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The investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in such type of study was obtained at admission. No specific IRB certification is needed for retrospective view of clinical cases at our institution. If further certificate is needed, we would like to provide at any time.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Since our institution is a university-affiliated hospital, all the inpatient patients need to sign a consent at admission, indicating their information; sample or tissue may be used for educational, research purpose. For a retrospective study, no specific consent is needed for data collection and publication according to regulation at the authors\u2019 institutional.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}