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Given the increasing number of TKAs performed annually, the rising demand for CIM implants, and the associated burden of revision surgeries, understanding the mid-term performance of CIM implants is crucial. Therefore, this study aims to report on the mid-term (minimum 5 years) outcomes of TKA using a CIM implant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective cohort study included a consecutive series of 116 patients who received the ConforMIS<jats:sup>\u00ae<\/jats:sup> iTotal CR implant between 2015 and 2018. Inclusion criteria were end-stage knee osteoarthritis with coronal deformities below 10\u00b0 and absence of ligamentous instability. Exclusion criteria included simultaneous bilateral TKA. Patients were followed up at a minimum of five years post-surgery. They completed a questionnaire reporting on satisfaction, pain levels using the Visual Analogue Scale (VAS), current weight, the Oxford Knee Score (OKS), and the Forgotten Joint Score for the knee (FJS-knee). Statistical analysis included descriptive statistics for demographic and clinical variables, and outcomes were reported as means with ranges.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean follow-up duration was 5.9\u2009\u00b1\u20090.8 years (range 5\u20137.4 years). 90% of patients stated they would undergo the same operation again, and 93% were either satisfied or very satisfied. The mean VAS for pain at rest was 2\u2009\u00b1\u20091.5 (range 0\u20136) and during exercise was 3\u2009\u00b1\u20092 (range 0\u20138). 58 patients (53%) managed to lose weight. The mean OKS was 41\u2009\u00b1\u20099 points (range 15\u201348), and the mean FJS-knee was 67\u2009\u00b1\u200923 points (range 4\u2013100). No severe complications occurred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CIM TKA using the ConforMIS<jats:sup>\u00ae<\/jats:sup> iTotal CR implant can achieve excellent results with 93% of patients being satisfied or very satisfied at mid-term follow-up of five years. Prospective, randomized, and patient-blinded trials comparing off-the-shelf (OTS) TKAs with CIM implants are necessary to evaluate whether these implants are superior or not.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00264-024-06325-y","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T06:05:29Z","timestamp":1727244329000},"page":"3101-3108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High patient satisfaction with Customized Total Knee Arthroplasty at five year follow-up"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0005-299X","authenticated-orcid":false,"given":"Philipp","family":"Schippers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yama","family":"Afghanyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Buschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klonschinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Drees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Eckhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"6325_CR1","doi-asserted-by":"publisher","first-page":"2325967120S0010","DOI":"10.1177\/2325967120s00104","volume":"8","author":"NC Budhiparama","year":"2020","unstructured":"Budhiparama NC, Lumban-Gaol I, Ifran NN et al (2020) Anthropometric Measurement of Caucasian and Asian knees, mismatch with knee systems? 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