{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:07:47Z","timestamp":1793718467513,"version":"4.6.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272881"],"award-info":[{"award-number":["82272881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-025-04168-z","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T02:26:10Z","timestamp":1757557570000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study"],"prefix":"10.1007","volume":"74","author":[{"given":"Yan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongjia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"4168_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"issue":"27","key":"4168_CR2","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1200\/JCO.2018.79.1483","volume":"36","author":"H Yang","year":"2018","unstructured":"Yang H, Liu H, Chen Y et al (2018) Neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced squamous cell carcinoma of the esophagus (NEOCRTEC5010): a phase III multicenter, randomized, open-label clinical trial. J Clin Oncol 36(27):2796\u20132803. https:\/\/doi.org\/10.1200\/JCO.2018.79.1483","journal-title":"J Clin Oncol"},{"issue":"22","key":"4168_CR3","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1056\/NEJMoa1112088","volume":"366","author":"P van Hagen","year":"2012","unstructured":"van Hagen P, Hulshof MCCM, van Lanschot JJB et al (2012) Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 366(22):2074\u20132084. https:\/\/doi.org\/10.1056\/NEJMoa1112088","journal-title":"N Engl J Med"},{"key":"4168_CR4","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Non-Small Cell Lung Cancer (2025 Version 5). Available from http:\/\/www.nccn.org."},{"issue":"7","key":"4168_CR5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/dote.12513","volume":"29","author":"TW Rice","year":"2016","unstructured":"Rice TW, Lerut TEMR, Orringer MB et al (2016) Worldwide esophageal cancer collaboration: neoadjuvant pathologic staging data. Dis Esophagus 29(7):715\u2013723. https:\/\/doi.org\/10.1111\/dote.12513","journal-title":"Dis Esophagus"},{"issue":"7","key":"4168_CR6","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/dote.12520","volume":"29","author":"TW Rice","year":"2016","unstructured":"Rice TW, Chen LQ, Hofstetter WL et al (2016) Worldwide esophageal cancer collaboration: pathologic staging data: WECC: pathologic staging data. Dis Esophagus 29(7):724\u2013733. https:\/\/doi.org\/10.1111\/dote.12520","journal-title":"Dis Esophagus"},{"issue":"6","key":"4168_CR7","doi-asserted-by":"publisher","first-page":"e1022","DOI":"10.1097\/SLA.0000000000003727","volume":"274","author":"X Leng","year":"2021","unstructured":"Leng X, He W, Yang H et al (2021) Prognostic impact of postoperative lymph node metastases after neoadjuvant chemoradiotherapy for locally advanced squamous cell carcinoma of Esophagus: from the results of NEOCRTEC5010, a randomized multicenter study. Ann Surg 274(6):e1022\u2013e1029. https:\/\/doi.org\/10.1097\/SLA.0000000000003727","journal-title":"Ann Surg"},{"issue":"1","key":"4168_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jtho.2016.10.016","volume":"12","author":"TW Rice","year":"2017","unstructured":"Rice TW, Ishwaran H, Ferguson MK, Blackstone EH, Goldstraw P (2017) Cancer of the esophagus and esophagogastric junction: an eighth edition staging primer. J Thorac Oncol 12(1):36\u201342. https:\/\/doi.org\/10.1016\/j.jtho.2016.10.016","journal-title":"J Thorac Oncol"},{"issue":"5","key":"4168_CR9","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/01.sla.0000254367.15810.38","volume":"245","author":"JV Reynolds","year":"2007","unstructured":"Reynolds JV, Muldoon C, Hollywood D et al (2007) Long-term outcomes following neoadjuvant chemoradiotherapy for esophageal cancer. Ann Surg 245(5):707\u2013716. https:\/\/doi.org\/10.1097\/01.sla.0000254367.15810.38","journal-title":"Ann Surg"},{"issue":"10302","key":"4168_CR10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0140-6736(21)01234-4","volume":"398","author":"JM Sun","year":"2021","unstructured":"Sun JM, Shen L, Shah MA et al (2021) Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study. Lancet 398(10302):759\u2013771. https:\/\/doi.org\/10.1016\/S0140-6736(21)01234-4","journal-title":"Lancet"},{"issue":"5","key":"4168_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1056\/NEJMoa2111380","volume":"386","author":"Y Doki","year":"2022","unstructured":"Doki Y, Ajani JA, Kato K et al (2022) Nivolumab combination therapy in advanced esophageal squamous-cell carcinoma. N Engl J Med 386(5):449\u2013462. https:\/\/doi.org\/10.1056\/NEJMoa2111380","journal-title":"N Engl J Med"},{"issue":"10","key":"4168_CR12","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.ccell.2024.09.008","volume":"42","author":"X Shang","year":"2024","unstructured":"Shang X, Xie Y, Yu J et al (2024) A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: the Keystone-001 trial. Cancer Cell 42(10):1747-1763.e7. https:\/\/doi.org\/10.1016\/j.ccell.2024.09.008","journal-title":"Cancer Cell"},{"key":"4168_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102118","volume":"62","author":"R Chen","year":"2023","unstructured":"Chen R, Liu Q, Li Q et al (2023) A phase II clinical trial of toripalimab combined with neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma (NEOCRTEC1901). EClinicalMedicine 62:102118. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102118","journal-title":"EClinicalMedicine"},{"issue":"1","key":"4168_CR14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/JS9.0000000000000774","volume":"110","author":"H Deng","year":"2024","unstructured":"Deng H, Zhou J, Chen H et al (2024) Impact of lymphadenectomy extent on immunotherapy efficacy in postresectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study. Int J Surg 110(1):238\u2013252. https:\/\/doi.org\/10.1097\/JS9.0000000000000774","journal-title":"Int J Surg"},{"key":"4168_CR15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137365","author":"K Inamori","year":"2021","unstructured":"Inamori K, Togashi Y, Fukuoka S et al (2021) Importance of lymph node immune responses in MSI-H\/dMMR colorectal cancer. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.137365","journal-title":"JCI Insight."},{"key":"4168_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216740","volume":"588","author":"ZY Xu","year":"2024","unstructured":"Xu ZY, Li ZZ, Cao LM et al (2024) Seizing the fate of lymph nodes in immunotherapy: to preserve or not? Cancer Lett 588:216740. https:\/\/doi.org\/10.1016\/j.canlet.2024.216740","journal-title":"Cancer Lett"},{"key":"4168_CR17","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Non-Small Cell Lung Cancer (2018 Version 1). Available from http:\/\/www.nccn.org."},{"issue":"2","key":"4168_CR18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/SLA.0000000000004798","volume":"277","author":"X Guo","year":"2023","unstructured":"Guo X, Wang Z, Yang H et al (2023) Impact of lymph node dissection on survival after neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: from the results of NEOCRTEC5010, a randomized multicenter study. Ann Surg 277(2):259\u2013266. https:\/\/doi.org\/10.1097\/SLA.0000000000004798","journal-title":"Ann Surg"},{"issue":"5","key":"4168_CR19","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1097\/SLA.0000000000000965","volume":"260","author":"AK Talsma","year":"2014","unstructured":"Talsma AK, Shapiro J, Looman CWN et al (2014) Lymph node retrieval during esophagectomy with and without neoadjuvant chemoradiotherapy: prognostic and therapeutic impact on survival. Ann Surg 260(5):786\u2013793. https:\/\/doi.org\/10.1097\/SLA.0000000000000965","journal-title":"Ann Surg"},{"issue":"5","key":"4168_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doac082","volume":"36","author":"D Jiang","year":"2023","unstructured":"Jiang D, Liu XB, Xing WQ et al (2023) Survival impact of the number of lymph nodes dissection in patients receiving neoadjuvant chemotherapy for esophageal squamous cell carcinoma. Dis Esophagus 36(5):doac082. https:\/\/doi.org\/10.1093\/dote\/doac082","journal-title":"Dis Esophagus"},{"issue":"63","key":"4168_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg3551","volume":"6","author":"H du Bois","year":"2021","unstructured":"du Bois H, Heim TA, Lund AW (2021) Tumor-draining lymph nodes: at the crossroads of metastasis and immunity. Sci Immunol 6(63):eabg3551. https:\/\/doi.org\/10.1126\/sciimmunol.abg3551","journal-title":"Sci Immunol"},{"issue":"12","key":"4168_CR22","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1038\/s41590-020-0791-5","volume":"21","author":"G Galletti","year":"2020","unstructured":"Galletti G, De Simone G, Mazza EMC et al (2020) Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nat Immunol 21(12):1552\u20131562. https:\/\/doi.org\/10.1038\/s41590-020-0791-5","journal-title":"Nat Immunol"},{"issue":"7969","key":"4168_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41586-023-06231-0","volume":"619","author":"L Bod","year":"2023","unstructured":"Bod L, Kye YC, Shi J et al (2023) B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature 619(7969):348\u2013356. https:\/\/doi.org\/10.1038\/s41586-023-06231-0","journal-title":"Nature"},{"issue":"11","key":"4168_CR24","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1007\/s00262-021-02934-3","volume":"70","author":"VS Fear","year":"2021","unstructured":"Fear VS, Forbes CA, Neeve SA et al (2021) Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used. Cancer Immunol Immunother 70(11):3249\u20133258. https:\/\/doi.org\/10.1007\/s00262-021-02934-3","journal-title":"Cancer Immunol Immunother"}],"updated-by":[{"DOI":"10.1007\/s00262-025-04201-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000}}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-025-04168-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-025-04168-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-025-04168-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:38:48Z","timestamp":1761741528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-025-04168-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["4168"],"URL":"https:\/\/doi.org\/10.1007\/s00262-025-04168-z","relation":{},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"14 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00262-025-04201-1","URL":"https:\/\/doi.org\/10.1007\/s00262-025-04201-1","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was approved by the Institutional Review Board of Sun Yat-sen University Cancer Center and the First Affiliated Hospital of Shantou University Medical College. The requirement for patient consent was waived due to the retrospective design of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"303"}}