{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:14Z","timestamp":1792788254442,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002061"],"award-info":[{"award-number":["82002061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s00262-023-03504-5","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:04:00Z","timestamp":1693224240000},"page":"3523-3541","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of single-cell ferroptosis regulation in intercellular communication and skin cutaneous melanoma progression and immunotherapy"],"prefix":"10.1007","volume":"72","author":[{"given":"Binyu","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"3504_CR1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ejca.2022.03.008","volume":"170","author":"C Garbe","year":"2022","unstructured":"Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dr\u00e9no B et al (2022) European consensus-based interdisciplinary guideline for melanoma. Part 1: diagnostics update 2022. Eur J Cancer. 170:236\u2013255. https:\/\/doi.org\/10.1016\/j.ejca.2022.03.008","journal-title":"Eur J Cancer."},{"key":"3504_CR2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.0160","author":"M Arnold","year":"2022","unstructured":"Arnold M, Singh D, Laversanne M, Vignat J, Vaccarella S, Meheus F, Cust AE, de Vries E, Whiteman DC, Bray F (2022) Global burden of cutaneous melanoma in 2020 and projections to 2040. JAMA Dermatol. https:\/\/doi.org\/10.1001\/jamadermatol.2022.0160","journal-title":"JAMA Dermatol"},{"key":"3504_CR3","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","volume":"35","author":"B Hassannia","year":"2019","unstructured":"Hassannia B, Vandenabeele P, Vanden BT (2019) Targeting ferroptosis to iron out cancer. Cancer Cell 35:830\u2013849. https:\/\/doi.org\/10.1016\/j.ccell.2019.04.002","journal-title":"Cancer Cell"},{"key":"3504_CR4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12:599\u2013620. https:\/\/doi.org\/10.1007\/s13238-020-00789-5","journal-title":"Protein Cell"},{"key":"3504_CR5","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","volume":"20","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H et al (2018) BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20:1181\u20131192. https:\/\/doi.org\/10.1038\/s41556-018-0178-0","journal-title":"Nat Cell Biol"},{"key":"3504_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang L, Kon N, Li T, Wang S-J, Su T, Hibshoosh H, Baer R, Gu W (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520:57\u201362. https:\/\/doi.org\/10.1038\/nature14344","journal-title":"Nature"},{"key":"3504_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/pcmr.13009","volume":"35","author":"R Talty","year":"2022","unstructured":"Talty R, Bosenberg M (2022) The role of ferroptosis in melanoma. Pigment Cell Melanoma Res 35:18\u201325. https:\/\/doi.org\/10.1111\/pcmr.13009","journal-title":"Pigment Cell Melanoma Res"},{"key":"3504_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12920-022-01194-z","volume":"15","author":"C Liu","year":"2022","unstructured":"Liu C, Liu Y, Yu Y, Zhao Y, Yu A (2022) Comprehensive analysis of ferroptosis-related genes and prognosis of cutaneous melanoma. BMC Med Genomics 15:39. https:\/\/doi.org\/10.1186\/s12920-022-01194-z","journal-title":"BMC Med Genomics"},{"key":"3504_CR9","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1002\/cam4.4706","volume":"11","author":"S Ping","year":"2022","unstructured":"Ping S, Wang S, Zhao Y, He J, Li G, Li D, Wei Z, Chen J (2022) Identification and validation of a ferroptosis-related gene signature for predicting survival in skin cutaneous melanoma. Cancer Med 11:3529\u20133541. https:\/\/doi.org\/10.1002\/cam4.4706","journal-title":"Cancer Med"},{"key":"3504_CR10","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3390\/cancers15041069","volume":"15","author":"S Duro-S\u00e1nchez","year":"2023","unstructured":"Duro-S\u00e1nchez S, Alonso MR, Arribas J (2023) Immunotherapies against HER2-positive breast cancer. Cancers (Basel) 15:1069. https:\/\/doi.org\/10.3390\/cancers15041069","journal-title":"Cancers (Basel)"},{"key":"3504_CR11","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.7150\/ijbs.79651","volume":"19","author":"D Wang","year":"2023","unstructured":"Wang D, Han Y, Peng L, Huang T, He X, Wang J, Ou C (2023) Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment. Int J Biol Sci 19:2198\u20132219. https:\/\/doi.org\/10.7150\/ijbs.79651","journal-title":"Int J Biol Sci"},{"key":"3504_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00048.2019","volume":"101","author":"G Biffi","year":"2021","unstructured":"Biffi G, Tuveson DA (2021) Diversity and biology of cancer-associated fibroblasts. Physiol Rev 101:147\u2013176. https:\/\/doi.org\/10.1152\/physrev.00048.2019","journal-title":"Physiol Rev"},{"key":"3504_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002054","author":"Y Xia","year":"2020","unstructured":"Xia Y, Rao L, Yao H, Wang Z, Ning P, Chen X (2020) Engineering macrophages for cancer immunotherapy and drug delivery. Adv Mater. https:\/\/doi.org\/10.1002\/adma.202002054","journal-title":"Adv Mater"},{"key":"3504_CR14","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1016\/j.immuni.2021.11.015","volume":"54","author":"DY Oh","year":"2021","unstructured":"Oh DY, Fong L (2021) Cytotoxic CD4+ T cells in cancer: expanding the immune effector toolbox. Immunity 54:2701\u20132711. https:\/\/doi.org\/10.1016\/j.immuni.2021.11.015","journal-title":"Immunity"},{"key":"3504_CR15","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/cells9051305","volume":"9","author":"M Yazdanifar","year":"2020","unstructured":"Yazdanifar M, Barbarito G, Bertaina A, Airoldi I (2020) \u03b3\u03b4 T cells: the ideal tool for cancer immunotherapy. Cells 9:1305. https:\/\/doi.org\/10.3390\/cells9051305","journal-title":"Cells"},{"key":"3504_CR16","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.ccell.2021.09.007","volume":"39","author":"V Engelhard","year":"2021","unstructured":"Engelhard V, Conejo-Garcia JR, Ahmed R, Nelson BH, Willard-Gallo K, Bruno TC, Fridman WH (2021) B cells and cancer. Cancer Cell 39:1293\u20131296. https:\/\/doi.org\/10.1016\/j.ccell.2021.09.007","journal-title":"Cancer Cell"},{"key":"3504_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/imr.12939","volume":"299","author":"D Michaud","year":"2021","unstructured":"Michaud D, Steward CR, Mirlekar B, Pylayeva-Gupta Y (2021) Regulatory B cells in cancer. Immunol Rev 299:74\u201392. https:\/\/doi.org\/10.1111\/imr.12939","journal-title":"Immunol Rev"},{"key":"3504_CR18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nature25501","volume":"554","author":"S Mariathasan","year":"2018","unstructured":"Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE, Koeppen H, Astarita JL, Cubas R et al (2018) TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554:544\u2013548. https:\/\/doi.org\/10.1038\/nature25501","journal-title":"Nature"},{"key":"3504_CR19","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1158\/1078-0432.CCR-20-4226","volume":"27","author":"PM Galbo","year":"2021","unstructured":"Galbo PM, Zang X, Zheng D (2021) Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance. Clin Cancer Res 27:2636\u20132647. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-4226","journal-title":"Clin Cancer Res"},{"key":"3504_CR20","doi-asserted-by":"publisher","first-page":"3658196","DOI":"10.1155\/2021\/3658196","volume":"2021","author":"H Zeng","year":"2021","unstructured":"Zeng H, You C, Zhao L, Wang J, Ye X, Yang T, Wan C, Deng L (2021) Ferroptosis-associated classifier and indicator for prognostic prediction in cutaneous melanoma. J Oncol 2021:3658196. https:\/\/doi.org\/10.1155\/2021\/3658196","journal-title":"J Oncol"},{"key":"3504_CR21","doi-asserted-by":"publisher","first-page":"818457","DOI":"10.3389\/fcell.2022.818457","volume":"10","author":"Y Liu","year":"2022","unstructured":"Liu Y, Shou Y, Zhu R, Qiu Z, Zhang Q, Xu J (2022) Construction and validation of a ferroptosis-related prognostic signature for melanoma based on single-cell RNA sequencing. Front Cell Dev Biol. 10:818457. https:\/\/doi.org\/10.3389\/fcell.2022.818457","journal-title":"Front Cell Dev Biol."},{"key":"3504_CR22","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.ccell.2023.03.001","volume":"41","author":"Y Chen","year":"2023","unstructured":"Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X et al (2023) Epithelial cells activate fibroblasts to promote esophageal cancer development. Cancer Cell 41:903-918.e8. https:\/\/doi.org\/10.1016\/j.ccell.2023.03.001","journal-title":"Cancer Cell"},{"key":"3504_CR23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12943-019-0976-4","volume":"18","author":"C Wei","year":"2019","unstructured":"Wei C, Yang C, Wang S, Shi D, Zhang C, Lin X, Liu Q, Dou R, Xiong B (2019) Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis. Mol Cancer 18:64. https:\/\/doi.org\/10.1186\/s12943-019-0976-4","journal-title":"Mol Cancer"},{"key":"3504_CR24","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1136\/thoraxjnl-2021-217997","volume":"77","author":"AM de Waal","year":"2022","unstructured":"de Waal AM, Hiemstra PS, Ottenhoff TH, Joosten SA, van der Does AM (2022) Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis. Thorax 77:408\u2013416. https:\/\/doi.org\/10.1136\/thoraxjnl-2021-217997","journal-title":"Thorax"},{"key":"3504_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.canlet.2017.11.010","volume":"414","author":"E Angelopoulou","year":"2018","unstructured":"Angelopoulou E, Piperi C (2018) Emerging role of plexins signaling in glioma progression and therapy. Cancer Lett 414:81\u201387. https:\/\/doi.org\/10.1016\/j.canlet.2017.11.010","journal-title":"Cancer Lett"},{"key":"3504_CR26","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3390\/ijms20030556","volume":"20","author":"S Toledano","year":"2019","unstructured":"Toledano S, Nir-Zvi I, Engelman R, Kessler O, Neufeld G (2019) Class-3 semaphorins and their receptors: potent multifunctional modulators of tumor progression. Int J Mol Sci 20:556. https:\/\/doi.org\/10.3390\/ijms20030556","journal-title":"Int J Mol Sci"},{"key":"3504_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ccr.2012.06.031","volume":"22","author":"L Tamagnone","year":"2012","unstructured":"Tamagnone L (2012) Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer. Cancer Cell 22:145\u2013152. https:\/\/doi.org\/10.1016\/j.ccr.2012.06.031","journal-title":"Cancer Cell"},{"key":"3504_CR28","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nrd4337","volume":"13","author":"T Worzfeld","year":"2014","unstructured":"Worzfeld T, Offermanns S (2014) Semaphorins and plexins as therapeutic targets. Nat Rev Drug Discov 13:603\u2013621. https:\/\/doi.org\/10.1038\/nrd4337","journal-title":"Nat Rev Drug Discov"},{"key":"3504_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12920-020-0682-5","volume":"13","author":"X Zhang","year":"2020","unstructured":"Zhang X, Klamer B, Li J, Fernandez S, Li L (2020) A pan-cancer study of class-3 semaphorins as therapeutic targets in cancer. BMC Med Genomics 13:45. https:\/\/doi.org\/10.1186\/s12920-020-0682-5","journal-title":"BMC Med Genomics"},{"key":"3504_CR30","doi-asserted-by":"publisher","first-page":"927390","DOI":"10.3389\/fendo.2022.927390","volume":"13","author":"AH Nwabo Kamdje","year":"2022","unstructured":"Nwabo Kamdje AH, Seke Etet PF, Kipanyula MJ, Vecchio L, Tagne Simo R, Njamnshi AK, Lukong KE, Mimche PN (2022) Insulin-like growth factor-1 signaling in the tumor microenvironment: carcinogenesis, cancer drug resistance, and therapeutic potential. Front Endocrinol (Lausanne). 13:927390. https:\/\/doi.org\/10.3389\/fendo.2022.927390","journal-title":"Front Endocrinol (Lausanne)."},{"key":"3504_CR31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/bs.acr.2020.04.005","volume":"147","author":"LM Fettig","year":"2020","unstructured":"Fettig LM, Yee D (2020) Advances in insulin-like growth factor biology and -directed cancer therapeutics. Adv Cancer Res 147:229\u2013257. https:\/\/doi.org\/10.1016\/bs.acr.2020.04.005","journal-title":"Adv Cancer Res"},{"key":"3504_CR32","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1158\/2159-8290.CD-21-0190","volume":"11","author":"MJ Parsons","year":"2021","unstructured":"Parsons MJ, Tammela T, Dow LE (2021) WNT as a driver and dependency in cancer. Cancer Discov 11:2413\u20132429. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-0190","journal-title":"Cancer Discov"},{"key":"3504_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09665-2","author":"S Jian","year":"2021","unstructured":"Jian S, Luo D, Wang Y, Xu W, Zhang H, Zhang L, Zhou X (2021) MiR-337-3p confers protective effect on facet joint osteoarthritis by targeting SKP2 to inhibit DUSP1 ubiquitination and inactivate MAPK pathway. Cell Biol Toxicol. https:\/\/doi.org\/10.1007\/s10565-021-09665-2","journal-title":"Cell Biol Toxicol"},{"key":"3504_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12867-019-0135-x","volume":"20","author":"J Shen","year":"2019","unstructured":"Shen J, Xing W, Liu R, Zhang Y, Xie C, Gong F (2019) MiR-32-5p influences high glucose-induced cardiac fibroblast proliferation and phenotypic alteration by inhibiting DUSP1. BMC Mol Biol 20:21. https:\/\/doi.org\/10.1186\/s12867-019-0135-x","journal-title":"BMC Mol Biol"},{"key":"3504_CR35","doi-asserted-by":"publisher","first-page":"10916","DOI":"10.3390\/ijms231810916","volume":"23","author":"L Li","year":"2022","unstructured":"Li L, Yang M, Yu J, Cheng S, Ahmad M, Wu C, Wan X, Xu B, Ben-David Y, Luo H (2022) A novel L-phenylalanine dipeptide inhibits the growth and metastasis of prostate cancer cells via targeting DUSP1 and TNFSF9. Int J Mol Sci 23:10916. https:\/\/doi.org\/10.3390\/ijms231810916","journal-title":"Int J Mol Sci"},{"key":"3504_CR36","doi-asserted-by":"publisher","first-page":"110428","DOI":"10.1016\/j.ygeno.2022.110428","volume":"114","author":"W Pan","year":"2022","unstructured":"Pan W, Han J, Wei N, Wu H, Wang Y, Sun J (2022) LINC00702-mediated DUSP1 transcription in the prevention of bladder cancer progression: Implications in cancer cell proliferation and tumor inflammatory microenvironment. Genomics. 114:110428. https:\/\/doi.org\/10.1016\/j.ygeno.2022.110428","journal-title":"Genomics."},{"key":"3504_CR37","doi-asserted-by":"publisher","first-page":"851540","DOI":"10.3389\/fphar.2022.851540","volume":"13","author":"C Huang","year":"2022","unstructured":"Huang C, Zhan L (2022) Network pharmacology identifies therapeutic targets and the mechanisms of glutathione action in ferroptosis occurring in oral cancer. Front Pharmacol. 13:851540. https:\/\/doi.org\/10.3389\/fphar.2022.851540","journal-title":"Front Pharmacol."},{"key":"3504_CR38","doi-asserted-by":"publisher","first-page":"5813522","DOI":"10.1155\/2022\/5813522","volume":"2022","author":"H Deng","year":"2022","unstructured":"Deng H, Lin Y, Gan F, Li B, Mou Z, Qin X, He X, Meng Y (2022) Prognostic model and immune infiltration of ferroptosis subcluster-related modular genes in gastric cancer. J Oncol 2022:5813522. https:\/\/doi.org\/10.1155\/2022\/5813522","journal-title":"J Oncol"},{"key":"3504_CR39","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, Yu C, Kang R, Kroemer G, Tang D (2021) Cellular degradation systems in ferroptosis. Cell Death Differ 28:1135\u20131148. https:\/\/doi.org\/10.1038\/s41418-020-00728-1","journal-title":"Cell Death Differ"},{"key":"3504_CR40","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.redox.2017.11.004","volume":"14","author":"Q Jin","year":"2018","unstructured":"Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, Ma S, Zhu H, Ren J, Zhou H (2018) DUSP1 alleviates cardiac ischemia\/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol 14:576\u2013587. https:\/\/doi.org\/10.1016\/j.redox.2017.11.004","journal-title":"Redox Biol"},{"key":"3504_CR41","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12872-020-01529-7","volume":"20","author":"J Ji","year":"2020","unstructured":"Ji J, Liu Z, Hong X, Liu Z, Gao J, Liu J (2020) Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts. BMC Cardiovasc Disord 20:242. https:\/\/doi.org\/10.1186\/s12872-020-01529-7","journal-title":"BMC Cardiovasc Disord"},{"key":"3504_CR42","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.3390\/cells10112836","volume":"10","author":"S Blumer","year":"2021","unstructured":"Blumer S, Fang L, Chen W-C, Khan P, Hostettler K, Tamm M, Roth M, Lambers C (2021) IPF-fibroblast Erk1\/2 activity is independent from microRNA cluster 17\u201392 but can be inhibited by treprostinil through DUSP1. Cells 10:2836. https:\/\/doi.org\/10.3390\/cells10112836","journal-title":"Cells"},{"key":"3504_CR43","doi-asserted-by":"publisher","first-page":"8441","DOI":"10.3892\/mmr.2017.7617","volume":"16","author":"H-Z Peng","year":"2017","unstructured":"Peng H-Z, Yun Z, Wang W, Ma B-A (2017) Dual specificity phosphatase 1 has a protective role in osteoarthritis fibroblast-like synoviocytes via inhibition of the MAPK signaling pathway. Mol Med Rep 16:8441\u20138447. https:\/\/doi.org\/10.3892\/mmr.2017.7617","journal-title":"Mol Med Rep"},{"key":"3504_CR44","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1158\/1078-0432.CCR-18-3224","volume":"25","author":"A Ramkissoon","year":"2019","unstructured":"Ramkissoon A, Chaney KE, Milewski D, Williams KB, Williams RL, Choi K, Miller A, Kalin TV, Pressey JG, Szabo S et al (2019) Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK. Clin Cancer Res 25:4117\u20134127. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-3224","journal-title":"Clin Cancer Res"},{"key":"3504_CR45","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1002\/cam4.5518","volume":"12","author":"L Zhang","year":"2023","unstructured":"Zhang L, Gao S, Shi X, Chen Y, Wei S, Mi Y, Zuo L, Qi C (2023) NUPR1 imparts oncogenic potential in bladder cancer. Cancer Med 12:7149\u20137163. https:\/\/doi.org\/10.1002\/cam4.5518","journal-title":"Cancer Med"},{"key":"3504_CR46","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41392-022-00939-7","volume":"7","author":"T Fan","year":"2022","unstructured":"Fan T, Wang X, Zhang S, Deng P, Jiang Y, Liang Y, Jie S, Wang Q, Li C, Tian G et al (2022) NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy. Signal Transduct Target Ther 7:130. https:\/\/doi.org\/10.1038\/s41392-022-00939-7","journal-title":"Signal Transduct Target Ther"},{"key":"3504_CR47","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/jpp\/rgab010","volume":"73","author":"L Jiang","year":"2021","unstructured":"Jiang L, Wang W, Li Z, Zhao Y, Qin Z (2021) NUPR1 participates in YAP-mediate gastric cancer malignancy and drug resistance via AKT and p21 activation. J Pharm Pharmacol 73:740\u2013748. https:\/\/doi.org\/10.1093\/jpp\/rgab010","journal-title":"J Pharm Pharmacol"},{"key":"3504_CR48","doi-asserted-by":"publisher","first-page":"107167","DOI":"10.1016\/j.intimp.2020.107167","volume":"90","author":"Q Dai","year":"2021","unstructured":"Dai Q, Wu W, Amei A, Yan X, Lu L, Wang Z (2021) Regulation and characterization of tumor-infiltrating immune cells in breast cancer. Int Immunopharmacol. 90:107167. https:\/\/doi.org\/10.1016\/j.intimp.2020.107167","journal-title":"Int Immunopharmacol."},{"key":"3504_CR49","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","volume":"40","author":"P Liao","year":"2022","unstructured":"Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK et al (2022) CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell 40:365-378.e6. https:\/\/doi.org\/10.1016\/j.ccell.2022.02.003","journal-title":"Cancer Cell"},{"key":"3504_CR50","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, Green M, Choi JE, Gij\u00f3n M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A et al (2019) CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569:270\u2013274. https:\/\/doi.org\/10.1038\/s41586-019-1170-y","journal-title":"Nature"},{"key":"3504_CR51","doi-asserted-by":"publisher","first-page":"715234","DOI":"10.3389\/fimmu.2021.715234","volume":"12","author":"JS Dolina","year":"2021","unstructured":"Dolina JS, Van Braeckel-Budimir N, Thomas GD, Salek-Ardakani S (2021) CD8+ T cell exhaustion in cancer. Front Immunol. 12:715234. https:\/\/doi.org\/10.3389\/fimmu.2021.715234","journal-title":"Front Immunol."},{"key":"3504_CR52","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","volume":"124","author":"H Raskov","year":"2021","unstructured":"Raskov H, Orhan A, Christensen JP, G\u00f6genur I (2021) Cytotoxic CD8+ T cells in cancer and cancer immunotherapy. Br J Cancer 124:359\u2013367. https:\/\/doi.org\/10.1038\/s41416-020-01048-4","journal-title":"Br J Cancer"},{"key":"3504_CR53","doi-asserted-by":"publisher","first-page":"107964","DOI":"10.1016\/j.pharmthera.2021.107964","volume":"230","author":"Y Kanai","year":"2022","unstructured":"Kanai Y (2022) Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics. Pharmacol Ther. 230:107964. https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107964","journal-title":"Pharmacol Ther."},{"key":"3504_CR54","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","volume":"27","author":"L Wang","year":"2020","unstructured":"Wang L, Liu Y, Du T, Yang H, Lei L, Guo M, Ding H-F, Zhang J, Wang H, Chen X et al (2020) ATF3 promotes erastin-induced ferroptosis by suppressing system Xc. Cell Death Differ 27:662\u2013675. https:\/\/doi.org\/10.1038\/s41418-019-0380-z","journal-title":"Cell Death Differ"},{"key":"3504_CR55","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-020-01016-8","volume":"14","author":"Y Ding","year":"2021","unstructured":"Ding Y, Chen X, Liu C, Ge W, Wang Q, Hao X, Wang M, Chen Y, Zhang Q (2021) Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol 14:19. https:\/\/doi.org\/10.1186\/s13045-020-01016-8","journal-title":"J Hematol Oncol"},{"key":"3504_CR56","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1139\/bcb-2021-0513","volume":"100","author":"Z Liu","year":"2022","unstructured":"Liu Z, Xu Y, Liu X, Wang B (2022) PCDH7 knockdown potentiates colon cancer cells to chemotherapy via inducing ferroptosis and changes in autophagy through restraining MEK1\/2\/ERK\/c-Fos axis. Biochem Cell Biol 100:445\u2013457. https:\/\/doi.org\/10.1139\/bcb-2021-0513","journal-title":"Biochem Cell Biol"},{"key":"3504_CR57","doi-asserted-by":"publisher","first-page":"172953","DOI":"10.1016\/j.ejphar.2020.172953","volume":"872","author":"C Ishikawa","year":"2020","unstructured":"Ishikawa C, Senba M, Mori N (2020) Evaluation of artesunate for the treatment of adult T-cell leukemia\/lymphoma. Eur J Pharmacol. 872:172953. https:\/\/doi.org\/10.1016\/j.ejphar.2020.172953","journal-title":"Eur J Pharmacol."},{"key":"3504_CR58","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1111\/febs.16272","volume":"289","author":"T-T Wei","year":"2022","unstructured":"Wei T-T, Zhang M-Y, Zheng X-H, Xie T-H, Wang W, Zou J, Li Y, Li H-Y, Cai J, Wang X et al (2022) Interferon-\u03b3 induces retinal pigment epithelial cell Ferroptosis by a JAK1-2\/STAT1\/SLC7A11 signaling pathway in age-related macular degeneration. FEBS J 289:1968\u20131983. https:\/\/doi.org\/10.1111\/febs.16272","journal-title":"FEBS J"},{"key":"3504_CR59","doi-asserted-by":"publisher","first-page":"104750","DOI":"10.1016\/j.isci.2022.104750","volume":"25","author":"Y Zhong","year":"2022","unstructured":"Zhong Y, Zhang W, Yu H, Lin L, Gao X, He J, Li D, Chen Y, Zeng Z, Xu Y et al (2022) Multi-platform-based characterization of ferroptosis in human colorectal cancer. iScience. 25:104750. https:\/\/doi.org\/10.1016\/j.isci.2022.104750","journal-title":"iScience."},{"key":"3504_CR60","doi-asserted-by":"publisher","first-page":"437","DOI":"10.17305\/bjbms.2022.8081","volume":"23","author":"Z Chen","year":"2023","unstructured":"Chen Z, Gu Q, Chen R (2023) Promotive role of IRF7 in ferroptosis of colonic epithelial cells in ulcerative colitis by the miR-375-3p\/SLC11A2 axis. Biomol Biomed 23:437\u2013449. https:\/\/doi.org\/10.17305\/bjbms.2022.8081","journal-title":"Biomol Biomed"},{"key":"3504_CR61","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41420-022-00902-z","volume":"8","author":"J Liu","year":"2022","unstructured":"Liu J, Ren Z, Yang L, Zhu L, Li Y, Bie C, Liu H, Ji Y, Chen D, Zhu M et al (2022) The NSUN5-FTH1\/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells. Cell Death Discov 8:99. https:\/\/doi.org\/10.1038\/s41420-022-00902-z","journal-title":"Cell Death Discov"},{"key":"3504_CR62","doi-asserted-by":"publisher","first-page":"897683","DOI":"10.3389\/fgene.2022.897683","volume":"13","author":"S Ke","year":"2022","unstructured":"Ke S, Wang C, Su Z, Lin S, Wu G (2022) Integrated analysis reveals critical ferroptosis regulators and FTL contribute to cancer progression in hepatocellular carcinoma. Front Genet. 13:897683. https:\/\/doi.org\/10.3389\/fgene.2022.897683","journal-title":"Front Genet."},{"key":"3504_CR63","first-page":"7865","volume":"10","author":"L Zhang","year":"2017","unstructured":"Zhang L, Chen Z, Xu A (2017) FTL: a novel predictor in gastric cancer. Int J Clin Exp Pathol 10:7865\u20137872","journal-title":"Int J Clin Exp Pathol"},{"key":"3504_CR64","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13046-020-01641-8","volume":"39","author":"J Liu","year":"2020","unstructured":"Liu J, Gao L, Zhan N, Xu P, Yang J, Yuan F, Xu Y, Cai Q, Geng R, Chen Q (2020) Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. J Exp Clin Cancer Res 39:137. https:\/\/doi.org\/10.1186\/s13046-020-01641-8","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-023-03504-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-023-03504-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-023-03504-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:04:06Z","timestamp":1697267046000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-023-03504-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["3504"],"URL":"https:\/\/doi.org\/10.1007\/s00262-023-03504-5","relation":{},"ISSN":["0340-7004","1432-0851"],"issn-type":[{"value":"0340-7004","type":"print"},{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"21 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}