{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:58:01Z","timestamp":1791435481291,"version":"4.3.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874110"],"award-info":[{"award-number":["81874110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672280"],"award-info":[{"award-number":["81672280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016803","name":"Natural Science Foundation of Suzhou Municipality","doi-asserted-by":"publisher","award":["SYS2021034"],"award-info":[{"award-number":["SYS2021034"]}],"id":[{"id":"10.13039\/100016803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-024-03881-5","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T04:56:14Z","timestamp":1735880174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High CD38 expression defines a mitochondrial function-adapted CD8+ T cell subset with implications for lung cancer immunotherapy"],"prefix":"10.1007","volume":"74","author":[{"given":"Lei-Lei","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Qin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Xia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"issue":"3","key":"3881_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/jama.2023.24735","volume":"331","author":"S Lu","year":"2024","unstructured":"Lu S, Zhang W, Wu L et al (2024) Perioperative toripalimab plus chemotherapy for patients with resectable non-small cell lung cancer: the neotorch randomized clinical trial [J]. JAMA 331(3):201\u2013211","journal-title":"JAMA"},{"issue":"9","key":"3881_CR2","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1158\/2159-8290.CD-17-1033","volume":"8","author":"L Chen","year":"2018","unstructured":"Chen L, Diao L, Yang Y et al (2018) CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1\/PD-L1 blockade [J]. Cancer Discov 8(9):1156\u20131175","journal-title":"Cancer Discov"},{"issue":"6","key":"3881_CR3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1200\/JCO.21.01845","volume":"40","author":"A Passaro","year":"2022","unstructured":"Passaro A, Brahmer J, Antonia S et al (2022) Managing resistance to immune checkpoint inhibitors in lung cancer: treatment and novel strategies [J]. J Clinic Oncol: Off J Am Soc Clinic Oncol 40(6):598\u2013610","journal-title":"J Clinic Oncol: Off J Am Soc Clinic Oncol"},{"issue":"1","key":"3881_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13045-022-01391-4","volume":"15","author":"K Fu","year":"2022","unstructured":"Fu K, Xie F, Wang F et al (2022) Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance [J]. J Hematol Oncol 15(1):173","journal-title":"J Hematol Oncol"},{"issue":"4","key":"3881_CR5","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1136\/gutjnl-2020-321031","volume":"71","author":"J Huang","year":"2022","unstructured":"Huang J, Liu D, Wang Y et al (2022) Ginseng polysaccharides alter the gut microbiota and kynurenine\/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1\/programmed cell death ligand 1 (anti-PD-1\/PD-L1) immunotherapy [J]. Gut 71(4):734\u201345","journal-title":"Gut"},{"issue":"7870","key":"3881_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41586-021-03752-4","volume":"596","author":"JX Caushi","year":"2021","unstructured":"Caushi JX, Zhang J, Ji Z et al (2021) Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers [J]. Nature 596(7870):126\u2013132","journal-title":"Nature"},{"issue":"1","key":"3881_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13046-019-1126-y","volume":"38","author":"L Fang","year":"2019","unstructured":"Fang L, Ly D, Wang S-S et al (2019) Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade [J]. J Exp Clinic Cancer Res: CR 38(1):123","journal-title":"J Exp Clinic Cancer Res: CR"},{"issue":"2","key":"3881_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","volume":"124","author":"H Raskov","year":"2021","unstructured":"Raskov H, Orhan A, Christensen JP et al (2021) Cytotoxic CD8+ T cells in cancer and cancer immunotherapy [J]. Br J Cancer 124(2):359\u2013367","journal-title":"Br J Cancer"},{"key":"3881_CR9","doi-asserted-by":"publisher","first-page":"104876","DOI":"10.1016\/j.phrs.2020.104876","volume":"159","author":"T Wang","year":"2020","unstructured":"Wang T, Shen Y, Luyten S et al (2020) Tissue-resident memory CD8+ T cells in cancer immunology and immunotherapy [J]. Pharmacol Res 159:104876","journal-title":"Pharmacol Res"},{"issue":"1","key":"3881_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","volume":"52","author":"PS Hegde","year":"2020","unstructured":"Hegde PS, Chen DS (2020) Top 10 Challenges in cancer immunotherapy [J]. Immunity 52(1):17\u201335","journal-title":"Immunity"},{"issue":"6","key":"3881_CR11","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.eururo.2021.01.017","volume":"79","author":"C Guo","year":"2021","unstructured":"Guo C, Crespo M, Gurel B et al (2021) CD38 in advanced prostate cancers [J]. Eur Urol 79(6):736\u2013746","journal-title":"Eur Urol"},{"key":"3881_CR12","doi-asserted-by":"publisher","first-page":"113395","DOI":"10.1016\/j.biopha.2022.113395","volume":"153","author":"W Li","year":"2022","unstructured":"Li W, Liang L, Liao Q et al (2022) CD38: An important regulator of T cell function [J]. Biomed Pharmacother 153:113395","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"3881_CR13","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1152\/physrev.00046.2020","volume":"101","author":"AL Horenstein","year":"2021","unstructured":"Horenstein AL, Faini AC, Malavasi F (2021) CD38 in the age of COVID-19: a medical perspective [J]. Physiol Rev 101(4):1457\u20131486","journal-title":"Physiol Rev"},{"issue":"9","key":"3881_CR14","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/s41590-019-0441-y","volume":"20","author":"V Verma","year":"2019","unstructured":"Verma V, Shrimali RK, Ahmad S et al (2019) PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance [J]. Nat Immunol 20(9):1231\u20131243","journal-title":"Nat Immunol"},{"issue":"1","key":"3881_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41392-020-00354-w","volume":"6","author":"LE Navas","year":"2021","unstructured":"Navas LE, Carnero A (2021) NAD+ metabolism, stemness, the immune response, and cancer [J]. Signal Transduct Target Ther 6(1):2","journal-title":"Signal Transduct Target Ther"},{"issue":"14","key":"3881_CR16","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.3390\/molecules25143146","volume":"25","author":"SA Almatroodi","year":"2020","unstructured":"Almatroodi SA, Almatroudi A, Khan AA et al (2020) Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer [J]. Molecul (Basel, Switzerland) 25(14):3146","journal-title":"Molecul (Basel, Switzerland)"},{"issue":"19","key":"3881_CR17","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.3390\/molecules25194553","volume":"25","author":"S Hayakawa","year":"2020","unstructured":"Hayakawa S, Ohishi T, Miyoshi N et al (2020) Anti-cancer effects of green tea epigallocatchin-3-gallate and coffee chlorogenic acid [J]. Molecul (Basel, Switzerland) 25(19):4553","journal-title":"Molecul (Basel, Switzerland)"},{"issue":"1","key":"3881_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41375-020-0810-4","volume":"35","author":"D Viola","year":"2021","unstructured":"Viola D, Dona A, Caserta E et al (2021) Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting [J]. Leukemia 35(1):189\u2013200","journal-title":"Leukemia"},{"issue":"85","key":"3881_CR19","doi-asserted-by":"publisher","first-page":"eadd1591","DOI":"10.1126\/sciimmunol.add1591","volume":"8","author":"R Wang","year":"2023","unstructured":"Wang R, Singaraju A, Marks KE et al (2023) Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis [J]. Sci Immunol 8(85):eadd1591","journal-title":"Sci Immunol"},{"issue":"2","key":"3881_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/bjh.18185","volume":"198","author":"LJ Costa","year":"2022","unstructured":"Costa LJ, Hungria V, Mohty M et al (2022) How I treat triple-class refractory multiple myeloma [J]. Br J Haematol 198(2):244\u2013256","journal-title":"Br J Haematol"},{"issue":"10","key":"3881_CR21","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/cac2.12359","volume":"42","author":"P Chen","year":"2022","unstructured":"Chen P, Liu Y, Wen Y et al (2022) Non-small cell lung cancer in China [J]. Cancer Commun (Lond, Eng) 42(10):937\u2013970","journal-title":"Cancer Commun (Lond, Eng)"},{"issue":"21","key":"3881_CR22","doi-asserted-by":"publisher","first-page":"eade4186","DOI":"10.1126\/sciadv.ade4186","volume":"9","author":"C Huang","year":"2023","unstructured":"Huang C, Ren S, Chen Y et al (2023) PD-L1 methylation restricts PD-L1\/PD-1 interactions to control cancer immune surveillance [J]. Sci Adv 9(21):eade4186","journal-title":"Sci Adv"},{"issue":"14","key":"3881_CR23","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1200\/JCO.22.01748","volume":"41","author":"L Sanchez-Magraner","year":"2023","unstructured":"Sanchez-Magraner L, Gumuzio J, Miles J et al (2023) Functional engagement of the PD-1\/PD-L1 complex but not PD-L1 expression is highly predictive of patient response to immunotherapy in non-small-cell lung cancer [J]. J Clinic Oncol: Off J Am Soc Clinic Oncol 41(14):2561\u20132570","journal-title":"J Clinic Oncol: Off J Am Soc Clinic Oncol"},{"issue":"4","key":"3881_CR24","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.cmet.2022.02.009","volume":"34","author":"L Ye","year":"2022","unstructured":"Ye L, Park JJ, Peng L et al (2022) A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy [J]. Cell Metabolism 34(4):595","journal-title":"Cell Metabolism"},{"issue":"6","key":"3881_CR25","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41590-021-00940-2","volume":"22","author":"Y Guo","year":"2021","unstructured":"Guo Y, Xie Y-Q, Gao M et al (2021) Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity [J]. Nat Immunol 22(6):746\u2013756","journal-title":"Nat Immunol"},{"issue":"2","key":"3881_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1136\/thoraxjnl-2021-218047","volume":"78","author":"S Tiwari-Heckler","year":"2023","unstructured":"Tiwari-Heckler S, Lee GR, Harbison J et al (2023) Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39 [J]. Thorax 78(2):151\u2013159","journal-title":"Thorax"},{"issue":"1","key":"3881_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s13046-022-02439-6","volume":"41","author":"L Zhang","year":"2022","unstructured":"Zhang L, Zhang W, Li Z et al (2022) Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review [J]. J Exp Clinic Cancer Res: CR 41(1):227","journal-title":"J Exp Clinic Cancer Res: CR"},{"issue":"12","key":"3881_CR28","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-020-0793-3","volume":"21","author":"Y-R Yu","year":"2020","unstructured":"Yu Y-R, Imrichova H, Wang H et al (2020) Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion [J]. Nat Immunol 21(12):1540\u20131551","journal-title":"Nat Immunol"},{"issue":"3","key":"3881_CR29","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.celrep.2019.12.050","volume":"30","author":"L Swadling","year":"2020","unstructured":"Swadling L, Pallett LJ, Diniz MO et al (2020) Human liver memory CD8+ T cells use autophagy for tissue residence [J]. Cell Rep 30(3):687","journal-title":"Cell Rep"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-024-03881-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-024-03881-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-024-03881-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T20:09:51Z","timestamp":1739131791000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-024-03881-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["3881"],"URL":"https:\/\/doi.org\/10.1007\/s00262-024-03881-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4815459\/v1","asserted-by":"object"}]},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"28 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of the First Affiliated Hospital of Soochow University (2019\u2013070). The processing of clinical tissue samples is in strict compliance with the ethical standards of the Declaration of Helsinki. Informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"49"}}