{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:09:01Z","timestamp":1793916541911,"version":"4.8.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s00264-022-05342-z","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T01:02:25Z","timestamp":1646010145000},"page":"963-970","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Salvaging lives in carbapenem-resistant Gram-negative osteoarticular and soft tissue infections: early compromises save lives"],"prefix":"10.1007","volume":"46","author":[{"given":"Vikas M.","family":"Agashe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Soman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Sunavala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Raghuvanshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-4736","authenticated-orcid":false,"given":"Aditya","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"5342_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3934\/MICROBIOL.2020012","volume":"6","author":"L Dong","year":"2020","unstructured":"Dong L, Espinoza H, Espinoza J (2020) Emerging superbugs: the threat of carbapenem resistant Enterobacteriaceae. AIMS Microbiol 6:176\u2013182. https:\/\/doi.org\/10.3934\/MICROBIOL.2020012","journal-title":"AIMS Microbiol"},{"key":"5342_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.diagmicrobio.2012.11.009","volume":"75","author":"D Van Duin","year":"2013","unstructured":"Van Duin D, Kaye KS, Neuner EA, Bonomo RA (2013) Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn Microbiol Infect Dis 75:115\u2013120. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2012.11.009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"5342_CR3","doi-asserted-by":"publisher","first-page":"522","DOI":"10.7705\/BIOMEDICA.V35I4.2572","volume":"35","author":"V Jm","year":"2015","unstructured":"Jm V, Lf H, Ca V et al (2015) Carbapenem-resistant Acinetobacter baumannii causing osteomyelitis and infections of skin and soft tissues in hospitals of Medell\u00edn, Colombia. Biomedica 35:522\u2013530. https:\/\/doi.org\/10.7705\/BIOMEDICA.V35I4.2572","journal-title":"Biomedica"},{"key":"5342_CR4","doi-asserted-by":"crossref","unstructured":"Babouee B, Widmer AF, Dubuis O, et al (2011) Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009\u201310. Euro Surveill 16:pii","DOI":"10.2807\/ese.16.11.19817-en"},{"key":"5342_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000506414","volume":"3","author":"DJ Cinats","year":"2020","unstructured":"Cinats DJ, Strovski E, Lee C-H, Viskontas D (2020) Tibial osteomyelitis caused by carbapenem-resistant Enterobacter cloacae. Case Reports Orthop Res 3:16\u201324. https:\/\/doi.org\/10.1159\/000506414","journal-title":"Case Reports Orthop Res"},{"key":"5342_CR6","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.2147\/IDR.S320056","volume":"14","author":"Z Ji","year":"2021","unstructured":"Ji Z, Sun K, Li Z et al (2021) Carbapenem-resistant Klebsiella pneumoniae osteomyelitis treated with ceftazidime-avibactam in an anfant: a case report. Infect Drug Resist 14:3109\u20133113. https:\/\/doi.org\/10.2147\/IDR.S320056","journal-title":"Infect Drug Resist"},{"key":"5342_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3126\/ajms.v11i6.29427","volume":"11","author":"S Lahiry","year":"2020","unstructured":"Lahiry S, Ramalingam R, Dalal K et al (2020) Tackling AMR crisis in India: changing paradigm. Asian J Med Sci 11:129\u2013137. https:\/\/doi.org\/10.3126\/ajms.v11i6.29427","journal-title":"Asian J Med Sci"},{"key":"5342_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4103\/ijmr.IJMR_331_18","volume":"149","author":"N Taneja","year":"2019","unstructured":"Taneja N, Sharma M (2019) Antimicrobial resistance in the environment: the Indian scenario. Indian J Med Res 149:119\u2013128","journal-title":"Indian J Med Res"},{"key":"5342_CR9","doi-asserted-by":"publisher","first-page":"130","DOI":"10.4103\/0971-5916.164228","volume":"142","author":"K Walia","year":"2015","unstructured":"Walia K, Ohri VC, Mathai D (2015) Antimicrobial stewardship programme (AMSP) practices in India. Indian J Med Res 142:130\u2013138. https:\/\/doi.org\/10.4103\/0971-5916.164228","journal-title":"Indian J Med Res"},{"key":"5342_CR10","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1086\/528867","volume":"46","author":"ME Falagas","year":"2008","unstructured":"Falagas ME, Karageorgopoulos DE (2008) Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin Infect Dis 46:1121\u20131122. https:\/\/doi.org\/10.1086\/528867","journal-title":"Clin Infect Dis"},{"key":"5342_CR11","unstructured":"Organization WH (2017) Antibacterial agents in clinical development"},{"key":"5342_CR12","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1093\/infdis\/jiw282","volume":"215","author":"LK Logan","year":"2017","unstructured":"Logan LK, Weinstein RA (2017) The epidemiology of carbapenem-resistant enterobacteriaceae: the impact and evolution of a global menace. J Infect Dis 215:S28\u2013S36. https:\/\/doi.org\/10.1093\/infdis\/jiw282","journal-title":"J Infect Dis"},{"key":"5342_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S1473-3099(10)70143-2","volume":"10","author":"KK Kumarasamy","year":"2010","unstructured":"Kumarasamy KK, Toleman MA, Walsh TR et al (2010) Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597\u2013602. https:\/\/doi.org\/10.1016\/S1473-3099(10)70143-2","journal-title":"Lancet Infect Dis"},{"key":"5342_CR14","first-page":"458","volume":"133","author":"RK Srivastava","year":"2011","unstructured":"Srivastava RK, Ichhpujani RI, Khare S et al (2011) Superbug\u2013the so-called NDM-1. Indian J Med Res 133:458\u2013460","journal-title":"Indian J Med Res"},{"key":"5342_CR15","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1086\/522287","volume":"45","author":"DL Paterson","year":"2007","unstructured":"Paterson DL, Doi Y (2007) A step closer to extreme drug resistance (XDR) in Gram-negative bacilli. Clin Infect Dis 45:1179\u20131181. https:\/\/doi.org\/10.1086\/522287","journal-title":"Clin Infect Dis"},{"key":"5342_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/J.IJID.2014.01.028","volume":"25","author":"J de Sanctis","year":"2014","unstructured":"de Sanctis J, Teixeira L, van Duin D et al (2014) Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections. Int J Infect Dis 25:73. https:\/\/doi.org\/10.1016\/J.IJID.2014.01.028","journal-title":"Int J Infect Dis"},{"key":"5342_CR17","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/J.IJANTIMICAG.2018.10.018","volume":"53","author":"A Papadopoulos","year":"2019","unstructured":"Papadopoulos A, Ribera A, Mavrogenis AF et al (2019) Multidrug-resistant and extensively drug-resistant Gram-negative prosthetic joint infections: role of surgery and impact of colistin administration. Int J Antimicrob Agents 53:294\u2013301. https:\/\/doi.org\/10.1016\/J.IJANTIMICAG.2018.10.018","journal-title":"Int J Antimicrob Agents"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-022-05342-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00264-022-05342-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-022-05342-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T06:05:49Z","timestamp":1649657149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00264-022-05342-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["5342"],"URL":"https:\/\/doi.org\/10.1007\/s00264-022-05342-z","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"18 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review boards. Application number 672\/12\/VA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}