{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:59:37Z","timestamp":1773802777690,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","award":["244\/GF3"],"award-info":[{"award-number":["244\/GF3"]}],"id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00262-017-2067-y","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T03:21:10Z","timestamp":1506482470000},"page":"101-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Daunorubicin conjugated with alpha-fetoprotein selectively eliminates myeloid-derived suppressor cells (MDSCs) and inhibits experimental tumor growth"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-9748","authenticated-orcid":false,"given":"Nikolai N.","family":"Belyaev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurshat","family":"Abdolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliya V.","family":"Perfilyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yekaterina O.","family":"Ostapchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir K.","family":"Krasnoshtanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikyn","family":"Kali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raikhan","family":"Tleulieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"2067_CR1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"RD Schreiber","year":"2011","unstructured":"Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion. Science 331:1565\u20131570. doi:\n                        10.1126\/science.1203486","journal-title":"Science"},{"key":"2067_CR2","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/ijc.25429","volume":"127","author":"H Nishikawa","year":"2010","unstructured":"Nishikawa H, Sakaguchi Sh (2010) Regulatory T cells in tumor immunity. Int J Cancer 127:759\u2013767. doi:\n                        10.1002\/ijc.25429","journal-title":"Int J Cancer"},{"key":"2067_CR3","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1158\/0008-5472.CAN-11-1156","volume":"71","author":"WL Byrne","year":"2011","unstructured":"Byrne WL, Mills KHG, Lederer JA, O\u2019Sullivan GC (2011) Targeting regulatory T cells in cancer. Cancer Res 71:6915\u20136920. doi:\n                        10.1158\/0008-5472.CAN-11-1156","journal-title":"Cancer Res"},{"key":"2067_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nri3175","volume":"12","author":"DI Gabrilovich","year":"2012","unstructured":"Gabrilovich DI, Ostrand-Rosenberg S, Bronte V (2012) Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 12:253\u2013268. doi:\n                        10.1038\/nri3175","journal-title":"Nat Rev Immunol"},{"key":"2067_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1189\/jlb.0311177","volume":"91","author":"Youn Je-In","year":"2012","unstructured":"Je-In Youn, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI (2012) Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol 91:167\u2013181. doi:\n                        10.1189\/jlb.0311177","journal-title":"J Leukoc Biol"},{"key":"2067_CR6","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.intimp.2011.01.003","volume":"11","author":"TF Greten","year":"2011","unstructured":"Greten TF, Manns MP, Korangy F (2011) Myeloid derived suppressor cells in human diseases. Int Immunopharmacol 11:802\u2013807. doi:\n                        10.1016\/j.intimp.2011.01.003","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"2067_CR7","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1182\/blood-2007-07-099226","volume":"111","author":"K Movahedi","year":"2008","unstructured":"Movahedi K, Guilliams M, Van den Bossche J, Van den Bergh R, Gysemans C, Beschin A, De Baetselier P, Van Ginderachter JA (2008) Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111(8):4233\u20134244. doi:\n                        10.1182\/blood-2007-07-099226","journal-title":"Blood"},{"key":"2067_CR8","doi-asserted-by":"publisher","first-page":"5791","DOI":"10.4049\/jimmunol.181.8.5791","volume":"181","author":"Youn Je-In","year":"2008","unstructured":"Je-In Youn, Nagaraj S, Collazo M, Gabrilovich DI (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 181:5791\u20135802. doi:\n                        10.4049\/jimmunol.181.8.5791","journal-title":"J Immunol"},{"key":"2067_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/eji.200939903","volume":"40","author":"L Dolcetti","year":"2010","unstructured":"Dolcetti L, Peranzoni E, Ugel S, Marigo I, Gomez AF, Mesa C, Geilich M, Winkels G, Traggiai E, Casati A, Grassi F, Bronte V (2010) Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur J Immunol 40:22\u201335. doi:\n                        10.1002\/eji.200939903","journal-title":"Eur J Immunol"},{"key":"2067_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.critrevonc.2010.02.004","volume":"77","author":"J Kao","year":"2011","unstructured":"Kao J, Ko EC, Eisenstein S, Sikora AG, Fu S, Chen SH (2011) Targeting immune suppressing myeloid-derived suppressor cells in oncology. Crit Rev Oncol Hematol 77:12\u201319. doi:\n                        10.1016\/j.critrevonc.2010.02.004","journal-title":"Crit Rev Oncol Hematol"},{"key":"2067_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2217\/imt.11.154","volume":"4","author":"F Martin","year":"2012","unstructured":"Martin F, Apetoh L, Ghiringhelli F (2012) Role of myeloid-derived suppressor cells in tumor immunotherapy. Immunotherapy 4:43\u201357. doi:\n                        10.2217\/imt.11.154","journal-title":"Immunotherapy"},{"issue":"1","key":"2067_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4161\/onci.1.1.18074","volume":"1","author":"J Djeu","year":"2012","unstructured":"Djeu J, Wei Sh (2012) Chemoimmunomodulation of MDSCs as a novel strategy for cancer therapy. Oncoimmunology 1(1):121\u2013122. doi:\n                        10.4161\/onci.1.1.18074","journal-title":"Oncoimmunology"},{"key":"2067_CR13","first-page":"353","volume-title":"Alpha-fetoprotein: functions and clinical applications","author":"VN Pak","year":"2016","unstructured":"Pak VN, Belyaev NN (2016) Alpha-fetoprotein-mediated immune tolerance and its reversal. In: Lakhi N, Moretti M (eds) Alpha-fetoprotein: functions and clinical applications. Nova Science Publishers Inc, New York, pp 353\u2013374"},{"key":"2067_CR14","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1159\/000030142","volume":"21","author":"SV Lutsenko","year":"2000","unstructured":"Lutsenko SV, Feldman NB, Finakova GV, Gukasova NV, Petukhov SP, Posypanova GA, Skryabin KG, Severin SE (2000) Antitumor activity of alpha fetoprotein and epidermal growth factor conjugates in vitro and in vivo. Tumor Biol 21:367\u2013374. doi:\n                        10.1159\/000030142","journal-title":"Tumor Biol"},{"issue":"2","key":"2067_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jconrel.2013.03.007","volume":"168","author":"NG Yabbarov","year":"2013","unstructured":"Yabbarov NG, Posypanova GA, Vorontsov EA, Obydenny SI, Severin ES (2013) A new system for targeted delivery of doxorubicin into tumor cells. J Control Release 168(2):135\u2013141. doi:\n                        10.1016\/j.jconrel.2013.03.007","journal-title":"J Control Release"},{"key":"2067_CR16","doi-asserted-by":"publisher","first-page":"885","DOI":"10.4155\/tde.14.59","volume":"5","author":"V Pak","year":"2014","unstructured":"Pak V (2014) The use of a-fetoprotein for the delivery of cytotoxic payloads to cancer cells. Ther Deliv 5:885\u2013892. doi:\n                        10.4155\/tde.14.59","journal-title":"Ther Deliv"},{"key":"2067_CR17","first-page":"403","volume-title":"Immunodiagnosis of cancer","author":"AHB Wu","year":"1990","unstructured":"Wu AHB, Sell S (1990) Markers for hepatic carcinoma. In: Herberman RB, Mercer DW (eds) Immunodiagnosis of cancer. Marcel Dekker, New York, pp 403\u2013422"},{"key":"2067_CR18","first-page":"323","volume-title":"Immunodiagnosis of cancer","author":"I Jacobs","year":"1990","unstructured":"Jacobs I, Bast RC (1990) Immunodiagnosis of germ cell tumors of the gonads. In: Herberman RB, Mercer DW (eds) Immunodiagnosis of cancer. Marcel Dekker, New York, pp 323\u2013338"},{"key":"2067_CR19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/153537020422900602","volume":"229","author":"GJ Mizejewski","year":"2004","unstructured":"Mizejewski GJ (2004) Biological roles of alpha-fetoprotein during pregnancy and perinatal development. Exp Biol Med (Maywood) 229:439\u2013463","journal-title":"Exp Biol Med (Maywood)"},{"key":"2067_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s13277-010-0134-5","volume":"32","author":"GJ Mizejewski","year":"2011","unstructured":"Mizejewski GJ (2011) Review of the putative cell-surface receptors for alpha-fetoprotein: identification of a candidate receptor protein family. Tumor Biol 32:241\u2013258. doi:\n                        10.1007\/s13277-010-0134-5","journal-title":"Tumor Biol"},{"key":"2067_CR21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4196\/kjpp.2008.12.4.193","volume":"12","author":"NN Belyaev","year":"2008","unstructured":"Belyaev NN, Bogdanov AYu, Savvulidi PhG, Krasnoshtanov VK, Tleulieva RT, Alipov GK, Sekine I, Bae JS, Lee JB, Min YK, Yang HM (2008) The influence of alpha-fetoprotein on natural suppressor cell activity and Ehrlich carcinoma growth. Korean J Physiol Pharmacol 12:193\u2013197. doi:\n                        10.4196\/kjpp.2008.12.4.193","journal-title":"Korean J Physiol Pharmacol"},{"key":"2067_CR22","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.2741\/454","volume":"4","author":"P Forghani","year":"2012","unstructured":"Forghani P, Khorramizadeh MR, Waller EK (2012) Natural suppressor cells; past, present and future. Front Biosci (Elite Ed) 4:1237\u20131245. doi:\n                        10.2741\/454","journal-title":"Front Biosci (Elite Ed)"},{"key":"2067_CR23","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nrc3581","volume":"13","author":"JE Talmadge","year":"2013","unstructured":"Talmadge JE, Gabrilovich DI (2013) History of myeloid-derived suppressor cells. Nat Rev Cancer 13:739\u2013752. doi:\n                        10.1038\/nrc3581","journal-title":"Nat Rev Cancer"},{"key":"2067_CR24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0006-291X(02)00909-9","volume":"296","author":"A Atemezem","year":"2002","unstructured":"Atemezem A, Mbemba E, Marfaing R, Vaysse J, Pontet M, Saffar L, Charnaux N, Gattegno L (2002) Human \u03b1-fetoprotein binds to primary macrophages. Biochem Biophy Res Commun 296:507\u2013514. doi:\n                        10.1016\/S0006-291X(02)00909-9","journal-title":"Biochem Biophy Res Commun"},{"key":"2067_CR25","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/ijc.2910440220","volume":"44","author":"JL Subiza","year":"1989","unstructured":"Subiza JL, Vinuela JE, Rodriguez R, Gil J, Figueredo MA, De la Concha EG (1989) Development of splenic natural suppressor (NS) cells in Ehrlich tumor-bearing mice. Int J Cancer 44:307\u2013314. doi:\n                        10.1002\/ijc.2910440220","journal-title":"Int J Cancer"},{"key":"2067_CR26","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1172\/JCI116021","volume":"90","author":"Y Suzuki","year":"1992","unstructured":"Suzuki Y, Zeng CQY, Alpert E (1992) Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes. J Clin Investig 90:1530\u20131536. doi:\n                        10.1172\/JCI116021","journal-title":"J Clin Investig"},{"issue":"4","key":"2067_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrc3245","volume":"12","author":"WH Fridman","year":"2012","unstructured":"Fridman WH, Pag\u00e8s F, Saut\u00e8s-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12(4):298\u2013306. doi:\n                        10.1038\/nrc3245","journal-title":"Nat Rev Cancer"},{"issue":"15","key":"2067_CR28","doi-asserted-by":"publisher","first-page":"13835","DOI":"10.18632\/oncotarget.3453","volume":"6","author":"I Levi","year":"2015","unstructured":"Levi I, Amsalem H, Nissan A, Darash-Yahana M, Peretz T, Mandelboim O, Rachmilewitz J (2015) Characterization of tumor infiltrating natural killer cell subset. Oncotarget 6(15):13835\u201313843. doi:\n                        10.18632\/oncotarget.3453","journal-title":"Oncotarget"},{"issue":"13","key":"2067_CR29","first-page":"5132","volume":"61","author":"O Nakano","year":"2001","unstructured":"Nakano O, Sato M, Naito Y, Suzuki K, Orikasa S, Aizawa M, Suzuki Y, Shintaku I, Nagura H, Ohtani H (2001) Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61(13):5132\u20135316","journal-title":"Cancer Res"},{"issue":"18","key":"2067_CR30","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1158\/1078-0432.CCR-10-0733","volume":"16","author":"KN Kodumudi","year":"2010","unstructured":"Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei Sh, Djeu JY (2010) A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin Cancer Res 16(18):4583\u20134594. doi:\n                        10.1158\/1078-0432.CCR-10-0733","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2067_CR31","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1158\/0008-5472.CAN-13-1545","volume":"74","author":"D Alizadeh","year":"2014","unstructured":"Alizadeh D, Trad M, Hanke NT, Larmonier CB, Janikashvili N, Bonnotte B, Katsanis E, Larmonier N (2014) Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer Res 74(1):104\u2013118. doi:\n                        10.1158\/0008-5472.CAN-13-1545","journal-title":"Cancer Res"},{"key":"2067_CR32","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s00262-013-1396-8","volume":"62","author":"C Iclozan","year":"2013","unstructured":"Iclozan C, Antonia S, Chiappori A, Chen DT, Gabrilovich DI (2013) Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother 62:909\u2013918. doi:\n                        10.1007\/s00262-013-1396-8","journal-title":"Cancer Immunol Immunother"},{"issue":"7","key":"2067_CR33","doi-asserted-by":"publisher","first-page":"e40677","DOI":"10.1371\/journal.pone.0040677","volume":"7","author":"MK Srivastava","year":"2012","unstructured":"Srivastava MK, Zhu L, Harris-White M, Kar UK, Huang M, Johnson MF, Lee JM, Elashoff D, Strieter R, Dubinett S, Sharma S (2012) Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS One 7(7):e40677. doi:\n                        10.1371\/journal.pone.0040677","journal-title":"PLoS One"},{"issue":"6","key":"2067_CR34","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1586\/14737140.2.6.709","volume":"2","author":"GJ Mizejewski","year":"2002","unstructured":"Mizejewski GJ (2002) Biological role of \u03b1-fetoprotein in cancer: prospects for anticancer therapy. Expert Rev Anticancer Ther 2(6):709\u2013735. doi:\n                        10.1586\/14737140.2.6.709","journal-title":"Expert Rev Anticancer Ther"},{"key":"2067_CR35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4172\/2329-8790.1000191","volume":"3","author":"GJ Mizejewski","year":"2015","unstructured":"Mizejewski GJ (2015) Alpha-fetoprotein (AFP) and inflammation: is AFP an acute and\/or chronic phase reactant? J Hematol Thrombo Dis 3:191. doi:\n                        10.4172\/2329-8790.1000191","journal-title":"J Hematol Thrombo Dis"},{"issue":"5","key":"2067_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/08820139309063412","volume":"22","author":"M Chakraborty","year":"1993","unstructured":"Chakraborty M, Mandal C (1993) Immuno-suppressive effect of human alpha-fetoprotein: a cross species study. Immunol Investig 22(5):329\u2013339. doi:\n                        10.3109\/08820139309063412","journal-title":"Immunol Investig"},{"issue":"2\u20133","key":"2067_CR37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000217553","volume":"9","author":"ME Baker","year":"1988","unstructured":"Baker ME (1988) Evolution of alpha-fetoprotein: sequence comparisons among AFP species and with albumin species. Tumor Biol 9(2\u20133):123\u2013136. doi:\n                        10.1159\/000217553","journal-title":"Tumor Biol"},{"issue":"3","key":"2067_CR38","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.it.2016.01.004","volume":"37","author":"V Kumar","year":"2016","unstructured":"Kumar V, Patel S, Tcyganov E, Gabrilovich DI (2016) The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol 37(3):208\u2013220. doi:\n                        10.1016\/j.it.2016.01.004","journal-title":"Trends Immunol"},{"key":"2067_CR39","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/225734a0","volume":"225","author":"L Chen","year":"1970","unstructured":"Chen L, Watkins GF (1970) Evidence against the presence of H2 histocompatibility antigens in Ehrlich ascites tumour cells. Nature 225:734\u2013735","journal-title":"Nature"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00262-017-2067-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-017-2067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-017-2067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T06:40:51Z","timestamp":1515048051000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00262-017-2067-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2067"],"URL":"https:\/\/doi.org\/10.1007\/s00262-017-2067-y","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}