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PICO search strategy was used to identify randomized controlled trials applying manual therapy on patients with CTS. Eligible studies and data extraction were conducted independently by two reviewers. Methodology quality and risk of bias were assessed by PEDro scale. Outcomes assessed were pain intensity, physical function, and nerve conduction studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighty-one potential studies were identified and six studies involving 401 patients were finally included. Pain intensity immediately after treatment showed a pooled standard mean difference (SMD) of\u2009\u2212\u20092.13 with 95% confidence interval (CI) (\u2212\u20092.39,\u2009\u2212\u20091.86). Physical function with Boston Carpal Tunnel Syndrome Questionnaire (BCTS-Q) showed a pooled SMD of\u2009\u2212\u20091.67 with 95% CI (\u2212\u20091.92,\u2009\u2212\u20091.43) on symptoms severity, and a SMD of\u2009\u2212\u20090.89 with 95% CI (\u2212\u20091.08,\u2009\u2212\u20090.70) on functional status. Nerve conduction studies showed a SMD of\u2009\u2212\u20090.19 with 95% CI (\u2212\u20090.40,\u2009\u2212\u20090.02) on motor conduction and a SMD of\u2009\u2212\u20091.15 with 95% CI (\u2212\u20091.36,\u2009\u2212\u20090.93) on sensory conduction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study highlights the effectiveness of manual therapy techniques based on soft tissue and neurodynamic mobilizations, in isolation, on pain, physical function, and nerve conduction studies in patients with CTS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00264-021-05272-2","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T19:02:41Z","timestamp":1638558161000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"46","author":[{"given":"Sandra","family":"Jim\u00e9nez-del-Barrio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Cadellans-Arr\u00f3niz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ceballos-Laita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Est\u00e9banez-de-Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"L\u00f3pez-de-Celis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bueno-Gracia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"P\u00e9rez-Bellmunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"issue":"1","key":"5272_CR1","first-page":"6","volume":"77","author":"S Aroori","year":"2008","unstructured":"Aroori S, Spence R (2008) Carpal tunnel syndrome. 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