{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:17:03Z","timestamp":1770563823250,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Aseptic loosening of the acetabular cup component is the primary cause for complex revision surgery following total hip arthroplasty. However, the extent to which the different zones of the prosthetic contribute to successful osseointegration and how reliable this integration can be assessed using conventional radiographs remain unclear. The aim of the study was to evaluate the osseointegration of cementless threaded acetabular cups through a combination of radiological analysis and histological validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight hemipelves of body donors with cementless threaded acetabular cups were included in this study. Conventional radiographs were used to assess the specimens for existing radiolucent lines, periprosthetic osteolysis, or fractures. For histological analysis, thin sections of the acetabular cup were examined for the presence of a periprosthetic membrane, particle debris or inflammatory cells. The areas of visible contact were identified and the bone-to-implant contact (BIC) was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Radiographic analysis revealed no signs of insufficient osseointegration, osteolytic lesions, or periprosthetic loosening, in any of the specimens. Histological examination showed an average osseointegration rate of 41.84%. Bone-to-implant contact analysis showed no significant differences between different sectors or zones, or between conical and bi-conical acetabular cups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights successful osseointegration of cementless threaded acetabular cups, with a mean survival of 18.2 years. Radiological imaging aligned closely to histological finding, confirming implant stability and long-term clinical effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00264-025-06687-x","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:59:40Z","timestamp":1762235980000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osseointegration of threaded acetabular cups - radiological and histological evaluation after total hip arthroplasty"],"prefix":"10.1007","volume":"50","author":[{"given":"Elisabeth M.","family":"Mandler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen G.","family":"Hofstaetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Hirtler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"issue":"1","key":"6687_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13244-024-01717-5","volume":"15","author":"D Albano","year":"2024","unstructured":"Albano D et al (2024) MRI of total hip arthroplasty: technical aspects and imaging findings. Insights Imaging 15(1):152","journal-title":"Insights Imaging"},{"issue":"9","key":"6687_CR2","doi-asserted-by":"publisher","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","volume":"5","author":"GBDO Collaborators","year":"2023","unstructured":"Collaborators GBDO (2023) Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the global burden of disease study 2021. Lancet Rheumatol 5(9):e508\u2013e522","journal-title":"Lancet Rheumatol"},{"key":"6687_CR3","doi-asserted-by":"publisher","first-page":"n1511","DOI":"10.1136\/bmj.n1511","volume":"374","author":"AW Blom","year":"2021","unstructured":"Blom AW et al (2021) Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence. BMJ 374:n1511","journal-title":"BMJ"},{"issue":"1","key":"6687_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s42836-022-00156-1","volume":"5","author":"I Patel","year":"2023","unstructured":"Patel I et al (2023) Epidemiology of total hip arthroplasty: demographics, comorbidities and outcomes. Arthroplasty 5(1):2","journal-title":"Arthroplasty"},{"issue":"12","key":"6687_CR5","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1007\/s00402-024-05379-2","volume":"144","author":"G Hauer","year":"2024","unstructured":"Hauer G et al (2024) Septic complications are on the rise and aseptic loosening has decreased in total joint arthroplasty: an updated complication based analysis using worldwide arthroplasty registers. Arch Orthop Trauma Surg 144(12):5199\u20135204","journal-title":"Arch Orthop Trauma Surg"},{"issue":"9597","key":"6687_CR6","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0140-6736(07)60457-7","volume":"370","author":"ID Learmonth","year":"2007","unstructured":"Learmonth ID, Young C, Rorabeck C (2007) The operation of the century: total hip replacement. Lancet 370(9597):1508\u20131519","journal-title":"Lancet"},{"key":"6687_CR7","doi-asserted-by":"crossref","unstructured":"Jones LC Hungerford DS (1987) Cement disease. Clin Orthop Relat Res. 225:192\u2013206","DOI":"10.1097\/00003086-198712000-00016"},{"issue":"6","key":"6687_CR8","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1177\/0300060517732697","volume":"46","author":"D Apostu","year":"2018","unstructured":"Apostu D et al (2018) Current methods of preventing aseptic loosening and improving osseointegration of titanium implants in cementless total hip arthroplasty: a review. J Int Med Res 46(6):2104\u20132119","journal-title":"J Int Med Res"},{"issue":"2","key":"6687_CR9","first-page":"61","volume":"9","author":"AF Mavrogenis","year":"2009","unstructured":"Mavrogenis AF et al (2009) Biology of implant osseointegration. J Musculoskelet Neuronal Interact 9(2):61\u201371","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"7","key":"6687_CR10","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/jor.24576","volume":"38","author":"AL Overmann","year":"2020","unstructured":"Overmann AL et al (2020) Orthopaedic osseointegration: implantology and future directions. J Orthop Res 38(7):1445\u20131454","journal-title":"J Orthop Res"},{"issue":"6","key":"6687_CR11","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/jcp.2005.027458","volume":"59","author":"L Morawietz","year":"2006","unstructured":"Morawietz L et al (2006) Proposal for a histopathological consensus classification of the periprosthetic interface membrane. J Clin Pathol 59(6):591\u2013597","journal-title":"J Clin Pathol"},{"issue":"2suppl","key":"6687_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/1120700018813210","volume":"28","author":"L Gala","year":"2018","unstructured":"Gala L et al (2018) Is there still a role for threaded acetabular cups? Hip Int 28(2suppl):15\u201320","journal-title":"Hip Int"},{"issue":"10","key":"6687_CR13","first-page":"7080","volume":"14","author":"X Feng","year":"2022","unstructured":"Feng X, Gu J, Zhou Y (2022) Primary total hip arthroplasty failure: aseptic loosening remains the most common cause of revision. Am J Transl Res 14(10):7080\u20137089","journal-title":"Am J Transl Res"},{"issue":"15","key":"6687_CR14","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1097\/CM9.0000000000002219","volume":"136","author":"L Gong","year":"2023","unstructured":"Gong L et al (2023) Clinicopathological analysis of the periprosthetic tissue of revision total hip and knee arthroplasty. Chin Med J (Engl) 136(15):1870\u20131872","journal-title":"Chin Med J (Engl)"},{"issue":"8","key":"6687_CR15","doi-asserted-by":"publisher","first-page":"620","DOI":"10.2106\/JBJS.22.01003","volume":"105","author":"GM Schwarz","year":"2023","unstructured":"Schwarz GM et al (2023) Influence of scan parameters of single and dual-energy CT protocols in combination with metal artifact suppression algorithms for THA: an ex vivo study. J Bone Joint Surg Am 105(8):620\u2013629","journal-title":"J Bone Joint Surg Am"},{"key":"6687_CR16","doi-asserted-by":"crossref","unstructured":"DeLee JG Charnley J (1976) Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop Relat Res. 121:20\u201332","DOI":"10.1097\/00003086-197611000-00003"},{"issue":"12","key":"6687_CR17","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1016\/j.ejrad.2011.03.103","volume":"81","author":"TT Miller","year":"2012","unstructured":"Miller TT (2012) Imaging of hip arthroplasty. Eur J Radiol 81(12):3802\u20133812","journal-title":"Eur J Radiol"},{"issue":"7","key":"6687_CR18","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.2106\/00004623-199707000-00007","volume":"79","author":"RD Bloebaum","year":"1997","unstructured":"Bloebaum RD et al (1997) Postmortem analysis of bone growth into porous-coated acetabular components. J Bone Joint Surg Am 79(7):1013\u20131022","journal-title":"J Bone Joint Surg Am"},{"issue":"6","key":"6687_CR19","doi-asserted-by":"publisher","first-page":"817","DOI":"10.2106\/00004623-200106000-00002","volume":"83","author":"A Tonino","year":"2001","unstructured":"Tonino A et al (2001) Hydroxyapatite-coated acetabular components. Histological and histomorphometric analysis of six cups retrieved at autopsy between three and seven years after successful implantation. J Bone Joint Surg Am 83(6):817\u2013825","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"6687_CR20","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1302\/0301-620X.70B2.3346311","volume":"70","author":"JD Bobyn","year":"1988","unstructured":"Bobyn JD, Engh CA, Glassman AH (1988) Radiography and histology of a threaded acetabular implant. One case studied at two years. J Bone Joint Surg Br 70(2):302\u2013304","journal-title":"J Bone Joint Surg Br"},{"key":"6687_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fsurg.2019.00035","volume":"6","author":"N Mushtaq","year":"2019","unstructured":"Mushtaq N et al (2019) Radiological imaging evaluation of the failing total hip replacement. Front Surg 6:35","journal-title":"Front Surg"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-025-06687-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00264-025-06687-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-025-06687-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:02:43Z","timestamp":1770476563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00264-025-06687-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["6687"],"URL":"https:\/\/doi.org\/10.1007\/s00264-025-06687-x","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Medical University of Vienna (EK. Nr.: 1102\/2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}