstructured":"Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, Carbone DP (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92(11):4150\u20134166","journal-title":"Blood"},{"issue":"12","key":"1246_CR60","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/bjc.1998.725","volume":"78","author":"H Saito","year":"1998","unstructured":"Saito H, Tsujitani S, Ikeguchi M, Maeta M, Kaibara N (1998) Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue. Br J Cancer 78(12):1573\u20131577","journal-title":"Br J Cancer"},{"issue":"10","key":"1246_CR61","first-page":"2963","volume":"5","author":"DI Gabrilovich","year":"1999","unstructured":"Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP (1999) Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 5(10):2963\u20132970","journal-title":"Clin Cancer Res"},{"key":"1246_CR62","author":"N Gaudenzio","year":"2009","unstructured":"Gaudenzio N, Espagnole N, Mars LT, Liblau R, Valitutti S, Espinosa E (2009) Cell-cell cooperation at the T helper cell\/mast cell immunological synapse. Blood. doi: 10.1182\/blood-2009-02-202648","journal-title":"Blood"},{"issue":"8","key":"1246_CR63","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.4049\/jimmunol.0803180","volume":"182","author":"T Kambayashi","year":"2009","unstructured":"Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA (2009) Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol 182(8):4686\u20134695. doi: 10.4049\/jimmunol.0803180","journal-title":"J Immunol"},{"issue":"6","key":"1246_CR64","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2010.08.050","volume":"126","author":"SS Aceves","year":"2010","unstructured":"Aceves SS, Chen D, Newbury RO, Dohil R, Bastian JF, Broide DH (2010) Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol 126(6):1198\u20131204. doi: 10.1016\/j.jaci.2010.08.050","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"1246_CR65","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10875-008-9251-y","volume":"28","author":"YY Wan","year":"2008","unstructured":"Wan YY, Flavell RA (2008) TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol 28(6):647\u2013659. doi: 10.1007\/s10875-008-9251-y","journal-title":"J Clin Immunol"},{"issue":"14","key":"1246_CR66","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1073\/pnas.0913683107","volume":"107","author":"NR Blatner","year":"2010","unstructured":"Blatner NR, Bonertz A, Beckhove P, Cheon EC, Krantz SB, Strouch M, Weitz J, Koch M, Halverson AL, Bentrem DJ, Khazaie K (2010) In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci USA 107(14):6430\u20136435. doi: 10.1073\/pnas.0913683107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1246_CR67","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10555-011-9286-z","volume":"30","author":"K Khazaie","year":"2011","unstructured":"Khazaie K, Blatner NR, Khan MW, Gounari F, Gounaris E, Dennis K, Bonertz A, Tsai FN, Strouch MJ, Cheon E, Phillips JD, Beckhove P, Bentrem DJ (2011) The significant role of mast cells in cancer. Cancer Metastasis Rev 30(1):45\u201360. doi: 10.1007\/s10555-011-9286-z","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"1246_CR68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11248-007-9153-4","volume":"17","author":"J Scholten","year":"2008","unstructured":"Scholten J, Hartmann K, Gerbaulet A et al (2008) Mast cell-specific Cre\/loxP-mediated recombination in vivo. Transgenic Res 17(2):307\u2013315","journal-title":"Transgenic Res"},{"issue":"6","key":"1246_CR69","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.immuni.2011.03.028","volume":"34","author":"A Dudeck","year":"2011","unstructured":"Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, Peschke K, Vohringer D, Waskow C, Krieg T, Muller W, Waisman A, Hartmann K, Gunzer M, Roers A (2011) Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity 34(6):973\u2013984. doi: 10.1016\/j.immuni.2011.03.028","journal-title":"Immunity"},{"key":"1246_CR70","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/dvg.20378","volume":"46","author":"W Musch","year":"2008","unstructured":"Musch W, Wege AK, Mannel DN et al (2008) Generation and characterization of alpha-chymase-Cre transgenic mice. Genesis 46:163\u2013166","journal-title":"Genesis"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-012-1246-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-012-1246-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-012-1246-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T21:36:04Z","timestamp":1687383364000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-012-1246-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["1246"],"URL":"https:\/\/doi.org\/10.1007\/s00262-012-1246-0","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}