{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:46:52Z","timestamp":1783036012397,"version":"3.54.6"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY13H060003"],"award-info":[{"award-number":["LY13H060003"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY15H180012"],"award-info":[{"award-number":["LY15H180012"]}]},{"name":"Scientific Research Foundation of Traditional Chinese Medicine in Zhejiang Province","award":["2012ZB161"],"award-info":[{"award-number":["2012ZB161"]}]},{"name":"Science & Technology Innovation Project of College Students in Zhejiang Province","award":["2013R426025"],"award-info":[{"award-number":["2013R426025"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00264-015-3021-2","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T01:48:25Z","timestamp":1445824105000},"page":"1545-1552","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of osteolysis after local administration of osthole in a TCP particles-induced osteolysis model"],"prefix":"10.1007","volume":"40","author":[{"given":"Shumin","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"3021_CR1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-200112000-00007","volume":"393","author":"WH Harris","year":"2001","unstructured":"Harris WH (2001) Wear and periprosthetic osteolysis: the problem. Clin Orthop Relat Res 393:66\u201370","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"3021_CR2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00264-013-2190-0","volume":"38","author":"CF Fu","year":"2014","unstructured":"Fu CF, Xie J, Hu N, Liang X, Chen RF, Wang CL, Chen C, Xu CM, Huang W, Paul Sung KL (2014) Titanium particles up-regulate the activity of matrix metalloproteinase-2 in human synovial cells. Int Orthop 38(5):1091\u20131098","journal-title":"Int Orthop"},{"issue":"2","key":"3021_CR3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1074\/jbc.M114.568360","volume":"290","author":"E Katsuyama","year":"2015","unstructured":"Katsuyama E, Miyamoto H, Kobayashi T, Sato Y, Hao W, Kanagawa H, Fujie A, Tando T, Watanabe R, Morita M, Miyamoto K, Niki Y, Morioka H, Matsumoto M, Toyama Y, Miyamoto T (2015) Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. J Biol Chem 290(2):716\u2013726","journal-title":"J Biol Chem"},{"issue":"1","key":"3021_CR4","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1016\/j.actbio.2012.08.027","volume":"9","author":"G Vall\u00e9s","year":"2013","unstructured":"Vall\u00e9s G, P\u00e9rez C, Bor\u00e9 A, Mart\u00edn-Saavedra F, Salda\u00f1a L, Vilaboa N (2013) Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells. Acta Biomater 9(1):4916\u20134925","journal-title":"Acta Biomater"},{"issue":"2","key":"3021_CR5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/17453670610045902","volume":"77","author":"M Sundfeldt","year":"2006","unstructured":"Sundfeldt M, Carlsson LV, Johansson CB, Thomsen P, Gretzer C (2006) Aseptic loosening, not only a question of wear: a review of different theories. Acta Orthop 77(2):177\u2013197","journal-title":"Acta Orthop"},{"issue":"9","key":"3021_CR6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1089\/jmf.2014.3314","volume":"18","author":"SJ Wu","year":"2015","unstructured":"Wu SJ (2015) Osthole attenuates inflammatory responses and regulates the expression of inflammatory mediators in HepG2 cells grown in differentiated medium from 3T3-L1 preadipocytes. J Med Food 18(9):972\u2013979","journal-title":"J Med Food"},{"issue":"2","key":"3021_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/08923973.2015.1009997","volume":"37","author":"XL Wang","year":"2015","unstructured":"Wang XL, Shang X, Cui Y, Zhao X, Zhang Y, Xie ML (2015) Osthole inhibits inflammatory cytokine release through PPAR\u03b1\/\u03b3-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes. Immunopharmacol Immunotoxicol 37(2):185\u2013192","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"1","key":"3021_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.intimp.2014.02.013","volume":"20","author":"ZP Li","year":"2014","unstructured":"Li ZP, Ji HJ, Song XY, Hu JF, Han N, Chen NH (2014) Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol 20(1):33\u201336","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"3021_CR9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000347191","volume":"91","author":"Y Zheng","year":"2013","unstructured":"Zheng Y, Lu M, Ma L, Zhang S, Qiu M, Ma X (2013) Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response. Urol Int 91(3):350\u2013356","journal-title":"Urol Int"},{"issue":"11","key":"3021_CR10","first-page":"1002","volume":"28","author":"J Liu","year":"2005","unstructured":"Liu J, Zhang W, Zhou L, Wang X, Lian Q (2005) Anti-inflammatory effect and mechanism of osthole in rats. Zhong Yao Cai 28(11):1002\u20131006","journal-title":"Zhong Yao Cai"},{"issue":"32","key":"3021_CR11","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1016\/j.biomaterials.2014.06.055","volume":"35","author":"B Tian","year":"2014","unstructured":"Tian B, Jiang T, Shao Z, Zhai Z, Li H, Fan Q, Liu X, Ouyang Z, Tang T, Jiang Q, Zheng M, Dai K, Qin A, Yu Y, Zhu Z (2014) The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis. Biomaterials 35(32):8937\u20138950","journal-title":"Biomaterials"},{"issue":"1","key":"3021_CR12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00264-014-2596-3","volume":"39","author":"JA Kim","year":"2015","unstructured":"Kim JA, Ihn HJ, Park JY, Lim J, Hong JM, Kim SH, Kim SY, Shin HI, Park EK (2015) Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-\u03baB ligand-mediated osteoclast differentiation. Int Orthop 39(1):173\u2013182","journal-title":"Int Orthop"},{"issue":"7","key":"3021_CR13","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00264-013-1887-4","volume":"37","author":"AJ Rao","year":"2013","unstructured":"Rao AJ, Zwingenberger S, Valladares R, Li C, Lane Smith R, Goodman SB, Nich C (2013) Direct subcutaneous injection of polyethylene particles over the murine calvaria results in dramatic osteolysis. Int Orthop 37(7):1393\u20131398","journal-title":"Int Orthop"},{"key":"3021_CR14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bone.2013.10.005","volume":"58","author":"BJ Smith","year":"2014","unstructured":"Smith BJ, Bu SY, Wang Y, Rendina E, Lim YF, Marlow D, Clarke SL, Cullen DM, Lucas EA (2014) A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone 58:151\u2013159","journal-title":"Bone"},{"issue":"1\u20133","key":"3021_CR15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2013.05.020","volume":"714","author":"N Iitsuka","year":"2013","unstructured":"Iitsuka N, Hie M, Tsukamoto I (2013) Zinc supplementation inhibits the increase in osteoclastogenesis and decrease in osteoblastogenesis in streptozotocin-induced diabetic rats. Eur J Pharmacol 714(1\u20133):41\u201347","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3021_CR16","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2015.05.012","volume":"63","author":"M Kandel-Kfir","year":"2015","unstructured":"Kandel-Kfir M, Almog T, Shaish A, Shlomai G, Anafi L, Avivi C, Barshack I, Grosskopf I, Harats D, Kamari Y (2015) Interleukin-1\u03b1 deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice. J Hepatol 63(4):926\u2013933","journal-title":"J Hepatol"},{"issue":"2","key":"3021_CR17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2337\/diabetes.54.2.452","volume":"54","author":"AK Cardozo","year":"2005","unstructured":"Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL (2005) Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 54(2):452\u2013461","journal-title":"Diabetes"},{"key":"3021_CR18","doi-asserted-by":"crossref","unstructured":"Liu G, Liu N, Xu Y, Ti Y, Chen J, Chen J, Zhang J, Zhao J (2015) Endoplasmic reticulum stress-mediated inflammatory signaling pathways within the osteolytic periosteum and interface membrane in particle-induced osteolysis. Cell Tissue Res. 2015 May 26. [Epub ahead of print]","DOI":"10.1007\/s00441-015-2205-9"},{"issue":"11","key":"3021_CR19","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.biomaterials.2013.01.025","volume":"34","author":"R Wang","year":"2013","unstructured":"Wang R, Wang ZH, Ma YT, Liu GY, Shi H, Chen JN, Dong L, Zhao JN, Zhang JF (2013) Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening. Biomaterials 34(11):2611\u20132623","journal-title":"Biomaterials"},{"issue":"9","key":"3021_CR20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nm.3917","volume":"21","author":"B Dankbar","year":"2015","unstructured":"Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T (2015) Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice. Nat Med 21(9):1085\u20131090","journal-title":"Nat Med"},{"issue":"1\u20132","key":"3021_CR21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000328776","volume":"88","author":"LG Ming","year":"2011","unstructured":"Ming LG, Zhou J, Cheng GZ, Ma HP, Chen KM (2011) Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro. Pharmacology 88(1\u20132):33\u201343","journal-title":"Pharmacology"},{"issue":"6","key":"3021_CR22","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/jbmr.21","volume":"25","author":"DZ Tang","year":"2010","unstructured":"Tang DZ, Hou W, Zhou Q, Zhang M, Holz J, Sheu TJ, Li TF, Cheng SD, Shi Q, Harris SE, Chen D, Wang YJ (2010) Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res 25(6):1234\u20131245","journal-title":"J Bone Miner Res"},{"issue":"8","key":"3021_CR23","first-page":"643","volume":"59","author":"F Meng","year":"2004","unstructured":"Meng F, Xiong Z, Sun Y, Li F (2004) Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells. Pharmazie 59(8):643\u2013645","journal-title":"Pharmazie"},{"issue":"2","key":"3021_CR24","first-page":"174","volume":"47","author":"LG Ming","year":"2012","unstructured":"Ming LG, Wang MG, Chen KM, Zhou J, Han GQ, Zhu RQ (2012) Effect of osthole on apoptosis and bone resorption of osteoclasts cultured in vitro. Yao Xue Xue Bao 47(2):174\u2013179","journal-title":"Yao Xue Xue Bao"},{"issue":"6","key":"3021_CR25","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1248\/bpb.25.738","volume":"25","author":"XX Li","year":"2002","unstructured":"Li XX, Hara I, Matsumiya T (2002) Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol. Biol Pharm Bull 25(6):738\u2013742","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"3021_CR26","doi-asserted-by":"crossref","first-page":"045019","DOI":"10.1088\/1748-6041\/7\/4\/045019","volume":"7","author":"Y Ding","year":"2012","unstructured":"Ding Y, Qin CQ, Fu YR, Xu J, Huang DS (2012) In vitro comparison of the biological activity of alumina ceramic and titanium particles associated with aseptic loosening. Biomed Mater 7(4):045019\u2013045019","journal-title":"Biomed Mater"},{"issue":"2","key":"3021_CR27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lfs.2013.11.008","volume":"97","author":"GA Obando-Pereda","year":"2014","unstructured":"Obando-Pereda GA, Fischer L, Stach-Machado DR (2014) Titanium and zirconia particle-induced pro-inflammatory gene expression in cultured macrophages and osteolysis, inflammatory hyperalgesia and edema in vivo. Life Sci 97(2):96\u2013106","journal-title":"Life Sci"},{"issue":"9","key":"3021_CR28","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.4049\/jimmunol.1401399","volume":"194","author":"S Kim","year":"2015","unstructured":"Kim S, Joe Y, Kim HJ, Kim YS, Jeong SO, Pae HO, Ryter SW, Surh YJ, Chung HT (2015) Endoplasmic reticulum stress-induced IRE1\u03b1 activation mediates cross-talk of GSK-3\u03b2 and XBP-1 to regulate inflammatory cytokine production. J Immunol 194(9):4498\u20134506","journal-title":"J Immunol"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-015-3021-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00264-015-3021-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-015-3021-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T23:27:04Z","timestamp":1567294024000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00264-015-3021-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["3021"],"URL":"https:\/\/doi.org\/10.1007\/s00264-015-3021-2","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}