{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:47:22Z","timestamp":1785847642449,"version":"3.56.0"},"reference-count":233,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Immunol Immunother"],"DOI":"10.1007\/s00262-026-04506-9","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:34:59Z","timestamp":1785828899000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The CREM\u2013IL-15 axis: decoding the persistence\u2013exhaustion paradox in NK cell immunotherapy"],"prefix":"10.1007","volume":"75","author":[{"given":"Amr Ali Mohamed Abdelgawwad","family":"El-Sehrawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz Jamal","family":"Al-khreisat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalpa R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makhfirat","family":"Kibriyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfullayeva","family":"Gulnoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khayriddin","family":"Qosimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lhyb Mohammed","family":"Abdul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin Kumar","family":"Tailor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"2","key":"4506_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1158\/1078-0432.CCR-11-1625","volume":"18","author":"H Lu","year":"2012","unstructured":"Lu H et al (2012) VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res 18(2):499\u2013509","journal-title":"Clin Cancer Res"},{"issue":"15","key":"4506_CR2","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1182\/bloodadvances.2018020388","volume":"2","author":"B Mundy-Bosse","year":"2018","unstructured":"Mundy-Bosse B et al (2018) Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma. Blood Adv 2(15):1818\u20131827","journal-title":"Blood Adv"},{"key":"4506_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113392","volume":"144","author":"D-Y Sun","year":"2025","unstructured":"Sun D-Y et al (2025) Unlocking the full potential of memory T cells in adoptive T cell therapy for hematologic malignancies. Int Immunopharmacol 144:113392","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4506_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000325","volume":"8","author":"L Minute","year":"2020","unstructured":"Minute L et al (2020) Cellular cytotoxicity is a form of immunogenic cell death. J Immunother Cancer 8(1):e000325","journal-title":"J Immunother Cancer"},{"key":"4506_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1381212","volume":"15","author":"L Li","year":"2024","unstructured":"Li L et al (2024) Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis. Front Immunol 15:1381212","journal-title":"Front Immunol"},{"issue":"6","key":"4506_CR6","first-page":"4956","volume":"18","author":"M Surcel","year":"2019","unstructured":"Surcel M et al (2019) Reinforcing involvement of NK cells in psoriasiform dermatitis animal model. Exp Ther Med 18(6):4956\u20134966","journal-title":"Exp Ther Med"},{"issue":"1","key":"4506_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/imm.13793","volume":"173","author":"ZB Wang","year":"2024","unstructured":"Wang ZB et al (2024) Immunotherapy and the ovarian cancer microenvironment: exploring potential strategies for enhanced treatment efficacy. Immunology 173(1):14\u201332","journal-title":"Immunology"},{"issue":"34","key":"4506_CR8","doi-asserted-by":"publisher","first-page":"57024","DOI":"10.18632\/oncotarget.18659","volume":"8","author":"Y Wu","year":"2017","unstructured":"Wu Y et al (2017) Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors. Oncotarget 8(34):57024","journal-title":"Oncotarget"},{"issue":"7","key":"4506_CR9","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1016\/j.cell.2018.10.028","volume":"175","author":"N van Montfoort","year":"2018","unstructured":"van Montfoort N et al (2018) NKG2A blockade potentiates CD8 T cell immunity induced by cancer vaccines. Cell 175(7):1744-1755. e15","journal-title":"Cell"},{"issue":"7","key":"4506_CR10","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.18632\/oncotarget.3081","volume":"6","author":"S Sch\u00f6lch","year":"2014","unstructured":"Sch\u00f6lch S et al (2014) Radiotherapy combined with TLR7\/8 activation induces strong immune responses against gastrointestinal tumors. Oncotarget 6(7):4663","journal-title":"Oncotarget"},{"issue":"8073","key":"4506_CR11","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41586-025-09087-8","volume":"643","author":"H Rafei","year":"2025","unstructured":"Rafei H et al (2025) CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells. Nature 643(8073):1076\u20131086","journal-title":"Nature"},{"key":"4506_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01414","volume":"10","author":"SM Poznanski","year":"2019","unstructured":"Poznanski SM, Ashkar AA (2019) What defines NK cell functional fate: phenotype or metabolism? Front Immunol 10:1414","journal-title":"Front Immunol"},{"issue":"1","key":"4506_CR13","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/imr.12725","volume":"287","author":"EM Mace","year":"2019","unstructured":"Mace EM, Orange JS (2019) Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev 287(1):202\u2013225","journal-title":"Immunol Rev"},{"issue":"3","key":"4506_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/icb.2013.96","volume":"92","author":"EM Mace","year":"2014","unstructured":"Mace EM et al (2014) Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol 92(3):245\u2013255","journal-title":"Immunol Cell Biol"},{"key":"4506_CR15","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.2014010804","author":"B Bonavida","year":"2014","unstructured":"Bonavida B (2014) NK cell phenotypic and functional heterogeneities and molecular mechanisms of cytotoxicity. Crit Rev Oncogenesis. https:\/\/doi.org\/10.1615\/CritRevOncog.2014010804","journal-title":"Crit Rev Oncogenesis"},{"issue":"8","key":"4506_CR16","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41590-020-0728-z","volume":"21","author":"T Bald","year":"2020","unstructured":"Bald T et al (2020) The NK cell\u2013cancer cycle: advances and new challenges in NK cell\u2013based immunotherapies. Nat Immunol 21(8):835\u2013847","journal-title":"Nat Immunol"},{"issue":"8","key":"4506_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41568-020-0272-z","volume":"20","author":"ND Huntington","year":"2020","unstructured":"Huntington ND, Cursons J, Rautela J (2020) The cancer\u2013natural killer cell immunity cycle. Nat Rev Cancer 20(8):437\u2013454","journal-title":"Nat Rev Cancer"},{"key":"4506_CR18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.coi.2021.11.001","volume":"74","author":"S Seo","year":"2022","unstructured":"Seo S, Mace EM (2022) Diversity of human NK cell developmental pathways defined by single-cell analyses. Curr Opin Immunol 74:106\u2013111","journal-title":"Curr Opin Immunol"},{"issue":"415","key":"4506_CR19","doi-asserted-by":"publisher","first-page":"ra19","DOI":"10.1126\/scisignal.aad1884","volume":"9","author":"S Viel","year":"2016","unstructured":"Viel S et al (2016) TGF-\u03b2 inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal 9(415):ra19\u2013ra19","journal-title":"Sci Signal"},{"issue":"1","key":"4506_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12943-020-01238-x","volume":"19","author":"S-Y Wu","year":"2020","unstructured":"Wu S-Y et al (2020) Natural killer cells in cancer biology and therapy. Mol Cancer 19(1):120","journal-title":"Mol Cancer"},{"issue":"1","key":"4506_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","volume":"31","author":"EO Long","year":"2013","unstructured":"Long EO et al (2013) Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol 31(1):227\u2013258","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"4506_CR22","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nri3044","volume":"11","author":"JC Sun","year":"2011","unstructured":"Sun JC, Lanier LL (2011) NK cell development, homeostasis and function: parallels with CD8+ T cells. Nat Rev Immunol 11(10):645\u2013657","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"4506_CR23","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1474-9726.2010.00584.x","volume":"9","author":"M Le Garff\u2010Tavernier","year":"2010","unstructured":"Le Garff\u2010Tavernier M et al (2010) Human NK cells display major phenotypic and functional changes over the life span. Aging Cell 9(4):527\u2013535","journal-title":"Aging Cell"},{"issue":"1","key":"4506_CR24","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41392-025-02371-z","volume":"10","author":"Y Fu","year":"2025","unstructured":"Fu Y et al (2025) Immunosenescence: signaling pathways, diseases and therapeutic targets. Signal Transduct Target Ther 10(1):250","journal-title":"Signal Transduct Target Ther"},{"key":"4506_CR25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fimmu.2020.00245","volume":"11","author":"I B\u00e4hr","year":"2020","unstructured":"B\u00e4hr I et al (2020) Obesity-associated alterations of natural killer cells and immunosurveillance of cancer. Front Immunol 11:245","journal-title":"Front Immunol"},{"issue":"21","key":"4506_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1182\/blood.V122.21.16.16","volume":"122","author":"K Sch\u00f6nberg","year":"2013","unstructured":"Sch\u00f6nberg K et al (2013) The JAK1\/JAK2 inhibitor ruxolitinib substantially affects NK cell biology. Blood 122(21):16","journal-title":"Blood"},{"issue":"1","key":"4506_CR27","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1186\/s12967-024-05829-w","volume":"22","author":"S Chen","year":"2024","unstructured":"Chen S et al (2024) Compromised C3b-VSIG4 axis between decidual NK cells and macrophages contributes to recurrent spontaneous abortion. J Transl Med 22(1):1017","journal-title":"J Transl Med"},{"key":"4506_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4684268","author":"C Cantoni","year":"2016","unstructured":"Cantoni C et al (2016) NK cells, tumor cell transition, and tumor progression in solid malignancies: new hints for NK\u2010based immunotherapy? J Immunol Res. https:\/\/doi.org\/10.1155\/2016\/4684268","journal-title":"J Immunol Res"},{"key":"4506_CR29","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3389\/fimmu.2017.00930","volume":"8","author":"Y Wu","year":"2017","unstructured":"Wu Y, Tian Z, Wei H (2017) Developmental and functional control of natural killer cells by cytokines. Front Immunol 8:930","journal-title":"Front Immunol"},{"issue":"1","key":"4506_CR30","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1038\/s41467-019-11878-3","volume":"10","author":"CL Zimmer","year":"2019","unstructured":"Zimmer CL et al (2019) NK cells are activated and primed for skin-homing during acute dengue virus infection in humans. Nat Commun 10(1):3897","journal-title":"Nat Commun"},{"issue":"4","key":"4506_CR31","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1002\/JLB.2MR0820-652R","volume":"108","author":"C Cantoni","year":"2020","unstructured":"Cantoni C et al (2020) Escape of tumor cells from the NK cell cytotoxic activity. J Leukoc Biol 108(4):1339\u20131360","journal-title":"J Leukoc Biol"},{"issue":"2","key":"4506_CR32","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2022.09.022","volume":"151","author":"EM Mace","year":"2023","unstructured":"Mace EM (2023) Human natural killer cells: form, function, and development. J Allergy Clin Immunol 151(2):371\u2013385","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"4506_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13045-020-01014-w","volume":"14","author":"S Liu","year":"2021","unstructured":"Liu S et al (2021) NK cell-based cancer immunotherapy: from basic biology to clinical development. J Hematol Oncol 14(1):7","journal-title":"J Hematol Oncol"},{"key":"4506_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fimmu.2018.00150","volume":"9","author":"NA Lieberman","year":"2018","unstructured":"Lieberman NA et al (2018) An uncoupling of canonical phenotypic markers and functional potency of ex vivo-expanded natural killer cells. Front Immunol 9:150","journal-title":"Front Immunol"},{"issue":"1","key":"4506_CR35","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41467-019-08384-x","volume":"10","author":"JP Goodridge","year":"2019","unstructured":"Goodridge JP et al (2019) Remodeling of secretory lysosomes during education tunes functional potential in NK cells. Nat Commun 10(1):514","journal-title":"Nat Commun"},{"issue":"5","key":"4506_CR36","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/icb.2011.71","volume":"90","author":"NS Wilson","year":"2012","unstructured":"Wilson NS et al (2012) ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway. Immunol Cell Biol 90(5):540\u2013552","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"4506_CR37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li X et al (2023) Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther 8(1):239","journal-title":"Signal Transduct Target Ther"},{"key":"4506_CR38","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.3389\/fimmu.2017.01124","volume":"8","author":"S Paul","year":"2017","unstructured":"Paul S, Lal G (2017) The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy. Front Immunol 8:1124","journal-title":"Front Immunol"},{"issue":"29","key":"4506_CR39","doi-asserted-by":"publisher","first-page":"20854","DOI":"10.1074\/jbc.M703060200","volume":"282","author":"TL-A Nguyen","year":"2007","unstructured":"Nguyen TL-A et al (2007) Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator \u03c4 isoform. J Biol Chem 282(29):20854\u201320867","journal-title":"J Biol Chem"},{"issue":"16","key":"4506_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612558","volume":"24","author":"DE S\u00e1nchez-Jasso","year":"2023","unstructured":"S\u00e1nchez-Jasso DE et al (2023) Novel aspects of cAMP-response element modulator (CREM) role in spermatogenesis and male fertility. Int J Mol Sci 24(16):12558","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4506_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1095\/biolreprod.115.134684","volume":"94","author":"PN Grozdanov","year":"2016","unstructured":"Grozdanov PN et al (2016) TauCstF-64 mediates correct mRNA polyadenylation and splicing of activator and repressor isoforms of the cyclic AMP-responsive element modulator (CREM) in mouse testis. Biol Reprod 94(2):34\u20131-12","journal-title":"Biol Reprod"},{"issue":"3","key":"4506_CR42","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1210\/en.2004-0761","volume":"146","author":"BF Clem","year":"2005","unstructured":"Clem BF, Hudson EA, Clark BJ (2005) Cyclic adenosine 3\u2032, 5\u2032-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 146(3):1348\u20131356","journal-title":"Endocrinology"},{"issue":"2","key":"4506_CR43","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.bbrc.2004.05.165","volume":"320","author":"J Poels","year":"2004","unstructured":"Poels J et al (2004) Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells. Biochem Biophys Res Commun 320(2):318\u2013324","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"4506_CR44","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1128\/MCB.24.7.2831-2841.2004","volume":"24","author":"A Inada","year":"2004","unstructured":"Inada A et al (2004) Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic \u03b2 cells. Mol Cell Biol 24(7):2831\u20132841","journal-title":"Mol Cell Biol"},{"issue":"2","key":"4506_CR45","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1095\/biolreprod.105.049486","volume":"75","author":"LC Mu\u00f1iz","year":"2006","unstructured":"Mu\u00f1iz LC et al (2006) Transcriptional regulation of cyclin D2 by the PKA pathway and inducible cAMP early repressor in granulosa cells. Biol Reprod 75(2):279\u2013288","journal-title":"Biol Reprod"},{"issue":"1","key":"4506_CR46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1096\/fj.13-231977","volume":"28","author":"MD Seidl","year":"2014","unstructured":"Seidl MD et al (2014) A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms. FASEB J 28(1):143\u2013152","journal-title":"FASEB J"},{"key":"4506_CR47","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/B978-0-12-374145-5.00253-9","volume-title":"Handbook of cell signaling","author":"PK Brindle","year":"2010","unstructured":"Brindle PK (2010) Transcriptional regulation via the cAMP responsive activator CREB. Handbook of cell signaling. Elsevier, pp 2077\u20132081"},{"issue":"2","key":"4506_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/jmcb\/mjs004","volume":"4","author":"R Lippe","year":"2012","unstructured":"Lippe R et al (2012) CREM \u03b1 overexpression decreases IL-2 production, induces a TH17 phenotype and accelerates autoimmunity. J Mol Cell Biol 4(2):121\u2013123","journal-title":"J Mol Cell Biol"},{"issue":"8","key":"4506_CR49","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01390-25","volume":"16","author":"AC Brown","year":"2025","unstructured":"Brown AC et al (2025) The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection. MBio 16(8):e01390-25","journal-title":"MBio"},{"issue":"1","key":"4506_CR50","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S1472-6483(10)60805-X","volume":"10","author":"C Krausz","year":"2005","unstructured":"Krausz C, Sassone-Corsi P (2005) Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility. Reprod Biomed Online 10(1):64\u201371","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"4506_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.autrev.2009.02.035","volume":"9","author":"D Gomez-Martin","year":"2009","unstructured":"Gomez-Martin D et al (2009) Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities. Autoimmun Rev 9(1):34\u201339","journal-title":"Autoimmun Rev"},{"issue":"4","key":"4506_CR52","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1210\/jcem.87.4.8360","volume":"87","author":"J Bailey","year":"2002","unstructured":"Bailey J et al (2002) Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties. J Clin Endocrinol Metab 87(4):1717\u20131728","journal-title":"J Clin Endocrinol Metab"},{"key":"4506_CR53","unstructured":"Ramsay, R., et al., Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. International journal of immunopathology and pharmacology, 2003. 16(2; SUPP): p. 59\u201367."},{"issue":"1","key":"4506_CR54","volume":"2015","author":"Q Guo","year":"2015","unstructured":"Guo Q et al (2015) Cyclic AMP-responsive element modulator \u03b1 polymorphisms are potential genetic risks for systemic lupus erythematosus. J Immunol Res 2015(1):906086","journal-title":"J Immunol Res"},{"issue":"6","key":"4506_CR55","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa267","volume":"44","author":"ME Wimmer","year":"2021","unstructured":"Wimmer ME et al (2021) Cyclic AMP response element-binding protein is required in excitatory neurons in the forebrain to sustain wakefulness. Sleep 44(6):zsaa267","journal-title":"Sleep"},{"issue":"11","key":"4506_CR56","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrn3111","volume":"12","author":"AJ Robison","year":"2011","unstructured":"Robison AJ, Nestler EJ (2011) Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12(11):623\u2013637","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"4506_CR57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020285","volume":"6","author":"H Sadamoto","year":"2011","unstructured":"Sadamoto H et al (2011) Direct observation of dimerization between different CREB1 isoforms in a living cell. PLoS ONE 6(6):e20285","journal-title":"PLoS ONE"},{"issue":"1","key":"4506_CR58","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1210\/mend.16.1.0759","volume":"16","author":"PR Manna","year":"2002","unstructured":"Manna PR et al (2002) Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol 16(1):184\u2013199","journal-title":"Mol Endocrinol"},{"issue":"2","key":"4506_CR59","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/jcp.20474","volume":"206","author":"SJ Kovach","year":"2006","unstructured":"Kovach SJ et al (2006) Role of cyclic-AMP responsive element binding (CREB) proteins in cell proliferation in a rat model of hepatocellular carcinoma. J Cell Physiol 206(2):411\u2013419","journal-title":"J Cell Physiol"},{"issue":"1\u20132","key":"4506_CR60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cellimm.2012.04.008","volume":"276","author":"W-D Xu","year":"2012","unstructured":"Xu W-D et al (2012) Role of CREM in systemic lupus erythematosus. Cell Immunol 276(1\u20132):10\u201315","journal-title":"Cell Immunol"},{"issue":"1","key":"4506_CR61","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12035-009-8072-1","volume":"40","author":"G Borlikova","year":"2009","unstructured":"Borlikova G, Endo S (2009) Inducible cAMP early repressor (ICER) and brain functions. Mol Neurobiol 40(1):73\u201386","journal-title":"Mol Neurobiol"},{"issue":"11","key":"4506_CR62","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/molehr\/8.11.965","volume":"8","author":"B Gellersen","year":"2002","unstructured":"Gellersen B et al (2002) Novel leader exons of the cyclic adenosine 3\u2032, 5\u2032-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. Mol Hum Reprod 8(11):965\u2013976","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"4506_CR63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1007111818628","volume":"212","author":"P Haus-Seuffert","year":"2000","unstructured":"Haus-Seuffert P, Meisterernst M (2000) Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB. Mol Cell Biochem 212(1):5\u20139","journal-title":"Mol Cell Biochem"},{"key":"4506_CR64","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fnmol.2015.00046","volume":"8","author":"S Ortega-Mart\u00ednez","year":"2015","unstructured":"Ortega-Mart\u00ednez S (2015) A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Front Mol Neurosci 8:46","journal-title":"Front Mol Neurosci"},{"key":"4506_CR65","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.3389\/fnbeh.2010.00025","volume":"4","author":"H Sadamoto","year":"2010","unstructured":"Sadamoto H et al (2010) Learning-dependent gene expression of CREB1 isoforms in the molluscan brain. Front Behav Neurosci 4:1533","journal-title":"Front Behav Neurosci"},{"issue":"5","key":"4506_CR66","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1210\/endo.143.5.8822","volume":"143","author":"G Stelzer","year":"2002","unstructured":"Stelzer G, Don J (2002) Atce1: a novel mouse cyclic adenosine 3\u2032, 5\u2032-monophosphate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids. Endocrinology 143(5):1578\u20131588","journal-title":"Endocrinology"},{"issue":"1","key":"4506_CR67","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1152\/physrev.00017.2008","volume":"89","author":"CM Alberini","year":"2009","unstructured":"Alberini CM (2009) Transcription factors in long-term memory and synaptic plasticity. Physiol Rev 89(1):121\u2013145","journal-title":"Physiol Rev"},{"issue":"2","key":"4506_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1385\/MN:30:2:143","volume":"30","author":"AC Conti","year":"2004","unstructured":"Conti AC, Blendy JA (2004) Regulation of antidepressant activity by cAMP response element binding proteins. Mol Neurobiol 30(2):143\u2013155","journal-title":"Mol Neurobiol"},{"issue":"21","key":"4506_CR69","doi-asserted-by":"publisher","first-page":"12887","DOI":"10.3390\/ijms232112887","volume":"23","author":"LJ Martin","year":"2022","unstructured":"Martin LJ, Nguyen HT (2022) Basic leucine zipper transcription factors as important regulators of Leydig cells\u2019 functions. Int J Mol Sci 23(21):12887","journal-title":"Int J Mol Sci"},{"issue":"24","key":"4506_CR70","doi-asserted-by":"publisher","first-page":"9120","DOI":"10.1128\/MCB.20.24.9120-9126.2000","volume":"20","author":"F Ledo","year":"2000","unstructured":"Ledo F et al (2000) DREAM-\u03b1CREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Mol Cell Biol 20(24):9120\u20139126","journal-title":"Mol Cell Biol"},{"issue":"S2","key":"4506_CR71","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B","volume":"56","author":"P Sassone-Corsi","year":"2000","unstructured":"Sassone-Corsi P (2000) CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells. Mol Reprod Dev 56(S2):228\u2013229","journal-title":"Mol Reprod Dev"},{"issue":"5","key":"4506_CR72","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1095\/biolreprod62.5.1344","volume":"62","author":"R Behr","year":"2000","unstructured":"Behr R et al (2000) Cloning and expression analysis of testis-specific cyclic 3\u2032, 5\u2032-adenosine monophosphate-responsive element modulator activators in the nonhuman primate (Macaca fascicularis): comparison with other primate and rodent species. Biol Reprod 62(5):1344\u20131351","journal-title":"Biol Reprod"},{"issue":"12","key":"4506_CR73","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/molehr\/gah194","volume":"11","author":"YS Lee","year":"2005","unstructured":"Lee YS et al (2005) The role of CCAAT\/enhancer-binding protein \u03b2 in the transcriptional regulation of COX-2 in human amnion. Mol Hum Reprod 11(12):853\u2013858","journal-title":"Mol Hum Reprod"},{"key":"4506_CR74","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0074-7696(04)41005-5","volume":"241","author":"J Poels","year":"2004","unstructured":"Poels J, Vanden Broeck J (2004) Insect basic leucine zipper proteins and their role in cyclic AMP-dependent regulation of gene expression. Int Rev Cytol 241:277\u2013309","journal-title":"Int Rev Cytol"},{"issue":"25","key":"4506_CR75","doi-asserted-by":"publisher","first-page":"19434","DOI":"10.1074\/jbc.M110.107607","volume":"285","author":"V Pierard","year":"2010","unstructured":"Pierard V et al (2010) DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein\/CRE modulator\/activation transcription factor binding. J Biol Chem 285(25):19434\u201319449","journal-title":"J Biol Chem"},{"issue":"3","key":"4506_CR76","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/icb.2014.1","volume":"92","author":"ND Huntington","year":"2014","unstructured":"Huntington ND (2014) The unconventional expression of IL-15 and its role in NK cell homeostasis. Immunol Cell Biol 92(3):210\u2013213","journal-title":"Immunol Cell Biol"},{"issue":"12","key":"4506_CR77","doi-asserted-by":"publisher","first-page":"4887","DOI":"10.1182\/blood-2002-11-3392","volume":"101","author":"T Ranson","year":"2003","unstructured":"Ranson T et al (2003) IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 101(12):4887\u20134893","journal-title":"Blood"},{"issue":"1","key":"4506_CR78","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1084\/jem.20082013","volume":"206","author":"ND Huntington","year":"2009","unstructured":"Huntington ND et al (2009) IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med 206(1):25\u201334","journal-title":"J Exp Med"},{"key":"4506_CR79","doi-asserted-by":"crossref","unstructured":"Pfefferle, A., et al., Deciphering Natural Killer Cell Homeostasis. Frontiers in Immunology, 2020. Volume 11 - 2020.","DOI":"10.3389\/fimmu.2020.00812"},{"issue":"5","key":"4506_CR80","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1073\/pnas.0535482100","volume":"100","author":"T Ranson","year":"2003","unstructured":"Ranson T et al (2003) IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A 100(5):2663\u20132668","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4506_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coi.2016.10.004","volume":"44","author":"J Rautela","year":"2017","unstructured":"Rautela J, Huntington ND (2017) IL-15 signaling in NK cell cancer immunotherapy. Curr Opin Immunol 44:1\u20136","journal-title":"Curr Opin Immunol"},{"issue":"7","key":"4506_CR82","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1084\/jem.20041389","volume":"200","author":"PR Burkett","year":"2004","unstructured":"Burkett PR et al (2004) Coordinate expression and trans presentation of interleukin (IL)-15R\u03b1 and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med 200(7):825\u2013834","journal-title":"J Exp Med"},{"key":"4506_CR83","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fimmu.2014.00187","volume":"5","author":"N Nandagopal","year":"2014","unstructured":"Nandagopal N et al (2014) The critical role of IL-15\u2013PI3K\u2013mTOR pathway in natural killer cell effector functions. Front Immunol 5:187","journal-title":"Front Immunol"},{"key":"4506_CR84","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3389\/fimmu.2013.00450","volume":"4","author":"A Mar\u00e7ais","year":"2013","unstructured":"Mar\u00e7ais A et al (2013) Regulation of mouse NK cell development and function by cytokines. Front Immunol 4:450","journal-title":"Front Immunol"},{"issue":"3","key":"4506_CR85","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96219","volume":"3","author":"M Felices","year":"2018","unstructured":"Felices M et al (2018) Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight 3(3):e96219","journal-title":"JCI Insight"},{"issue":"8","key":"4506_CR86","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/ni.2936","volume":"15","author":"A Mar\u00e7ais","year":"2014","unstructured":"Mar\u00e7ais A et al (2014) The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol 15(8):749\u2013757","journal-title":"Nat Immunol"},{"issue":"11","key":"4506_CR87","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1182\/blood-2016-02-698027","volume":"128","author":"Y Mao","year":"2016","unstructured":"Mao Y et al (2016) IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. Blood 128(11):1475\u20131489","journal-title":"Blood"},{"issue":"3","key":"4506_CR88","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.cyto.2012.06.017","volume":"59","author":"EF Castillo","year":"2012","unstructured":"Castillo EF, Schluns KS (2012) Regulating the immune system via IL-15 transpresentation. Cytokine 59(3):479\u2013490","journal-title":"Cytokine"},{"key":"4506_CR89","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fimmu.2015.00355","volume":"6","author":"AK Ali","year":"2015","unstructured":"Ali AK, Nandagopal N, Lee S-H (2015) IL-15\u2013PI3K\u2013AKT\u2013mTOR: a critical pathway in the life journey of natural killer cells. Front Immunol 6:355","journal-title":"Front Immunol"},{"key":"4506_CR90","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0065-2776(04)86006-1","volume":"86","author":"B Becknell","year":"2005","unstructured":"Becknell B, Caligiuri MA (2005) Interleukin-2, interleukin-15, and their roles in human natural killer cells. Adv Immunol 86:209\u2013239","journal-title":"Adv Immunol"},{"issue":"6","key":"4506_CR91","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S1359-6101(02)00029-1","volume":"13","author":"JP Lodolce","year":"2002","unstructured":"Lodolce JP et al (2002) Regulation of lymphoid homeostasis by interleukin-15. Cytokine Growth Factor Rev 13(6):429\u2013439","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"4506_CR92","doi-asserted-by":"publisher","first-page":"12730","DOI":"10.1038\/ncomms12730","volume":"7","author":"M Yang","year":"2016","unstructured":"Yang M et al (2016) NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun 7(1):12730","journal-title":"Nat Commun"},{"issue":"1","key":"4506_CR93","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41590-018-0265-1","volume":"20","author":"Y Wang","year":"2019","unstructured":"Wang Y et al (2019) The IL-15\u2013AKT\u2013XBP1s signaling pathway contributes to effector functions and survival in human NK cells. Nat Immunol 20(1):10\u201317","journal-title":"Nat Immunol"},{"issue":"17","key":"4506_CR94","doi-asserted-by":"publisher","first-page":"6967","DOI":"10.1073\/pnas.1304410110","volume":"110","author":"CL Zawislak","year":"2013","unstructured":"Zawislak CL et al (2013) Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci 110(17):6967\u20136972","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"4506_CR95","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s00262-020-02553-4","volume":"69","author":"N Oka","year":"2020","unstructured":"Oka N et al (2020) IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18. Cancer Immunol Immunother 69(9):1699\u20131712","journal-title":"Cancer Immunol Immunother"},{"issue":"10","key":"4506_CR96","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s00018-012-0968-7","volume":"69","author":"O Boyman","year":"2012","unstructured":"Boyman O et al (2012) Homeostatic maintenance of T cells and natural killer cells. Cell Mol Life Sci 69(10):1597\u20131608","journal-title":"Cell Mol Life Sci"},{"issue":"50","key":"4506_CR97","doi-asserted-by":"publisher","first-page":"21647","DOI":"10.1073\/pnas.1012128107","volume":"107","author":"KG Elpek","year":"2010","unstructured":"Elpek KG et al (2010) Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15\/IL-15R\u03b1 complexes. Proc Natl Acad Sci 107(50):21647\u201321652","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"4506_CR98","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1365-2249.2004.02586.x","volume":"138","author":"L Golden-Mason","year":"2004","unstructured":"Golden-Mason L et al (2004) Hepatic interleuklin 15 (IL-15) expression: implications for local NK\/NKT cell homeostasis and development. Clin Exp Immunol 138(1):94\u2013101","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"4506_CR99","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cellimm.2009.03.010","volume":"258","author":"N Gill","year":"2009","unstructured":"Gill N, Paltser G, Ashkar AA (2009) Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-\u03b3. Cell Immunol 258(1):59\u201364","journal-title":"Cell Immunol"},{"key":"4506_CR100","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cyto.2015.12.012","volume":"82","author":"Y Cepero-Donates","year":"2016","unstructured":"Cepero-Donates Y et al (2016) Homeostasis of IL-15 dependent lymphocyte subsets in the liver. Cytokine 82:95\u2013101","journal-title":"Cytokine"},{"issue":"1","key":"4506_CR101","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1182\/blood-2004-08-3232","volume":"106","author":"SA Perez","year":"2005","unstructured":"Perez SA et al (2005) A potential role for hydrocortisone in the positive regulation of IL-15\u2013activated NK-cell proliferation and survival. Blood 106(1):158\u2013166","journal-title":"Blood"},{"issue":"3","key":"4506_CR102","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cyto.2012.05.020","volume":"59","author":"KC Verbist","year":"2012","unstructured":"Verbist KC, Klonowski KD (2012) Functions of IL-15 in anti-viral immunity: multiplicity and variety. Cytokine 59(3):467\u2013478","journal-title":"Cytokine"},{"issue":"5","key":"4506_CR103","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1084\/jem.20071913","volume":"205","author":"E Mortier","year":"2008","unstructured":"Mortier E et al (2008) IL-15R\u03b1 chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 205(5):1213\u20131225","journal-title":"J Exp Med"},{"issue":"4","key":"4506_CR104","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/biof.107","volume":"36","author":"NW Zwirner","year":"2010","unstructured":"Zwirner NW, Domaica CI (2010) Cytokine regulation of natural killer cell effector functions. BioFactors 36(4):274\u2013288","journal-title":"BioFactors"},{"issue":"1","key":"4506_CR105","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1146\/annurev.immunol.24.021605.090727","volume":"24","author":"A Ma","year":"2006","unstructured":"Ma A, Koka R, Burkett P (2006) Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 24(1):657\u2013679","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"4506_CR106","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1172\/JCI31751","volume":"117","author":"F Brilot","year":"2007","unstructured":"Brilot F et al (2007) NK cell survival mediated through the regulatory synapse with human DCs requires IL-15R\u03b1. J Clin Invest 117(11):3316\u20133329","journal-title":"J Clin Invest"},{"key":"4506_CR107","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.3389\/fimmu.2019.02401","volume":"10","author":"A Coulibaly","year":"2019","unstructured":"Coulibaly A et al (2019) Interleukin-15 signaling in HIF-1\u03b1 regulation in natural killer cells, insights through mathematical models. Front Immunol 10:2401","journal-title":"Front Immunol"},{"key":"4506_CR108","doi-asserted-by":"crossref","unstructured":"Felices, M., et al., Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight, 2018. 3(3).","DOI":"10.1172\/jci.insight.96219"},{"issue":"4","key":"4506_CR109","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.bbrc.2009.06.120","volume":"386","author":"J Lee","year":"2009","unstructured":"Lee J et al (2009) Tumor necrosis factor-\u03b1 enhances IL-15-induced natural killer cell differentiation. Biochem Biophys Res Commun 386(4):718\u2013723","journal-title":"Biochem Biophys Res Commun"},{"key":"4506_CR110","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00075","volume":"11","author":"RB Delconte","year":"2020","unstructured":"Delconte RB et al (2020) NK cell priming from endogenous homeostatic signals is modulated by CIS. Front Immunol 11:75","journal-title":"Front Immunol"},{"issue":"2","key":"4506_CR111","doi-asserted-by":"publisher","DOI":"10.4110\/in.2025.25.e17","volume":"25","author":"B Marr","year":"2025","unstructured":"Marr B et al (2025) Cytokines in focus: IL-2 and IL-15 in NK adoptive cell cancer immunotherapy. Immune Netw 25(2):e17","journal-title":"Immune Netw"},{"issue":"1","key":"4506_CR112","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13045-025-01669-3","volume":"18","author":"RM Shapiro","year":"2025","unstructured":"Shapiro RM et al (2025) First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer. J Hematol Oncol 18(1):17","journal-title":"J Hematol Oncol"},{"key":"4506_CR113","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1639732","volume":"16","author":"X Su","year":"2025","unstructured":"Su X, Liu F (2025) Targeting the IL-15\/CD122 signaling pathway: reversing TRM cell-mediated immune memory in vitiligo. Front Immunol 16:1639732","journal-title":"Front Immunol"},{"issue":"19","key":"4506_CR114","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1016\/j.cell.2023.07.034","volume":"186","author":"F Tang","year":"2023","unstructured":"Tang F et al (2023) A pan-cancer single-cell panorama of human natural killer cells. Cell 186(19):4235-4251.e20","journal-title":"Cell"},{"issue":"35","key":"4506_CR115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306782120","volume":"120","author":"JL Wong","year":"2023","unstructured":"Wong JL et al (2023) IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer. Proc Natl Acad Sci U S A 120(35):e2306782120","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4506_CR116","doi-asserted-by":"crossref","unstructured":"Pedde, A.-M., et al., Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity. Cell reports, 2024. 43(11).","DOI":"10.1016\/j.celrep.2024.114855"},{"issue":"8","key":"4506_CR117","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.3390\/biomedicines13081908","volume":"13","author":"M Agrez","year":"2025","unstructured":"Agrez M et al (2025) An immunomodulating peptide with potential to promote anticancer immunity without compromising immune tolerance. Biomedicines 13(8):1908","journal-title":"Biomedicines"},{"issue":"13","key":"4506_CR118","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1182\/blood.2024027931","volume":"145","author":"F Simonetta","year":"2025","unstructured":"Simonetta F (2025) PGE2 inhibition to prevent AML escape from NK cells. Blood 145(13):1338\u20131339","journal-title":"Blood"},{"key":"4506_CR119","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1612352","volume":"16","author":"M Shen","year":"2025","unstructured":"Shen M et al (2025) Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications. Front Immunol 16:1612352","journal-title":"Front Immunol"},{"issue":"4","key":"4506_CR120","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/PPO.0000000000000610","volume":"28","author":"MdSF Pereira","year":"2022","unstructured":"Pereira MdSF et al (2022) Natural killer cell recognition and control of epithelial cancers. Cancer J 28(4):263\u2013269","journal-title":"Cancer J"},{"key":"4506_CR121","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.866703","volume":"13","author":"K Fukuda","year":"2022","unstructured":"Fukuda K (2022) Networks of CD8+ T cell response activation in melanoma and vitiligo. Front Immunol 13:866703","journal-title":"Front Immunol"},{"issue":"3","key":"4506_CR122","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jdermsci.2023.12.008","volume":"113","author":"S Inoue","year":"2024","unstructured":"Inoue S et al (2024) JAK inhibitors for the treatment of vitiligo. J Dermatol Sci 113(3):86\u201392","journal-title":"J Dermatol Sci"},{"issue":"16","key":"4506_CR123","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167811","volume":"26","author":"D-L Demetrius","year":"2025","unstructured":"Demetrius D-L et al (2025) IL-15 promotes the survival of anti-inflammatory (M2), immunoinhibitory (IL-10+) dermal macrophages in human eyelid skin under IFN\u03b3-dominated inflammatory conditions. Int J Mol Sci 26(16):7811","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4506_CR124","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.3390\/jpm13111556","volume":"13","author":"M Surcel","year":"2023","unstructured":"Surcel M et al (2023) Immune portrayal of a new therapy targeting microbiota in an animal model of psoriasis. J Pers Med 13(11):1556","journal-title":"J Pers Med"},{"issue":"1","key":"4506_CR125","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/biomedicines11010064","volume":"11","author":"I Veneziani","year":"2022","unstructured":"Veneziani I et al (2022) The latest approach of immunotherapy with endosomal TLR agonists improving NK cell function: an overview. Biomedicines 11(1):64","journal-title":"Biomedicines"},{"key":"4506_CR126","doi-asserted-by":"crossref","unstructured":"Peng, L., et al., Perturbomics of tumor-infiltrating NK cells. bioRxiv, 2023: p. 2023.03. 14.532653.","DOI":"10.1101\/2023.03.14.532653"},{"issue":"6","key":"4506_CR127","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s40257-023-00808-1","volume":"24","author":"D Dahabreh","year":"2023","unstructured":"Dahabreh D et al (2023) Alopecia areata: current treatments and new directions. Am J Clin Dermatol 24(6):895\u2013912","journal-title":"Am J Clin Dermatol"},{"key":"4506_CR128","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.797026","volume":"9","author":"W-L Chang","year":"2021","unstructured":"Chang W-L et al (2021) Vitiligo: an autoimmune skin disease and its immunomodulatory therapeutic intervention. Front Cell Dev Biol 9:797026","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4506_CR129","doi-asserted-by":"publisher","first-page":"9230","DOI":"10.1038\/s41467-024-53384-1","volume":"15","author":"JI Silverberg","year":"2024","unstructured":"Silverberg JI et al (2024) The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials. Nat Commun 15(1):9230","journal-title":"Nat Commun"},{"issue":"6","key":"4506_CR130","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1109\/TCBB.2022.3143770","volume":"19","author":"W Li","year":"2022","unstructured":"Li W et al (2022) Inferring latent microRNA-disease associations on a gene-mediated tripartite heterogeneous multiplexing network. IEEE ACM Trans Comput Biol Bioinform 19(6):3190\u20133201","journal-title":"IEEE ACM Trans Comput Biol Bioinform"},{"issue":"7","key":"4506_CR131","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1158\/2767-9764.CRC-24-0199","volume":"4","author":"H Ishigaki","year":"2024","unstructured":"Ishigaki H et al (2024) Generation, transcriptomic states, and clinical relevance of CX3CR1+ CD8 T cells in melanoma. Cancer Res Commun 4(7):1802\u20131814","journal-title":"Cancer Res Commun"},{"issue":"1","key":"4506_CR132","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s42003-025-07816-3","volume":"8","author":"X Duan","year":"2025","unstructured":"Duan X et al (2025) Impact of immune cell metabolism on membranous nephropathy and prospective therapy. Commun Biol 8(1):405","journal-title":"Commun Biol"},{"issue":"3","key":"4506_CR133","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","volume":"61","author":"H Li","year":"2021","unstructured":"Li H et al (2021) Update on the pathogenesis and therapy of atopic dermatitis. Clin Rev Allergy Immunol 61(3):324\u2013338","journal-title":"Clin Rev Allergy Immunol"},{"issue":"25","key":"4506_CR134","doi-asserted-by":"publisher","first-page":"6081","DOI":"10.1016\/j.cell.2021.11.016","volume":"184","author":"CR Good","year":"2021","unstructured":"Good CR et al (2021) An NK-like CAR T cell transition in CAR T cell dysfunction. Cell 184(25):6081-6100.e26","journal-title":"Cell"},{"issue":"1","key":"4506_CR135","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/genes13010035","volume":"13","author":"Y Hou","year":"2021","unstructured":"Hou Y et al (2021) Somatic reversion of a novel IL2RG mutation resulting in atypical X-linked combined immunodeficiency. Genes (Basel) 13(1):35","journal-title":"Genes (Basel)"},{"issue":"1","key":"4506_CR136","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50925-6","volume":"15","author":"J-X Lin","year":"2024","unstructured":"Lin J-X et al (2024) Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nat Commun 15(1):7372","journal-title":"Nat Commun"},{"issue":"4","key":"4506_CR137","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5021\/ad.24.038","volume":"36","author":"SH Seong","year":"2024","unstructured":"Seong SH, Oh SH (2024) Up-and-coming drugs for the treatment of vitiligo. Ann Dermatol 36(4):197","journal-title":"Ann Dermatol"},{"issue":"7","key":"4506_CR138","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071639","volume":"10","author":"N Hla\u010da","year":"2022","unstructured":"Hla\u010da N et al (2022) Current concepts of vitiligo immunopathogenesis. Biomedicines 10(7):1639","journal-title":"Biomedicines"},{"key":"4506_CR139","doi-asserted-by":"crossref","unstructured":"Holmes, T.D., et al., The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation. Science immunology, 2021. 6(57): p. eabc9801.","DOI":"10.1126\/sciimmunol.abc9801"},{"issue":"3","key":"4506_CR140","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12016-021-08883-0","volume":"61","author":"C Zhou","year":"2021","unstructured":"Zhou C et al (2021) Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol 61(3):403\u2013423","journal-title":"Clin Rev Allergy Immunol"},{"issue":"5","key":"4506_CR141","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.7150\/ijbs.92988","volume":"20","author":"W-X Xu","year":"2024","unstructured":"Xu W-X et al (2024) The burgeoning significance of liquid-liquid phase separation in the pathogenesis and therapeutics of cancers. Int J Biol Sci 20(5):1652","journal-title":"Int J Biol Sci"},{"key":"4506_CR142","unstructured":"M\u00fchlenbeck, L.H., Hepatic NK cell education in monobenzone-induced contact hypersensitivity. 2021, Universit\u00e4ts-und Landesbibliothek Bonn."},{"issue":"8011","key":"4506_CR143","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41586-024-07352-w","volume":"629","author":"M Morotti","year":"2024","unstructured":"Morotti M et al (2024) PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function. Nature 629(8011):426\u2013434","journal-title":"Nature"},{"key":"4506_CR144","doi-asserted-by":"publisher","first-page":"1243556","DOI":"10.3389\/fimmu.2023.1243556","volume":"14","author":"T Passeron","year":"2023","unstructured":"Passeron T et al (2023) Inhibition of T-cell activity in alopecia areata: recent developments and new directions. Front Immunol 14:1243556","journal-title":"Front Immunol"},{"issue":"11","key":"4506_CR145","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3390\/cells14110825","volume":"14","author":"X Yao","year":"2025","unstructured":"Yao X et al (2025) Innate lymphoid cells in inflammatory bowel disease. Cells 14(11):825","journal-title":"Cells"},{"key":"4506_CR146","doi-asserted-by":"crossref","unstructured":"Yin, D., et al., Novel insights into HBV\u2010hepatocellular carcinoma at single\u2010cell sequencing. MedComm\u2013Oncology, 2023. 2(4): p. e60.","DOI":"10.1002\/mog2.60"},{"issue":"8","key":"4506_CR147","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/s41590-024-01883-0","volume":"25","author":"L Rebuffet","year":"2024","unstructured":"Rebuffet L et al (2024) High-dimensional single-cell analysis of human natural killer cell heterogeneity. Nat Immunol 25(8):1474\u20131488","journal-title":"Nat Immunol"},{"key":"4506_CR148","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1277120","volume":"14","author":"H Jia","year":"2023","unstructured":"Jia H, Wan H, Zhang D (2023) Innate lymphoid cells: a new key player in atopic dermatitis. Front Immunol 14:1277120","journal-title":"Front Immunol"},{"issue":"5","key":"4506_CR149","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1093\/bjd\/ljae472","volume":"192","author":"Y Liu","year":"2025","unstructured":"Liu Y et al (2025) Emerging role of regulatory T cells in the immunopathogenesis of vitiligo and implications for treatment. Br J Dermatol 192(5):796\u2013806","journal-title":"Br J Dermatol"},{"key":"4506_CR150","unstructured":"Gratz, H.P., Functional characterization of a novel IL2RG mutation causing atypical SCID. 2024, Dissertation, T\u00fcbingen, Universit\u00e4t T\u00fcbingen, 2023."},{"key":"4506_CR151","doi-asserted-by":"publisher","first-page":"0948","DOI":"10.34133\/research.0948","volume":"8","author":"B Huang","year":"2025","unstructured":"Huang B et al (2025) Chronic psychological stress in oncogenesis: multisystem crosstalk and multimodal interventions. Research 8:0948","journal-title":"Research"},{"issue":"2","key":"4506_CR152","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3390\/nu17020234","volume":"17","author":"E Aitella","year":"2025","unstructured":"Aitella E et al (2025) Celiac disease: a transitional point of view. Nutrients 17(2):234","journal-title":"Nutrients"},{"issue":"5","key":"4506_CR153","doi-asserted-by":"publisher","DOI":"10.4110\/in.2024.24.e33","volume":"24","author":"R Speeckaert","year":"2024","unstructured":"Speeckaert R et al (2024) Th pathways in immune-mediated skin disorders: a guide for strategic treatment decisions. Immune Netw 24(5):e33","journal-title":"Immune Netw"},{"issue":"7","key":"4506_CR154","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.molmed.2022.04.010","volume":"28","author":"Y Yuan","year":"2022","unstructured":"Yuan Y et al (2022) Therapeutic potential of interleukin-2 in autoimmune diseases. Trends Mol Med 28(7):596\u2013612","journal-title":"Trends Mol Med"},{"key":"4506_CR155","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1176781","volume":"10","author":"AA Touni","year":"2023","unstructured":"Touni AA et al (2023) Melanocyte-keratinocyte cross-talk in vitiligo. Front Med 10:1176781","journal-title":"Front Med"},{"key":"4506_CR156","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.613056","volume":"12","author":"K Boniface","year":"2021","unstructured":"Boniface K et al (2021) Targeting innate immunity to combat cutaneous stress: the vitiligo perspective. Front Immunol 12:613056","journal-title":"Front Immunol"},{"issue":"18","key":"4506_CR157","doi-asserted-by":"publisher","first-page":"9233","DOI":"10.3390\/ijms26189233","volume":"26","author":"L Wang","year":"2025","unstructured":"Wang L et al (2025) Advances in psoriasis research: decoding immune circuits and developing novel therapies. Int J Mol Sci 26(18):9233","journal-title":"Int J Mol Sci"},{"key":"4506_CR158","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1055958","volume":"13","author":"C Lyu","year":"2022","unstructured":"Lyu C, Sun Y (2022) Immunometabolism in the pathogenesis of vitiligo. Front Immunol 13:1055958","journal-title":"Front Immunol"},{"issue":"4","key":"4506_CR159","doi-asserted-by":"publisher","first-page":"465","DOI":"10.4103\/idoj.idoj_452_22","volume":"14","author":"K Sardana","year":"2023","unstructured":"Sardana K, Bathula S, Khurana A (2023) Which is the ideal JAK inhibitor for alopecia areata\u2013baricitinib, tofacitinib, ritlecitinib or ifidancitinib-revisiting the immunomechanisms of the JAK pathway. Indian Dermatol Online J 14(4):465\u2013474","journal-title":"Indian Dermatol Online J"},{"issue":"3","key":"4506_CR160","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s40291-025-00776-8","volume":"29","author":"Y Pan","year":"2025","unstructured":"Pan Y et al (2025) Psoriasis: a multidimensional review of onset, progression, treatment, and the evolution of disease models. Mol Diagn Ther 29(3):345\u2013366","journal-title":"Mol Diagn Ther"},{"issue":"11","key":"4506_CR161","doi-asserted-by":"publisher","first-page":"377","DOI":"10.31083\/j.fbl2911377","volume":"29","author":"M Singer","year":"2024","unstructured":"Singer M, Elsayed AM, Husseiny MI (2024) Regulatory T-cells: the face-off of the immune balance. Front Biosci-Landmark 29(11):377","journal-title":"Front Biosci-Landmark"},{"issue":"8011","key":"4506_CR162","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41586-024-07254-x","volume":"629","author":"SB Lacher","year":"2024","unstructured":"Lacher SB et al (2024) PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells. Nature 629(8011):417\u2013425","journal-title":"Nature"},{"issue":"2","key":"4506_CR163","first-page":"216","volume":"8","author":"X Xu","year":"2024","unstructured":"Xu X et al (2024) FHL2 determines poor outcomes and responsiveness of immunotherapy plus tyrosine kinase inhibition in metastatic renal cell carcinoma. Eurasian J Med Oncol 8(2):216","journal-title":"Eurasian J Med Oncol"},{"issue":"1","key":"4506_CR164","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/1346-8138.16207","volume":"49","author":"M Fukuyama","year":"2022","unstructured":"Fukuyama M, Ito T, Ohyama M (2022) Alopecia areata: current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines. J Dermatol 49(1):19\u201336","journal-title":"J Dermatol"},{"issue":"77","key":"4506_CR165","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq3254","volume":"7","author":"SK Whitley","year":"2022","unstructured":"Whitley SK et al (2022) Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells. Sci Immunol 7(77):eabq3254","journal-title":"Sci Immunol"},{"key":"4506_CR166","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.566401","volume":"11","author":"Y Shi","year":"2021","unstructured":"Shi Y et al (2021) Next-generation immunotherapies to improve anticancer immunity. Front Pharmacol 11:566401","journal-title":"Front Pharmacol"},{"issue":"10","key":"4506_CR167","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1016\/j.immuni.2021.09.001","volume":"54","author":"K Sakamoto","year":"2021","unstructured":"Sakamoto K et al (2021) Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. Immunity 54(10):2321-2337.e10","journal-title":"Immunity"},{"issue":"3","key":"4506_CR168","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/14728222.2023.2193329","volume":"27","author":"B Xie","year":"2023","unstructured":"Xie B et al (2023) Treatment update for vitiligo based on autoimmune inhibition and melanocyte protection. Expert Opin Ther Targets 27(3):189\u2013206","journal-title":"Expert Opin Ther Targets"},{"key":"4506_CR169","doi-asserted-by":"crossref","unstructured":"Ni, G., et al., Topical application of temperature-sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour-bearing mice induced high-level immune response in the tumour microenvironment. Frontiers in oncology, 2021. 11: p. 754770.","DOI":"10.3389\/fonc.2021.754770"},{"key":"4506_CR170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.790125","volume":"12","author":"F Qi","year":"2021","unstructured":"Qi F, Liu F, Gao L (2021) Janus kinase inhibitors in the treatment of vitiligo: a review. Front Immunol 12:790125","journal-title":"Front Immunol"},{"issue":"1","key":"4506_CR171","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12967-024-05132-8","volume":"22","author":"Y Wei","year":"2024","unstructured":"Wei Y et al (2024) Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing \u03b3\u03b4(low) T cells. J Transl Med 22(1):328","journal-title":"J Transl Med"},{"issue":"3","key":"4506_CR172","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/jdv.20311","volume":"39","author":"HL Yamaguchi","year":"2025","unstructured":"Yamaguchi HL, Yamaguchi Y, Peeva E (2025) Hair regrowth in alopecia areata and re-pigmentation in vitiligo in response to treatment: commonalities and differences. J Eur Acad Dermatol Venereol 39(3):498\u2013511","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"4506_CR173","doi-asserted-by":"publisher","first-page":"7165","DOI":"10.1038\/s41467-024-51496-2","volume":"15","author":"J Holzgruber","year":"2024","unstructured":"Holzgruber J et al (2024) Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade. Nat Commun 15(1):7165","journal-title":"Nat Commun"},{"issue":"14","key":"4506_CR174","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.7150\/thno.93745","volume":"14","author":"L Huang","year":"2024","unstructured":"Huang L et al (2024) Advances in targeted delivery of mRNA into immune cells for enhanced cancer therapy. Theranostics 14(14):5528\u20135550","journal-title":"Theranostics"},{"key":"4506_CR175","doi-asserted-by":"crossref","unstructured":"Jayasinghe, R.G., et al., Single cell resolution analysis of multi-tissue derived human iNKT cells reveals novel transcriptional paradigms. bioRxiv, 2024: p. 2024.03. 22.583992.","DOI":"10.1101\/2024.03.22.583992"},{"key":"4506_CR176","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1523272","volume":"16","author":"Z Huang","year":"2025","unstructured":"Huang Z et al (2025) Traditional Chinese medicine for lupus nephritis: modulation of autoimmune pathogenesis. Front Pharmacol 16:1523272","journal-title":"Front Pharmacol"},{"issue":"2","key":"4506_CR177","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.cclet.2021.08.090","volume":"33","author":"Y Song","year":"2022","unstructured":"Song Y et al (2022) Macrophage-targeted nanomedicine for chronic diseases immunotherapy. Chin Chem Lett 33(2):597\u2013612","journal-title":"Chin Chem Lett"},{"issue":"3","key":"4506_CR178","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/cimb47030191","volume":"47","author":"W Li","year":"2025","unstructured":"Li W et al (2025) Emerging therapeutic innovations for vitiligo treatment. Curr Issues Mol Biol 47(3):191","journal-title":"Curr Issues Mol Biol"},{"key":"4506_CR179","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1596686","volume":"16","author":"F Yin","year":"2025","unstructured":"Yin F et al (2025) Immune cell senescence in autoimmunity: implications for disease pathogenesis and therapeutic targeting. Front Immunol 16:1596686","journal-title":"Front Immunol"},{"issue":"7","key":"4506_CR180","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s13555-025-01421-2","volume":"15","author":"S Gregoire","year":"2025","unstructured":"Gregoire S et al (2025) Local corticosteroids for alopecia areata: a narrative review. Dermatol Ther 15(7):1607\u20131631","journal-title":"Dermatol Ther"},{"issue":"7","key":"4506_CR181","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s13555-022-00737-7","volume":"12","author":"E-B Haddad","year":"2022","unstructured":"Haddad E-B et al (2022) Current and emerging strategies to inhibit type 2 inflammation in atopic dermatitis. Dermatol Ther 12(7):1501\u20131533","journal-title":"Dermatol Ther"},{"issue":"19","key":"4506_CR182","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1158\/1078-0432.CCR-23-2266","volume":"30","author":"JN Bryan","year":"2024","unstructured":"Bryan JN, Maitz CA (2024) Translational history and hope of immunotherapy of canine tumors. Clin Cancer Res 30(19):4272\u20134285","journal-title":"Clin Cancer Res"},{"key":"4506_CR183","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1340677","volume":"14","author":"L Li","year":"2024","unstructured":"Li L et al (2024) Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets. Front Immunol 14:1340677","journal-title":"Front Immunol"},{"key":"4506_CR184","doi-asserted-by":"publisher","first-page":"1149622","DOI":"10.3389\/fimmu.2023.1149622","volume":"14","author":"J-T Ding","year":"2023","unstructured":"Ding J-T et al (2023) Landscapes and mechanisms of CD8+ T cell exhaustion in gastrointestinal cancer. Front Immunol 14:1149622","journal-title":"Front Immunol"},{"key":"4506_CR185","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101412","author":"T Pulliam","year":"2024","unstructured":"Pulliam T et al (2024) Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma. Cell Rep Med. https:\/\/doi.org\/10.1016\/j.xcrm.2024.101412","journal-title":"Cell Rep Med"},{"issue":"10","key":"4506_CR186","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3390\/vaccines12101179","volume":"12","author":"A Lafleur","year":"2024","unstructured":"Lafleur A et al (2024) Immunotherapeutic strategies as potential treatment options for cutaneous leishmaniasis. Vaccines 12(10):1179","journal-title":"Vaccines"},{"issue":"3","key":"4506_CR187","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/antib14030052","volume":"14","author":"G Yang","year":"2025","unstructured":"Yang G, Massumi M (2025) Fragment-based immune cell engager antibodies in treatment of cancer, infectious and autoimmune diseases: lessons and insights from clinical and translational studies. Antibodies 14(3):52","journal-title":"Antibodies"},{"issue":"6","key":"4506_CR188","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/cells13060510","volume":"13","author":"J Fonseca","year":"2024","unstructured":"Fonseca J, Vaz JA, Ricardo S (2024) The potential of mushroom extracts to improve chemotherapy efficacy in cancer cells: a systematic review. Cells 13(6):510","journal-title":"Cells"},{"issue":"6","key":"4506_CR189","first-page":"624","volume":"14","author":"R Higos","year":"2025","unstructured":"Higos R et al (2025) The critical role of adipocytes in leukemia. Biology (Basel) 14(6):624","journal-title":"Biology (Basel)"},{"key":"4506_CR190","doi-asserted-by":"crossref","unstructured":"Thomas, M.F., et al., Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors. BioRxiv, 2021: p. 2021.09. 17.460868.","DOI":"10.1101\/2021.09.17.460868"},{"issue":"8","key":"4506_CR191","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/s41590-025-02228-1","volume":"26","author":"KSP Devi","year":"2025","unstructured":"Devi KSP et al (2025) PD-1 is requisite for skin TRM cell formation and specification by TGF\u03b2. Nat Immunol 26(8):1339\u20131351","journal-title":"Nat Immunol"},{"key":"4506_CR192","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112670","author":"T Gastaldi","year":"2025","unstructured":"Gastaldi T et al (2025) Multi-omics and functional characterization of the tumor-killing capacity of Imiquimod-activated plasmacytoid dendritic cells. iScience. https:\/\/doi.org\/10.1016\/j.isci.2025.112670","journal-title":"iScience"},{"issue":"1","key":"4506_CR193","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-025-00397-z","volume":"10","author":"R Whitaker","year":"2025","unstructured":"Whitaker R et al (2025) Effects of injury size on local and systemic immune cell dynamics in volumetric muscle loss. npj Regen Med 10(1):9","journal-title":"npj Regen Med"},{"key":"4506_CR194","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s309215","author":"K-AL Dillon","year":"2021","unstructured":"Dillon K-AL (2021) A comprehensive literature review of JAK inhibitors in treatment of alopecia areata. Clin Cosmet Investig Dermatol. https:\/\/doi.org\/10.2147\/ccid.s309215","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"6","key":"4506_CR195","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/s41590-025-02146-2","volume":"26","author":"ME FitzPatrick","year":"2025","unstructured":"FitzPatrick ME et al (2025) Immune\u2013epithelial\u2013stromal networks define the cellular ecosystem of the small intestine in celiac disease. Nat Immunol 26(6):947\u2013962","journal-title":"Nat Immunol"},{"issue":"3","key":"4506_CR196","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/1346-8138.15743","volume":"48","author":"C Bergqvist","year":"2021","unstructured":"Bergqvist C, Ezzedine K (2021) Vitiligo: a focus on pathogenesis and its therapeutic implications. J Dermatol 48(3):252\u2013270","journal-title":"J Dermatol"},{"issue":"16","key":"4506_CR197","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.3390\/cancers13163948","volume":"13","author":"K Oya","year":"2021","unstructured":"Oya K et al (2021) Combination treatment of topical imiquimod plus anti-PD-1 antibody exerts significantly potent antitumor effect. Cancers 13(16):3948","journal-title":"Cancers"},{"issue":"8","key":"4506_CR198","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3390\/biom11081107","volume":"11","author":"J Lee","year":"2021","unstructured":"Lee J et al (2021) Phytochemicals in cancer immune checkpoint inhibitor therapy. Biomolecules 11(8):1107","journal-title":"Biomolecules"},{"key":"4506_CR199","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/978-3-031-52197-3_14","volume-title":"Ion channels as targets in drug discovery","author":"A Selezneva","year":"2024","unstructured":"Selezneva A, Gibb AJ, Willis D (2024) Immune cell ion channels as therapeutic targets. Ion channels as targets in drug discovery. pp 461\u2013495"},{"issue":"1","key":"4506_CR200","doi-asserted-by":"publisher","DOI":"10.4110\/in.2022.22.e7","volume":"22","author":"A Song","year":"2022","unstructured":"Song A, Lee SE, Kim JH (2022) Immunopathology and immunotherapy of inflammatory skin diseases. Immune Netw 22(1):e7","journal-title":"Immune Netw"},{"issue":"11","key":"4506_CR201","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.3390\/cells10112944","volume":"10","author":"J Ban","year":"2021","unstructured":"Ban J et al (2021) Mechanisms, diagnosis and treatment of bone metastases. Cells 10(11):2944","journal-title":"Cells"},{"key":"4506_CR202","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.ccell.2022.11.002","volume":"40","author":"M Duhamel","year":"2022","unstructured":"Duhamel M et al (2022) Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1 T lymphocyte niches through a feed-forward loop. Cancer Cell 40:1600\u20131618","journal-title":"Cancer Cell"},{"key":"4506_CR203","doi-asserted-by":"crossref","unstructured":"Avellar, A.C.d.S., et al., Gestational diabetes mellitus changes human colostrum immune composition. Frontiers in immunology, 2022. 13: p. 910807.","DOI":"10.3389\/fimmu.2022.910807"},{"key":"4506_CR204","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1110765","volume":"11","author":"Q Hu","year":"2023","unstructured":"Hu Q et al (2023) JAK\/STAT pathway: extracellular signals, diseases, immunity, and therapeutic regimens. Front Bioeng Biotechnol 11:1110765","journal-title":"Front Bioeng Biotechnol"},{"key":"4506_CR205","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1341632","volume":"15","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Jiang G (2024) Application of JAK inhibitors in paradoxical reaction through immune-related dermatoses. Front Immunol 15:1341632","journal-title":"Front Immunol"},{"issue":"1","key":"4506_CR206","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/15569527.2022.2034842","volume":"41","author":"M Bhardwaj","year":"2022","unstructured":"Bhardwaj M, Chiu MN, Pilkhwal Sah S (2022) Adverse cutaneous toxicities by PD-1\/PD-L1 immune checkpoint inhibitors: pathogenesis, treatment, and surveillance. Cutaneous Ocular Toxicol 41(1):73\u201390","journal-title":"Cutaneous Ocular Toxicol"},{"issue":"3","key":"4506_CR207","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4103\/ds.DS-D-23-00054","volume":"41","author":"P-C Shen","year":"2023","unstructured":"Shen P-C et al (2023) From zero to one: recent advances in the pathogenesis, diagnosis, and treatment of vitiligo. Dermatol Sin 41(3):133\u2013144","journal-title":"Dermatol Sin"},{"issue":"3","key":"4506_CR208","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4103\/ijp.ijp_1089_20","volume":"54","author":"H Deepak","year":"2022","unstructured":"Deepak H, Prince SE, Deshpande P (2022) Effect of baricitinib in regulating programmed death 1 and ligand programmed cell death ligand 1 through JAK\/STAT pathway in psoriasis. Indian J Pharmacol 54(3):183\u2013193","journal-title":"Indian J Pharmacol"},{"issue":"5","key":"4506_CR209","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41423-023-00992-4","volume":"20","author":"P Facheris","year":"2023","unstructured":"Facheris P et al (2023) The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment. Cell Mol Immunol 20(5):448\u2013474","journal-title":"Cell Mol Immunol"},{"issue":"8","key":"4506_CR210","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3390\/nu17081323","volume":"17","author":"MG Bonomo","year":"2025","unstructured":"Bonomo MG et al (2025) Recent advances in gut microbiota in psoriatic arthritis. Nutrients 17(8):1323","journal-title":"Nutrients"},{"issue":"1","key":"4506_CR211","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10408363.2021.1965535","volume":"59","author":"R Ghosh","year":"2022","unstructured":"Ghosh R et al (2022) T helper cells in depression: central role of Th17 cells. Crit Rev Clin Lab Sci 59(1):19\u201339","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"1","key":"4506_CR212","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00403-025-04162-6","volume":"317","author":"BB Kuriakose","year":"2025","unstructured":"Kuriakose BB (2025) Beyond skin deep: exploring the complex molecular mechanisms and holistic management strategies of vitiligo. Arch Dermatol Res 317(1):685","journal-title":"Arch Dermatol Res"},{"key":"4506_CR213","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1498808","volume":"15","author":"Z Liu","year":"2024","unstructured":"Liu Z et al (2024) T cell metabolism in kidney immune homeostasis. Front Immunol 15:1498808","journal-title":"Front Immunol"},{"issue":"15","key":"4506_CR214","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14155522","volume":"14","author":"A Di Petrillo","year":"2025","unstructured":"Di Petrillo A et al (2025) Interplay between depression and inflammatory bowel disease: shared pathogenetic mechanisms and reciprocal therapeutic impacts\u2014a comprehensive review. J Clin Med 14(15):5522","journal-title":"J Clin Med"},{"issue":"2","key":"4506_CR215","first-page":"5","volume":"25","author":"N Bugaev-Makarovskiy","year":"2023","unstructured":"Bugaev-Makarovskiy N et al (2023) Approaches to the development of the dendritic cell and neoantigen-based antitumor vaccines. Extreme Med 25(2):5\u201314","journal-title":"Extreme Med"},{"issue":"4","key":"4506_CR216","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1109\/TCBB.2021.3059046","volume":"19","author":"X Li","year":"2021","unstructured":"Li X et al (2021) A dual ranking algorithm based on the multiplex network for heterogeneous complex disease analysis. IEEE ACM Trans Comput Biol Bioinform 19(4):1993\u20132002","journal-title":"IEEE ACM Trans Comput Biol Bioinform"},{"issue":"3","key":"4506_CR217","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3892\/etm.2022.11124","volume":"23","author":"DE Branisteanu","year":"2022","unstructured":"Branisteanu DE et al (2022) Update on the etiopathogenesis of psoriasis. Exp Ther Med 23(3):201","journal-title":"Exp Ther Med"},{"issue":"4","key":"4506_CR218","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s40521-024-00374-9","volume":"11","author":"K Grafanaki","year":"2024","unstructured":"Grafanaki K et al (2024) Immunological advancements in hand eczema treatment: progress with small molecules and biologics. Curr Treat Options Allergy 11(4):211\u2013227","journal-title":"Curr Treat Options Allergy"},{"issue":"12","key":"4506_CR219","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1681\/ASN.2021030426","volume":"32","author":"T Schmidt","year":"2021","unstructured":"Schmidt T et al (2021) IL-17 receptor C signaling controls CD4+ TH17 immune responses and tissue injury in immune-mediated kidney diseases. J Am Soc Nephrol 32(12):3081\u20133098","journal-title":"J Am Soc Nephrol"},{"key":"4506_CR220","doi-asserted-by":"crossref","unstructured":"Zwicky, P., et al., IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Science immunology, 2021. 6(64): p. eabg9012.","DOI":"10.1126\/sciimmunol.abg9012"},{"key":"4506_CR221","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114705","author":"L Loh","year":"2024","unstructured":"Loh L et al (2024) Unraveling the phenotypic states of human innate-like T cells: comparative insights with conventional T cells and mouse models. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2024.114705","journal-title":"Cell Rep"},{"key":"4506_CR222","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1591123","volume":"16","author":"Y Sun","year":"2025","unstructured":"Sun Y et al (2025) Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasion. Front Immunol 16:1591123","journal-title":"Front Immunol"},{"key":"4506_CR223","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1393799","volume":"15","author":"M Morelli","year":"2024","unstructured":"Morelli M, Madonna S, Albanesi C (2024) SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation. Front Immunol 15:1393799","journal-title":"Front Immunol"},{"issue":"16","key":"4506_CR224","doi-asserted-by":"publisher","first-page":"7697","DOI":"10.3390\/ijms26167697","volume":"26","author":"C Constantin","year":"2025","unstructured":"Constantin C et al (2025) Microbial signatures of obesity-aggravated psoriasis: insights from an imiquimod-based mouse model. Int J Mol Sci 26(16):7697","journal-title":"Int J Mol Sci"},{"issue":"3","key":"4506_CR225","doi-asserted-by":"publisher","DOI":"10.31083\/FBL27910","volume":"30","author":"T Kaur","year":"2025","unstructured":"Kaur T et al (2025) Emerging therapeutic agents and nanotechnology-driven innovations in psoriasis management. Front Biosci-Landmark 30(3):27910","journal-title":"Front Biosci-Landmark"},{"issue":"3","key":"4506_CR226","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae254","volume":"117","author":"J Saavedra-Almarza","year":"2025","unstructured":"Saavedra-Almarza J et al (2025) Unveiling the role of resident memory T cells in psoriasis. J Leukoc Biol 117(3):qiae254","journal-title":"J Leukoc Biol"},{"key":"4506_CR227","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S374060","author":"AL Tatu","year":"2022","unstructured":"Tatu AL et al (2022) Interrelationship and sequencing of interleukins4, 13, 31, and 33\u2013an integrated systematic review: dermatological and multidisciplinary perspectives. J Inflamm Res. https:\/\/doi.org\/10.2147\/JIR.S374060","journal-title":"J Inflamm Res"},{"issue":"1","key":"4506_CR228","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/der2.115","volume":"3","author":"A Bowles","year":"2022","unstructured":"Bowles A et al (2022) Emerging therapies in pediatric atopic dermatitis patients. Dermatol Rev 3(1):29\u201333","journal-title":"Dermatol Rev"},{"key":"4506_CR229","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1092028","volume":"13","author":"M Heimli","year":"2023","unstructured":"Heimli M et al (2023) Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection. Front Immunol 13:1092028","journal-title":"Front Immunol"},{"issue":"3","key":"4506_CR230","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1159\/000537810","volume":"240","author":"HJ Ju","year":"2024","unstructured":"Ju HJ, Bae JM (2024) Bridging molecular mechanism and clinical practice in vitiligo treatment: an updated review. Dermatology 240(3):474\u2013486","journal-title":"Dermatology"},{"issue":"4","key":"4506_CR231","doi-asserted-by":"publisher","first-page":"259","DOI":"10.5114\/dr.2024.146623","volume":"111","author":"MJ Le\u017canko","year":"2024","unstructured":"Le\u017canko MJ et al (2024) Vitiligo treatment: a literature review. Dermatol Rev 111(4):259\u2013272","journal-title":"Dermatol Rev"},{"issue":"1","key":"4506_CR232","first-page":"81","volume":"4","author":"N Ebrahimnejad","year":"2024","unstructured":"Ebrahimnejad N, Jaafar D, Goodarzi H (2024) The past, present, future: pathophysiology, diagnosis, and treatment of human skin diseases. Physiol 4(1):81\u201399","journal-title":"Physiol"},{"issue":"8","key":"4506_CR233","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/ph15080936","volume":"15","author":"P Kotyla","year":"2022","unstructured":"Kotyla P et al (2022) Jak inhibitors for treatment of autoimmune diseases: lessons from systemic sclerosis and systemic lupus erythematosus. Pharmaceuticals (Basel) 15(8):936","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Cancer Immunology, Immunotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00262-026-04506-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04506-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00262-026-04506-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:07:03Z","timestamp":1785845223000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00262-026-04506-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":233,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["4506"],"URL":"https:\/\/doi.org\/10.1007\/s00262-026-04506-9","relation":{},"ISSN":["1432-0851"],"issn-type":[{"value":"1432-0851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"198"}}