{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:02:19Z","timestamp":1769112139367,"version":"3.49.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s00264-022-05617-5","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T16:02:52Z","timestamp":1668268972000},"page":"5-15","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Localization of osteomyelitis lesions for operative eradication of chronic osteomyelitis of the lower extremities by bone SPECT\/CT: a feasibility study"],"prefix":"10.1007","volume":"47","author":[{"given":"Seung Hoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Bom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"5617_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0002-9610(03)00292-7","volume":"188","author":"B Parsons","year":"2004","unstructured":"Parsons B, Strauss E (2004) Surgical management of chronic osteomyelitis. Am J Sur 188:57\u201366. https:\/\/doi.org\/10.1016\/S0002-9610(03)00292-7","journal-title":"Am J Sur"},{"key":"5617_CR2","volume-title":"Rockwood and Green\u2019s fractures in adults","author":"JD Heckman","year":"2014","unstructured":"Heckman JD, McKee M, McQueen MM, Ricci W, Tornetta P III (2014) Rockwood and Green\u2019s fractures in adults. Lippincott Williams & Wilkins"},{"key":"5617_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.idc.2006.09.009","volume":"20","author":"C Pineda","year":"2006","unstructured":"Pineda C, Vargas A, Rodriguez AV (2006) Imaging of osteomyelitis: current concepts. Infect Dis Clin North Am 20:789\u2013825. https:\/\/doi.org\/10.1016\/j.idc.2006.09.009","journal-title":"Infect Dis Clin North Am"},{"key":"5617_CR4","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.2106\/00004623-200410000-00028","volume":"86","author":"L Lazzarini","year":"2004","unstructured":"Lazzarini L, Mader JT, Calhoun JH (2004) Osteomyelitis in long bones. J Bone Joint Surg Am 86:2305\u20132318. https:\/\/doi.org\/10.2106\/00004623-200410000-00028","journal-title":"J Bone Joint Surg Am"},{"key":"5617_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.4274\/mirt.galenos.2019.20053","volume":"28","author":"P Ar\u0131can","year":"2019","unstructured":"Ar\u0131can P, Okudan B, \u015eefizade R, Nald\u00f6ken S (2019) Diagnostic value of bone SPECT\/CT in patients with suspected osteomyelitis. Mol Imaging Radionucl Ther 28:89\u201395. https:\/\/doi.org\/10.4274\/mirt.galenos.2019.20053","journal-title":"Mol Imaging Radionucl Ther"},{"key":"5617_CR6","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s00259-003-1321-z","volume":"30","author":"M Horger","year":"2003","unstructured":"Horger M, Eschmann SM, Pfannenberg C, Storek D, Dammann F, Vonthein R, Claussen CD, Bares R (2003) The value of SPET\/CT in chronic osteomyelitis. Eur J Nucl Med Mol Imaging 30:1665\u20131673. https:\/\/doi.org\/10.1007\/s00259-003-1321-z","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"5617_CR7","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/mnm.0000000000001027","volume":"40","author":"Q Song","year":"2019","unstructured":"Song Q, Long L, Cui S, Shu H, Wan C, Wu B, Ma X (2019) Utility of technetium-99m-methylene diphosphonate single-photon emission computed tomography\/computed tomography fusion in detecting post-traumatic chronic-infected nonunion in the lower limb. Nucl Med Commun 40:778\u2013785. https:\/\/doi.org\/10.1097\/mnm.0000000000001027","journal-title":"Nucl Med Commun"},{"key":"5617_CR8","doi-asserted-by":"publisher","unstructured":"Cierny G, 3rd, Mader JT, Penninck JJ (2003) A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res\u00a0Sep;(414):7\u201324. https:\/\/doi.org\/10.1097\/01.blo.0000088564.81746.62","DOI":"10.1097\/01.blo.0000088564.81746.62"},{"key":"5617_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00590-013-1196-z","volume":"24","author":"MA Gokalp","year":"2014","unstructured":"Gokalp MA, Guner S, Ceylan MF, Do\u011fan A, Sebik A (2014) Results of treatment of chronic osteomyelitis by \u201cgutter procedure and muscle flap transposition operation.\u201d Eur J Orthop Surg Traumatol 24:415\u2013419. https:\/\/doi.org\/10.1007\/s00590-013-1196-z","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"5617_CR10","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00264-007-0342-9","volume":"32","author":"H Kinik","year":"2008","unstructured":"Kinik H, Karaduman M (2008) Cierny-Mader Type III chronic osteomyelitis: the results of patients treated with debridement, irrigation, vancomycin beads and systemic antibiotics. Int Orthop 32:551\u2013558. https:\/\/doi.org\/10.1007\/s00264-007-0342-9","journal-title":"Int Orthop"},{"key":"5617_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00402-013-1907-2","volume":"134","author":"S Ayta\u00e7","year":"2014","unstructured":"Ayta\u00e7 S, Schnetzke M, Swartman B, Herrmann P, Woelfl C, Heppert V, Gruetzner PA, Guehring T (2014) Posttraumatic and postoperative osteomyelitis: surgical revision strategy with persisting fistula. Arch Orthop Trauma Surg 134:159\u2013165. https:\/\/doi.org\/10.1007\/s00402-013-1907-2","journal-title":"Arch Orthop Trauma Surg"},{"key":"5617_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/bpo.0000000000000619","volume":"37","author":"A Yildirim","year":"2017","unstructured":"Yildirim A, Kapukaya A, Ati\u00e7 R, Mertsoy Y, Yi\u011fit \u015e, \u00c7a\u00e7an MA, Alemdar C (2017) The use of an \u201cinternal fixator technique\u201d to stabilize pathologic fractures developing secondary to osteomyelitis. J Pediatr Orthop 37:222\u2013226. https:\/\/doi.org\/10.1097\/bpo.0000000000000619","journal-title":"J Pediatr Orthop"},{"key":"5617_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.semnuclmed.2009.08.005","volume":"40","author":"W van der Bruggen","year":"2010","unstructured":"van der Bruggen W, Bleeker-Rovers CP, Boerman OC, Gotthardt M, Oyen WJ (2010) PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med 40:3\u201315. https:\/\/doi.org\/10.1053\/j.semnuclmed.2009.08.005","journal-title":"Semin Nucl Med"},{"key":"5617_CR14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1097\/RLU.0b013e318184b9b4","volume":"33","author":"JL Madsen","year":"2008","unstructured":"Madsen JL (2008) Bone SPECT\/CT detection of a sequestrum in chronic-infected nonunion of the tibia. Clin Nucl Med 33:700\u2013701. https:\/\/doi.org\/10.1097\/RLU.0b013e318184b9b4","journal-title":"Clin Nucl Med"},{"key":"5617_CR15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1055\/s-0034-1371020","volume":"18","author":"SP Thang","year":"2014","unstructured":"Thang SP, Tong AK, Lam WW, Ng DC (2014) SPECT\/CT in musculoskeletal infections. Semin Musculoskelet Radiol 18:194\u2013202. https:\/\/doi.org\/10.1055\/s-0034-1371020","journal-title":"Semin Musculoskelet Radiol"},{"key":"5617_CR16","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s12891-015-0704-1","volume":"16","author":"XS Qiu","year":"2015","unstructured":"Qiu XS, Zheng X, Shi HF, Zhu YC, Guo X, Mao HJ, Xu GY, Chen YX (2015) Antibiotic-impregnated cement spacer as definitive management for osteomyelitis. BMC Musculoskelet Disord 16:254. https:\/\/doi.org\/10.1186\/s12891-015-0704-1","journal-title":"BMC Musculoskelet Disord"},{"key":"5617_CR17","doi-asserted-by":"publisher","first-page":"502","DOI":"10.22038\/abjs.2020.44143.2208","volume":"8","author":"N Fernando","year":"2020","unstructured":"Fernando N, Werner S, Elhaddad M, Davies J, Firoozabadi R (2020) Do antibiotic beads need to be removed? Arch Bone Jt Surg 8:502\u2013505. https:\/\/doi.org\/10.22038\/abjs.2020.44143.2208","journal-title":"Arch Bone Jt Surg"},{"key":"5617_CR18","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.2106\/jbjs.M.01280","volume":"96","author":"HS Lee","year":"2014","unstructured":"Lee HS, Ahn JY, Lee JS, Lee JY, Jeong JJ, Choi YR (2014) Cement arthroplasty for ankle joint destruction. J Bone Joint Surg Am 96:1468\u20131475. https:\/\/doi.org\/10.2106\/jbjs.M.01280","journal-title":"J Bone Joint Surg Am"},{"key":"5617_CR19","doi-asserted-by":"publisher","first-page":"C161","DOI":"10.12968\/hmed.2016.77.10.C161","volume":"77","author":"H Taki","year":"2016","unstructured":"Taki H, Krkovic M, Moore E, Abood A, Norrish A (2016) Chronic long bone osteomyelitis: diagnosis, management and current trends. Br J Hosp Med (Lond) 77:C161\u2013C164. https:\/\/doi.org\/10.12968\/hmed.2016.77.10.C161","journal-title":"Br J Hosp Med (Lond)"},{"key":"5617_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2022.07.008","author":"G Wang","year":"2022","unstructured":"Wang G, Alagboso FI, Walter N, Baertl S, Brochhausen C, Docheva D, Rupp M, Alt V (2022) Bone regeneration after marginal bone resection in two-stage treatment of chronic long bone infection - a combined histopathological and clinical pilot study. Injury. https:\/\/doi.org\/10.1016\/j.injury.2022.07.008","journal-title":"Injury"},{"key":"5617_CR21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1302\/0301-620x.83b3.10727","volume":"83","author":"AH Simpson","year":"2001","unstructured":"Simpson AH, Deakin M, Latham JM (2001) Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival. J Bone Joint Surg Br 83:403\u2013407. https:\/\/doi.org\/10.1302\/0301-620x.83b3.10727","journal-title":"J Bone Joint Surg Br"},{"key":"5617_CR22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","volume":"49","author":"WJ Metsemakers","year":"2018","unstructured":"Metsemakers WJ, Morgenstern M, McNally MA, Moriarty TF, McFadyen I, Scarborough M, Athanasou NA, Ochsner PE, Kuehl R, Raschke M, Borens O, Xie Z, Velkes S, Hungerer S, Kates SL, Zalavras C, Giannoudis PV, Richards RG, Verhofstad MHJ (2018) Fracture-related infection: a consensus on definition from an international expert group. Injury 49:505\u2013510. https:\/\/doi.org\/10.1016\/j.injury.2017.08.040","journal-title":"Injury"},{"key":"5617_CR23","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1302\/2058-5241.5.190072","volume":"5","author":"M McNally","year":"2020","unstructured":"McNally M, Govaert G, Dudareva M, Morgenstern M, Metsemakers WJ (2020) Definition and diagnosis of fracture-related infection. EFORT Open Rev 5:614\u2013619. https:\/\/doi.org\/10.1302\/2058-5241.5.190072","journal-title":"EFORT Open Rev"},{"key":"5617_CR24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00068-016-0647-8","volume":"42","author":"GAM Govaert","year":"2016","unstructured":"Govaert GAM, Glaudemans A (2016) Nuclear medicine imaging of posttraumatic osteomyelitis. Eur J Trauma Emerg Surg 42:397\u2013410. https:\/\/doi.org\/10.1007\/s00068-016-0647-8","journal-title":"Eur J Trauma Emerg Surg"},{"key":"5617_CR25","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1056\/nejm197002052820606","volume":"282","author":"FA Waldvogel","year":"1970","unstructured":"Waldvogel FA, Medoff G, Swartz MN (1970) Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects. 3. Osteomyelitis associated with vascular insufficiency. N Engl J Med 282:316\u2013322. https:\/\/doi.org\/10.1056\/nejm197002052820606","journal-title":"N Engl J Med"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-022-05617-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00264-022-05617-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-022-05617-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T08:09:26Z","timestamp":1672733366000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00264-022-05617-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["5617"],"URL":"https:\/\/doi.org\/10.1007\/s00264-022-05617-5","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"22 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We obtained approval from the Seoul National University Hospital Institutional Review Board (IRB No.: H-2203\u2013050-1303).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in all figures in the submitted manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}