{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:32:39Z","timestamp":1791091959577,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T00:00:00Z","timestamp":1272931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s00266-010-9519-5","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T20:45:10Z","timestamp":1272919510000},"page":"603-611","source":"Crossref","is-referenced-by-count":26,"title":["Mechanotransduction: The Missing Link in the Facial Aging Puzzle?"],"prefix":"10.1007","volume":"34","author":[{"given":"Safa E.","family":"Sharabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Hatef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Larry H.","family":"Hollier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yaremchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,4]]},"reference":[{"key":"9519_CR1","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1097\/01.prs.0000279348.09156.c3","volume":"120","author":"V Lambros","year":"2007","unstructured":"Lambros V (2007) Observations on periorbital and midface aging. Plast Reconstr Surg 120:1367","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1136\/bjo.83.3.347","volume":"83","author":"WA Bosch Van den","year":"1999","unstructured":"Van den Bosch WA, Leenders I, Mulder P (1999) Topographic anatomy of the eyelids, and the effects of sex and age. Br J Ophthalmol 83:347","journal-title":"Br J Ophthalmol"},{"key":"9519_CR3","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/00006534-200209010-00025","volume":"110","author":"AR Muzaffar","year":"2002","unstructured":"Muzaffar AR, Mendelson BC, Adams WP (2002) Surgical anatomy of the ligamentous attachments of the lower lid and lateral canthus. Plast Reconstr Surg 110:873","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/00006534-199401000-00010","volume":"93","author":"NJ Yousif","year":"1994","unstructured":"Yousif NJ, Gosain A, Sanger JR, Larson DL, Matloub HS (1994) The nasolabial fold: a photogrammetric analysis. Plast Reconstr Surg 93:70","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/00006534-199802000-00037","volume":"101","author":"JE Pessa","year":"1998","unstructured":"Pessa JE, Garza PA, Love VM, Zadoo VP, Garza JR (1998) The anatomy of the labiomandibular fold. Plast Reconstr Surg 101:482","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00006534-196508000-00013","volume":"36","author":"M Gonzalez-Ulloa","year":"1965","unstructured":"Gonzalez-Ulloa M, Flores ES (1965) Senility of the face: basic study to understand its causes and effects. Plast Reconstr Surg 36:239","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR7","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1097\/PRS.0b013e31819c4d42","volume":"123","author":"B Guyuron","year":"2009","unstructured":"Guyuron B, Rowe DJ, Weinfeld AB, Eshraghi Y, Fathi A, Iamphongsai S (2009) Factors contributing to the facial aging of identical twins. Plast Reconstr Surg 123:1321","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/00006534-200202000-00051","volume":"109","author":"JE Pessa","year":"2002","unstructured":"Pessa JE, Chen Y (2002) Curve analysis of the aging orbital aperture. Plast Reconstr Surg 109:751","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR9","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.asj.2008.02.007","volume":"28","author":"DM Kahn","year":"2008","unstructured":"Kahn DM, Shaw RB (2008) Aging of the bony orbit: a three-dimensional computed tomography study. Aesth Surg J 28:258","journal-title":"Aesth Surg J"},{"key":"9519_CR10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/00006534-199210000-00007","volume":"90","author":"SP Barlett","year":"1992","unstructured":"Barlett SP, Grossman R, Whitaker LA (1992) Age-related changes of the craniofacial skeleton: an anthropometric and histological analysis. Plast Reconstr Surg 90:592","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/00006534-199807000-00034","volume":"102","author":"JE Pessa","year":"1998","unstructured":"Pessa JE, Zadoo VP, Mutimer KL et al (1998) Relative maxillary retrusion as a natural consequence of aging: combining skeletal and soft-tissue changes into an integrated model of midfacial aging. Plast Reconstr Surg 102:205","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR12","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/00006534-200008000-00036","volume":"106","author":"VP Zadoo","year":"2000","unstructured":"Zadoo VP, Pessa JE (2000) Biological arches and changes to the curvilinear form of the aging maxilla. Plast Reconstr Surg 106:460","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR13","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1097\/00006534-200008000-00040","volume":"106","author":"JE Pessa","year":"2000","unstructured":"Pessa JE (2000) An algorithm of facial aging: verification of Lambros\u2019s theory by three-dimensional stereolithography, with reference to the pathogenesis of midfacial aging, scleral show, and the lateral suborbital trough deformity. Plast Reconstr Surg 106:479","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1067\/mod.2001.110984","volume":"119","author":"JE Pessa","year":"2001","unstructured":"Pessa JE (2001) The potential role of stereolithography in the study of facial aging. Am J Orthod Dentofac Orthop 119:117","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"9519_CR15","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00266-006-0120-x","volume":"31","author":"BC Mendelson","year":"2007","unstructured":"Mendelson BC, Hartley W, Scott M, McNab A, Granzow JW (2007) Age-related changes of the orbit and midcheek and the implications for facial rejuvenation. Aesth Plast Surg 31:419","journal-title":"Aesth Plast Surg"},{"key":"9519_CR16","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/01.prs.0000246596.79795.a8","volume":"119","author":"RB Shaw","year":"2007","unstructured":"Shaw RB, Kahn DM (2007) Aging of the midface bony elements: a three-dimensional computed tomographic study. Plast Reconstr Surg 119:675","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/01.prs.0000293864.94138.ae","volume":"121","author":"JE Pessa","year":"2008","unstructured":"Pessa JE, Slice DE, Hanz KR, Broadbend TH, Rohrich RJ (2008) Aging and the shape of the mandible. Plast Reconstr Surg 121:196","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S0889-5406(97)70267-1","volume":"112","author":"ML Moss","year":"1997","unstructured":"Moss ML (1997) The functional matrix hypothesis revisited: 1. The role of mechanotransduction. Am J Orthod Dentofac Orthop 112:8","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"9519_CR19","unstructured":"Shaw RB, Katzel E, Koltz P, Kahn DM, Girotto JA, Langstein HN (2008) Aging of the mandible and its aesthetic implications: a three dimensional CT study (Abstract). Presented at the 88th annual meeting of the American Association of Plastic Surgeons, Rancho Mirage, CA, 21\u201324 March 2008"},{"key":"9519_CR20","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/00001665-200403000-00027","volume":"15","author":"LG Farkas","year":"2004","unstructured":"Farkas LG, Eiben OG, Sivkov S, Tompson B, Katic MJ, Forrest CR (2004) Anthropometric measurements of the facial framework in adulthood: age-related changes in eight age categories in 600 healthy white North Americans of European ancestry from 16 to 90\u00a0years of age. J Craniofac Surg 15:288","journal-title":"J Craniofac Surg"},{"key":"9519_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s002669900275","volume":"23","author":"JE Pessa","year":"1999","unstructured":"Pessa JE, Desvigne LD, Zadoo VP (1999) The effect of skeletal remodeling on the nasal profile: considerations for rhinoplasty in the older patient. Aesth Plast Surg 23:239","journal-title":"Aesth Plast Surg"},{"key":"9519_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00266-003-2112-4","volume":"7","author":"RA Levine","year":"2003","unstructured":"Levine RA, Garza JR, Wang PT, Hurst CL, Dev VR (2003) Adult facial growth: application to aesthetic surgery. Aesth Plast Surg 7:265","journal-title":"Aesth Plast Surg"},{"key":"9519_CR23","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/01.prs.0000294951.48009.e2","volume":"121","author":"RA Levine","year":"2008","unstructured":"Levine RA (2008) Aging of the midface bony elements (letter). Plast Reconstr Surg 121:698","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR24","first-page":"699","volume":"121","author":"JE Pessa","year":"2008","unstructured":"Pessa JE (2008) Aging of the midface bony elements (reply). Plast Reconstr Surg 121:699","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR25","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/00006534-200008000-00041","volume":"106","author":"V Lambros","year":"2000","unstructured":"Lambros V (2000) An algorithm of facial aging: verification of Lambros\u2019s theory by three-dimensional stereolithography, with reference to the pathogenesis of midfacial aging, scleral show, and the lateral suborbital trough deformity (discussion). Plast Reconstr Surg 106:489","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/00220345830620051201","volume":"62","author":"WR Proffit","year":"1983","unstructured":"Proffit WR, Fields HW, Nixon WL (1983) Occlusal forces in normal and long-face adults. J Dent Res 62:566","journal-title":"J Dent Res"},{"key":"9519_CR27","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1097\/00006534-199811000-00014","volume":"102","author":"NK Sinsel","year":"1998","unstructured":"Sinsel NK, Opdebeeck H, Guelinckx PJ (1998) The effect of unilateral partial facial paralysis and muscle ablation on craniofacial growth and development: an experimental study in the rabbit. Plast Reconstr Surg 102:1894","journal-title":"Plast Reconstr Surg"},{"key":"9519_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jss.2006.09.003","volume":"139","author":"DB Matic","year":"2007","unstructured":"Matic DB, Yazdani A, Wells RG, Lee TY, Gan BS (2007) The effects of masseter muscle paralysis on facial bone growth. J Surg Res 139:243","journal-title":"J Surg Res"},{"key":"9519_CR29","unstructured":"Instrum SM (1999) Cephalometric comparison of the craniofacial skeletal morphology between mobius syndrome and nonsyndromic controls. Dissertation from the University of Toronto, National Library of Canada"},{"key":"9519_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1203\/00006450-199408000-00020","volume":"36","author":"K Houston","year":"1994","unstructured":"Houston K, Buschang PH, Iannaccone ST, Seale NS (1994) Craniofacial morphology of spinal muscular atrophy. Pediatr Res 36:265","journal-title":"Pediatr Res"},{"key":"9519_CR31","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1597\/1545-1569(1992)029<0456:CDIMD>2.3.CO;2","volume":"29","author":"RN Staley","year":"1992","unstructured":"Staley RN, Bishara SE, Hanson JW, Nowak AJ (1992) Craniofacial development in myotonic dystrophy. Cleft Palate Craniofac J 29:456","journal-title":"Cleft Palate Craniofac J"},{"key":"9519_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/BF01556727","volume":"18","author":"ML Moss","year":"1968","unstructured":"Moss ML (1968) A theoretical analysis of the functional matrix. Acta Biotheor 18:195","journal-title":"Acta Biotheor"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-010-9519-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00266-010-9519-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-010-9519-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-010-9519-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T21:39:39Z","timestamp":1581975579000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00266-010-9519-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,4]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["9519"],"URL":"https:\/\/doi.org\/10.1007\/s00266-010-9519-5","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,4]]}}}