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They act primarily as mediators of intercellular communication through the transport of their contents from donor to recipient cells. Immune cells, including T cells, secrete sEVs following activation. T cell-derived sEVs (T-sEVs) have gained attention in cell-to-cell signalling and as promising immunotherapeutic agents. Growing evidence suggests that T-sEVs are key players in cancer immunotherapy responses. A better understanding of T-sEVs production and properties is key for grasping their biological functions. Extensive current literature on tumour-derived sEVs and their applications in diagnostics or therapeutics is in disconnect with fewer reports on T-sEVs. In this review, we discuss T-sEV biogenesis, their roles in cell-to-cell communication and potential applications in immunotherapy for cancer.<\/jats:p>","DOI":"10.1007\/s00262-025-04109-w","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:17:05Z","timestamp":1750832225000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["T cell-derived small extracellular vesicles in cancer\u2013immune interactions"],"prefix":"10.1007","volume":"74","author":[{"given":"Ma Janelle Chichoco","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Su Thae","family":"Hnit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Shklovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"4109_CR1","doi-asserted-by":"publisher","first-page":"15611","DOI":"10.1038\/s41598-017-15961-x","volume":"7","author":"X Hong","year":"2017","unstructured":"Hong X, Schouest B, Xu H (2017) Effects of exosome on the activation of CD4+ T cells in rhesus macaques: a potential application for HIV latency reactivation. 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