{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:11:40Z","timestamp":1792782700202,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Kumamoto University","id":[{"id":"https:\/\/ror.org\/02cgss904","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-026-04497-7","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:55:39Z","timestamp":1785074139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naringin promotes cancer immunity by inducing cross-presentation by antigen-presenting cells"],"prefix":"10.1007","volume":"75","author":[{"given":"Cheng","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Miyasato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Mizue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Hirohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"4497_CR1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41416-021-01413-x","volume":"125","author":"C Pilard","year":"2021","unstructured":"Pilard C, Ancion M, Delvenne P et al (2021) Cancer immunotherapy: it\u2019s time to better predict patients\u2019 response. Br J Cancer 125:927\u2013938. https:\/\/doi.org\/10.1038\/s41416-021-01413-x","journal-title":"Br J Cancer"},{"key":"4497_CR2","doi-asserted-by":"publisher","first-page":"e14613","DOI":"10.1200\/JCO.2024.42.16_suppl.e14613","volume":"42","author":"V Prasad","year":"2024","unstructured":"Prasad V, Haslam A, Olivier T (2024) Updated estimates of eligibility and response: immune checkpoint inhibitors. J Clin Oncol 42:e14613. https:\/\/doi.org\/10.1200\/JCO.2024.42.16_suppl.e14613","journal-title":"J Clin Oncol"},{"key":"4497_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","volume":"18","author":"J Galon","year":"2019","unstructured":"Galon J, Bruni D (2019) Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov 18:197\u2013218. https:\/\/doi.org\/10.1038\/s41573-018-0007-y","journal-title":"Nat Rev Drug Discov"},{"key":"4497_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.immuni.2010.12.011","volume":"34","author":"K Asano","year":"2011","unstructured":"Asano K, Nabeyama A, Miyake Y et al (2011) CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34:85\u201395. https:\/\/doi.org\/10.1016\/j.immuni.2010.12.011","journal-title":"Immunity"},{"key":"4497_CR5","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1111\/cas.12212","volume":"104","author":"K Ohnishi","year":"2013","unstructured":"Ohnishi K, Komohara Y, Saito Y et al (2013) CD 169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma. Cancer Sci 104:1237\u20131244. https:\/\/doi.org\/10.1111\/cas.12212","journal-title":"Cancer Sci"},{"key":"4497_CR6","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1158\/2326-6066.CIR-14-0180","volume":"3","author":"Y Saito","year":"2015","unstructured":"Saito Y, Ohnishi K, Miyashita A et al (2015) Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma. Cancer Immunol Res 3:1356\u20131363. https:\/\/doi.org\/10.1158\/2326-6066.CIR-14-0180","journal-title":"Cancer Immunol Res"},{"key":"4497_CR7","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/cas.12929","volume":"107","author":"K Ohnishi","year":"2016","unstructured":"Ohnishi K, Yamaguchi M, Erdenebaatar C et al (2016) Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma. Cancer Sci 107:846\u2013852. https:\/\/doi.org\/10.1111\/cas.12929","journal-title":"Cancer Sci"},{"key":"4497_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166680","volume":"11","author":"T Shiota","year":"2016","unstructured":"Shiota T, Miyasato Y, Ohnishi K et al (2016) The clinical significance of CD169-positive lymph node macrophage in patients with breast cancer. PLoS ONE 11:e0166680. https:\/\/doi.org\/10.1371\/journal.pone.0166680","journal-title":"PLoS ONE"},{"key":"4497_CR9","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/pros.23407","volume":"77","author":"K Str\u00f6mvall","year":"2017","unstructured":"Str\u00f6mvall K, Sundkvist K, Ljungberg B et al (2017) Reduced number of CD169+ macrophages in pre-metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients. Prostate 77:1468\u20131477. https:\/\/doi.org\/10.1002\/pros.23407","journal-title":"Prostate"},{"key":"4497_CR10","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/pin.12736","volume":"68","author":"H Takeya","year":"2018","unstructured":"Takeya H, Shiota T, Yagi T et al (2018) High CD169 expression in lymph node macrophages predicts a favorable clinical course in patients with esophageal cancer. Pathol Int 68:685\u2013693. https:\/\/doi.org\/10.1111\/pin.12736","journal-title":"Pathol Int"},{"key":"4497_CR11","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1111\/cas.13565","volume":"109","author":"T Asano","year":"2018","unstructured":"Asano T, Ohnishi K, Shiota T et al (2018) CD 169-positive sinus macrophages in the lymph nodes determine bladder cancer prognosis. Cancer Sci 109:1723\u20131730. https:\/\/doi.org\/10.1111\/cas.13565","journal-title":"Cancer Sci"},{"key":"4497_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.636751","volume":"11","author":"K Kumamoto","year":"2021","unstructured":"Kumamoto K, Tasaki T, Ohnishi K et al (2021) CD169 expression on lymph node macrophages predicts in patients with gastric cancer. Front Oncol 11:636751. https:\/\/doi.org\/10.3389\/fonc.2021.636751","journal-title":"Front Oncol"},{"key":"4497_CR13","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1007\/s00262-022-03149-w","volume":"71","author":"S Kawaguchi","year":"2022","unstructured":"Kawaguchi S, Kawahara K, Fujiwara Y et al (2022) Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother 71:2127\u20132139. https:\/\/doi.org\/10.1007\/s00262-022-03149-w","journal-title":"Cancer Immunol Immunother"},{"key":"4497_CR14","doi-asserted-by":"publisher","first-page":"10199","DOI":"10.1002\/cam4.5747","volume":"12","author":"Y Saito","year":"2023","unstructured":"Saito Y, Fujiwara Y, Miyamoto Y et al (2023) CD169 + sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer. Cancer Med 12:10199\u201310211. https:\/\/doi.org\/10.1002\/cam4.5747","journal-title":"Cancer Med"},{"key":"4497_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3960\/jslrt.17032","volume":"58","author":"Y Fujiwara","year":"2018","unstructured":"Fujiwara Y, Saito Y, Shiota T et al (2018) Natural compounds that regulate lymph node sinus macrophages: inducing an anti-tumor effect by regulating macrophage activation. J Clin Exp Hematopathol 58:17\u201323. https:\/\/doi.org\/10.3960\/jslrt.17032","journal-title":"J Clin Exp Hematopathol"},{"key":"4497_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/cas.16003","volume":"115","author":"T Anami","year":"2024","unstructured":"Anami T, Pan C, Fujiwara Y et al (2024) Dysfunction of sinus macrophages in tumor-bearing host induces resistance to immunotherapy. Cancer Sci 115:59\u201369. https:\/\/doi.org\/10.1111\/cas.16003","journal-title":"Cancer Sci"},{"key":"4497_CR17","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1128\/MCB.26.4.1549-1557.2006","volume":"26","author":"C Oetke","year":"2006","unstructured":"Oetke C, Vinson MC, Jones C, Crocker PR (2006) Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol 26:1549\u20131557. https:\/\/doi.org\/10.1128\/MCB.26.4.1549-1557.2006","journal-title":"Mol Cell Biol"},{"key":"4497_CR18","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","volume":"56","author":"I Mellman","year":"2023","unstructured":"Mellman I, Chen DS, Powles T, Turley SJ (2023) The cancer-immunity cycle: indication, genotype, and immunotype. Immunity 56:2188\u20132205. https:\/\/doi.org\/10.1016\/j.immuni.2023.09.011","journal-title":"Immunity"},{"key":"4497_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01276","volume":"11","author":"EM Muntjewerff","year":"2020","unstructured":"Muntjewerff EM, Meesters LD, van den Bogaart G (2020) Antigen cross-presentation by macrophages. Front Immunol 11:01276. https:\/\/doi.org\/10.3389\/fimmu.2020.01276","journal-title":"Front Immunol"},{"key":"4497_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101729","volume":"66","author":"FM Cruz","year":"2023","unstructured":"Cruz FM, Chan A, Rock KL (2023) Pathways of MHC I cross-presentation of exogenous antigens. Semin Immunol 66:101729. https:\/\/doi.org\/10.1016\/j.smim.2023.101729","journal-title":"Semin Immunol"},{"key":"4497_CR21","doi-asserted-by":"publisher","unstructured":"Maria, Embgenbroich Sven, Burgdorf (2018) Current Concepts of Antigen Cross-Presentation Frontiers in Immunology 9. https:\/\/doi.org\/10.3389\/fimmu.2018.01643","DOI":"10.3389\/fimmu.2018.01643"},{"key":"4497_CR22","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/path.6083","volume":"260","author":"T Minowa","year":"2023","unstructured":"Minowa T, Hirohashi Y, Murata K et al (2023) Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes. J Pathol 260:304\u2013316. https:\/\/doi.org\/10.1002\/path.6083","journal-title":"J Pathol"},{"key":"4497_CR23","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.4049\/jimmunol.162.6.3263","volume":"162","author":"L Ramachandra","year":"1999","unstructured":"Ramachandra L, Song R, Harding CV (1999) Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide: class II MHC complexes. J Immunol 162:3263\u20133272. https:\/\/doi.org\/10.4049\/jimmunol.162.6.3263","journal-title":"J Immunol"},{"key":"4497_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111205","volume":"40","author":"M Gros","year":"2022","unstructured":"Gros M, Segura E, Rookhuizen DC et al (2022) Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Cell Rep 40:111205. https:\/\/doi.org\/10.1016\/j.celrep.2022.111205","journal-title":"Cell Rep"},{"key":"4497_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243807","volume":"15","author":"S Monkley","year":"2020","unstructured":"Monkley S, Krishnaswamy JK, G\u00f6ransson M et al (2020) Optimised generation of iPSC-derived macrophages and dendritic cells that are functionally and transcriptionally similar to their primary counterparts. PLoS ONE 15:e0243807. https:\/\/doi.org\/10.1371\/journal.pone.0243807","journal-title":"PLoS ONE"},{"key":"4497_CR26","doi-asserted-by":"publisher","unstructured":"The Tabula Sapiens Consortium* Robert C., Jones Jim, Karkanias Mark A., Krasnow Angela Oliveira, Pisco Stephen R., Quake Julia, Salzman Nir, Yosef Bryan, Bulthaup Phillip, Brown William, Harper Marisa, Hemenez Ravikumar, Ponnusamy Ahmad, Salehi Bhavani A., Sanagavarapu Eileen, Spallino Ksenia A., Aaron Waldo, Concepcion James M., Gardner Burnett, Kelly Nikole, Neidlinger Zifa, Wang Sheela, Crasta Saroja, Kolluru Maurizio, Morri Serena Y., Tan Kyle J., Travaglini Chenling, Xu Marcela, Alc\u00e1ntara-Hern\u00e1ndez Nicole, Almanzar Jane, Antony Benjamin, Beyersdorf Deviana, Burhan Kruti, Calcuttawala Matthew M., Carter Charles K. F., Chan Charles A., Chang Stephen, Chang Alex, Colville Rebecca N., Culver Ivana, Cvijovi\u0107 Gaetano, D\u2019Amato Camille, Ezran Francisco X., Galdos Astrid, Gillich William R., Goodyer Yan, Hang Alyssa, Hayashi Sahar, Houshdaran Xianxi, Huang Juan C., Irwin SoRi, Jang Julia Vallve, Juanico Aaron M., Kershner Soochi, Kim Bernhard, Kiss William, Kong Maya E., Kumar Angera H., Kuo Rebecca, Leylek Baoxiang, Li Gabriel B., Loeb Wan-Jin, Lu Sruthi, Mantri Maxim, Markovic Patrick L., McAlpine Antoine, de Morree Karim, Mrouj Shravani, Mukherjee Tyler, Muser Patrick, Neuh\u00f6fer Thi D., Nguyen Kimberly, Perez Ragini, Phansalkar Nazan, Puluca Zhen, Qi Poorvi, Rao Hayley, Raquer-McKay Nicholas, Schaum Bronwyn, Scott Bobak, Seddighzadeh Joe, Segal Sushmita, Sen Shaheen, Sikandar Sean P., Spencer Lea C., Steffes Varun R., Subramaniam Aditi, Swarup Michael, Swift Will, Van Treuren Emily, Trimm Stefan, Veizades Sivakamasundari, Vijayakumar Kim Chi, Vo Sevahn K., Vorperian Wanxin, Wang Hannah N. W., Weinstein Juliane, Winkler Timothy T. H., Wu Jamie, Xie Andrea R., Yung Yue, Zhang Angela M., Detweiler Honey, Mekonen Norma F., Neff Rene V., Sit Michelle, Tan Jia, Yan Gregory R., Bean Vivek, Charu Erna, Forg\u00f3 Brock A., Martin Michael G., Ozawa Oscar, Silva Angus, Toland Venkata N. P., Vemuri Shaked, Afik Kyle, Awayan Olga Borisovna, Botvinnik Ashley, Byrne Michelle, Chen Roozbeh, Dehghannasiri Adam, Gayoso Alejandro A., Granados Qiqing, Li Gita, Mahmoudabadi Aaron, McGeever Julia Eve, Olivieri Madeline, Park Neha, Ravikumar Geoff, Stanley Weilun, Tan Alexander J., Tarashansky Rohan, Vanheusden Peter, Wang Sheng, Wang Galen, Xing Les, Dethlefsen Po-Yi, Ho Shixuan, Liu Jonathan S., Maltzman Ross J., Metzger Koki, Sasagawa Rahul, Sinha Hanbing, Song Bruce, Wang Steven E., Artandi Philip A., Beachy Michael F., Clarke Linda C., Giudice Franklin W., Huang Kerwyn Casey, Huang Juliana, Idoyaga Seung K., Kim Christin S., Kuo Patricia, Nguyen Thomas A., Rando Kristy, Red-Horse Jeremy, Reiter David A., Relman Justin L., Sonnenburg Albert, Wu Sean M., Wu Tony, Wyss-Coray (2022) The Tabula Sapiens: A multiple-organ single-cell transcriptomic atlas of humans Mapping cell types in the human body Science 376(6594). https:\/\/doi.org\/10.1126\/science.abl4896","DOI":"10.1126\/science.abl4896"},{"key":"4497_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3960\/jslrt.24001","volume":"64","author":"K Kanemitsu","year":"2024","unstructured":"Kanemitsu K, Yamada R, Pan C et al (2024) Age-associated reduction of sinus macrophages in human mesenteric lymph nodes. J Clin Exp Hematopathol 64:79\u201385. https:\/\/doi.org\/10.3960\/jslrt.24001","journal-title":"J Clin Exp Hematopathol"},{"key":"4497_CR28","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1126\/science.1108003","volume":"307","author":"L Delamarre","year":"2005","unstructured":"Delamarre L, Pack M, Chang H et al (2005) Differential Lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307:1630\u20131634. https:\/\/doi.org\/10.1126\/science.1108003","journal-title":"Science"},{"key":"4497_CR29","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1084\/jem.20051106","volume":"202","author":"D Accapezzato","year":"2005","unstructured":"Accapezzato D, Visco V, Francavilla V et al (2005) Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo. J Exp Med 202:817\u2013828. https:\/\/doi.org\/10.1084\/jem.20051106","journal-title":"J Exp Med"},{"key":"4497_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cell.2006.05.035","volume":"126","author":"A Savina","year":"2006","unstructured":"Savina A, Jancic C, Hugues S et al (2006) NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126:205\u2013218. https:\/\/doi.org\/10.1016\/j.cell.2006.05.035","journal-title":"Cell"},{"key":"4497_CR31","doi-asserted-by":"publisher","first-page":"17463","DOI":"10.1073\/pnas.0908583106","volume":"106","author":"R Belizaire","year":"2009","unstructured":"Belizaire R, Unanue ER (2009) Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A 106:17463\u201317468. https:\/\/doi.org\/10.1073\/pnas.0908583106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4497_CR32","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/j.cell.2011.11.021","volume":"147","author":"I Cebrian","year":"2011","unstructured":"Cebrian I, Visentin G, Blanchard N et al (2011) Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells. Cell 147:1355\u20131368. https:\/\/doi.org\/10.1016\/j.cell.2011.11.021","journal-title":"Cell"},{"key":"4497_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107905","volume":"32","author":"P Kozik","year":"2020","unstructured":"Kozik P, Gros M, Itzhak DN et al (2020) Small molecule enhancers of endosome-to-cytosol import augment anti-tumor immunity. Cell Rep 32:107905. https:\/\/doi.org\/10.1016\/j.celrep.2020.107905","journal-title":"Cell Rep"},{"key":"4497_CR34","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1126\/science.adg8802","volume":"380","author":"P Rodr\u00edguez-Silvestre","year":"2023","unstructured":"Rodr\u00edguez-Silvestre P, Laub M, Krawczyk PA et al (2023) Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science 380:1258\u20131265. https:\/\/doi.org\/10.1126\/science.adg8802","journal-title":"Science"},{"key":"4497_CR35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","volume":"44","author":"F Ginhoux","year":"2016","unstructured":"Ginhoux F, Guilliams M (2016) Tissue-resident macrophage ontogeny and homeostasis. Immunity 44:439\u2013449. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.024","journal-title":"Immunity"},{"key":"4497_CR36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ni.3341","volume":"17","author":"EG Perdiguero","year":"2016","unstructured":"Perdiguero EG, Geissmann F (2016) The development and maintenance of resident macrophages. Nat Immunol 17:2\u20138. https:\/\/doi.org\/10.1038\/ni.3341","journal-title":"Nat Immunol"},{"key":"4497_CR37","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/0006-2952(90)90414-G","volume":"40","author":"PS Tietz","year":"1990","unstructured":"Tietz PS, Yamazaki K, Larusso NF (1990) Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. Biochem Pharmacol 40:1419\u20131421. https:\/\/doi.org\/10.1016\/0006-2952(90)90414-G","journal-title":"Biochem Pharmacol"},{"key":"4497_CR38","doi-asserted-by":"publisher","unstructured":"Sachiko, Hirosue Juan, Dubrot (2015) Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications Frontiers in Immunology 6 https:\/\/doi.org\/10.3389\/fimmu.2015.00446","DOI":"10.3389\/fimmu.2015.00446"},{"key":"4497_CR39","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1084\/jem.192.10.1425","volume":"192","author":"JE Gretz","year":"2000","unstructured":"Gretz JE, Norbury CC, Anderson AO et al (2000) Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med 192:1425\u20131440. https:\/\/doi.org\/10.1084\/jem.192.10.1425","journal-title":"J Exp Med"},{"key":"4497_CR40","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.celrep.2017.02.026","volume":"18","author":"N Chatziandreou","year":"2017","unstructured":"Chatziandreou N, Farsakoglu Y, Palomino-Segura M et al (2017) Macrophage death following influenza vaccination initiates the inflammatory response that promotes dendritic cell function in the draining lymph node. Cell Rep 18:2427\u20132440. https:\/\/doi.org\/10.1016\/j.celrep.2017.02.026","journal-title":"Cell Rep"},{"key":"4497_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108993","volume":"35","author":"C Tacconi","year":"2021","unstructured":"Tacconi C, Commerford CD, Dieterich LC et al (2021) CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis. Cell Rep 35:108993. https:\/\/doi.org\/10.1016\/j.celrep.2021.108993","journal-title":"Cell Rep"},{"key":"4497_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038258","volume":"7","author":"EE Gray","year":"2012","unstructured":"Gray EE, Friend S, Suzuki K et al (2012) Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS ONE 7:e38258. https:\/\/doi.org\/10.1371\/journal.pone.0038258","journal-title":"PLoS ONE"},{"key":"4497_CR43","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.immuni.2012.01.013","volume":"36","author":"EA Moseman","year":"2012","unstructured":"Moseman EA, Iannacone M, Bosurgi L et al (2012) B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity 36:415\u2013426. https:\/\/doi.org\/10.1016\/j.immuni.2012.01.013","journal-title":"Immunity"},{"key":"4497_CR44","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.immuni.2019.05.008","volume":"50","author":"A Camara","year":"2019","unstructured":"Camara A, Cordeiro OG, Alloush F et al (2019) Lymph node mesenchymal and endothelial stromal cells cooperate via the RANK-RANKL cytokine axis to shape the sinusoidal macrophage niche. Immunity 50:1467-1481.e6. https:\/\/doi.org\/10.1016\/j.immuni.2019.05.008","journal-title":"Immunity"},{"key":"4497_CR45","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.immuni.2019.04.002","volume":"50","author":"I Mondor","year":"2019","unstructured":"Mondor I, Baratin M, Lagueyrie M et al (2019) Lymphatic endothelial cells are essential components of the subcapsular sinus macrophage niche. Immunity 50:1453-1466.e4. https:\/\/doi.org\/10.1016\/j.immuni.2019.04.002","journal-title":"Immunity"},{"key":"4497_CR46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108540119","volume":"119","author":"A Camara","year":"2022","unstructured":"Camara A, Lavanant AC, Abe J et al (2022) CD169 + macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling. Proc Natl Acad Sci U S A 119:e2108540119. https:\/\/doi.org\/10.1073\/pnas.2108540119","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-026-04497-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04497-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04497-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:11:03Z","timestamp":1792635063000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-026-04497-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["4497"],"URL":"https:\/\/doi.org\/10.1007\/s00262-026-04497-7","relation":{},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"14 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"253"}}