{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:02:48Z","timestamp":1784685768247,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1302800"],"award-info":[{"award-number":["2022YFA1302800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32022036"],"award-info":[{"award-number":["32022036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Innovative Research Team of High-level Local Universities in Shanghai","award":["SHSMU-ZLCX20212300 and JWAIZD-2"],"award-info":[{"award-number":["SHSMU-ZLCX20212300 and JWAIZD-2"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-026-04420-0","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:06:33Z","timestamp":1779296793000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8+ T cell responses"],"prefix":"10.1007","volume":"75","author":[{"given":"Yupan","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"4420_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","volume":"25","author":"P Puchalska","year":"2017","unstructured":"Puchalska P, Crawford PA (2017) Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab 25:262\u2013284. https:\/\/doi.org\/10.1016\/j.cmet.2016.12.022","journal-title":"Cell Metab"},{"key":"4420_CR2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/CIRCRESAHA.123.321872","volume":"132","author":"TR Matsuura","year":"2023","unstructured":"Matsuura TR, Puchalska P, Crawford PA, Kelly DP (2023) Ketones and the heart: metabolic principles and therapeutic implications. Circ Res 132:882\u2013898. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.321872","journal-title":"Circ Res"},{"key":"4420_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.molmet.2019.06.026","volume":"33","author":"DD Weber","year":"2020","unstructured":"Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B (2020) Ketogenic diet in the treatment of cancer\u2014where do we stand? Mol Metab 33:102\u2013121. https:\/\/doi.org\/10.1016\/j.molmet.2019.06.026","journal-title":"Mol Metab"},{"key":"4420_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225550","author":"P Kesarwani","year":"2022","unstructured":"Kesarwani P, Kant S, Zhao Y, Miller CR, Chinnaiyan P (2022) The influence of the ketogenic diet on the immune tolerant microenvironment in glioblastoma. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14225550","journal-title":"Cancers (Basel)"},{"key":"4420_CR5","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.4049\/jimmunol.1202702","volume":"191","author":"Z Husain","year":"2013","unstructured":"Husain Z, Huang Y, Seth P, Sukhatme VP (2013) Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J Immunol 191:1486\u20131495. https:\/\/doi.org\/10.4049\/jimmunol.1202702","journal-title":"J Immunol"},{"key":"4420_CR6","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1158\/0008-5472.CAN-21-2778","volume":"82","author":"R Wei","year":"2022","unstructured":"Wei R, Zhou Y, Li C et al (2022) Ketogenesis attenuates KLF5-dependent production of CXCL12 to overcome the immunosuppressive tumor microenvironment in colorectal cancer. Cancer Res 82:1575\u20131588. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-2778","journal-title":"Cancer Res"},{"key":"4420_CR7","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1016\/j.molcel.2021.03.037","volume":"81","author":"X Dai","year":"2021","unstructured":"Dai X, Bu X, Gao Y et al (2021) Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell 81:2317\u201331 e6. https:\/\/doi.org\/10.1016\/j.molcel.2021.03.037","journal-title":"Mol Cell"},{"key":"4420_CR8","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145207","author":"G Ferrere","year":"2021","unstructured":"Ferrere G, Tidjani Alou M, Liu P et al (2021) Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.145207","journal-title":"JCI Insight"},{"key":"4420_CR9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41586-022-04649-6","volume":"605","author":"O Dmitrieva-Posocco","year":"2022","unstructured":"Dmitrieva-Posocco O, Wong AC, Lundgren P et al (2022) beta-Hydroxybutyrate suppresses colorectal cancer. Nature 605:160\u2013165. https:\/\/doi.org\/10.1038\/s41586-022-04649-6","journal-title":"Nature"},{"key":"4420_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216940","volume":"593","author":"C Huang","year":"2024","unstructured":"Huang C, Tan H, Wang J et al (2024) beta-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1alpha-mediated angiogenesis. Cancer Lett 593:216940. https:\/\/doi.org\/10.1016\/j.canlet.2024.216940","journal-title":"Cancer Lett"},{"key":"4420_CR11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1227166","volume":"339","author":"T Shimazu","year":"2013","unstructured":"Shimazu T, Hirschey MD, Newman J et al (2013) Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339:211\u2013214. https:\/\/doi.org\/10.1126\/science.1227166","journal-title":"Science"},{"key":"4420_CR12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41577-021-00574-3","volume":"22","author":"M Philip","year":"2022","unstructured":"Philip M, Schietinger A (2022) CD8(+) T cell differentiation and dysfunction in cancer. Nat Rev Immunol 22:209\u2013223. https:\/\/doi.org\/10.1038\/s41577-021-00574-3","journal-title":"Nat Rev Immunol"},{"key":"4420_CR13","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ni.2035","volume":"12","author":"EJ Wherry","year":"2011","unstructured":"Wherry EJ (2011) T cell exhaustion. Nat Immunol 12:492\u2013499. https:\/\/doi.org\/10.1038\/ni.2035","journal-title":"Nat Immunol"},{"key":"4420_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","volume":"37","author":"LM McLane","year":"2019","unstructured":"McLane LM, Abdel-Hakeem MS, Wherry EJ (2019) CD8 T cell exhaustion during chronic viral infection and cancer. Annu Rev Immunol 37:457\u2013495. https:\/\/doi.org\/10.1146\/annurev-immunol-041015-055318","journal-title":"Annu Rev Immunol"},{"key":"4420_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","volume":"52","author":"JC Beltra","year":"2020","unstructured":"Beltra JC, Manne S, Abdel-Hakeem MS et al (2020) Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms. Immunity 52:825\u201341 e8. https:\/\/doi.org\/10.1016\/j.immuni.2020.04.014","journal-title":"Immunity"},{"key":"4420_CR16","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/ni.3031","volume":"15","author":"JT Chang","year":"2014","unstructured":"Chang JT, Wherry EJ, Goldrath AW (2014) Molecular regulation of effector and memory T cell differentiation. Nat Immunol 15:1104\u20131115. https:\/\/doi.org\/10.1038\/ni.3031","journal-title":"Nat Immunol"},{"key":"4420_CR17","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ni1268","volume":"6","author":"AM Intlekofer","year":"2005","unstructured":"Intlekofer AM, Takemoto N, Wherry EJ et al (2005) Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol 6:1236\u20131244. https:\/\/doi.org\/10.1038\/ni1268","journal-title":"Nat Immunol"},{"key":"4420_CR18","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.cmet.2021.03.002","volume":"33","author":"Y He","year":"2021","unstructured":"He Y, Fu L, Li Y et al (2021) Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8(+) T cell immunity. Cell Metab 33:988\u20131000. https:\/\/doi.org\/10.1016\/j.cmet.2021.03.002","journal-title":"Cell Metab"},{"key":"4420_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.immuni.2009.06.021","volume":"31","author":"A Kallies","year":"2009","unstructured":"Kallies A, Xin A, Belz GT, Nutt SL (2009) Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity 31:283\u2013295. https:\/\/doi.org\/10.1016\/j.immuni.2009.06.021","journal-title":"Immunity"},{"key":"4420_CR20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","volume":"35","author":"W Cui","year":"2011","unstructured":"Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM (2011) An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35:792\u2013805. https:\/\/doi.org\/10.1016\/j.immuni.2011.09.017","journal-title":"Immunity"},{"key":"4420_CR21","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/s41423-020-0436-5","volume":"18","author":"Q Shan","year":"2021","unstructured":"Shan Q, Hu S, Chen X, Danahy DB, Badovinac VP, Zang C, Xue HH (2021) Ectopic Tcf1 expression instills a stem-like program in exhausted CD8(+) T cells to enhance viral and tumor immunity. Cell Mol Immunol 18:1262\u20131277. https:\/\/doi.org\/10.1038\/s41423-020-0436-5","journal-title":"Cell Mol Immunol"},{"key":"4420_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.immuni.2010.08.002","volume":"33","author":"X Zhou","year":"2010","unstructured":"Zhou X, Yu S, Zhao DM, Harty JT, Badovinac VP, Xue HH (2010) Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 33:229\u2013240. https:\/\/doi.org\/10.1016\/j.immuni.2010.08.002","journal-title":"Immunity"},{"key":"4420_CR23","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2021.12.039","volume":"185","author":"J Lotscher","year":"2022","unstructured":"Lotscher J, Marti ILAA, Kirchhammer N et al (2022) Magnesium sensing via LFA-1 regulates CD8(+) T cell effector function. Cell 185:585\u2013602. https:\/\/doi.org\/10.1016\/j.cell.2021.12.039","journal-title":"Cell"},{"key":"4420_CR24","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/s42255-023-00856-1","volume":"5","author":"JNR Gnanaprakasam","year":"2023","unstructured":"Gnanaprakasam JNR, Kushwaha B, Liu L et al (2023) Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response. Nat Metab 5:1423\u20131439. https:\/\/doi.org\/10.1038\/s42255-023-00856-1","journal-title":"Nat Metab"},{"key":"4420_CR25","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/j.immuni.2023.07.002","volume":"56","author":"KM Luda","year":"2023","unstructured":"Luda KM, Longo J, Kitchen-Goosen SM et al (2023) Ketolysis drives CD8(+) T cell effector function through effects on histone acetylation. Immunity 56:2021\u201335 e8. https:\/\/doi.org\/10.1016\/j.immuni.2023.07.002","journal-title":"Immunity"},{"key":"4420_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41556-019-0440-0","volume":"22","author":"H Zhang","year":"2020","unstructured":"Zhang H, Tang K, Ma J et al (2020) Ketogenesis-generated beta-hydroxybutyrate is an epigenetic regulator of CD8(+) T-cell memory development. Nat Cell Biol 22:18\u201325. https:\/\/doi.org\/10.1038\/s41556-019-0440-0","journal-title":"Nat Cell Biol"},{"key":"4420_CR27","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1038\/s42255-025-01415-6","volume":"7","author":"BM Oswald","year":"2025","unstructured":"Oswald BM, DeCamp LM, Longo J et al (2025) Dietary restriction reprograms CD8(+) T cell fate to enhance anti-tumour immunity and immunotherapy responses. Nat Metab 7:2489\u20132509. https:\/\/doi.org\/10.1038\/s42255-025-01415-6","journal-title":"Nat Metab"},{"key":"4420_CR28","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41590-019-0312-6","volume":"20","author":"BC Miller","year":"2019","unstructured":"Miller BC, Sen DR, Al Abosy R et al (2019) Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade. Nat Immunol 20:326\u2013336. https:\/\/doi.org\/10.1038\/s41590-019-0312-6","journal-title":"Nat Immunol"},{"key":"4420_CR29","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1324-y","volume":"571","author":"AC Scott","year":"2019","unstructured":"Scott AC, Dundar F, Zumbo P et al (2019) TOX is a critical regulator of tumour-specific T cell differentiation. Nature 571:270\u2013274. https:\/\/doi.org\/10.1038\/s41586-019-1324-y","journal-title":"Nature"},{"key":"4420_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01322","volume":"10","author":"KM Valentine","year":"2019","unstructured":"Valentine KM, Hoyer KK (2019) CXCR5+ CD8 T cells: protective or pathogenic? Front Immunol 10:1322. https:\/\/doi.org\/10.3389\/fimmu.2019.01322","journal-title":"Front Immunol"},{"key":"4420_CR31","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41590-022-01194-2","volume":"23","author":"F Gounari","year":"2022","unstructured":"Gounari F, Khazaie K (2022) TCF-1: a maverick in T cell development and function. Nat Immunol 23:671\u2013678. https:\/\/doi.org\/10.1038\/s41590-022-01194-2","journal-title":"Nat Immunol"},{"key":"4420_CR32","doi-asserted-by":"publisher","first-page":"20060","DOI":"10.1073\/pnas.1110230108","volume":"108","author":"K Germar","year":"2011","unstructured":"Germar K, Dose M, Konstantinou T et al (2011) T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A 108:20060\u201320065. https:\/\/doi.org\/10.1073\/pnas.1110230108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4420_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41577-021-00563-6","volume":"22","author":"X Zhao","year":"2022","unstructured":"Zhao X, Shan Q, Xue HH (2022) TCF1 in T cell immunity: a broadened frontier. Nat Rev Immunol 22:147\u2013157. https:\/\/doi.org\/10.1038\/s41577-021-00563-6","journal-title":"Nat Rev Immunol"},{"key":"4420_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nature10279","volume":"476","author":"BN Weber","year":"2011","unstructured":"Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A (2011) A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476:63\u201368. https:\/\/doi.org\/10.1038\/nature10279","journal-title":"Nature"},{"key":"4420_CR35","doi-asserted-by":"publisher","first-page":"26649","DOI":"10.1074\/jbc.C500213200","volume":"280","author":"AK Taggart","year":"2005","unstructured":"Taggart AK, Kero J, Gan X et al (2005) (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280:26649\u201326652. https:\/\/doi.org\/10.1074\/jbc.C500213200","journal-title":"J Biol Chem"},{"key":"4420_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101718","volume":"5","author":"Y Yang","year":"2024","unstructured":"Yang Y, Pei T, Hu X et al (2024) Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell. Cell Rep Med 5:101718. https:\/\/doi.org\/10.1016\/j.xcrm.2024.101718","journal-title":"Cell Rep Med"},{"key":"4420_CR37","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jhep.2018.04.004","volume":"69","author":"Y Chen","year":"2018","unstructured":"Chen Y, Ouyang X, Hoque R et al (2018) \u03b2-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway. J Hepatol 69:687\u2013696. https:\/\/doi.org\/10.1016\/j.jhep.2018.04.004","journal-title":"J Hepatol"},{"key":"4420_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104500","volume":"150","author":"S Feng","year":"2019","unstructured":"Feng S, Wang H, Liu J, Aa J, Zhou F, Wang G (2019) Multi-dimensional roles of ketone bodies in cancer biology: opportunities for cancer therapy. Pharmacol Res 150:104500. https:\/\/doi.org\/10.1016\/j.phrs.2019.104500","journal-title":"Pharmacol Res"},{"key":"4420_CR39","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/s11427-023-2637-2","volume":"68","author":"S Wan","year":"2025","unstructured":"Wan S, Zhou X, Xie F, Zhou F, Zhang L (2025) Ketogenic diet and cancer: multidimensional exploration and research. Sci China Life Sci 68:1010\u20131024. https:\/\/doi.org\/10.1007\/s11427-023-2637-2","journal-title":"Sci China Life Sci"},{"key":"4420_CR40","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114323","volume":"13","author":"S Hirschberger","year":"2021","unstructured":"Hirschberger S, Strauss G, Effinger D et al (2021) Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming. EMBO Mol Med 13:e14323. https:\/\/doi.org\/10.15252\/emmm.202114323","journal-title":"EMBO Mol Med"},{"key":"4420_CR41","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.omto.2020.12.003","volume":"20","author":"W Deng","year":"2021","unstructured":"Deng W, Ma Y, Su Z et al (2021) Single-cell RNA-sequencing analyses identify heterogeneity of CD8(+) T cell subpopulations and novel therapy targets in melanoma. Mol Ther Oncolytics 20:105\u2013118. https:\/\/doi.org\/10.1016\/j.omto.2020.12.003","journal-title":"Mol Ther Oncolytics"},{"key":"4420_CR42","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.cell.2018.10.038","volume":"175","author":"M Sade-Feldman","year":"2018","unstructured":"Sade-Feldman M, Yizhak K, Bjorgaard SL et al (2018) Defining T cell states associated with response to checkpoint immunotherapy in melanoma. Cell 175:998\u20131013. https:\/\/doi.org\/10.1016\/j.cell.2018.10.038","journal-title":"Cell"},{"key":"4420_CR43","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.abb9847","volume":"370","author":"S Krishna","year":"2020","unstructured":"Krishna S, Lowery FJ, Copeland AR et al (2020) Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science 370:1328\u20131334. https:\/\/doi.org\/10.1126\/science.abb9847","journal-title":"Science"},{"key":"4420_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2026.01.002","author":"Y Zhu","year":"2026","unstructured":"Zhu Y, Ding B, Lv H et al (2026) Fasting impairs humoral immunological memory by beta-hydroxybutyrate-mediated depletion of plasma cells. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2026.01.002","journal-title":"Immunity"},{"key":"4420_CR45","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41586-024-07630-7","volume":"631","author":"M Bosch","year":"2024","unstructured":"Bosch M, Kallin N, Donakonda S et al (2024) A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature 631:867\u2013875. https:\/\/doi.org\/10.1038\/s41586-024-07630-7","journal-title":"Nature"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-026-04420-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04420-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04420-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:37:14Z","timestamp":1784684234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-026-04420-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["4420"],"URL":"https:\/\/doi.org\/10.1007\/s00262-026-04420-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8428666\/v1","asserted-by":"object"}]},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"22 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declared that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animal experiments were conducted in accordance with the ARRIVE guidelines and approved by the Laboratory Animal Ethics Committee of the Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine (SH9H-2022-A8-1). Human samples were obtained after written informed consent from all participants. All experiments involving human specimens were conducted in accordance with the ethical principles of the Declaration of Helsinki and were approved by the Institutional Review Board (IRB) of Renji Hospital, Shanghai Jiao Tong University School of Medicine (RA-2022-411).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"188"}}