{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:23:45Z","timestamp":1792686225808,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICO"],"published-print":{"date-parts":[[2007,11,16]]},"DOI":"10.1007\/s00264-007-0422-x","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T12:42:06Z","timestamp":1185280926000},"page":"735-741","source":"Crossref","is-referenced-by-count":234,"title":["Clinical applications of BMP-7\/OP-1 in fractures, nonunions and spinal fusion"],"prefix":"10.1007","volume":"31","author":[{"given":"Andrew P.","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Whang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Friel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"McKee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,7,25]]},"reference":[{"key":"422_CR1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00264-005-0045-z","volume":"30","author":"R Bilic","year":"2006","unstructured":"Bilic R, Simic P, Jelic M et al (2006) Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. Int Orthop 30:128\u2013134","journal-title":"Int Orthop"},{"key":"422_CR2","first-page":"1284","volume-title":"The lumbar spine (2nd edn)","author":"SD Boden","year":"1996","unstructured":"Boden SD, Schimandle JH (1996) Biology of lumbar spine fusion and bone graft materials. In: International Society for Study of the Lumbar Spine (ed) The lumbar spine (2nd edn). WB Saunders, Philadelphia, pp 1284\u20131306"},{"key":"422_CR3","first-page":"20","volume":"63","author":"MR Bong","year":"2005","unstructured":"Bong MR, Capla EL, Egol KA et al (2005) Osteogenic protein-1 (bone morphogenic protein-7) combined with various adjuncts in the treatment of humeral diaphyseal nonunions. Bull Hosp Jt Dis Orthop Inst 63:20\u201323","journal-title":"Bull Hosp Jt Dis Orthop Inst"},{"key":"422_CR4","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.2106\/00004623-200100022-00013","volume":"83","author":"GE Friedlaender","year":"2001","unstructured":"Friedlaender GE, Perry CR, Cole JD et al (2001) Osteogenic protein 1 (bone morphogenic protein-7) in the treatment of tibial non-unions. J Bone Jt Surg [Am] 83:S151\u2013S158","journal-title":"J Bone Jt Surg [Am]"},{"key":"422_CR5","doi-asserted-by":"crossref","unstructured":"Govender VG, Rampersaud YR, Rickards L, Fehlings MG (2002) Use of osteogenic protein-1 in spinal fusion: literature review and preliminary results in a prospective series of high-risk cases. Neurosurg Focus 13","DOI":"10.3171\/foc.2002.13.6.5"},{"key":"422_CR6","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1097\/00007632-200212010-00004","volume":"27","author":"R Johnsson","year":"2002","unstructured":"Johnsson R, Stromqvist B, Aspenberg P (2002) Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine 27: 2654\u20132661","journal-title":"Spine"},{"key":"422_CR7","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/01.brs.0000216444.01888.21","volume":"31","author":"M Kanayama","year":"2006","unstructured":"Kanayama M, Hashimoto T, Shigenobu K, Yamana S, Bauer T, Togwa D (2006) A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute; emphasis of surgical exploration and histologic assessment. Spine 31:1067\u20131074","journal-title":"Spine"},{"key":"422_CR8","unstructured":"McKee MD, Schemitsch EH, Waddell JP et al (2002) The effect of human recombinant bone morphogenic protein (RHBMP-7) on the healing of open tibial shaft fractures: results of a multi-center, prospective, randomized clinical trial. In: Proceedings of the 18th Annual Meeting of the Orthopaedic Trauma Association; Oct 11\u201313; Toronto Ontario, Canada, pp 157\u2013158"},{"key":"422_CR9","unstructured":"McKee MD, Schemitsch EH, Waddell JP, Wild L (2004) The treatment of long bone nonunion with rhBMP: results of a prospective pilot study. American Academy of Orthopaedic Surgeons 71st Annual Meeting, San Francisco, CA, March 10\u201314. P242"},{"key":"422_CR10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s002640100262","volume":"25","author":"M Pecina","year":"2001","unstructured":"Pecina M, Giltaj LR, Vukicevic S (2001) Orthopaedic applications of osteogenic protein-1 (BMP-7). Int Orthop 25:203\u2013208","journal-title":"Int Orthop"},{"key":"422_CR11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00264-003-0475-4","volume":"27","author":"M Pecina","year":"2003","unstructured":"Pecina M, Haspl M, Jelic M, Vukicevic S (2003) Repair of a resistant tibial non-union with a recombinant bone morphogenetic protein-7 (rh-BMP-7). Int Orthop 27:320\u2013321","journal-title":"Int Orthop"},{"key":"422_CR12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1302\/0301-620X.89B2.18230","volume":"89-B","author":"J Ristiniemi","year":"2007","unstructured":"Ristiniemi J, Flinkkila T, Hyvonen P et al (2007) RhBMP-7 accelerated the healing of distal tibial fractures treated by external fixation. J Bone Jt Surg [Br] 89-B:265\u2013272","journal-title":"J Bone Jt Surg [Br]"},{"key":"422_CR13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S1529-9430(02)00180-8","volume":"2","author":"AR Vaccaro","year":"2002","unstructured":"Vaccaro AR, Chiba K, Heller JG et al (2002) Bone grafting alternatives in spinal surgery. Spine J 2:206\u2013215","journal-title":"Spine J"},{"key":"422_CR14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00586-003-0561-8","volume":"12","author":"AR Vaccaro","year":"2003","unstructured":"Vaccaro AR, Patel T, Fischgrund J et al (2003) A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J. 12:495\u2013500","journal-title":"Eur Spine J"},{"key":"422_CR15","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1097\/01.brs.0000137062.79201.98","volume":"29","author":"AR Vaccaro","year":"2004","unstructured":"Vaccaro AR, Patel T, Fischgrund J et al (2004) A pilot study evaluating the safety and efficacy of OP-1 putty (rhBMP-7) as a replacement of iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine 29:1885\u20131892","journal-title":"Spine"},{"key":"422_CR16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00586-004-0845-7","volume":"14","author":"AR Vaccaro","year":"2005","unstructured":"Vaccaro AR, Patel T, Fischgrund J et al (2005) A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 14:623\u2013629","journal-title":"Eur Spine J"},{"key":"422_CR17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00005131-200501000-00007","volume":"19","author":"A VanHouwelingen","year":"2005","unstructured":"VanHouwelingen A, McKee MD (2005) Treatment of osteopenic humeral shaft nonunion with compression plating, humeral cortical allograft struts and bone grafting. J Orthop Trauma 19:36\u201341","journal-title":"J Orthop Trauma"},{"key":"422_CR18","doi-asserted-by":"crossref","unstructured":"Vukicevic S, Sampath TK (eds) (2004) Bone morphogenetic proteins: regeneration of bone and beyond. PIR Series, Birkauser Verlag AG, Basel Boston Berlin","DOI":"10.1007\/978-3-0348-7857-9"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-007-0422-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00264-007-0422-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-007-0422-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:35:07Z","timestamp":1558701307000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00264-007-0422-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,25]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11,16]]}},"alternative-id":["422"],"URL":"https:\/\/doi.org\/10.1007\/s00264-007-0422-x","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,25]]}}}