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Given the fact that MRSA carriers are at high risk for developing periprosthetic infections regardless of the administration of eradication treatment pre-operatively, the need for developing new prevention modalities is high.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The antibacterial and antibiofilm properties of vancomycin, Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> nanowires, and TiO<jats:sub>2<\/jats:sub> nanoparticles were evaluated in vitro using MIC and MBIC assays. MRSA biofilms were grown on titanium disks simulating orthopedic implants, and the infection prevention potential of vancomycin-, Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> nanowire-, and TiO<jats:sub>2<\/jats:sub> nanoparticle-supplemented Resomer\u00ae coating was evaluated against biofilm controls using the XTT reduction proliferation assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the tested modalities, high- and low-dose vancomycin-loaded Resomer\u00ae coating yielded the most satisfactory metalwork protection against MRSA (median absorbance was 0.1705; [IQR\u2009=\u20090.1745] vs control absorbance 0.42 [IQR\u2009=\u20090.07]; <jats:italic>p<\/jats:italic>\u2009=\u20090.016; biofilm reduction was 100%; and 0.209 [IQR\u2009=\u20090.1295] vs control 0.42 [IQR\u2009=\u20090.07]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; biofilm reduction was 84%, respectively). On the other hand, polymer coating alone did not provide clinically meaningful biofilm growth prevention (median absorbance was 0.2585 [IQR\u2009=\u20090.1235] vs control 0.395 [IQR\u2009=\u20090.218]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; biofilm reduction was 62%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We advocate that apart from the well-established preventative measures for MRSA carriers, loading implants with bioresorbable Resomer\u00ae vancomycin-supplemented coating may decrease the incidence of early post-op surgical site infections with titanium implants. Of note, the payoff between localized toxicity and antibiofilm efficacy should be considered when loading polymers with highly concentrated antimicrobial agents.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00264-023-05757-2","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T06:02:35Z","timestamp":1679983355000},"page":"1415-1422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is nanomaterial- and vancomycin-loaded polymer coating effective at preventing methicillin-resistant Staphylococcus aureus growth on titanium disks? 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