{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:21:17Z","timestamp":1790630477632,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Agencia Nacional de Investigacion e Innovacion","award":["FMV_1_2017_1_136442"],"award-info":[{"award-number":["FMV_1_2017_1_136442"]}]},{"name":"Universidad de la Republica","award":["908"],"award-info":[{"award-number":["908"]}]},{"name":"Fondo para la Convergencia Estructural del MERCOSUR","award":["COF 03\/11"],"award-info":[{"award-number":["COF 03\/11"]}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FSGSK_1_2017_1_145466"],"award-info":[{"award-number":["FSGSK_1_2017_1_145466"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00262-021-02948-x","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T08:04:42Z","timestamp":1620115482000},"page":"3617-3627","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1+ cell activation in mice"],"prefix":"10.1007","volume":"70","author":[{"given":"Edgardo","family":"Berriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Chiale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mor\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Fern\u00e1ndez-Gra\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Crispo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Berois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-7066","authenticated-orcid":false,"given":"Eduardo","family":"Osinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"2948_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67:7\u201330. https:\/\/doi.org\/10.3322\/caac.21387","journal-title":"CA Cancer J Clin"},{"key":"2948_CR2","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/S0140-6736(16)31473-8","volume":"388","author":"FR Hirsch","year":"2016","unstructured":"Hirsch FR, Suda K, Wiens J, Bunn PA Jr (2016) New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet 388:1012\u20131024. https:\/\/doi.org\/10.1016\/S0140-6736(16)31473-8","journal-title":"Lancet"},{"key":"2948_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.hoc.2016.08.004","volume":"31","author":"L Du","year":"2017","unstructured":"Du L, Herbst RS, Morgensztern D (2017) Immunotherapy in lung cancer. Hematol Oncol Clin North Am 31:131\u2013141. https:\/\/doi.org\/10.1016\/j.hoc.2016.08.004","journal-title":"Hematol Oncol Clin North Am"},{"key":"2948_CR4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1538","author":"DB Doroshow","year":"2019","unstructured":"Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, Melero I, Schalper KA, Herbst RS (2019) Immunotherapy in non-small cell lung cancer: facts and hopes. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-1538","journal-title":"Clin Cancer Res"},{"key":"2948_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/B978-0-12-800249-0.00002-0","volume":"121","author":"J Schlom","year":"2014","unstructured":"Schlom J, Hodge JW, Palena C, Tsang KY, Jochems C, Greiner JW, Farsaci B, Madan RA, Heery CR, Gulley JL (2014) Therapeutic cancer vaccines. Adv Cancer Res 121:67\u2013124. https:\/\/doi.org\/10.1016\/B978-0-12-800249-0.00002-0","journal-title":"Adv Cancer Res"},{"key":"2948_CR6","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1093\/annonc\/mdv323","volume":"26","author":"A Thomas","year":"2015","unstructured":"Thomas A, Giaccone G (2015) Why has active immunotherapy not worked in lung cancer? Ann Oncol 26:2213\u20132220. https:\/\/doi.org\/10.1093\/annonc\/mdv323","journal-title":"Ann Oncol"},{"key":"2948_CR7","doi-asserted-by":"publisher","first-page":"S185","DOI":"10.1016\/j.semcancer.2015.03.004","volume":"35","author":"DS Vinay","year":"2015","unstructured":"Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HMCS, Signori E, Honoki K, Georgakilas AG, Amin A, Helferich WG, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Choi BK, Kwon BS (2015) Immune evasion in cancer: mechanistic basis and therapeutic strategies. Semin Cancer Biol 35:S185\u2013S198. https:\/\/doi.org\/10.1016\/j.semcancer.2015.03.004","journal-title":"Semin Cancer Biol"},{"key":"2948_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00428-018-2477-z","volume":"474","author":"A Tuccitto","year":"2019","unstructured":"Tuccitto A, Shahaj E, Vergani E, Ferro S, Huber V, Rodolfo M, Castelli C, Rivoltini L, Vallacchi V (2019) Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy. Virchows Arch 474:407\u2013420. https:\/\/doi.org\/10.1007\/s00428-018-2477-z","journal-title":"Virchows Arch"},{"key":"2948_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/15216540601188553","volume":"59","author":"E Osinaga","year":"2007","unstructured":"Osinaga E (2007) Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites. Crit Rev Iubmb Life 59:269\u2013273. https:\/\/doi.org\/10.1080\/15216540601188553","journal-title":"Crit Rev Iubmb Life"},{"key":"2948_CR10","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.2217\/fon.12.155","volume":"8","author":"HY Darani","year":"2012","unstructured":"Darani HY, Yousefi M (2012) Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy. Future Oncol 8:1529\u20131535. https:\/\/doi.org\/10.2217\/fon.12.155","journal-title":"Future Oncol"},{"key":"2948_CR11","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/00000658-192810000-00002","volume":"88","author":"WB Coley","year":"1928","unstructured":"Coley WB (1928) End results in Hodgkin\u2019s disease and lymphosarcoma treated by the mixed toxins of Erysipelas and Bacillus prodigiosus, alone or combined with radiation. Ann Surg 88:641\u2013667. https:\/\/doi.org\/10.1097\/00000658-192810000-00002","journal-title":"Ann Surg"},{"key":"2948_CR12","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.juro.2016.12.090","volume":"197","author":"R Chou","year":"2017","unstructured":"Chou R, Selph S, Buckley DI, Fu R, Griffin JC, Grusing S, Gore JL (2017) Intravesical therapy for the treatment of nonmuscle invasive bladder cancer: a systematic review and meta-analysis. J Urol 197:1189\u20131199. https:\/\/doi.org\/10.1016\/j.juro.2016.12.090","journal-title":"J Urol"},{"key":"2948_CR13","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/ijc.29910","volume":"138","author":"L Ubillos","year":"2016","unstructured":"Ubillos L, Freire T, Berriel E, Chiribao ML, Chiale C, Festari MF, Medeiros A, Mazal D, Rond\u00e1n M, Bollati-Fogol\u00edn M, Rabinovich GA, Robello C, Osinaga E (2016) Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers. Int J Cancer 138:1719\u20131731. https:\/\/doi.org\/10.1002\/ijc.29910","journal-title":"Int J Cancer"},{"key":"2948_CR14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4049\/jimmunol.1201209","volume":"190","author":"JR Baird","year":"2013","unstructured":"Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S (2013) Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol 190:469\u2013478. https:\/\/doi.org\/10.4049\/jimmunol.1201209","journal-title":"J Immunol"},{"key":"2948_CR15","doi-asserted-by":"publisher","first-page":"e24407","DOI":"10.1371\/journal.pone.0024407","volume":"6","author":"L Chen","year":"2011","unstructured":"Chen L, He Z, Qin L, Li Q, Shi X, Zhao S, Chen L, Zhong N, Chen X (2011) Antitumor effect of malaria parasite infection in a murine Lewis lung cancer model through induction of innate and adaptive immunity. PLoS ONE 6:e24407. https:\/\/doi.org\/10.1371\/journal.pone.0024407","journal-title":"PLoS ONE"},{"issue":"9","key":"2948_CR16","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1002\/cncr.11752","volume":"98","author":"H Akg\u00fcl","year":"2003","unstructured":"Akg\u00fcl H, Tez M, Unal AE, Ke\u015fkek M, Sayek I, Oz\u00e7elik T (2003) Echinococcus against cancer: why not? Cancer 98(9):1999\u20132000. https:\/\/doi.org\/10.1002\/cncr.11752","journal-title":"Cancer"},{"key":"2948_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/230176","author":"E Berriel","year":"2013","unstructured":"Berriel E, Russo S, Monin L, Festari MF, Berois N, Fern\u00e1ndez G, Freire T, Osinaga E (2013) Anti-tumor activity of human hydatid cyst fluid in a murine model of colon cancer. Sci World J. https:\/\/doi.org\/10.1155\/2013\/230176","journal-title":"Sci World J"},{"key":"2948_CR18","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3892\/ijo.2013.2000","volume":"43","author":"V Noya","year":"2013","unstructured":"Noya V, Bay S, Festari MF, Garc\u00eda E, Rodriguez E, Chiale C, Ganneau C, Baleux F, Astrada S, Bollati-Fogol\u00edn M, Osinaga E, Freire T (2013) Mucin-like peptides from Echinococcus granulosus induce antitumor activity. Int J Oncol 43:775\u2013784. https:\/\/doi.org\/10.3892\/ijo.2013.2000","journal-title":"Int J Oncol"},{"key":"2948_CR19","doi-asserted-by":"publisher","first-page":"e0004234","DOI":"10.1371\/journal.pntd.0004234","volume":"9","author":"E Rodr\u00edguez","year":"2015","unstructured":"Rodr\u00edguez E, Noya V, Cervi L, Chiribao ML, Brossard N, Chiale C, Carmona C, Giacomini C, Freire T (2015) Glycans from Fasciola hepatica modulate the host immune response and TLR-induced maturation of dendritic cells. PLoS Negl Trop Dis 9:e0004234. https:\/\/doi.org\/10.1371\/journal.pntd.0004234","journal-title":"PLoS Negl Trop Dis"},{"key":"2948_CR20","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1128\/IAI.72.1.398-407.2004","volume":"72","author":"S Tawill","year":"2004","unstructured":"Tawill S, le Goff L, Ali F, Blaxter M, Allen J (2004) Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans. Infect Immun 72:398\u2013407. https:\/\/doi.org\/10.1128\/IAI.72.1.398-407.2004","journal-title":"Infect Immun"},{"key":"2948_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ijpara.2012.10.021","volume":"43","author":"EJ Klaver","year":"2013","unstructured":"Klaver EJ, Kuijk LM, Laan LC, Kringel H, van Vliet SJ, Bouma G, Cummings RD, Kraal G, van Die I (2013) Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated. Int J Parasitol 43:191\u2013200. https:\/\/doi.org\/10.1016\/j.ijpara.2012.10.021","journal-title":"Int J Parasitol"},{"key":"2948_CR22","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1007\/s11033-013-2565-8","volume":"40","author":"S Karadayi","year":"2013","unstructured":"Karadayi S, Arslan S, Sumer Z, Turan M, Sumer H, Karadayi K (2013) Does hydatid disease have protective effects against lung cancer? Mol Biol Rep 40:4701\u20134704. https:\/\/doi.org\/10.1007\/s11033-013-2565-8","journal-title":"Mol Biol Rep"},{"key":"2948_CR23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/expr.2001.4620","volume":"98","author":"D Alvarez Errico","year":"2001","unstructured":"Alvarez Errico D, Medeiros A, M\u00edguez M, Casaravilla C, Malgor R, Carmona C, Nieto A, Osinaga E (2001) O-glycosylation in Echinococcus granulosus: identification and characterization of the carcinoma associated Tn antigen. Exp Parasitol 98:100\u2013109. https:\/\/doi.org\/10.1006\/expr.2001.4620","journal-title":"Exp Parasitol"},{"key":"2948_CR24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1615\/CritRevImmunol.v37.i2-6.110","volume":"37","author":"V Apostolopoulos","year":"2017","unstructured":"Apostolopoulos V, McKenzie IFC (2017) Cellular mucins: targets for Immunotherapy. Crit Rev Immunol 37:421\u2013437. https:\/\/doi.org\/10.1615\/CritRevImmunol.v37.i2-6.110","journal-title":"Crit Rev Immunol"},{"key":"2948_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-019-01143-y","author":"N Kim","year":"2019","unstructured":"Kim N, Lee HH, Lee HJ, Choi WS, Lee J, Kim HS (2019) Natural killer cells as a promising therapeutic target for cancer immunotherapy. Arch Pharm Res. https:\/\/doi.org\/10.1007\/s12272-019-01143-y","journal-title":"Arch Pharm Res"},{"key":"2948_CR26","doi-asserted-by":"publisher","first-page":"24801","DOI":"10.18632\/oncotarget.24835","volume":"9","author":"RA Soo","year":"2018","unstructured":"Soo RA, Chen Z, Yan Teng RS, Tan HL, Iacopetta B, Tai BC, Soong R (2018) Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis. Oncotarget 9:24801\u201324820. https:\/\/doi.org\/10.18632\/oncotarget.24835","journal-title":"Oncotarget"},{"key":"2948_CR27","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1128\/iai.56.5.1011-1016.1988","volume":"56","author":"JY Niederkorn","year":"1988","unstructured":"Niederkorn JY, Stewart GL, Ghazizadeh S, Mayhew E, Ross J, Fischer B (1988) Trichinella pseudospiralis larvae express natural killer (NK) cell-associated asialo-GM1 antigen and stimulate pulmonary NK activity. Infect Immun 56:1011\u20131016","journal-title":"Infect Immun"},{"key":"2948_CR28","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.4049\/jimmunol.179.4.2445","volume":"179","author":"S Babu","year":"2007","unstructured":"Babu S, Blauvelt CP, Nutman TB (2007) Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death. J Immunol 179:2445\u20132456. https:\/\/doi.org\/10.4049\/jimmunol.179.4.2445","journal-title":"J Immunol"},{"key":"2948_CR29","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.161.3.1428","volume":"161","author":"S Babu","year":"1998","unstructured":"Babu S, Porte P, Klei TR, Shultz LD, Rajan TV (1998) Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161:1428\u20131432","journal-title":"J Immunol"},{"key":"2948_CR30","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1007\/s004360050664","volume":"85","author":"A Hern\u00e1ndez","year":"1999","unstructured":"Hern\u00e1ndez A, O\u2019Connor JE, Mir A (1999) Phenotypic analysis of peripheral lymphocyte subpopulations in hydatid patients. Parasitol Res 85:948\u2013950","journal-title":"Parasitol Res"},{"key":"2948_CR31","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.4049\/jimmunol.168.10.5199","volume":"168","author":"S Korten","year":"2002","unstructured":"Korten S, Volkmann L, Saeftel M, Fischer K, Taniguchi M, Fleischer B, Hoerauf A (2002) Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite control. J Immunol 168:5199\u20135206. https:\/\/doi.org\/10.4049\/jimmunol.168.10.5199","journal-title":"J Immunol"},{"key":"2948_CR32","doi-asserted-by":"publisher","first-page":"e1293","DOI":"10.1371\/journal.pntd.0001293","volume":"5","author":"G Mourglia-Ettlin","year":"2011","unstructured":"Mourglia-Ettlin G, Marqu\u00e9s JM, Chabalgoity JA, Dematteis S (2011) Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior. PLoS Negl Trop Dis 5:e1293. https:\/\/doi.org\/10.1371\/journal.pntd.0001293","journal-title":"PLoS Negl Trop Dis"},{"key":"2948_CR33","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2183\/pjab.87.463","volume":"87","author":"K Takatsu","year":"2011","unstructured":"Takatsu K (2011) Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci 87:463\u2013485. https:\/\/doi.org\/10.2183\/pjab.87.463","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"2948_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nri3341","volume":"13","author":"HF Rosenberg","year":"2013","unstructured":"Rosenberg HF, Dyer KD, Foster PS (2013) Eosinophils: changing perspectives in health and disease. Nat Rev Immunol 13:9\u201322. https:\/\/doi.org\/10.1038\/nri3341","journal-title":"Nat Rev Immunol"},{"key":"2948_CR35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/CJI.0b013e318174a512","volume":"31","author":"A Capobianco","year":"2008","unstructured":"Capobianco A, Manfredi AA, Monno A, Rovere-Querini P, Rugarli C (2008) Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK\/LAK cells. J Immunother 31:458\u2013465. https:\/\/doi.org\/10.1097\/CJI.0b013e318174a512","journal-title":"J Immunother"},{"key":"2948_CR36","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/ni.3159","volume":"16","author":"R Carretero","year":"2015","unstructured":"Carretero R, Sektioglu IM, Garbi N, Salgado OC, Beckhove P, H\u00e4mmerling GJ (2015) Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. Nat Immunol 16:609\u2013617. https:\/\/doi.org\/10.1038\/ni.3159","journal-title":"Nat Immunol"},{"key":"2948_CR37","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1189\/jlb.0108075","volume":"84","author":"S Buonocore","year":"2008","unstructured":"Buonocore S, Haddou NO, Moore F, Florquin S, Paulart F, Heirman C, Thielemans K, Goldman M, Flamand V (2008) Neutrophil-dependent tumor rejection and priming of tumoricidal CD8+ T cell response induced by dendritic cells overexpressing CD95L. J Leukoc Biol 84:713\u2013720. https:\/\/doi.org\/10.1189\/jlb.0108075","journal-title":"J Leukoc Biol"},{"key":"2948_CR38","doi-asserted-by":"publisher","first-page":"14355","DOI":"10.1007\/s13277-016-5328-z","volume":"37","author":"M Garley","year":"2016","unstructured":"Garley M, Jab\u0142o\u0144ska E, D\u0105browska D (2016) NETs in cancer. Tumour Biol 37:14355\u201314361. https:\/\/doi.org\/10.1007\/s13277-016-5328-z","journal-title":"Tumour Biol"},{"key":"2948_CR39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2249.1995.tb05569.x","volume":"99","author":"R Rigan\u00f2","year":"1995","unstructured":"Rigan\u00f2 R, Profumo E, di Felice G, Ortona E, Teggi A, Siracusano A (1995) In vitro production of cytokines by peripheral blood mononuclear cells from hydatid patients. Clin Exp Immunol 99:433\u2013439. https:\/\/doi.org\/10.1111\/j.1365-2249.1995.tb05569.x","journal-title":"Clin Exp Immunol"},{"key":"2948_CR40","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-2567.2006.02375.x","volume":"118","author":"JH Kanan","year":"2006","unstructured":"Kanan JH, Chain BM (2006) Modulation of dendritic cell differentiation and cytokine secretion by the hydatid cyst fluid of Echinococcus granulosus. Immunology 118:271\u2013278. https:\/\/doi.org\/10.1111\/j.1365-2567.2006.02375.x","journal-title":"Immunology"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-021-02948-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-021-02948-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-021-02948-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:48:14Z","timestamp":1698994094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-021-02948-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2948"],"URL":"https:\/\/doi.org\/10.1007\/s00262-021-02948-x","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,4]]},"assertion":[{"value":"10 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All mice were maintained under specific pathogen-free conditions and used in accordance with protocols established by the Animal Care Committee of the Institut Pasteur de Montevideo, Uruguay. All work with mice was performed according to protocol # 010\/12 approved by the Institutional Animal Care Committee and following the National Law of Animal Experimentation (# 18.611).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}