{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:55:58Z","timestamp":1793271358500,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00266-005-5049-y","type":"journal-article","created":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T13:14:22Z","timestamp":1132233262000},"page":"510-518","source":"Crossref","is-referenced-by-count":52,"title":["Serologic and Histologic Findings in Patients with Capsular Contracture After Breast Augmentation with Smooth Silicone Gel Implants: Is Serum Hyaluronan a Potential Predictor?"],"prefix":"10.1007","volume":"29","author":[{"given":"L.","family":"Prantl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"P\u00f6ppl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Heine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eisenmann-Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"5049_CR1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00266-004-4005-6","volume":"28","author":"C Alfano","year":"2004","unstructured":"Alfano C, Mazzocchi M, Scuderi N: Mammary compliance: An objective measurement of capsular contracture. Aesth Plast Surg28:75\u201379, 2004","journal-title":"Aesth Plast Surg"},{"key":"5049_CR2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/00006534-198112000-00010","volume":"68","author":"JL Baker Jr","year":"1981","unstructured":"Baker JL Jr, Chandler ML, LeVier RR: Occurrence and activity of myofibroblasts in human capsular tissue surrounding mammary implants. Plast Reconstr Surg 68:905, 1981","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00266-001-0003-0","volume":"25","author":"CN Baran","year":"2001","unstructured":"Baran CN, Peker F, Ortak T, Sensoz O, Baran NK: A different strategy in the surgical treatment of capsular contracture: Leave capsule intact. Aesth Plast Surg 25:427\u2013431, 2001","journal-title":"Aesth Plast Surg"},{"key":"5049_CR4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/00000637-199910000-00019","volume":"43","author":"WH Beekman","year":"1999","unstructured":"Beekman WH, Hage JJ, Jorna LB, Mulder JW: Augmentation mammaplasty: The story before the silicone bag prosthesis. Ann Plast Surg 43:446\u2013451, 1999","journal-title":"Ann Plast Surg"},{"key":"5049_CR5","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/00006534-199710000-00039","volume":"100","author":"GS Brody","year":"1997","unstructured":"Brody GS: On the safety of breast implants. Plast Reconstr Surg 100:1314\u20131321, 1997","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR6","first-page":"996","volume":"28","author":"SL Brown","year":"2001","unstructured":"Brown SL, Pennello G, Berg WA, Soo MS, Middleton MS: Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol 28:996\u20131003, 2001","journal-title":"J Rheumatol"},{"key":"5049_CR7","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.4049\/jimmunol.159.4.1676","volume":"159","author":"A Brunmark","year":"1997","unstructured":"Brunmark A, O\u2019Rourke AM: Augmentation of mature CD44 cell response to isolated antigenic class II proteins by fibronectin and intercellular cell adhesion molecule-1. J Immunol 159:1676\u20131685, 1997","journal-title":"J Immunol"},{"key":"5049_CR8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0094-1298(20)31387-0","volume":"15","author":"BR Burckhardt","year":"1988","unstructured":"Burckhardt BR: Capsular contracture: Hard breasts, soft data. Clin Plast Surg 15:521, 1988","journal-title":"Clin Plast Surg"},{"key":"5049_CR9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s002660010037","volume":"24","author":"A Camirand","year":"2000","unstructured":"Camirand A, Doucet J: Breast augmentation: Teaching our patients how compression can help prevent capsular contracture. Aesth Plast Surg 24:221\u2013226, 2000","journal-title":"Aesth Plast Surg"},{"key":"5049_CR10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0945-053X(99)00039-6","volume":"18","author":"M Chiquet","year":"1999","unstructured":"Chiquet M: Regulation of extracellular matrix gene expression by mechanical stress. Matrix Biol 18:417\u2013426, 1999","journal-title":"Matrix Biol"},{"key":"5049_CR11","unstructured":"Cimons M: FDA plans safety reviews of several medical devices. Los Angeles Times, April 28, 1992, A-14"},{"key":"5049_CR12","unstructured":"Cunningham B: Update on situation of breast implants in the U.S. Presented at EQUAM\u2019s 3rd Consensus Conference, Regensburg, Germany, 1998"},{"key":"5049_CR13","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/00006534-199705000-00022","volume":"5","author":"DM Deapen","year":"1997","unstructured":"Deapen DM, Bestein L, Brody GS: Are breast implants anticarcinogenic? A 14-year\u2013follow-up of the Los Angeles Study. Plast Reconst Surg 5:1346\u20131353, 1997","journal-title":"Plast Reconst Surg"},{"key":"5049_CR14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jaut.2004.03.005","volume":"23","author":"W Dolores","year":"2004","unstructured":"Dolores W, Rainer C, Niederegger H, Piza H, Wick G: Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions. J Autoimmunity 23:81\u201391, 2004","journal-title":"J Autoimmunity"},{"key":"5049_CR15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s002669900268","volume":"23","author":"M Embrey","year":"1999","unstructured":"Embrey M, Adams EE, Cunningham B, Peters W, Young VL, Carlo GL: A review of the literature on the aetiology of capsular contracture and a pilot study to determine the outcome of capsular contracture interventions. Aesth Plast Surg 23:197\u2013206, 1999","journal-title":"Aesth Plast Surg"},{"key":"5049_CR16","unstructured":"European Commission: Guidelines for conformity assessment of breast implants according to directive, 93\/42\/EEC relating to medical devices. European Commission. Directorate\u2014General III Industry, Brussels, July 1998"},{"key":"5049_CR17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s002660010108","volume":"25","author":"J Frangou","year":"2001","unstructured":"Frangou J, Kanellaki M: The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: An experimental study in mice. Aesth Plast Surg 25:118\u2013128, 2001","journal-title":"Aesth Plast Surg"},{"key":"5049_CR18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199703063361001","volume":"336","author":"SE Gabriel","year":"1997","unstructured":"Gabriel SE, et al.: Complications leading to surgery after breast implantation. N Engl J Med 336:677\u2013682, 1997","journal-title":"N Engl J Med"},{"key":"5049_CR19","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0142-9612(99)00008-3","volume":"20","author":"PC Gerszten","year":"1999","unstructured":"Gerszten PC: A formal risk assessment of silicone breast implants. Biomaterial 20:1063\u20131069, 1999","journal-title":"Biomaterial"},{"key":"5049_CR20","unstructured":"Grigg M, Bondurand S, Ernster VL, Herdman R: Information for women about the safety of silicone breast implants. Report of the Institute of Medicine, Washington DC, June 1999"},{"key":"5049_CR21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00006534-199008000-00010","volume":"86","author":"L Gylbert","year":"1990","unstructured":"Gylbert L, Asplund O, Jurell G: Capsular contracture after breast reconstruction with silicone- and saline-filled implants: A 6-year follow-up. Plast Reconstr Surg 86:809\u2013811, 1990","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR22","unstructured":"Heppleston AG, Styles JA, cited by Carr I: The macrophage. Academic Press: London, 1973,84"},{"key":"5049_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0002-9343(98)00358-1","volume":"106","author":"EW Karlson","year":"1999","unstructured":"Karlson EW, Hankinson SE, Liang MH, Sanchez-Guerrero J, Colditz GA, Rosenau BJ, et al.: Association of silicone breast implants with immunologic abnormalities: A prospective study. Am J Med 106:11\u201319, 1999","journal-title":"Am J Med"},{"key":"5049_CR24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2741\/A305","volume":"3","author":"W Knudson","year":"1998","unstructured":"Knudson W: The role of CD44 as a cell surface hyaluronan receptor during tumor invasion and metastasis. Frontiers Biosci 3:604\u2013615, 1998","journal-title":"Frontiers Biosci"},{"key":"5049_CR25","doi-asserted-by":"crossref","first-page":"32539","DOI":"10.1074\/jbc.272.51.32539","volume":"272","author":"K Kumari","year":"1997","unstructured":"Kumari K, Weigel PH: Molecular cloning, expression, and characterization of the authentic hyaluronan synthase form group C Streptococcus equisimilis. J Biol Chem 272:32539\u201332546, 1997","journal-title":"J Biol Chem"},{"key":"5049_CR26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/00006534-199306000-00014","volume":"91","author":"C Lossing","year":"1993","unstructured":"Lossing C, Hansson H-A: Peptide growth factors and myofibroblasts in capsules around human breast implants. Plast Reconstr Surg 91:1277, 1993","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR27","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/S0021-9258(18)69812-6","volume":"234","author":"M Markovitz","year":"1959","unstructured":"Markovitz M, Cifonelli JA, Dorfman A: The biosynthesis of hyaluronic acid by group A streptococcus: VI. Biosynthesis from uridine nucleotides in cell-free extracts. J Biol Chem 234:2342\u20132350, 1959","journal-title":"J Biol Chem"},{"key":"5049_CR28","unstructured":"Martin-Moreno J, Gorgojo L, Gonzales J, Wiesbaum W: Draft final report study: Health Risk Posed by Silicone Implants in General With a Special Attention to Breast Implants. European Commission Directorate General III Industry, Brussels, March 2000"},{"key":"5049_CR29","unstructured":"Maxwell GP, Lugston PA: Management of complications following augmentation mammaplasty. In: Georgeade GS, Riefkohl R, Levin LS (eds) Georgeade plastic, maxillofacial and reconstructive surgery. 3rd ed. Williams & Wilkins: Baltimore, MD, 1997"},{"key":"5049_CR30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0021-9258(18)75338-6","volume":"107","author":"K Meyer","year":"1934","unstructured":"Meyer K, Palmer JW: The polysaccharide of the vitreous humor. J Biol Chem 107:629\u2013634, 1934","journal-title":"J Biol Chem"},{"key":"5049_CR31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2133.2004.05805.x","volume":"150","author":"BA Neudecker","year":"2004","unstructured":"Neudecker BA, Stern R, Connolly MK: Aberrant serum hyaluronan and hyaluronidase levels in scleroderma. Br J Dermatol 150:469\u2013476, 2004","journal-title":"Br J Dermatol"},{"key":"5049_CR32","unstructured":"Olivari N: Infection and capsular fibrosis. ISAPS 2004 postgraduate course, Berlin, March 2004"},{"key":"5049_CR33","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/eji.1830250228","volume":"25","author":"A Perschl","year":"1995","unstructured":"Perschl A, Lesley J, English N, Trowbridge I, Hyman R: Role of CD44 cytoplasmic domain in hyaluronan binding. Eur J Immunol 25:495\u2013501, 1995","journal-title":"Eur J Immunol"},{"key":"5049_CR34","first-page":"3","volume":"34","author":"WJ Peters","year":"1995","unstructured":"Peters WJ, Smith D, Lugowsky S: Failure properties of 352 explanted silicone implants: A report of 300 patients. Ann Plast Surg 34:3\u20136, 1995","journal-title":"Ann Plast Surg"},{"key":"5049_CR35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s002660010102","volume":"25","author":"J Planas","year":"2001","unstructured":"Planas J, Cervelli V, Planas G: Five-year experience on ultrasonic treatment of breast contractures. Aesth Plast Surg 25:89\u201393, 2001","journal-title":"Aesth Plast Surg"},{"key":"5049_CR36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/07357900009031831","volume":"18","author":"CL Puckett","year":"2000","unstructured":"Puckett CL: On the safety of silicone gel implants. Cancer Invest 18:278\u2013280, 2000","journal-title":"Cancer Invest"},{"key":"5049_CR37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2307\/3579625","volume":"147","author":"D Rosenbaum","year":"1997","unstructured":"Rosenbaum D, Peric S, Holecek M, Ward HE: Hyaluronan in radiation-induced lung disease in the rat. Radiat Res 147:585, 1997","journal-title":"Radiat Res"},{"key":"5049_CR38","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1182\/blood.V90.6.2217","volume":"90","author":"R Schmits","year":"1997","unstructured":"Schmits R, et al.: CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90:2217\u20132223, 1997","journal-title":"Blood"},{"key":"5049_CR39","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1096\/fasebj.6.9.1612287","volume":"6","author":"JE Scott","year":"1992","unstructured":"Scott JE: Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues. FASEB J 6:2639\u20132645, 1992","journal-title":"FASEB J"},{"key":"5049_CR40","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00006534-198607000-00018","volume":"78","author":"TJ Sergott","year":"1986","unstructured":"Sergott TJ, Limoli JP, Baldwin CM, Laub DR: human adjuvant disease, possible autoimmune disease after silicone implantation. Plast Reconstr Surg 78:104\u2013111, 1986","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR41","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0142-9612(02)00429-5","volume":"24","author":"W Siggelkow","year":"2003","unstructured":"Siggelkow W, Faridi A, Spiritus K, et al: Histological analysis of silicone breast implant capsules and correlation with capsular contracture. Biomaterials 24:1101, 2003","journal-title":"Biomaterials"},{"key":"5049_CR42","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1034\/j.1600-0609.2002.01617.x","volume":"68","author":"G Sundstrom","year":"2002","unstructured":"Sundstrom G, Lofvenberg E, Hassan I, Engstrom-Laurent A: Localisation and distribution of hyaluronan in normal bone marrow matrix: A novel method to evaluate impending fibrosis? Eur J Haematol 68:194, 2002","journal-title":"Eur J Haematol"},{"key":"5049_CR43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00266-004-3118-2","volume":"28","author":"S Takayanagi","year":"2004","unstructured":"Takayanagi S, Nakagawa C, Sugimoto Y: Augmentation mammaplasty: Where should the implant be placed? Aesth Plast Surg 28:83\u201388, 2004","journal-title":"Aesth Plast Surg"},{"key":"5049_CR44","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.3748\/wjg.v9.i11.2497","volume":"9","author":"J Tao","year":"2003","unstructured":"Tao J, Peng HQ, Cai WM, Dong FQ, Weng HL, Liu RH: Influence factors of serum fibrosis markers in liver fibrosis. World J Gastroenterol 9:2497\u20132500, 2003","journal-title":"World J Gastroenterol"},{"key":"5049_CR45","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(96)07131-0","volume":"349","author":"SA Tenenbaum","year":"1997","unstructured":"Tenenbaum SA, Rice JC, Espinoza LR, Cu\u00e8llar ML, Plymale DR, Sander DM, et al.: Use of antipolymer antibody assay in recipients of silicone breast implants. Lancet 349:449\u2013454, 1997","journal-title":"Lancet"},{"key":"5049_CR46","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/1529-0131(200111)44:11<2477::AID-ART427>3.0.CO;2-Q","volume":"44","author":"P Tugwell","year":"2001","unstructured":"Tugwell P, Wells G, Peterson J, Welch V, Page J, Davison C, et al.: Do silicone breast implants cause rheumatologic disorders? A systemic review for a court-appointed national science panel. Arthritis Rheum 44:2477\u20132484, 2001","journal-title":"Arthritis Rheum"},{"key":"5049_CR47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1523-1747.ep12319402","volume":"109","author":"A-L Tuhkanen","year":"1997","unstructured":"Tuhkanen A-L, Tammi M, Tammi R: CD44 substituted with heparan sulfate and endo-beta-galactosidase-sensitive oligosaccharides: A major proteoglycan in adult human epidermis. J Invest Dermatol 109:213\u2013218, 1997","journal-title":"J Invest Dermatol"},{"key":"5049_CR48","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0305-4179(02)00193-6","volume":"28","author":"D Ulrich","year":"2002","unstructured":"Ulrich D, Noah EM, Burchardt ER, Atkins D, Pallua N: Serum concentration of aminoterminal propeptide of type III procollagen (PIIINP) as a prognostic marker of skin fibrosis after scar correction in burned patients. Burns 28:766, 2002","journal-title":"Burns"},{"key":"5049_CR49","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1097\/01.PRS.0000049450.95669.07","volume":"111","author":"D Ulrich","year":"2003","unstructured":"Ulrich D, Noah EM, von Heimburg D, Pallua N: TIMP-1, MMP-2, -9, and PIIINP as serum markers for skin fibrosis in patients following severe burn trauma. Plast Reconstr Surg 111:1423, 2003","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01575494","volume":"11","author":"B Vasquez","year":"1987","unstructured":"Vasquez B, Given KS, Housten GC: Breast augmentation: Review of subglandular and submascular implantation. Aesth Plast Surg 11:101\u2013105, 1987","journal-title":"Aesth Plast Surg"},{"key":"5049_CR51","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/ja01636a010","volume":"76","author":"B Weissmann","year":"1954","unstructured":"Weissmann B, Meyer K: The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc 76:1753\u20131757, 1954","journal-title":"J Am Chem Soc"},{"key":"5049_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000637-199407000-00001","volume":"33","author":"AF Wells","year":"1994","unstructured":"Wells AF, Daniels S, Gunasekaran S, Wells KE: Local increase in hyaluronic acid and interleukin-2 in the capsules surrounding silicone breast implants. Ann Plast Surg 33:1\u20135, 1994","journal-title":"Ann Plast Surg"},{"key":"5049_CR53","doi-asserted-by":"crossref","unstructured":"Wick G, Wagner R, Klima G, Wilfingseder P: Immunohistochemical analysis of the connective tissue capsule formation and constriction around mammary silicone prostheses. In: Kano K, Mori S, Sugisaki T, Torisu M (ed) Cellular, molecular, and genetic approaches to immunodiagnosis and immunotherapy. University of Tokyo Press. pp. 231\u2013241, 1987","DOI":"10.1159\/000415043"},{"key":"5049_CR54","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/adc.86.3.190","volume":"86","author":"HA Wyatt","year":"2002","unstructured":"Wyatt HA, Dhawan A, Cheeseman P, Mieli-Vergani G, Price JF: Serum hyaluronic acid concentrations are increased in cystic fibrosis patients with liver disease. Arch Dis Child 86:190\u2013193, 2002","journal-title":"Arch Dis Child"},{"key":"5049_CR55","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1097\/00006534-199811000-00017","volume":"102","author":"E Wyatt Lance","year":"1998","unstructured":"Wyatt Lance E, Sinow J, Wollman JS, Sami DABS, Miller TA: The influence of time on human breast capsule histology: Smooth and textured silicone-surfaced implants. Plast Reconstr Surg 102:1922\u20131931, 1998","journal-title":"Plast Reconstr Surg"},{"key":"5049_CR56","first-page":"69","volume":"2","author":"SB Xie","year":"2003","unstructured":"Xie SB, Yao JL, Zheng RQ, Peng XM, Gao ZL: Serum hyaluronic acid, procollagen type III and IV in histological diagnosis of liver fibrosis. Hepatobiliary Pancreat Dis Int 2:69\u201372, 2003","journal-title":"Hepatobiliary Pancreat Dis Int"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-005-5049-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00266-005-5049-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-005-5049-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T13:37:03Z","timestamp":1683293823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00266-005-5049-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,16]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["5049"],"URL":"https:\/\/doi.org\/10.1007\/s00266-005-5049-y","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,16]]}}}