{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:59:01Z","timestamp":1789664341565,"version":"4.0.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province of China","doi-asserted-by":"crossref","award":["2023JJ60063"],"award-info":[{"award-number":["2023JJ60063"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-026-04320-3","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T07:37:34Z","timestamp":1772869054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A STING-activating biomimetic mineralized nanovaccine triggers robust anti-tumor immunity"],"prefix":"10.1007","volume":"75","author":[{"given":"Suxing","family":"Tuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daozhu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"4320_CR1","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature07317","volume":"455","author":"H Ishikawa","year":"2008","unstructured":"Ishikawa H, Barber GN (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674\u2013678. https:\/\/doi.org\/10.1038\/nature07317","journal-title":"Nature"},{"key":"4320_CR2","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.immuni.2008.09.003","volume":"29","author":"B Zhong","year":"2008","unstructured":"Zhong B et al (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29:538\u2013550. https:\/\/doi.org\/10.1016\/j.immuni.2008.09.003","journal-title":"Immunity"},{"key":"4320_CR3","doi-asserted-by":"publisher","first-page":"8653","DOI":"10.1073\/pnas.0900850106","volume":"106","author":"W Sun","year":"2009","unstructured":"Sun W et al (2009) Eris, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA 106:8653\u20138658. https:\/\/doi.org\/10.1073\/pnas.0900850106","journal-title":"Proc Natl Acad Sci USA"},{"key":"4320_CR4","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1128\/MCB.00640-08","volume":"28","author":"L Jin","year":"2008","unstructured":"Jin L et al (2008) MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol 28:5014\u20135026. https:\/\/doi.org\/10.1128\/MCB.00640-08","journal-title":"Mol Cell Biol"},{"key":"4320_CR5","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nature08476","volume":"461","author":"H Ishikawa","year":"2009","unstructured":"Ishikawa H, Ma Z, Barber GN (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:788\u2013792. https:\/\/doi.org\/10.1038\/nature08476","journal-title":"Nature"},{"key":"4320_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/imr.12765","volume":"290","author":"BA Flood","year":"2019","unstructured":"Flood BA, Higgs EF, Li S, Luke JJ, Gajewski TF (2019) STING pathway agonism as a cancer therapeutic. Immunol Rev 290:24\u201338. https:\/\/doi.org\/10.1111\/imr.12765","journal-title":"Immunol Rev"},{"key":"4320_CR7","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1084\/jem.20101158","volume":"208","author":"MS Diamond","year":"2011","unstructured":"Diamond MS et al (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 208:1989\u20132003. https:\/\/doi.org\/10.1084\/jem.20101158","journal-title":"J Exp Med"},{"key":"4320_CR8","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1084\/jem.20101159","volume":"208","author":"MB Fuertes","year":"2011","unstructured":"Fuertes MB et al (2011) Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8\u03b1+ dendritic cells. J Exp Med 208:2005\u20132016. https:\/\/doi.org\/10.1084\/jem.20101159","journal-title":"J Exp Med"},{"key":"4320_CR9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.ccell.2017.04.003","volume":"31","author":"S Spranger","year":"2017","unstructured":"Spranger S, Dai D, Horton B, Gajewski TF (2017) Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy. Cancer Cell 31:711-723.e714. https:\/\/doi.org\/10.1016\/j.ccell.2017.04.003","journal-title":"Cancer Cell"},{"key":"4320_CR10","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.immuni.2014.10.019","volume":"41","author":"L Deng","year":"2014","unstructured":"Deng L et al (2014) STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41:843\u2013852. https:\/\/doi.org\/10.1016\/j.immuni.2014.10.019","journal-title":"Immunity"},{"key":"4320_CR11","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.immuni.2014.10.017","volume":"41","author":"SR Woo","year":"2014","unstructured":"Woo SR et al (2014) STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41:830\u2013842. https:\/\/doi.org\/10.1016\/j.immuni.2014.10.017","journal-title":"Immunity"},{"key":"4320_CR12","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","volume":"16","author":"X Sun","year":"2021","unstructured":"Sun X et al (2021) Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nat Nanotechnol 16:1260\u20131270. https:\/\/doi.org\/10.1038\/s41565-021-00962-9","journal-title":"Nat Nanotechnol"},{"key":"4320_CR13","doi-asserted-by":"publisher","first-page":"9904","DOI":"10.1021\/acsnano.0c02765","volume":"14","author":"D Shae","year":"2020","unstructured":"Shae D et al (2020) Co-delivery of peptide neoantigens and stimulator of interferon genes agonists enhances response to cancer vaccines. ACS Nano 14:9904\u20139916. https:\/\/doi.org\/10.1021\/acsnano.0c02765","journal-title":"ACS Nano"},{"key":"4320_CR14","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/s41563-022-01251-z","volume":"21","author":"EL Dane","year":"2022","unstructured":"Dane EL et al (2022) STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity. Nat Mater 21:710\u2013720. https:\/\/doi.org\/10.1038\/s41563-022-01251-z","journal-title":"Nat Mater"},{"key":"4320_CR15","doi-asserted-by":"publisher","first-page":"101109","DOI":"10.1016\/j.nantod.2021.101109","volume":"38","author":"X Yang","year":"2021","unstructured":"Yang X et al (2021) Converting primary tumor towards an in situ STING-activating vaccine via a biomimetic nanoplatform against recurrent and metastatic tumors. Nano Today 38:101109. https:\/\/doi.org\/10.1016\/j.nantod.2021.101109","journal-title":"Nano Today"},{"key":"4320_CR16","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nnano.2017.52","volume":"12","author":"M Luo","year":"2017","unstructured":"Luo M et al (2017) A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnol 12:648\u2013654. https:\/\/doi.org\/10.1038\/nnano.2017.52","journal-title":"Nat Nanotechnol"},{"key":"4320_CR17","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1002\/anie.201810735","volume":"58","author":"M Li","year":"2019","unstructured":"Li M et al (2019) Engineering multifunctional DNA hybrid nanospheres through coordination-driven self-assembly. Angew Chem Int Ed 58:1350\u20131354. https:\/\/doi.org\/10.1002\/anie.201810735","journal-title":"Angew Chem Int Ed"},{"key":"4320_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204782","author":"W Yang","year":"2023","unstructured":"Yang W, Zhu L, Yang M, Xu W (2023) Synthesis of amorphous\/crystalline hetero-phase nanozymes with peroxidase-like activity by coordination-driven self-assembly for biosensors. Small. https:\/\/doi.org\/10.1002\/smll.202204782","journal-title":"Small"},{"key":"4320_CR19","doi-asserted-by":"publisher","first-page":"18682","DOI":"10.1039\/d0nr04751a","volume":"12","author":"K Jiang","year":"2020","unstructured":"Jiang K et al (2020) A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery. Nanoscale 12:18682\u201318691. https:\/\/doi.org\/10.1039\/d0nr04751a","journal-title":"Nanoscale"},{"key":"4320_CR20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","volume":"48","author":"C Wang","year":"2018","unstructured":"Wang C et al (2018) Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses. Immunity 48:675-687.e677. https:\/\/doi.org\/10.1016\/j.immuni.2018.03.017","journal-title":"Immunity"},{"key":"4320_CR21","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","volume":"30","author":"M Lv","year":"2020","unstructured":"Lv M et al (2020) Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res 30:966\u2013979. https:\/\/doi.org\/10.1038\/s41422-020-00395-4","journal-title":"Cell Res"},{"key":"4320_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00524-4","author":"Y Song","year":"2020","unstructured":"Song Y et al (2020) Manganese enhances the antitumor function of CD8(+) T cells by inducing type I interferon production. Cell Mol Immunol. https:\/\/doi.org\/10.1038\/s41423-020-00524-4","journal-title":"Cell Mol Immunol"},{"key":"4320_CR23","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1021\/acsnano.9b06111","volume":"14","author":"L Hou","year":"2020","unstructured":"Hou L et al (2020) Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity. ACS Nano 14:3927\u20133940. https:\/\/doi.org\/10.1021\/acsnano.9b06111","journal-title":"ACS Nano"},{"key":"4320_CR24","doi-asserted-by":"publisher","first-page":"e2006970","DOI":"10.1002\/smll.202006970","volume":"17","author":"C Chen","year":"2021","unstructured":"Chen C et al (2021) Cytosolic delivery of thiolated Mn-cGAMP nanovaccine to enhance the antitumor immune responses. Small 17:e2006970. https:\/\/doi.org\/10.1002\/smll.202006970","journal-title":"Small"},{"key":"4320_CR25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.biomaterials.2016.05.008","volume":"98","author":"Y Qian","year":"2016","unstructured":"Qian Y et al (2016) Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy. Biomaterials 98:171\u2013183. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.05.008","journal-title":"Biomaterials"},{"key":"4320_CR26","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/adma.200801393","volume":"21","author":"S Zhang","year":"2009","unstructured":"Zhang S et al (2009) Size-dependent endocytosis of nanoparticles. Adv Mater 21:419\u2013424. https:\/\/doi.org\/10.1002\/adma.200801393","journal-title":"Adv Mater"},{"key":"4320_CR27","doi-asserted-by":"publisher","first-page":"22970","DOI":"10.1002\/anie.202110404","volume":"60","author":"Z Zou","year":"2021","unstructured":"Zou Z et al (2021) Zn(2+)-coordination-driven RNA assembly with retained integrity and biological functions. Angew Chem Int Ed Engl 60:22970\u201322976. https:\/\/doi.org\/10.1002\/anie.202110404","journal-title":"Angew Chem Int Ed Engl"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04320-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-026-04320-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04320-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T07:37:36Z","timestamp":1772869056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-026-04320-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["4320"],"URL":"https:\/\/doi.org\/10.1007\/s00262-026-04320-3","relation":{},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,7]]},"assertion":[{"value":"5 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"95"}}