{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:43Z","timestamp":1787161603818,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00264-013-1864-y","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:58:56Z","timestamp":1363827536000},"page":"1387-1392","source":"Crossref","is-referenced-by-count":20,"title":["Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with increased bFGF expression"],"prefix":"10.1007","volume":"37","author":[{"given":"Sittisak","family":"Honsawek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jariya","family":"Poonpukdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chookiet","family":"Chalermpanpipat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunchai","family":"Payungporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worawat","family":"Limthongkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wicharn","family":"Yingsakmongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voranuch","family":"Thanakit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinai","family":"Parkpian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"1864_CR1","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.1007\/s00586-003-0612-1","volume":"12","author":"M Szpalski","year":"2003","unstructured":"Szpalski M, Gunzburg R (2003) Lumbar spinal stenosis in the elderly: an overview. Eur Spine J 12:S170\u2013S175","journal-title":"Eur Spine J"},{"key":"1864_CR2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00586-009-0919-7","volume":"18","author":"T Hansson","year":"2009","unstructured":"Hansson T, Suzuki N, Hebelka H, Gaulitz A (2009) The narrowing of the lumbar spinal canal during loaded MRI: the effects of the disc and ligamentum flavum. Eur Spine J 18:679\u2013686","journal-title":"Eur Spine J"},{"key":"1864_CR3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00003086-200103000-00015","volume":"384","author":"LA Saint-Louis","year":"2001","unstructured":"Saint-Louis LA (2001) Lumbar spinal stenosis assessment with computed tomography, magnetic resonance imaging, and myelography. Clin Orthop Relat Res 384:122\u2013136","journal-title":"Clin Orthop Relat Res"},{"key":"1864_CR4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4615-0123-7_12","volume":"513","author":"C Alzheimer","year":"2002","unstructured":"Alzheimer C, Werner S (2002) Fibroblast growth factors and neuroprotection. Adv Exp Med Biol 513:335\u2013351","journal-title":"Adv Exp Med Biol"},{"key":"1864_CR5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1096\/fasebj.1.6.3315806","volume":"1","author":"KA Thomas","year":"1987","unstructured":"Thomas KA (1987) Fibroblast growth factors. FASEB J 1:434\u2013440","journal-title":"FASEB J"},{"key":"1864_CR6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00264-011-1435-z","volume":"36","author":"S Honsawek","year":"2012","unstructured":"Honsawek S, Yuktanandana P, Tanavalee A, Saetan N, Anomasiri W, Parkpian V (2012) Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis. Int Orthop 36:981\u2013985","journal-title":"Int Orthop"},{"key":"1864_CR7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","volume":"16","author":"S Barrientos","year":"2008","unstructured":"Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16:585\u2013601","journal-title":"Wound Repair Regen"},{"key":"1864_CR8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.12968\/jowc.2009.18.12.45609","volume":"18","author":"M Przybylski","year":"2009","unstructured":"Przybylski M (2009) A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care 18:516\u2013519","journal-title":"J Wound Care"},{"key":"1864_CR9","first-page":"637","volume":"23","author":"T Yayama","year":"2005","unstructured":"Yayama T, Baba H, Furusawa N, Kobayashi S, Uchida K, Kokubo Y, Noriki S, Imamura Y, Fukuda M (2005) Pathogenesis of calcium crystal deposition in the ligamentum flavum correlates with lumbar spinal canal stenosis. Clin Exp Rheumatol 23:637\u2013643","journal-title":"Clin Exp Rheumatol"},{"key":"1864_CR10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1864_CR11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00002517-199504000-00006","volume":"8","author":"S Fukuyama","year":"1995","unstructured":"Fukuyama S, Nakamura T, Ikeda T, Takagi K (1995) The effect of mechanical stress on hypertrophy of the lumbar ligamentum flavum. J Spinal Disord 8:126\u2013130","journal-title":"J Spinal Disord"},{"key":"1864_CR12","doi-asserted-by":"crossref","first-page":"E492","DOI":"10.1097\/00007632-200111010-00007","volume":"26","author":"JB Park","year":"2001","unstructured":"Park JB, Chang H, Lee JK (2001) Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. Spine (Phila Pa 1976) 26:E492\u2013E495","journal-title":"Spine (Phila Pa 1976)"},{"key":"1864_CR13","first-page":"1474","volume":"17","author":"LG Giles","year":"1990","unstructured":"Giles LG, Kaveri MJ (1990) Some osseous and soft tissue causes of human intervertebral canal (foramen) stenosis. J Rheumatol 17:1474\u20131481","journal-title":"J Rheumatol"},{"key":"1864_CR14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-2002-36539","volume":"22","author":"DK Binder","year":"2002","unstructured":"Binder DK, Schmidt MH, Weinstein PR (2002) Lumbar spinal stenosis. Semin Neurol 22:157\u2013166","journal-title":"Semin Neurol"},{"key":"1864_CR15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s005860050181","volume":"8","author":"P Schrader","year":"1999","unstructured":"Schrader P, Grob D, Rahn BA, Cordey J, Dvorak J (1999) Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis. Eur Spine J 8:323\u2013328","journal-title":"Eur Spine J"},{"key":"1864_CR16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/00007632-199004000-00002","volume":"15","author":"LH Yahia","year":"1990","unstructured":"Yahia LH, Garzon S, Strykowski H, Rivard CH (1990) Ultrastructure of the human interspinous ligament and ligamentum flavum. A preliminary study. Spine 15:262\u2013268","journal-title":"Spine"},{"key":"1864_CR17","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/00007632-199211000-00015","volume":"17","author":"M Yoshida","year":"1992","unstructured":"Yoshida M, Shima K, Tangiguti Y, Tamaki T, Tanaka T (1992) Hypertrophied ligamentum flavum in lumbar spinal canal stenosis. Pathogenesis and morphologic and immunohistochemical observation. Spine 17:1353\u20131360","journal-title":"Spine"},{"key":"1864_CR18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s00701-010-0839-7","volume":"153","author":"M L\u00f6hr","year":"2011","unstructured":"L\u00f6hr M, Hampl JA, Lee JY, Ernestus RI, Deckert M, Stenzel W (2011) Hypertrophy of the lumbar ligamentum flavum is associated with inflammation-related TGF-\u03b2 expression. Acta Neurochir (Wien) 153:134\u2013141","journal-title":"Acta Neurochir (Wien)"},{"key":"1864_CR19","doi-asserted-by":"crossref","first-page":"E1479","DOI":"10.1097\/BRS.0b013e3181f3d2df","volume":"35","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Chen J, Zhong ZM, Yang D, Zhu Q (2010) Is platelet-derived growth factor-BB expression proportional to fibrosis in the hypertrophied lumber ligamentum flavum? Spine (Phila Pa 1976) 35:E1479\u2013E1486","journal-title":"Spine (Phila Pa 1976)"},{"key":"1864_CR20","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/jor.21431","volume":"29","author":"ZM Zhong","year":"2011","unstructured":"Zhong ZM, Zha DS, Xiao WD, Wu SH, Wu Q, Zhang Y, Liu FQ, Chen JT (2011) Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor. J Orthop Res 29:1592\u20131597","journal-title":"J Orthop Res"},{"key":"1864_CR21","first-page":"528","volume":"71","author":"H Morita","year":"1994","unstructured":"Morita H, Shinzato T, David G, Mizutani A, Habuchi H, Fujita Y, Ito M, Asai J, Maeda K, Kimata K (1994) Basic fibroblast growth factor-binding domain of heparan sulfate in the human glomerulosclerosis and renal tubulointerstitial fibrosis. Lab Invest 71:528\u2013535","journal-title":"Lab Invest"},{"key":"1864_CR22","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1164\/rccm.2010014","volume":"166","author":"Y Inoue","year":"2002","unstructured":"Inoue Y, King TE Jr, Barker E, Daniloff E, Newman LS (2002) Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis. Am J Respir Crit Care Med 166:765\u2013773","journal-title":"Am J Respir Crit Care Med"},{"key":"1864_CR23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/BF02896166","volume":"25","author":"X Peng","year":"2005","unstructured":"Peng X, Wang B, Wang T, Zhao Q (2005) Expression of basic fibroblast growth factor in rat liver fibrosis and hepatic stellate cells. J Huazhong Univ Sci Technolog Med Sci 25:166\u2013169","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"1864_CR24","unstructured":"Poonpukdee J, Chalermpanpipat C, Payungporn S, Honsawek S (2012) Basic fibroblast growth factor expression in hypertrophic ligamentum flavum of lumbar spinal stenosis. Asian Biomed 6:99\u2013104"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-013-1864-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00264-013-1864-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-013-1864-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T01:35:03Z","timestamp":1562808903000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00264-013-1864-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["1864"],"URL":"https:\/\/doi.org\/10.1007\/s00264-013-1864-y","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}