{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:08:28Z","timestamp":1792613308258,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00264-017-3744-3","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T03:35:55Z","timestamp":1514864155000},"page":"1213-1226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Diagnostic accuracy of interleukin-6 and procalcitonin in patients with periprosthetic joint infection: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"42","author":[{"given":"Jung-Ro","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Hyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-9979","authenticated-orcid":false,"given":"Young-Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"issue":"Suppl 2","key":"3744_CR1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2106\/JBJS.J.01046","volume":"92","author":"WY Matar","year":"2010","unstructured":"Matar WY, Jafari SM, Restrepo C et al (2010) Preventing infection in total joint arthroplasty. J Bone Joint Surg Am 92(Suppl 2):36\u201346","journal-title":"J Bone Joint Surg Am"},{"issue":"6","key":"3744_CR2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.arth.2014.01.014","volume":"29","author":"M Lenski","year":"2014","unstructured":"Lenski M, Scherer MA (2014) Synovial IL-6 as inflammatory marker in periprosthetic joint infections. J Arthroplast 29(6):1105\u20131109","journal-title":"J Arthroplast"},{"issue":"suppl 4","key":"3744_CR3","first-page":"138","volume":"88","author":"J Parvizi","year":"2006","unstructured":"Parvizi J, Ghanem E, Menashe S et al (2006) Periprosthetic infection: what are the diagnostic challenges? J Bone Joint Surg Am 88(suppl 4):138\u2013147","journal-title":"J Bone Joint Surg Am"},{"issue":"16","key":"3744_CR4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMra040181","volume":"351","author":"W Zimmerli","year":"2004","unstructured":"Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. N Engl J Med 351(16):1645\u20131654","journal-title":"N Engl J Med"},{"issue":"1","key":"3744_CR5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.arth.2007.09.005","volume":"23","author":"MS Austin","year":"2008","unstructured":"Austin MS, Ghanem E, Joshi A et al (2008) A simple, cost-effective screening protocol to rule out periprosthetic infection. J Arthroplast 23(1):65\u201368","journal-title":"J Arthroplast"},{"issue":"6","key":"3744_CR6","doi-asserted-by":"crossref","first-page":"e444","DOI":"10.1016\/j.ijid.2009.02.017","volume":"13","author":"E Ghanem","year":"2009","unstructured":"Ghanem E, Antoci V, Pulido L et al (2009) The use of receiver operating characteristics analysis in determining erythrocyte sedimentation rate and C-reactive protein levels in diagnosing periprosthetic infection prior to revision total hip arthroplasty. Int J Infect Dis 13(6):e444\u2013e449","journal-title":"Int J Infect Dis"},{"issue":"8","key":"3744_CR7","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s11999-010-1298-4","volume":"468","author":"C Deirmengian","year":"2010","unstructured":"Deirmengian C, Hallab N, Tarabishy A et al (2010) Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res 468(8):2017\u20132023","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"3744_CR8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ocl.2016.03.001","volume":"47","author":"J Parvizi","year":"2016","unstructured":"Parvizi J, Fassihi SC, Enayatollahi MA (2016) Diagnosis of periprosthetic joint infection following hip and knee Arthroplasty. Orthop Clin N Am 47(3):505\u2013515","journal-title":"Orthop Clin N Am"},{"issue":"4","key":"3744_CR9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5792\/ksrr.2013.25.4.155","volume":"25","author":"J Parvizi","year":"2013","unstructured":"Parvizi J, Cavanaugh PK, Diaz-Ledezma C (2013) Periprosthetic knee infection: ten strategies that work. Knee Surg Relat Res 25(4):155\u2013164","journal-title":"Knee Surg Relat Res"},{"issue":"9","key":"3744_CR10","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.2106\/JBJS.D.01803","volume":"87","author":"PE Cesare Di","year":"2005","unstructured":"Di Cesare PE, Chang E, Preston CF et al (2005) Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am 87(9):1921\u20131927","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"3744_CR11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1749-799X-8-19","volume":"8","author":"K Maharajan","year":"2013","unstructured":"Maharajan K, Patro DK, Menon J et al (2013) Serum procalcitonin is a sensitive and specific marker in the diagnosis of septic arthritis and acute osteomyelitis. J Orthop Surg Res 8(1):19","journal-title":"J Orthop Surg Res"},{"issue":"8","key":"3744_CR12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","volume":"155","author":"PF Whiting","year":"2011","unstructured":"Whiting PF, Rutjes AW, Westwood ME et al (2011) QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155(8):529\u2013536","journal-title":"Ann Intern Med"},{"issue":"7305","key":"3744_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/bmj.323.7305.157","volume":"323","author":"JJ Deeks","year":"2001","unstructured":"Deeks JJ (2001) Systematic reviews in health care: systematic reviews of evaluations of diagnostic and screening tests. BMJ 323(7305):157\u2013162","journal-title":"BMJ"},{"issue":"11","key":"3744_CR14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","volume":"56","author":"AS Glas","year":"2003","unstructured":"Glas AS, Lijmer JG, Prins MH et al (2003) The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol 56(11):1129\u20131135","journal-title":"J Clin Epidemiol"},{"issue":"9","key":"3744_CR15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","volume":"58","author":"JJ Deeks","year":"2005","unstructured":"Deeks JJ, Macaskill P, Irwig L (2005) The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 58(9):882\u2013893","journal-title":"J Clin Epidemiol"},{"issue":"Suppl 6","key":"3744_CR16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.arth.2011.03.025","volume":"26","author":"CL Jacovides","year":"2011","unstructured":"Jacovides CL, Parvizi J, Adeli B et al (2011) Molecular markers for diagnosis of periprosthetic joint infection. J Arthroplast 26(Suppl 6):99\u2013103","journal-title":"J Arthroplast"},{"issue":"2","key":"3744_CR17","first-page":"93","volume":"20","author":"NT Abou El-Khier","year":"2013","unstructured":"Abou El-Khier NT, El Ganainy AR, Elgeidy A et al (2013) Assessment of interleukin-6 and other inflammatory markers in the diagnosis of Egyptian patients with periprosthetic joint infection. Egypt J Immunol 20(2):93\u201399","journal-title":"Egypt J Immunol"},{"issue":"7","key":"3744_CR18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2106\/JBJS.L.00205","volume":"95","author":"H Gollwitzer","year":"2013","unstructured":"Gollwitzer H, Dombrowski Y, Prodinger PM et al (2013) Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection. J Bone Joint Surg Am 95(7):644\u2013651","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"3744_CR19","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1007\/s00264-014-2475-y","volume":"38","author":"A Elgeidi","year":"2014","unstructured":"Elgeidi A, Elganainy AE, Abou Elkhier N et al (2014) Interleukin-6 and other inflammatory markers in diagnosis of periprosthetic joint infection. Int Orthop 38(12):2591\u20132595","journal-title":"Int Orthop"},{"issue":"1","key":"3744_CR20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1302\/0301-620X.89B1.17485","volume":"89","author":"F Bottner","year":"2007","unstructured":"Bottner F, Wegner A, Winkelmann W et al (2007) Interleukin-6, procalcitonin and TNF-alpha: markers of peri-prosthetic infection following total joint replacement. J Bone Joint Surg Br 89(1):94\u201399","journal-title":"J Bone Joint Surg Br"},{"issue":"11","key":"3744_CR21","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s11999-014-3543-8","volume":"472","author":"C Deirmengian","year":"2014","unstructured":"Deirmengian C, Kardos K, Kilmartin P et al (2014) Diagnosing periprosthetic joint infection: has the era of the biomarker arrived? Clin Orthop Relat Res 472(11):3254\u20133262","journal-title":"Clin Orthop Relat Res"},{"issue":"8","key":"3744_CR22","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s11999-013-2998-3","volume":"471","author":"M Glehr","year":"2013","unstructured":"Glehr M, Friesenbichler J, Hofmann G et al (2013) Novel biomarkers to detect infection in revision hip and knee arthroplasties. Clin Orthop Relat Res 471(8):2621\u20132628","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"3744_CR23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/09674845.2010.11730294","volume":"67","author":"T Worthington","year":"2010","unstructured":"Worthington T, Dunlop D, Casey A et al (2010) Serum procalcitonin, interleukin-6, soluble intercellular adhesin molecule-1 and IgG to shortchain exocellular lipoteichoic acid as predictors of infection in total joint prosthesis revision. Br J Biomed Sci 67(2):71\u201376","journal-title":"Br J Biomed Sci"},{"issue":"7","key":"3744_CR24","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1007\/s11999-016-4710-x","volume":"474","author":"SJ Frangiamore","year":"2016","unstructured":"Frangiamore SJ, Siqueira MB, Saleh A et al (2016) Synovial cytokines and the MSIS criteria are not useful for determining infection resolution after periprosthetic joint infection explantation. Clin Orthop Relat Res 474(7):1630\u20131639","journal-title":"Clin Orthop Relat Res"},{"key":"3744_CR25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/cid\/civ286","volume":"61","author":"M Ettinger","year":"2015","unstructured":"Ettinger M, Calliess T, Kielstein JT et al (2015) Circulating biomarkers for discrimination between aseptic joint failure, low-grade infection and high-grade septic failure. Clin Infect Dis 61:332\u2013341","journal-title":"Clin Infect Dis"},{"issue":"2","key":"3744_CR26","doi-asserted-by":"crossref","first-page":"e89045","DOI":"10.1371\/journal.pone.0089045","volume":"9","author":"TM Randau","year":"2014","unstructured":"Randau TM, Friedrich MJ, Wimmer MD et al (2014) Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PloS One 9(2):e89045","journal-title":"PloS One"},{"issue":"4","key":"3744_CR27","first-page":"251","volume":"54","author":"X Tang","year":"2016","unstructured":"Tang X, Wang Q, Wang H et al (2016) [Comparison and estimation of different diagnostic methods in detecting the presence of periprosthetic joint infection]. Zhonghua Wai Ke Za Zhi 54(4):251\u2013257","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"2","key":"3744_CR28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1089\/sur.2014.034","volume":"16","author":"K Yuan","year":"2015","unstructured":"Yuan K, Li W-D, Qiang Y et al (2015) Comparison of procalcitonin and C-reactive protein for the diagnosis of periprosthetic joint infection before revision total hip arthroplasty. Surg Infect 16(2):146\u2013150","journal-title":"Surg Infect"},{"issue":"4","key":"3744_CR29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s15010-013-0467-2","volume":"41","author":"K Saeed","year":"2013","unstructured":"Saeed K, Dryden M, Sitjar A et al (2013) Measuring synovial fluid procalcitonin levels in distinguishing cases of septic arthritis, including prosthetic joints, from other causes of arthritis and aseptic loosening. Infection 41(4):845\u2013849","journal-title":"Infection"},{"issue":"5","key":"3744_CR30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/17453670710014329","volume":"78","author":"A Nilsdotter-Augustinsson","year":"2007","unstructured":"Nilsdotter-Augustinsson A, Briheim G, Herder A et al (2007) Inflammatory response in 85 patients with loosened hip prostheses: a prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening. Acta Orthop 78(5):629\u2013639","journal-title":"Acta Orthop"},{"issue":"4","key":"3744_CR31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002640000136","volume":"24","author":"DC Wirtz","year":"2000","unstructured":"Wirtz DC, Heller KD, Miltner O et al (2000) Interleukin-6: a potential inflammatory marker after total joint replacement. Int Orthop 24(4):194\u2013196","journal-title":"Int Orthop"},{"issue":"434","key":"3744_CR32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.blo.0000155079.29604.d4","volume":"434","author":"J Waddell","year":"2005","unstructured":"Waddell J, Pritzker KP, Boynton EL (2005) Increased cytokine secretion in patients with failed implants compared with patients with primary implants. Clin Orthop Relat Res 434(434):170\u2013176","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"3744_CR33","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1007\/s00167-016-4230-y","volume":"24","author":"SS Ahmad","year":"2016","unstructured":"Ahmad SS, Shaker A, Saffarini M et al (2016) Accuracy of diagnostic tests for prosthetic joint infection: a systematic review. Knee Surg Sports Traumatol Arthrosc 24(10):3064\u20133074","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"11","key":"3744_CR34","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s11999-011-2102-9","volume":"469","author":"J Parvizi","year":"2011","unstructured":"Parvizi J, Zmistowski B, Berbari EF et al (2011) New definition for periprosthetic joint infection: from the workgroup of the musculoskeletal infection society. Clin Orthop Relat Res 469(11):2992\u20132994","journal-title":"Clin Orthop Relat Res"},{"issue":"7","key":"3744_CR35","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00134-003-1761-8","volume":"29","author":"JE Fischer","year":"2003","unstructured":"Fischer JE, Bachmann LM, Jaeschke R (2003) A readers\u2019 guide to the interpretation of diagnostic test properties: clinical example of sepsis. Intensive Care Med 29(7):1043\u20131051","journal-title":"Intensive Care Med"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00264-017-3744-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-017-3744-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-017-3744-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T03:27:47Z","timestamp":1526441267000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00264-017-3744-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["3744"],"URL":"https:\/\/doi.org\/10.1007\/s00264-017-3744-3","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}