{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T16:22:33Z","timestamp":1794068553538,"version":"4.8.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-024-03916-x","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T10:04:35Z","timestamp":1735898675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tumor-colonizing Lachnoclostridium-mediated chemokine expression enhances the immune infiltration of bladder urothelial carcinoma"],"prefix":"10.1007","volume":"74","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"issue":"1","key":"3916_CR1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13045-022-01291-7","volume":"15","author":"N Xu","year":"2022","unstructured":"Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z et al (2022) Integrated proteogenomic characterization of urothelial carcinoma of the bladder. J Hematol Oncol 15(1):76","journal-title":"J Hematol Oncol"},{"issue":"2","key":"3916_CR2","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","volume":"11","author":"D Singh","year":"2023","unstructured":"Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, Arbyn M, Basu P, Bray F, Vaccarella S (2023) Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO global cervical cancer elimination initiative. Lancet Glob Health 11(2):e197\u2013e206","journal-title":"Lancet Glob Health"},{"issue":"1","key":"3916_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrc3817","volume":"15","author":"MA Knowles","year":"2015","unstructured":"Knowles MA, Hurst CD (2015) Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer 15(1):25\u201341","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"3916_CR4","first-page":"162","volume":"22","author":"T Gevaert","year":"2021","unstructured":"Gevaert T, Cimadamore A, Montironi R, Eckstein M (2021) PD-L1 Testing for urothelial carcinoma: interchangeability, reliability and future perspectives. Curr Drug Targets 22(2):162\u2013170","journal-title":"Curr Drug Targets"},{"issue":"22","key":"3916_CR5","doi-asserted-by":"publisher","first-page":"690","DOI":"10.21037\/atm.2019.10.24","volume":"7","author":"M Eckstein","year":"2019","unstructured":"Eckstein M, Cimadamore A, Hartmann A, Lopez-Beltran A, Cheng L, Scarpelli M, Montironi R, Gevaert T (2019) PD-L1 assessment in urothelial carcinoma: a practical approach. Ann Transl Med 7(22):690","journal-title":"Ann Transl Med"},{"issue":"20","key":"3916_CR6","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1016\/j.cell.2022.09.015","volume":"185","author":"AB Dohlman","year":"2022","unstructured":"Dohlman AB, Klug J, Mesko M, Gao IH, Lipkin SM, Shen X, Iliev ID (2022) A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell 185(20):3807\u20133822","journal-title":"Cell"},{"issue":"7937","key":"3916_CR7","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s41586-022-05435-0","volume":"611","author":"JL Galeano Nino","year":"2022","unstructured":"Galeano Nino JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E et al (2022) Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature 611(7937):810\u2013817","journal-title":"Nature"},{"issue":"20","key":"3916_CR8","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1016\/j.cell.2022.09.005","volume":"185","author":"L Narunsky-Haziza","year":"2022","unstructured":"Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, Gavert N, Stajich JE, Amit G, Gonzalez A et al (2022) Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 185(20):3789\u20133806","journal-title":"Cell"},{"issue":"6494","key":"3916_CR9","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","volume":"368","author":"D Nejman","year":"2020","unstructured":"Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E et al (2020) The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 368(6494):973\u2013980","journal-title":"Science"},{"issue":"7800","key":"3916_CR10","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41586-020-2095-1","volume":"579","author":"GD Poore","year":"2020","unstructured":"Poore GD, Kopylova E, Zhu Q, Carpenter C, Fraraccio S, Wandro S, Kosciolek T, Janssen S, Metcalf J, Song SJ et al (2020) Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature 579(7800):567\u2013574","journal-title":"Nature"},{"issue":"4","key":"3916_CR11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","volume":"178","author":"E Riquelme","year":"2019","unstructured":"Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A et al (2019) Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell 178(4):795\u2013806","journal-title":"Cell"},{"issue":"7","key":"3916_CR12","doi-asserted-by":"publisher","first-page":"e1331","DOI":"10.1002\/ctm2.1331","volume":"13","author":"L Sun","year":"2023","unstructured":"Sun L, Ke X, Guan A, Jin B, Qu J, Wang Y, Xu X, Li C, Sun H, Xu H et al (2023) Intratumoural microbiome can predict the prognosis of hepatocellular carcinoma after surgery. Clin Transl Med 13(7):e1331","journal-title":"Clin Transl Med"},{"issue":"10","key":"3916_CR13","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.ccell.2022.09.009","volume":"40","author":"B Ghaddar","year":"2022","unstructured":"Ghaddar B, Biswas A, Harris C, Omary MB, Carpizo DR, Blaser MJ, De S (2022) Tumor microbiome links cellular programs and immunity in pancreatic cancer. Cancer Cell 40(10):1240\u20131253","journal-title":"Cancer Cell"},{"issue":"16","key":"3916_CR14","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1002\/cam4.2419","volume":"8","author":"F Liu","year":"2019","unstructured":"Liu F, Liu A, Lu X, Zhang Z, Xue Y, Xu J, Zeng S, Xiong Q, Tan H, He X et al (2019) Dysbiosis signatures of the microbial profile in tissue from bladder cancer. Cancer Med 8(16):6904\u20136914","journal-title":"Cancer Med"},{"issue":"1","key":"3916_CR15","doi-asserted-by":"publisher","first-page":"11042","DOI":"10.1038\/s41598-020-67443-2","volume":"10","author":"B Mansour","year":"2020","unstructured":"Mansour B, Monyok A, Makra N, Gajdacs M, Vadnay I, Ligeti B, Juhasz J, Szabo D, Ostorhazi E (2020) Bladder cancer-related microbiota: examining differences in urine and tissue samples. Sci Rep 10(1):11042","journal-title":"Sci Rep"},{"issue":"4","key":"3916_CR16","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1097\/MOU.0000000000000789","volume":"30","author":"F Soria","year":"2020","unstructured":"Soria F, Giordano A, Shariat SF, Gontero P (2020) Bladder sparing landscape for bacillus Calmette-Guerin unresponsive bladder cancer. Curr Opin Urol 30(4):542\u2013546","journal-title":"Curr Opin Urol"},{"issue":"9","key":"3916_CR17","first-page":"986","volume":"31","author":"GN Wang","year":"2023","unstructured":"Wang GN, Zhang YP, Wang MC, Han W, Zhang YC (2023) Overexpression of Nei endonuclease VIII-like protein 3 in hepatocellular carcinoma indicates increased levels of immune infiltration and an unfavorable prognosis. Zhonghua Gan Zang Bing Za Zhi 31(9):986\u2013995","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"1","key":"3916_CR18","doi-asserted-by":"publisher","first-page":"e000110","DOI":"10.1136\/jitc-2019-000110","volume":"8","author":"J Sun","year":"2020","unstructured":"Sun J, Zhang Z, Bao S, Yan C, Hou P, Wu N, Su J, Xu L, Zhou M (2020) Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer. J Immunother Cancer 8(1):e000110","journal-title":"J Immunother Cancer"},{"issue":"4","key":"3916_CR19","first-page":"308","volume":"9","author":"AC Gomes","year":"2018","unstructured":"Gomes AC, Hoffmann C, Mota JF (2018) The human gut microbiota: metabolism and perspective in obesity. Gut Microbes 9(4):308\u2013325","journal-title":"Gut Microbes"},{"issue":"3","key":"3916_CR20","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00345-020-03243-7","volume":"39","author":"T Okamoto","year":"2021","unstructured":"Okamoto T, Hatakeyama S, Imai A, Yamamoto H, Yoneyama T, Mori K, Yoneyama T, Hashimoto Y, Nakaji S, Ohyama C (2021) Altered gut microbiome associated with overactive bladder and daily urinary urgency. World J Urol 39(3):847\u2013853","journal-title":"World J Urol"},{"issue":"5","key":"3916_CR21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41564-022-01107-x","volume":"7","author":"CJ Worby","year":"2022","unstructured":"Worby CJ, Schreiber HLT, Straub TJ, van Dijk LR, Bronson RA, Olson BS, Pinkner JS, Obernuefemann CLP, Munoz VL, Paharik AE et al (2022) Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women. Nat Microbiol 7(5):630\u2013639","journal-title":"Nat Microbiol"},{"issue":"18","key":"3916_CR22","doi-asserted-by":"publisher","first-page":"9804","DOI":"10.3390\/ijms22189804","volume":"22","author":"P Bule","year":"2021","unstructured":"Bule P, Aguiar SI, Aires-Da-Silva F, Dias JNR (2021) Chemokine-directed tumor microenvironment modulation in cancer immunotherapy. Int J Mol Sci 22(18):9804","journal-title":"Int J Mol Sci"},{"issue":"25","key":"3916_CR23","doi-asserted-by":"publisher","first-page":"e2300110","DOI":"10.1002\/advs.202300110","volume":"10","author":"H Li","year":"2023","unstructured":"Li H, Chen J, Li Z, Chen M, Ou Z, Mo M, Wang R, Tong S, Liu P, Cai Z et al (2023) S100A5 attenuates efficiency of Anti-PD-L1\/PD-1 immunotherapy by inhibiting CD8(+) T cell-mediated anti-cancer immunity in bladder carcinoma. Adv Sci (Weinh) 10(25):e2300110","journal-title":"Adv Sci (Weinh)"},{"issue":"7693","key":"3916_CR24","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nature25501","volume":"554","author":"S Mariathasan","year":"2018","unstructured":"Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R et al (2018) TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554(7693):544\u2013548","journal-title":"Nature"},{"issue":"9","key":"3916_CR25","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/s41416-021-01488-6","volume":"125","author":"TL Rose","year":"2021","unstructured":"Rose TL, Weir WH, Mayhew GM, Shibata Y, Eulitt P, Uronis JM, Zhou M, Nielsen M, Smith AB, Woods M et al (2021) Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience. Br J Cancer 125(9):1251\u20131260","journal-title":"Br J Cancer"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-024-03916-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-024-03916-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-024-03916-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:09:40Z","timestamp":1739149780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-024-03916-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["3916"],"URL":"https:\/\/doi.org\/10.1007\/s00262-024-03916-x","relation":{},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"29 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"62"}}