{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:24:30Z","timestamp":1778642670978,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","award":["\u2116AP05130612"],"award-info":[{"award-number":["\u2116AP05130612"]}],"id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00262-020-02763-w","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T02:03:07Z","timestamp":1603245787000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Notch signaling defects in NK cells in patients with cancer"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-6312","authenticated-orcid":false,"given":"Gulnur K.","family":"Zakiryanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Kustova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya T.","family":"Urazalieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile T.","family":"Baimukhametov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriy A.","family":"Makarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulmariya M.","family":"Turaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina V.","family":"Shurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarema M.","family":"Biyasheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narymzhan N.","family":"Nakisbekov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Shurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"2763_CR1","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1038\/emboj.2013.97","volume":"32","author":"C Vicente-Duenas","year":"2013","unstructured":"Vicente-Duenas C, Romero-Camarero I, Cobaleda C, Sanchez-Garcia I (2013) Function of oncogenes in cancer development: a changing paradigm. EMBO J 32:1502\u20131513","journal-title":"EMBO J"},{"issue":"2","key":"2763_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1080\/21541248.2017.1364821","volume":"11","author":"N Venkateswaran","year":"2017","unstructured":"Venkateswaran N, Conacci-Sorrell M (2017) MYC leads the way. Small GTPases 11(2):86\u201394","journal-title":"Small GTPases"},{"key":"2763_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cell.2014.12.016","volume":"160","author":"JW Hofmann","year":"2015","unstructured":"Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM (2015) Reduced expression of MYC increases longevity and enhances healthspan. Cell 160:477\u2013488","journal-title":"Cell"},{"key":"2763_CR4","doi-asserted-by":"publisher","first-page":"a014357","DOI":"10.1101\/cshperspect.a014357","volume":"4","author":"M Conacci-Sorrell","year":"2014","unstructured":"Conacci-Sorrell M, McFerrin L, Eisenman RN (2014) An overview of MYC and its interactome. Cold Spring Harb Perspect Med 4:a014357","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2763_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1126\/science.aac9935","volume":"352","author":"SC Casey","year":"2016","unstructured":"Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gutgemann I, Eilers M, Felsher DW (2016) MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352:227\u2013231","journal-title":"Science"},{"key":"2763_CR6","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1182\/blood-2017-11-742577","volume":"131","author":"SC Casey","year":"2018","unstructured":"Casey SC, Baylot V, Felsher DW (2018) The MYC oncogene is a global regulator of the immune response. Blood 131:2007\u20132015","journal-title":"Blood"},{"key":"2763_CR7","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.15252\/embj.201490252","volume":"34","author":"GC Preston","year":"2015","unstructured":"Preston GC, Sinclair LV, Kaskar A, Hukelmann JL, Navarro MN, Ferrero I, MacDonald HR, Cowling VH, Cantrell DA (2015) Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J 34:2008\u20132024","journal-title":"EMBO J"},{"issue":"3","key":"2763_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/genes8030088","volume":"8","author":"JN Gnanaprakasam","year":"2017","unstructured":"Gnanaprakasam JN, Wang R (2017) MYC in regulating immunity: metabolism and beyond. Genes (Basel) 8(3):88","journal-title":"Genes (Basel)"},{"key":"2763_CR9","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1073\/pnas.1518000113","volume":"113","author":"L Liu","year":"2016","unstructured":"Liu L, Lu Y, Martinez J, Bi Y, Lian G, Wang T, Milasta S, Wang J, Yang M, Liu G, Green DR, Wang R (2016) Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1alpha-dependent. Proc Natl Acad Sci U S A 113:1564\u20131569","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2763_CR10","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3389\/fimmu.2019.01171","volume":"10","author":"PA Garcia-Gonzalez","year":"2019","unstructured":"Garcia-Gonzalez PA, Maggi J, Schinnerling K, Sepulveda-Gutierrez A, Soto L, Neira O, Mehdi AM, Nel HJ, Pesce B, Aravena O, Molina MC, Catalan D, Thomas R, Verdugo RA, Aguillon JC (2019) Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC. Front Immunol 10:1171","journal-title":"Front Immunol"},{"issue":"11","key":"2763_CR11","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3390\/cells8111365","volume":"8","author":"MC Robaina","year":"2019","unstructured":"Robaina MC, Mazzoccoli L, Klumb CE (2019) Germinal centre B cell functions and lymphomagenesis: circuits involving MYC and MicroRNAs. Cells 8(11):1365","journal-title":"Cells"},{"key":"2763_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/iid3.179","volume":"5","author":"GK Zakiryanova","year":"2017","unstructured":"Zakiryanova GK, Kustova E, Urazalieva NT, Amirbekov A, Baimuchametov ET, Nakisbekov NN, Shurin MR (2017) Alterations of oncogenes expression in NK cells in patients with cancer. Immun Inflamm Dis 5:493\u2013502","journal-title":"Immun Inflamm Dis"},{"issue":"3","key":"2763_CR13","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3390\/ijms20030756","volume":"20","author":"GK Zakiryanova","year":"2019","unstructured":"Zakiryanova GK, Kustova E, Urazalieva NT, Baimuchametov ET, Nakisbekov NN, Shurin MR (2019) Abnormal expression of c-Myc oncogene in NK cells in patients with cancer. Int J Mol Sci 20(3):756","journal-title":"Int J Mol Sci"},{"key":"2763_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/ITT.S150586","volume":"7","author":"GK Zakiryanova","year":"2018","unstructured":"Zakiryanova GK, Wheeler S, Shurin MR (2018) Oncogenes in immune cells as potential therapeutic targets. Immunotargets Ther 7:21\u201328","journal-title":"Immunotargets Ther"},{"issue":"6","key":"2763_CR15","doi-asserted-by":"publisher","first-page":"a014241","DOI":"10.1101\/cshperspect.a014241","volume":"4","author":"M Gabay","year":"2014","unstructured":"Gabay M, Li Y, Felsher DW (2014) MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb Perspect Med 4(6):a014241","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2763_CR16","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.trecan.2018.10.003","volume":"4","author":"O Lancho","year":"2018","unstructured":"Lancho O, Herranz D (2018) The MYC enhancer-ome: long-range transcriptional regulation of MYC in cancer. Trends Cancer 4:810\u2013822","journal-title":"Trends Cancer"},{"key":"2763_CR17","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.1128\/MCB.25.17.7423-7431.2005","volume":"25","author":"JS Ho","year":"2005","unstructured":"Ho JS, Ma W, Mao DY, Benchimol S (2005) p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol 25:7423\u20137431","journal-title":"Mol Cell Biol"},{"key":"2763_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307\u2013310","journal-title":"Nature"},{"key":"2763_CR19","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.4161\/cc.8.9.8362","volume":"8","author":"M Sachdeva","year":"2009","unstructured":"Sachdeva M, Mo YY (2009) p53 and c-myc: how does the cell balance \u201cyin\u201d and \u201cyang\u201d? Cell Cycle 8:1303","journal-title":"Cell Cycle"},{"key":"2763_CR20","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.4049\/jimmunol.1600789","volume":"199","author":"R Collin","year":"2017","unstructured":"Collin R, St-Pierre C, Guilbault L, Mullins-Dansereau V, Policheni A, Guimont-Desrochers F, Pelletier AN, Gray DH, Drobetsky E, Perreault C, Hillhouse EE, Lesage S (2017) An unbiased linkage approach reveals that the p53 pathway is coupled to NK cell maturation. J Immunol 199:1490\u20131504","journal-title":"J Immunol"},{"key":"2763_CR21","doi-asserted-by":"publisher","first-page":"18261","DOI":"10.1073\/pnas.0606108103","volume":"103","author":"T Palomero","year":"2006","unstructured":"Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O\u2019Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA (2006) NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A 103:18261\u201318266","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2763_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jri.2009.10.009","volume":"84","author":"I Manaster","year":"2010","unstructured":"Manaster I, Gazit R, Goldman-Wohl D, Stern-Ginossar N, Mizrahi S, Yagel S, Mandelboim O (2010) Notch activation enhances IFN-gamma secretion by human peripheral blood and decidual NK cells. J Reprod Immunol 84:1\u20137","journal-title":"J Reprod Immunol"},{"key":"2763_CR23","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.4049\/jimmunol.1400534","volume":"193","author":"M Felices","year":"2014","unstructured":"Felices M, Ankarlo DE, Lenvik TR, Nelson HH, Blazar BR, Verneris MR, Miller JS (2014) Notch signaling at later stages of NK cell development enhances KIR expression and functional maturation. J Immunol 193:3344\u20133354","journal-title":"J Immunol"},{"key":"2763_CR24","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.bbmt.2009.06.002","volume":"15","author":"RC Beck","year":"2009","unstructured":"Beck RC, Padival M, Yeh D, Ralston J, Cooke KR, Lowe JB (2009) The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34+ cord blood hematopoietic progenitor cells. Biol Blood Marrow Transplant 15:1026\u20131037","journal-title":"Biol Blood Marrow Transplant"},{"key":"2763_CR25","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/314366a0","volume":"314","author":"SR Hann","year":"1985","unstructured":"Hann SR, Thompson CB, Eisenman RN (1985) c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature 314:366\u2013369","journal-title":"Nature"},{"key":"2763_CR26","first-page":"93","volume":"4","author":"M Shichiri","year":"1993","unstructured":"Shichiri M, Hanson KD, Sedivy JM (1993) Effects of c-myc expression on proliferation, quiescence, and the G0 to G1 transition in nontransformed cells. Cell Growth Differ 4:93\u2013104","journal-title":"Cell Growth Differ"},{"key":"2763_CR27","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.tibs.2005.09.005","volume":"30","author":"M Malumbres","year":"2005","unstructured":"Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem Sci 30:630\u2013641","journal-title":"Trends Biochem Sci"},{"key":"2763_CR28","doi-asserted-by":"publisher","first-page":"4672","DOI":"10.1128\/MCB.19.7.4672","volume":"19","author":"MK Mateyak","year":"1999","unstructured":"Mateyak MK, Obaya AJ, Sedivy JM (1999) c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol 19:4672\u20134683","journal-title":"Mol Cell Biol"},{"key":"2763_CR29","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1101\/gad.1450406","volume":"20","author":"AP Weng","year":"2006","unstructured":"Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC (2006) c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma. Genes Dev 20:2096\u20132109","journal-title":"Genes Dev"},{"key":"2763_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.imlet.2006.07.005","volume":"107","author":"AG Rolink","year":"2006","unstructured":"Rolink AG, Balciunaite G, Demoliere C, Ceredig R (2006) The potential involvement of Notch signaling in NK cell development. Immunol Lett 107:50\u201357","journal-title":"Immunol Lett"},{"key":"2763_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbmt.2008.11.031","volume":"15","author":"V Bachanova","year":"2009","unstructured":"Bachanova V, McCullar V, Lenvik T, Wangen R, Peterson KA, Ankarlo DE, Panoskaltsis-Mortari A, Wagner JE, Miller JS (2009) Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functions. Biol Blood Marrow Transplant 15:183\u2013194","journal-title":"Biol Blood Marrow Transplant"},{"key":"2763_CR32","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1038\/onc.2015.407","volume":"35","author":"AS Tigan","year":"2016","unstructured":"Tigan AS, Bellutti F, Kollmann K, Tebb G, Sexl V (2016) CDK6-a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation. Oncogene 35:3083\u20133091","journal-title":"Oncogene"},{"key":"2763_CR33","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1182\/blood-2008-03-147967","volume":"113","author":"I Joshi","year":"2009","unstructured":"Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA (2009) Notch signaling mediates G1\/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood 113:1689\u20131698","journal-title":"Blood"},{"key":"2763_CR34","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1182\/blood.V89.11.4092","volume":"89","author":"A Yamauchi","year":"1997","unstructured":"Yamauchi A, Bloom ET (1997) Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein. Blood 89:4092\u20134099","journal-title":"Blood"},{"key":"2763_CR35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ccell.2018.03.012","volume":"33","author":"DS Thommen","year":"2018","unstructured":"Thommen DS, Schumacher TN (2018) T cell dysfunction in cancer. Cancer Cell 33:547\u2013562","journal-title":"Cancer Cell"},{"key":"2763_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41423-019-0344-8","volume":"17","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Shao Q, Peng G (2020) Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment. Cell Mol Immunol 17:27\u201335","journal-title":"Cell Mol Immunol"},{"key":"2763_CR37","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1126\/science.aae0491","volume":"354","author":"DR Sen","year":"2016","unstructured":"Sen DR, Kaminski J, Barnitz RA, Kurachi M, Gerdemann U, Yates KB, Tsao HW, Godec J, LaFleur MW, Brown FD, Tonnerre P, Chung RT, Tully DC, Allen TM, Frahm N, Lauer GM, Wherry EJ, Yosef N, Haining WN (2016) The epigenetic landscape of T cell exhaustion. Science 354:1165\u20131169","journal-title":"Science"},{"key":"2763_CR38","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.intimp.2011.03.003","volume":"11","author":"S Ueha","year":"2011","unstructured":"Ueha S, Shand FH, Matsushima K (2011) Myeloid cell population dynamics in healthy and tumor-bearing mice. Int Immunopharmacol 11:783\u2013788","journal-title":"Int Immunopharmacol"},{"key":"2763_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.15698\/cst2019.09.197","volume":"3","author":"A Sica","year":"2019","unstructured":"Sica A, Guarneri V, Gennari A (2019) Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression. Cell Stress 3:284\u2013294","journal-title":"Cell Stress"},{"key":"2763_CR40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12307-012-0123-x","volume":"6","author":"DM Richards","year":"2013","unstructured":"Richards DM, Hettinger J, Feuerer M (2013) Monocytes and macrophages in cancer: development and functions. Cancer Microenviron 6:179\u2013191","journal-title":"Cancer Microenviron"},{"key":"2763_CR41","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.celrep.2018.07.097","volume":"24","author":"YP Zhu","year":"2018","unstructured":"Zhu YP, Padgett L, Dinh HQ, Marcovecchio P, Blatchley A, Wu R, Ehinger E, Kim C, Mikulski Z, Seumois G, Madrigal A, Vijayanand P, Hedrick CC (2018) Identification of an early unipotent neutrophil progenitor with pro-tumoral activity in mouse and human bone marrow. Cell Rep 24:2329-2341.e2328","journal-title":"Cell Rep"},{"key":"2763_CR42","doi-asserted-by":"publisher","first-page":"E566","DOI":"10.1073\/pnas.1424927112","volume":"112","author":"A-J Casbon","year":"2015","unstructured":"Casbon A-J, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegu\u00e9 E, Werb Z (2015) Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A 112:E566\u2013E575","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2763_CR43","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3389\/fimmu.2019.02155","volume":"10","author":"P Lecot","year":"2019","unstructured":"Lecot P, Sarabi M, Pereira Abrantes M, Mussard J, Koenderman L, Caux C, Bendriss-Vermare N, Michallet MC (2019) Neutrophil heterogeneity in cancer: from biology to therapies. Front Immunol 10:2155","journal-title":"Front Immunol"},{"key":"2763_CR44","doi-asserted-by":"publisher","first-page":"57452","DOI":"10.18632\/oncotarget.10767","volume":"7","author":"C Zhang","year":"2016","unstructured":"Zhang C, Wang S, Liu Y, Yang C (2016) Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer. Oncotarget 7:57452\u201357463","journal-title":"Oncotarget"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-020-02763-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-020-02763-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-020-02763-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:21:06Z","timestamp":1634772066000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-020-02763-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2763"],"URL":"https:\/\/doi.org\/10.1007\/s00262-020-02763-w","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"4 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}