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All animal experiments were approved by the Institutional Animal Care and Use Committee of Asahikawa Medical University (R6-035).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"As this was a retrospective study using existing specimens and clinical information, the Institutional Review Board approved a waiver of the standard informed consent process for IHC analyses. Instead, an opt-out approach was implemented through the Asahikawa Medical University website that ensured patients retained the right to decline participation in the study. All patients from whom PBMCs were collected received a written explanation of the study and provided written informed consent before participation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"251"}}