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Whether intraoperatively detected bacteria should be considered relevant or not is often difficult to assess.<\/jats:p>\n                    <jats:p>\n                      This retrospective cohort study analyzes the relevance of\n                      <jats:italic>C. acnes<\/jats:italic>\n                      cultured from deep intraoperative specimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All deep tissue samples collected intraoperatively between 2015 and 2020 from a quartiary care provider were evaluated for detection of\n                      <jats:italic>C. acnes<\/jats:italic>\n                      and its therapeutical consequences. Infection rates were determined according to a standardized definition and protocol and analyzed in dependence of patient\u2019s demographic data (age and gender), operative parameters (type of surgery, body region\/location of surgery, and impression of the surgeon), and initiated therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 270 cases of more than 8500 samples,\n                      <jats:italic>C. acnes<\/jats:italic>\n                      was detected. In 30%, the detection was considered an infection. The number of samples taken and tested positive for\n                      <jats:italic>C. acnes<\/jats:italic>\n                      correlated significantly with its classification as a cause of infection. If more than one sample of the patient was positive, the detection was significantly more likely to be treated as infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                    <jats:p>In 76% of cases, a consultation to the infectious diseases (ID) department took place regarding the classification of the pathogen detection and the therapy to be carried out.<\/jats:p>\n                    <jats:p>Almost all of the tested isolates demonstrated the wild-type susceptibility for penicillin and clindamycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Intraoperative detection of skin-colonizing bacteria such as\n                      <jats:italic>C. acnes<\/jats:italic>\n                      is not always synonymous with infection. In particular, if other examination results contradict an infection (pathological sample without evidence of an infectious event, detection of malignant cells, etc.), the situation must be considered in a very differentiated manner. Interdisciplinary boards, for example, are suitable for this purpose. Care should be taken to obtain a sufficiently large number of tissue samples for microbiological examination to be able to better classify the result.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00264-023-05981-w","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T16:31:16Z","timestamp":1695227476000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Detection of Cutibacterium (Propionibacterium) acnes in orthopaedic surgery: serious problem or contamination?"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-7078","authenticated-orcid":false,"given":"Christina","family":"Otto-Lambertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1723-5995","authenticated-orcid":false,"given":"Ayla","family":"Yagdiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-8966","authenticated-orcid":false,"given":"Alessa Lalinka","family":"Boschert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9929-3370","authenticated-orcid":false,"given":"Peer","family":"Eysel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-1793","authenticated-orcid":false,"given":"Sarah Victoria","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"issue":"1","key":"5981_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3928\/01477447-20191213-02","volume":"43","author":"ZX Lin","year":"2020","unstructured":"Lin ZX, Steed LL, Marculescu CE, Slone HS, Woolf SK (2020) Cutibacterium acnes infection in orthopedics: microbiology, clinical findings, diagnostic strategies, and management. 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