{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:38:53Z","timestamp":1790231933099,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00262-014-1623-y","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T07:03:52Z","timestamp":1414047832000},"page":"213-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells"],"prefix":"10.1007","volume":"64","author":[{"given":"Thibaud","family":"Andr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Najar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlien","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pradier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Meuleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lagneaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"1623_CR1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMra041875","volume":"351","author":"RA Kyle","year":"2004","unstructured":"Kyle RA, Rajkumar SV (2004) Multiple myeloma. N Engl J Med 351:1860\u20131873. doi: 10.1056\/NEJMra041875","journal-title":"N Engl J Med"},{"key":"1623_CR2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1634\/theoncologist.2010-0327","volume":"16","author":"M Tucci","year":"2011","unstructured":"Tucci M, Stucci S, Strippoli S, Dammacco F, Silvestris F (2011) Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression? Oncologist 16:1040\u20131048. doi: 10.1634\/theoncologist.2010-0327","journal-title":"Oncologist"},{"key":"1623_CR3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2141.2007.06705.x","volume":"138","author":"G Pratt","year":"2007","unstructured":"Pratt G, Goodyear O, Moss P (2007) Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 138:563\u2013579. doi: 10.1111\/j.1365-2141.2007.06705.x","journal-title":"Br J Haematol"},{"key":"1623_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1054\/blre.1999.0111","volume":"13","author":"G Cook","year":"1999","unstructured":"Cook G, Campbell JD (1999) Immune regulation in multiple myeloma: the host\u2013tumour conflict. Blood Rev 13:151\u2013162. doi: 10.1054\/blre.1999.0111","journal-title":"Blood Rev"},{"key":"1623_CR5","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2141.2008.07530.x","volume":"144","author":"S Feyler","year":"2009","unstructured":"Feyler S, von Lilienfeld-Toal M, Jarmin S, Marles L, Rawstron A, Ashcroft AJ, Owen RG, Selby PJ, Cook G (2009) CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden. Br J Haematol 144:686\u2013695. doi: 10.1111\/j.1365-2141.2008.07530.x","journal-title":"Br J Haematol"},{"issue":"5","key":"1623_CR6","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3109\/10428194.2013.825905","volume":"55","author":"J Favaloro","year":"2013","unstructured":"Favaloro J, Brown R, Aklilu E, Yang S, Suen H, Hart D, Fromm P, Gibson J, Khoo L, Ho PJ, Joshua D (2013) Myeloma skews Treg and Th17 cell balance in favor of a suppressive state. Leuk Lymphoma 55(5):1090\u20131098. doi: 10.3109\/10428194.2013.825905","journal-title":"Leuk Lymphoma"},{"key":"1623_CR7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1177\/147323001204000217","volume":"40","author":"CJ Shen","year":"2012","unstructured":"Shen CJ, Yuan ZH, Liu YX, Hu GY (2012) Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma. J Int Med Res 40:556\u2013564","journal-title":"J Int Med Res"},{"key":"1623_CR8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.leu.2404466","volume":"21","author":"B Arnulf","year":"2007","unstructured":"Arnulf B, Lecourt S, Soulier J, Ternaux B, Lacassagne MN, Crinquette A, Dessoly J, Sciaini AK, Benbunan M, Chomienne C, Fermand JP, Marolleau JP, Larghero J (2007) Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma. Leukemia 21:158\u2013163. doi: 10.1038\/sj.leu.2404466","journal-title":"Leukemia"},{"key":"1623_CR9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.arcmed.2010.11.008","volume":"41","author":"B Li","year":"2010","unstructured":"Li B, Fu J, Chen P, Zhuang W (2010) Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients. Arch Med Res 41:623\u2013633. doi: 10.1016\/j.arcmed.2010.11.008","journal-title":"Arch Med Res"},{"key":"1623_CR10","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","volume":"99","author":"M Nicola Di","year":"2002","unstructured":"Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838\u20133843","journal-title":"Blood"},{"key":"1623_CR11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4049\/jimmunol.0902007","volume":"185","author":"S Ghannam","year":"2010","unstructured":"Ghannam S, Pene J, Torcy-Moquet G, Jorgensen C, Yssel H (2010) Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 185:302\u2013312. doi: 10.4049\/jimmunol.0902007","journal-title":"J Immunol"},{"key":"1623_CR12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.imlet.2010.09.006","volume":"135","author":"F Carrion","year":"2011","unstructured":"Carrion F, Nova E, Luz P, Apablaza F, Figueroa F (2011) Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation. Immunol Lett 135:10\u201316. doi: 10.1016\/j.imlet.2010.09.006","journal-title":"Immunol Lett"},{"key":"1623_CR13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.stem.2010.09.009","volume":"7","author":"K English","year":"2010","unstructured":"English K, French A, Wood KJ (2010) Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 7:431\u2013442. doi: 10.1016\/j.stem.2010.09.009","journal-title":"Cell Stem Cell"},{"key":"1623_CR14","doi-asserted-by":"crossref","first-page":"e59756","DOI":"10.1371\/journal.pone.0059756","volume":"8","author":"T Andre","year":"2013","unstructured":"Andre T, Meuleman N, Stamatopoulos B, De BC, Pieters K, Bron D, Lagneaux L (2013) Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells. PLoS One 8:e59756. doi: 10.1371\/journal.pone.0059756","journal-title":"PLoS One"},{"key":"1623_CR15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1080\/14653240903079377","volume":"11","author":"M Najar","year":"2009","unstructured":"Najar M, Rouas R, Raicevic G, Boufker HI, Lewalle P, Meuleman N, Bron D, Toungouz M, Martiat P, Lagneaux L (2009) Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6. Cytotherapy 11:570\u2013583. doi: 10.1080\/14653240903079377","journal-title":"Cytotherapy"},{"key":"1623_CR16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14653240500319234","volume":"7","author":"EM Horwitz","year":"2005","unstructured":"Horwitz EM, Le BK, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A (2005) Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 7:393\u2013395. doi: 10.1080\/14653240500319234","journal-title":"Cytotherapy"},{"key":"1623_CR17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jlb.58.2.209","volume":"58","author":"MJ Yellin","year":"1995","unstructured":"Yellin MJ, Winikoff S, Fortune SM, Baum D, Crow MK, Lederman S, Chess L (1995) Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J Leukoc Biol 58:209\u2013216","journal-title":"J Leukoc Biol"},{"key":"1623_CR18","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.4049\/jimmunol.159.11.5640","volume":"159","author":"J Dechanet","year":"1997","unstructured":"Dechanet J, Grosset C, Taupin JL, Merville P, Banchereau J, Ripoche J, Moreau JF (1997) CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells. J Immunol 159:5640\u20135647","journal-title":"J Immunol"},{"key":"1623_CR19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1615\/CritRevImmunol.v23.i12.50","volume":"23","author":"B O\u2019Sullivan","year":"2003","unstructured":"O\u2019Sullivan B, Thomas R (2003) CD40 and dendritic cell function. Crit Rev Immunol 23:83\u2013107","journal-title":"Crit Rev Immunol"},{"key":"1623_CR20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/1097-0142(20010401)91:7<1219::AID-CNCR1122>3.0.CO;2-1","volume":"91","author":"SR Wallace","year":"2001","unstructured":"Wallace SR, Oken MM, Lunetta KL, Panoskaltsis-Mortari A, Masellis AM (2001) Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients. Cancer 91:1219\u20131230","journal-title":"Cancer"},{"key":"1623_CR21","doi-asserted-by":"crossref","first-page":"e59354","DOI":"10.1371\/journal.pone.0059354","volume":"8","author":"ZX Yang","year":"2013","unstructured":"Yang ZX, Han ZB, Ji YR, Wang YW, Liang L, Chi Y, Yang SG, Li LN, Luo WF, Li JP, Chen DD, Du WJ, Cao XC, Zhuo GS, Wang T, Han ZC (2013) CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One 8:e59354. doi: 10.1371\/journal.pone.0059354","journal-title":"PLoS One"},{"key":"1623_CR22","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1002\/eji.1830211132","volume":"21","author":"LC Burkly","year":"1991","unstructured":"Burkly LC, Jakubowski A, Newman BM, Rosa MD, Chi-Rosso G, Lobb RR (1991) Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation. Eur J Immunol 21:2871\u20132875. doi: 10.1002\/eji.1830211132","journal-title":"Eur J Immunol"},{"key":"1623_CR23","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.4049\/jimmunol.0902023","volume":"184","author":"G Ren","year":"2010","unstructured":"Ren G, Zhao X, Zhang L, Zhang J, L\u2019Huillier A, Ling W, Roberts AI, Le AD, Shi S, Shao C, Shi Y (2010) Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 184:2321\u20132328. doi: 10.4049\/jimmunol.0902023","journal-title":"J Immunol"},{"key":"1623_CR24","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.4049\/jimmunol.167.6.3107","volume":"167","author":"A Wakkach","year":"2001","unstructured":"Wakkach A, Cottrez F, Groux H (2001) Differentiation of regulatory T cells 1 is induced by CD2 costimulation. J Immunol 167:3107\u20133113","journal-title":"J Immunol"},{"key":"1623_CR25","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood-2007-02-075481","volume":"110","author":"D Chabannes","year":"2007","unstructured":"Chabannes D, Hill M, Merieau E, Rossignol J, Brion R, Soulillou JP, Anegon I, Cuturi MC (2007) A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 110:3691\u20133694. doi: 10.1182\/blood-2007-02-075481","journal-title":"Blood"},{"key":"1623_CR26","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1182\/blood-2010-12-324038","volume":"117","author":"D Mougiakakos","year":"2011","unstructured":"Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, Le BK (2011) The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 117:4826\u20134835. doi: 10.1182\/blood-2010-12-324038","journal-title":"Blood"},{"key":"1623_CR27","doi-asserted-by":"crossref","first-page":"34612","DOI":"10.1074\/jbc.M113.494369","volume":"288","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Zhang L, Wu J, Di C, Xia Z (2013) Heme oxygenase-1 exerts a protective role in ovalbumin-induced neutrophilic airway inflammation by inhibiting Th17 cell-mediated immune response. J Biol Chem 288:34612\u201334626. doi: 10.1074\/jbc.M113.494369","journal-title":"J Biol Chem"},{"key":"1623_CR28","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1182\/blood-2006-01-0057","volume":"107","author":"JL Chan","year":"2006","unstructured":"Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM, Rameshwar P (2006) Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 107:4817\u20134824. doi: 10.1182\/blood-2006-01-0057","journal-title":"Blood"},{"key":"1623_CR29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","author":"E Bettelli","year":"2006","unstructured":"Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235\u2013238. doi: 10.1038\/nature04753","journal-title":"Nature"},{"key":"1623_CR30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3727\/000000006780666957","volume":"13","author":"A Nasef","year":"2007","unstructured":"Nasef A, Chapel A, Mazurier C, Bouchet S, Lopez M, Mathieu N, Sensebe L, Zhang Y, Gorin NC, Thierry D, Fouillard L (2007) Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. Gene Expr 13:217\u2013226","journal-title":"Gene Expr"},{"key":"1623_CR31","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1182\/blood.V81.11.2964.2964","volume":"81","author":"K Taga","year":"1993","unstructured":"Taga K, Mostowski H, Tosato G (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81:2964\u20132971","journal-title":"Blood"},{"key":"1623_CR32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/ar2843","volume":"11","author":"F Annunziato","year":"2009","unstructured":"Annunziato F, Romagnani S (2009) Heterogeneity of human effector CD4+ T cells. Arthritis Res Ther 11:257. doi: 10.1186\/ar2843","journal-title":"Arthritis Res Ther"},{"key":"1623_CR33","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1189\/jlb.1006610","volume":"81","author":"S Nakae","year":"2007","unstructured":"Nakae S, Iwakura Y, Suto H, Galli SJ (2007) Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81:1258\u20131268. doi: 10.1189\/jlb.1006610","journal-title":"J Leukoc Biol"},{"key":"1623_CR34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/cei.12111","volume":"173","author":"P Cipriani","year":"2013","unstructured":"Cipriani P, Di BP, Liakouli V, Del PB, Di PM, Di IM, Marrelli A, Alesse E, Giacomelli R (2013) Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy. Clin Exp Immunol 173:195\u2013206. doi: 10.1111\/cei.12111","journal-title":"Clin Exp Immunol"},{"key":"1623_CR35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.trim.2011.06.007","volume":"25","author":"K Landgraf","year":"2011","unstructured":"Landgraf K, Brunauer R, Lepperdinger G, Grubeck-Loebenstein B (2011) The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age. Transpl Immunol 25:167\u2013172. doi: 10.1016\/j.trim.2011.06.007","journal-title":"Transpl Immunol"},{"key":"1623_CR36","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.2003.026278","volume":"53","author":"S Danese","year":"2004","unstructured":"Danese S, Sans M, Fiocchi C (2004) The CD40\/CD40L costimulatory pathway in inflammatory bowel disease. Gut 53:1035\u20131043","journal-title":"Gut"},{"key":"1623_CR37","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood.V78.7.1770.1770","volume":"78","author":"M Massaia","year":"1991","unstructured":"Massaia M, Bianchi A, Attisano C, Peola S, Redoglia V, Dianzani U, Pileri A (1991) Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3\/TCR complex. Blood 78:1770\u20131780","journal-title":"Blood"},{"key":"1623_CR38","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood.V85.7.1903.bloodjournal8571903","volume":"85","author":"M Urashima","year":"1995","unstructured":"Urashima M, Chauhan D, Uchiyama H, Freeman GJ, Anderson KC (1995) CD40 ligand triggered interleukin-6 secretion in multiple myeloma. Blood 85:1903\u20131912","journal-title":"Blood"},{"key":"1623_CR39","first-page":"6174","volume":"63","author":"D Chauhan","year":"2003","unstructured":"Chauhan D, Li G, Shringarpure R, Podar K, Ohtake Y, Hideshima T, Anderson KC (2003) Blockade of Hsp27 overcomes Bortezomib\/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 63:6174\u20136177","journal-title":"Cancer Res"},{"key":"1623_CR40","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4049\/jimmunol.171.3.1534","volume":"171","author":"ME Reinders","year":"2003","unstructured":"Reinders ME, Sho M, Robertson SW, Geehan CS, Briscoe DM (2003) Proangiogenic function of CD40 ligand-CD40 interactions. J Immunol 171:1534\u20131541","journal-title":"J Immunol"},{"key":"1623_CR41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(96)01495-0","volume":"402","author":"D Feuerbach","year":"1997","unstructured":"Feuerbach D, Feyen JH (1997) Expression of the cell-adhesion molecule VCAM-1 by stromal cells is necessary for osteoclastogenesis. FEBS Lett 402:21\u201324. doi: 10.1016\/S0014-5793(96)01495-0","journal-title":"FEBS Lett"},{"key":"1623_CR42","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1158\/0008-5472.CAN-07-1543","volume":"67","author":"TC Wu","year":"2007","unstructured":"Wu TC (2007) The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res 67:6003\u20136006. doi: 10.1158\/0008-5472.CAN-07-1543","journal-title":"Cancer Res"},{"key":"1623_CR43","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1038\/sj.onc.1206315","volume":"22","author":"TH Landowski","year":"2003","unstructured":"Landowski TH, Olashaw NE, Agrawal D, Dalton WS (2003) Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-kappa B (RelB\/p50) in myeloma cells. Oncogene 22:2417\u20132421. doi: 10.1038\/sj.onc.1206315","journal-title":"Oncogene"},{"key":"1623_CR44","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1182\/blood-2008-03-143222","volume":"112","author":"KM Dhodapkar","year":"2008","unstructured":"Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, Vesole D, Jagannath S, Dhodapkar MV (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112:2878\u20132885. doi: 10.1182\/blood-2008-03-143222","journal-title":"Blood"},{"key":"1623_CR45","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1182\/blood-2010-05-283895","volume":"116","author":"K Noonan","year":"2010","unstructured":"Noonan K, Marchionni L, Anderson J, Pardoll D, Roodman GD, Borrello I (2010) A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 116:3554\u20133563. doi: 10.1182\/blood-2010-05-283895","journal-title":"Blood"},{"key":"1623_CR46","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1038\/bcj.2013.34","volume":"3","author":"C Bryant","year":"2013","unstructured":"Bryant C, Suen H, Brown R, Yang S, Favaloro J, Aklilu E, Gibson J, Ho PJ, Iland H, Fromm P, Woodland N, Nassif N, Hart D, Joshua DE (2013) Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg\/Th17 balance. Blood Cancer J 3:e148. doi: 10.1038\/bcj.2013.34","journal-title":"Blood Cancer J"},{"key":"1623_CR47","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1038\/sj.onc.1204623","volume":"20","author":"T Hideshima","year":"2001","unstructured":"Hideshima T, Chauhan D, Schlossman R, Richardson P, Anderson KC (2001) The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 20:4519\u20134527. doi: 10.1038\/sj.onc.1204623","journal-title":"Oncogene"},{"key":"1623_CR48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cellimm.2004.09.003","volume":"230","author":"F Payvandi","year":"2004","unstructured":"Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI (2004) Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell Immunol 230:81\u201388. doi: 10.1016\/j.cellimm.2004.09.003","journal-title":"Cell Immunol"},{"key":"1623_CR49","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1158\/1078-0432.CCR-11-1221","volume":"18","author":"K Noonan","year":"2012","unstructured":"Noonan K, Rudraraju L, Ferguson A, Emerling A, Pasetti MF, Huff CA, Borrello I (2012) Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses. Clin Cancer Res 18:1426\u20131434. doi: 10.1158\/1078-0432.CCR-11-1221","journal-title":"Clin Cancer Res"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-014-1623-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-014-1623-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-014-1623-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T14:20:03Z","timestamp":1689603603000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-014-1623-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["1623"],"URL":"https:\/\/doi.org\/10.1007\/s00262-014-1623-y","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}