{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:33:09Z","timestamp":1791988389936,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Regrow Bioscience Pvt Ltd."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Research shows autologous chondrocyte implantation (ACI) is a promising treatment for articular cartilage lesions. In this study, we assessed mid-term efficacy and safety of gel-based ACI or autologous adult live cultured chondrocytes (CARTIGROW\u00ae) implantation in patients with cartilage defects of the knee joint.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective, open-label study, patients (19\u201338\u00a0years) with focal, international cartilage repair society grade III or IV articular cartilage defects of the knee joint were enroled at four centres across India from April 2015 to September 2015. Punch biopsy was conducted to harvest cartilage, from which chondrocytes were isolated and cultured, and the characterised chondrocytes were implanted into the cartilage defect. Key efficacy outcomes were assessed by quantitative changes in international knee documentation committee (IKDC), visual analogue scale (VAS) scores, and qualitative changes in magnetic resonance imaging at six\u00a0months and four\u00a0years from baseline.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the14 patients enroled in the study, all patients completed the six\u00a0month follow-up and 11 completed the four\u00a0year follow-up. The IKDC score improved significantly from 32.84\u2009\u00b1\u20099.25 at baseline to 67.49\u2009\u00b1\u200913.03 at six\u00a0months (mean difference [MD] 34.66\u2009\u00b1\u200913.00, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and to 60.18\u2009\u00b1\u200910.33 at four\u00a0years (MD 28.21\u2009\u00b1\u200915.14, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001). The VAS score reduced from 72.00\u2009\u00b1\u200914.40 at baseline to 16.64\u2009\u00b1\u200917.03 at six\u00a0months (MD 55.36\u2009\u00b1\u200924.50, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and further to 12.72\u2009\u00b1\u20099.05 at four\u00a0years (MD 62.09\u2009\u00b1\u200910.66, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). All patients showed improvement on MRI of the knee joint. No adverse events were reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Autologous adult live cultured chondrocytes (CARTIGROW\u00ae) implantation showed good mid-term efficacy in patients with cartilage defects of the knee joint with no side-effects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00264-022-05369-2","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T12:08:42Z","timestamp":1648469322000},"page":"1313-1321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of CARTIGROW\u00ae in patients with articular cartilage defects of the knee joint: a four\u00a0year prospective studys"],"prefix":"10.1007","volume":"46","author":[{"given":"Shirish","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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