{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:58:34Z","timestamp":1793059114094,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:00:00Z","timestamp":1471046400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011852","name":"Paracelsus Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011852","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00264-016-3262-8","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T01:48:28Z","timestamp":1471052908000},"page":"2339-2345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparative study suggests that human bone morphogenetic proteins have no influence on the outcome of operative treatment of aseptic clavicle non-unions"],"prefix":"10.1007","volume":"40","author":[{"given":"Christian","family":"von R\u00fcden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Friederichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Augat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hackl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Woltmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"B\u00fchren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hierholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,13]]},"reference":[{"issue":"4","key":"3262_CR1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2106\/00004623-196749040-00024","volume":"49","author":"FL Allman Jr","year":"1967","unstructured":"Allman FL Jr (1967) Fractures and ligamentous injuries of the clavicle and its articulation. J Bone Joint Surg Am 49(4):774\u2013784","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"3262_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00402-012-1631-3","volume":"133","author":"CL Wu","year":"2013","unstructured":"Wu CL, Chang HC, Lu KH (2013) Risk factors for nonunion in 337 displaced midshaft clavicular fractures treated with Knowles pin fixation. Arch Orthop Trauma Surg 133(1):15\u201322. doi: 10.1007\/s00402-012-1631-3","journal-title":"Arch Orthop Trauma Surg"},{"issue":"6","key":"3262_CR3","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.injury.2016.02.005","volume":"47","author":"S Asadollahi","year":"2016","unstructured":"Asadollahi S, Hau RC, Page RS, Richardson M, Edwards ER (2016) Complications associated with operative fixation of acute midshaft clavicle fractures. Injury 47(6):1248\u20131252. doi: 10.1016\/j.injury.2016.02.005","journal-title":"Injury"},{"issue":"5","key":"3262_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jse.2006.12.002","volume":"16","author":"N Rosenberg","year":"2007","unstructured":"Rosenberg N, Neumann L, Wallace AW (2007) Functional outcome of surgical treatment of symptomatic nonunion and malunion of midshaft clavicle fractures. J Shoulder Elbow Surg 16(5):510\u2013513. doi: 10.1016\/j.jse.2006.12.002","journal-title":"J Shoulder Elbow Surg"},{"issue":"3","key":"3262_CR5","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00264-016-3120-8","volume":"40","author":"I Ban","year":"2016","unstructured":"Ban I, Troelsen A (2016) Risk profile of patients developing nonunion of the clavicle and outcome of treatment-analysis of fifty five nonunions in seven hundred and twenty nine consecutive fractures. Int Orthop 40(3):587\u2013593. doi: 10.1007\/s00264-016-3120-8","journal-title":"Int Orthop"},{"issue":"Suppl 4","key":"3262_CR6","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1016\/j.injury.2005.10.010","volume":"36","author":"R Dimitriou","year":"2005","unstructured":"Dimitriou R, Dahabreh Z, Katsoulis E, Matthews SJ, Branfoot T, Giannoudis PV (2005) Application of recombinant BMP-7 on persistent upper and lower limb non-unions. Injury 36(Suppl 4):S51\u2013S59. doi: 10.1016\/j.injury.2005.10.010","journal-title":"Injury"},{"issue":"6","key":"3262_CR7","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.jse.2013.01.022","volume":"22","author":"F Martetschlager","year":"2013","unstructured":"Martetschlager F, Gaskill TR, Millett PJ (2013) Management of clavicle nonunion and malunion. J Shoulder Elbow Surg 22(6):862\u2013868. doi: 10.1016\/j.jse.2013.01.022","journal-title":"J Shoulder Elbow Surg"},{"key":"3262_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bone.2014.07.033","volume":"70","author":"E G\u00f3mez-Barrena","year":"2015","unstructured":"G\u00f3mez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F (2015) Bone fracture healing: cell therapy in delayed unions and nonunions. Bone 70:93\u2013101. doi: 10.1016\/j.bone.2014.07.033","journal-title":"Bone"},{"issue":"5","key":"3262_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00064-013-0257-0","volume":"25","author":"C Kirchhoff","year":"2013","unstructured":"Kirchhoff C, Banke IJ, Beirer M, Imhoff AB, Biberthaler P (2013) Operative management of clavicular non-union: Iliac crest bone graft and anatomic locking compression plate. Oper Orthop Traumatol 25(5):483\u2013498. doi: 10.1007\/s00064-013-0257-0","journal-title":"Oper Orthop Traumatol"},{"issue":"1","key":"3262_CR10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2106\/00004623-198769010-00004","volume":"69","author":"MS Calkins","year":"1987","unstructured":"Calkins MS, Burkhalter W, Reyes F (1987) Traumatic segmental bone defects in the upper extremity. Treatment with exposed grafts of corticocancellous bone. J Bone Joint Surg Am 69(1):19\u201327","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"3262_CR11","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.injury.2008.08.011","volume":"39","author":"GM Calori","year":"2008","unstructured":"Calori GM, Tagliabue L, Gala L, d\u2019Imporzano M, Peretti G, Albisetti W (2008) Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients. Injury 39(12):1391\u20131402. doi: 10.1016\/j.injury.2008.08.011","journal-title":"Injury"},{"issue":"Suppl 1","key":"3262_CR12","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/S0020-1383(13)70008-1","volume":"44","author":"M Ronga","year":"2013","unstructured":"Ronga M, Fagetti A, Canton G, Paiusco E, Surace MF, Cherubino P (2013) Clinical applications of growth factors in bone injuries: experience with BMPs. Injury 44(Suppl 1):S34\u2013S39. doi: 10.1016\/S0020-1383(13)70008-1","journal-title":"Injury"},{"key":"3262_CR13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00000542-197810000-00001","volume":"49","author":"AS Keats","year":"1978","unstructured":"Keats AS (1978) The ASA classification of physical status\u2014a recapitulation. Anesthesiology 49:233\u2013236","journal-title":"Anesthesiology"},{"key":"3262_CR14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2106\/00004623-199401000-00004","volume":"76","author":"JD Heckman","year":"1994","unstructured":"Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF (1994) Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am 76:26\u201334","journal-title":"J Bone Joint Surg Am"},{"issue":"7","key":"3262_CR15","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1302\/0301-620X.97B7.35089","volume":"97-B","author":"M Papanagiotou","year":"2015","unstructured":"Papanagiotou M, Dailiana ZH, Karachalios T, Varitimidis S, Vlychou M, Hantes M, Malizos KN (2015) RhBMP-7 for the treatment of nonunion of fractures of long bones. Bone Joint J 97-B(7):997\u20131003. doi: 10.1302\/0301-620X.97B7.35089","journal-title":"Bone Joint J"},{"issue":"4","key":"3262_CR16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00132585-199300140-00001","volume":"1","author":"RB Caspari","year":"1993","unstructured":"Caspari RB, Beach WR (1993) Arthroscopic anterior shoulder capsulorrhaphy. Sports Med Arthrosc 1(4):237\u2013241","journal-title":"Sports Med Arthrosc"},{"issue":"6","key":"3262_CR17","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L","volume":"29","author":"PL Hudak","year":"1996","unstructured":"Hudak PL, Amadio PC, Bombardier C (1996) Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med 29(6):602\u2013608. doi: 10.1002\/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L","journal-title":"Am J Ind Med"},{"issue":"6","key":"3262_CR18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00264-007-0422-x","volume":"31","author":"AP White","year":"2007","unstructured":"White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD (2007) Clinical applications of BMP-7\/OP-1 in fractures, nonunions and spinal fusion. Int Orthop 31(6):735\u2013741","journal-title":"Int Orthop"},{"issue":"13","key":"3262_CR19","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.2106\/JBJS.M.00607","volume":"96","author":"T Leroux","year":"2014","unstructured":"Leroux T, Wasserstein D, Henry P, Khoshbin A, Dwyer T, Ogilvie-Harris D, Mahomed N, Veillette C (2014) Rate of and risk factors for reoperations after open reduction and internal fixation of midshaft clavicle fractures: a population-based study in Ontario, Canada. J Bone Joint Surg Am 96(13):1119\u20131125. doi: 10.2106\/JBJS.M.00607","journal-title":"J Bone Joint Surg Am"},{"issue":"Suppl 4","key":"3262_CR20","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0020-1383(08)70003-2","volume":"38","author":"PV Giannoudis","year":"2007","unstructured":"Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38(Suppl 4):S3\u2013S6","journal-title":"Injury"},{"key":"3262_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2016.01.028","author":"B McKnight","year":"2016","unstructured":"McKnight B, Heckmann N, Hill JR, Pannell WC, Mostofi A, Omid R, Hatch GF (2016) Surgical management of midshaft clavicle nonunions is associated with a higher rate of short-term complications compared with acute fractures. J Shoulder Elbow Surg. doi: 10.1016\/j.jse.2016.01.028","journal-title":"J Shoulder Elbow Surg"},{"key":"3262_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006950.pub2","volume":"6","author":"KR Garrison","year":"2010","unstructured":"Garrison KR, Shemilt I, Donell S, Ryder JJ, Mugford M, Harvey I, Song F, Alt V (2010) Bone morphogenetic protein (BMP) for fracture healing in adults. Cochrane Database Syst Rev 6, CD006950. doi: 10.1002\/14651858.CD006950.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"3262_CR23","doi-asserted-by":"publisher","unstructured":"Hausmann M, Ehnert S, Hofmann V, Dobele S, Freude T, Stockle U, Nussler A (2014) Use of bone morphogenetic proteins (BMPs) for the treatment of pseudarthroses\u2014efficiency and therapy failure. Z Orthop Unfall 152(2):144\u2013151. doi: 10.1055\/s-0034-1368208","DOI":"10.1055\/s-0034-1368208"},{"issue":"2","key":"3262_CR24","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.injury.2015.11.035","volume":"47","author":"Z Morison","year":"2016","unstructured":"Morison Z, Vicente M, Schemitsch EH, McKee MD (2016) The treatment of atrophic, recalcitrant long-bone nonunion in the upper extremity with human recombinant bone morphogenetic protein-7 (rhBMP-7) and plate fixation: a retrospective review. Injury 47(2):356\u2013363. doi: 10.1016\/j.injury.2015.11.035","journal-title":"Injury"},{"issue":"3","key":"3262_CR25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.injury.2006.08.055","volume":"38","author":"Z Dahabreh","year":"2007","unstructured":"Dahabreh Z, Dimitriou R, Giannoudis PV (2007) Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. Injury 38(3):371\u2013377. doi: 10.1016\/j.injury.2006.08.055","journal-title":"Injury"},{"issue":"Suppl 1","key":"3262_CR26","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/S0020-1383(13)70009-3","volume":"44","author":"TJ Blokhuis","year":"2013","unstructured":"Blokhuis TJ, Calori GM, Schmidmaier G (2013) Autograft versus BMPs for the treatment of non-unions: what is the evidence? Injury 44(Suppl 1):S40\u2013S42. doi: 10.1016\/S0020-1383(13)70009-3","journal-title":"Injury"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-016-3262-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00264-016-3262-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-016-3262-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T03:19:58Z","timestamp":1589685598000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00264-016-3262-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,13]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["3262"],"URL":"https:\/\/doi.org\/10.1007\/s00264-016-3262-8","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,13]]}}}