{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:41:22Z","timestamp":1792734082988,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["International Orthopaedics (SICOT)"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00264-026-06967-0","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:00:25Z","timestamp":1784862025000},"page":"3025-3034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcomes of proximal tibial tumour resection and reconstruction using the Global Modular Replacement System prosthetic system"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2151-4902","authenticated-orcid":false,"given":"Marco","family":"Fava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Maria","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Danna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolin","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"3","key":"6967_CR1","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1007\/s11999-016-4843-y","volume":"475","author":"JI Albergo","year":"2017","unstructured":"Albergo JI, Gaston CL, Aponte-Tinao LA, Ayerza MA, Muscolo DL, Farfalli GL et al (2017) Proximal tibia reconstruction after bone tumor resection: are survivorship and outcomes of endoprosthetic replacement and osteoarticular allograft similar? Clin Orthop 475(3):676\u2013682","journal-title":"Clin Orthop"},{"key":"6967_CR2","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00003086-200204000-00034","volume":"397","author":"Y Refaat","year":"2002","unstructured":"Refaat Y, Gunnoe J, Hornicek FJ, Mankin HJ (2002) Comparison of quality of life after amputation or limb salvage. Clin Orthop 397:298\u2013305","journal-title":"Clin Orthop"},{"issue":"9","key":"6967_CR3","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.2106\/00004623-198668090-00005","volume":"68","author":"MA Simon","year":"1986","unstructured":"Simon MA, Aschliman MA, Thomas N, Mankin HJ (1986) Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am 68(9):1331\u20131337","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"6967_CR4","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s11999-014-3699-2","volume":"473","author":"E Pala","year":"2015","unstructured":"Pala E, Trovarelli G, Calabr\u00f2 T, Angelini A, Abati CN, Ruggieri P (2015) Survival of modern knee tumor megaprostheses: failures, functional results, and a comparative statistical analysis. Clin Orthop 473(3):891\u2013899","journal-title":"Clin Orthop"},{"issue":"6","key":"6967_CR5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1302\/0301-620X.88B6.17519","volume":"88","author":"ER Ahlmann","year":"2006","unstructured":"Ahlmann ER, Menendez LR, Kermani C, Gotha H (2006) Survivorship and clinical outcome of modular endoprosthetic reconstruction for neoplastic disease of the lower limb. J Bone Joint Surg Br 88(6):790\u2013795","journal-title":"J Bone Joint Surg Br"},{"key":"6967_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00003086-200403000-00034","volume":"420","author":"EN Zeegen","year":"2004","unstructured":"Zeegen EN, Aponte-Tinao LA, Hornicek FJ, Gebhardt MC, Mankin HJ (2004) Survivorship analysis of 141 modular metallic endoprostheses at early followup. Clin Orthop 420:239\u2013250","journal-title":"Clin Orthop"},{"issue":"5","key":"6967_CR7","doi-asserted-by":"publisher","first-page":"e672","DOI":"10.3928\/01477447-20120426-21","volume":"35","author":"AF Mavrogenis","year":"2012","unstructured":"Mavrogenis AF, Angelini A, Pala E, Sakellariou VI, Ruggieri P, Papagelopoulos PJ (2012) Reconstruction of the extensor mechanism after major knee resection. Orthopedics 35(5):e672\u2013e680","journal-title":"Orthopedics"},{"issue":"6","key":"6967_CR8","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1302\/0301-620X.87B6.15363","volume":"87-B","author":"MJ Oddy","year":"2005","unstructured":"Oddy MJ, Pendegrass CJ, Goodship AE, Cannon SR, Briggs TWR, Blunn GW (2005) Extensor mechanism reconstruction after proximal tibial replacement. J Bone Joint Surg Br 87-B(6):873\u2013878","journal-title":"J Bone Joint Surg Br"},{"issue":"9","key":"6967_CR9","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1302\/0301-620X.91B9.22383","volume":"91-B","author":"S Sundar","year":"2009","unstructured":"Sundar S, Pendegrass CJ, Oddy MJ, Blunn GW (2009) Tendon re-attachment to metal prostheses in an in vivo animal model using demineralised bone matrix. J Bone Joint Surg Br 91-B(9):1257\u20131262","journal-title":"J Bone Joint Surg Br"},{"issue":"10","key":"6967_CR10","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1007\/s00264-018-3893-z","volume":"42","author":"J Hardes","year":"2018","unstructured":"Hardes J, Henrichs M-P, Gosheger G, Guder W, Nottrott M, Andreou D et al (2018) Tumour endoprosthesis replacement in the proximal tibia after intra-articular knee resection in patients with sarcoma and recurrent giant cell tumour. Int Orthop 42(10):2475\u20132481","journal-title":"Int Orthop"},{"issue":"7","key":"6967_CR11","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1007\/s11999-013-2851-8","volume":"471","author":"T Jentzsch","year":"2013","unstructured":"Jentzsch T, Erschbamer M, Seeli F, Fuchs B (2013) Extensor function after medial gastrocnemius flap reconstruction of the proximal tibia. Clin Orthop 471(7):2333\u20132339","journal-title":"Clin Orthop"},{"issue":"3","key":"6967_CR12","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CORR.0000000000000564","volume":"477","author":"CA Cipriano","year":"2019","unstructured":"Cipriano CA, Dalton J, McDonald DJ (2019) Does patellar tendon repair with gastrocnemius flap augmentation effectively restore active extension after proximal tibial sarcoma resection? Clin Orthop 477(3):584\u2013593","journal-title":"Clin Orthop"},{"issue":"5","key":"6967_CR13","doi-asserted-by":"publisher","first-page":"418","DOI":"10.2106\/JBJS.J.00834","volume":"93","author":"ER Henderson","year":"2011","unstructured":"Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D et al (2011) Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am 93(5):418\u2013429","journal-title":"J Bone Joint Surg Am"},{"key":"6967_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/00003086-198603000-00003","volume":"204","author":"WF Enneking","year":"1986","unstructured":"Enneking WF (1986) A system of staging musculoskeletal neoplasms. Clin Orthop 204:9\u201324","journal-title":"Clin Orthop"},{"key":"6967_CR15","doi-asserted-by":"crossref","unstructured":"Sm H, Jm L, Jc O, Jh H (1991) Prosthetic arthroplasty of the knee after resection of a sarcoma in the proximal end of the tibia. A report of sixteen cases. J Bone Joint Surg Am [Internet]. [cited 2021 Nov 17];73(2). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/1993723\/","DOI":"10.2106\/00004623-199173020-00017"},{"issue":"7","key":"6967_CR16","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1054\/arth.2001.25502","volume":"16","author":"J Bickels","year":"2001","unstructured":"Bickels J, Wittig JC, Kollender Y, Neff RS, Kellar-Graney K, Meller I et al (2001) Reconstruction of the extensor mechanism after proximal tibia endoprosthetic replacement. J Arthroplasty 16(7):856\u2013862","journal-title":"J Arthroplasty"},{"issue":"3","key":"6967_CR17","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1302\/0301-620X.81B3.0810488","volume":"81","author":"RJ Grimer","year":"1999","unstructured":"Grimer RJ, Carter SR, Tillman RM, Sneath RS, Walker PS, Unwin PS et al (1999) Endoprosthetic replacement of the proximal tibia. J Bone Joint Surg Br 81(3):488\u2013494","journal-title":"J Bone Joint Surg Br"},{"key":"6967_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/BLO.0b013e318059b8c9","volume":"459","author":"TA Damron","year":"2007","unstructured":"Damron TA, Ward WG, Stewart A (2007) Osteosarcoma, chondrosarcoma, and Ewing\u2019s sarcoma: National Cancer Data Base report. Clin Orthop 459:40\u201347","journal-title":"Clin Orthop"},{"issue":"4","key":"6967_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/jso.23216","volume":"107","author":"AF Mavrogenis","year":"2013","unstructured":"Mavrogenis AF, Pala E, Angelini A, Ferraro A, Ruggieri P (2013) Proximal tibial resections and reconstructions: clinical outcome of 225 patients. J Surg Oncol 107(4):335\u2013342","journal-title":"J Surg Oncol"},{"issue":"12","key":"6967_CR20","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1302\/0301-620X.89B12.19481","volume":"89","author":"GJC Myers","year":"2007","unstructured":"Myers GJC, Abudu AT, Carter SR, Tillman RM, Grimer RJ (2007) The long-term results of endoprosthetic replacement of the proximal tibia for bone tumours. J Bone Joint Surg Br 89(12):1632\u20131637","journal-title":"J Bone Joint Surg Br"}],"container-title":["International Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-026-06967-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00264-026-06967-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00264-026-06967-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:33:11Z","timestamp":1792733591000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00264-026-06967-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["6967"],"URL":"https:\/\/doi.org\/10.1007\/s00264-026-06967-0","relation":{},"ISSN":["0341-2695","1432-5195"],"issn-type":[{"value":"0341-2695","type":"print"},{"value":"1432-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"4 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The mandatory \"IRCCS\" designation is omitted from affiliations 1 and 2.  The original article has been updated accordingly.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was obtained for the present study. The study was conducted in accordance with the Declaration of Helsinki and approved by the Comitato Etico di Area Vasta Emilia Centro (Protocol code 521\/2025\/Oss\/IOR, date of approval 2 October 2025). All patients signed a specific informed consent for the study.","order":1,"name":"Ethics","label":"Institutional review board statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}