{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:08:06Z","timestamp":1789510086463,"version":"build-2803163510"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00266-018-01303-3","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T11:50:32Z","timestamp":1547034632000},"page":"480-489","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Managing Pathologic Scars by Injecting Auto-Cross-linked Hyaluronic Acid: A Preliminary Prospective Clinical Study"],"prefix":"10.1007","volume":"43","author":[{"given":"Michele","family":"Riccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marchesini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Senesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edlira","family":"Skrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Gesuita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-7828","authenticated-orcid":false,"given":"Francesco","family":"De Francesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"issue":"2","key":"1303_CR1","first-page":"152","volume":"33","author":"EE Tredget","year":"1994","unstructured":"Tredget EE (1994) The molecular biology of fibroproliferative disorders of the skin: potential cytokine therapeutics. Ann Plast Surg 33(2):152\u2013154","journal-title":"Ann Plast Surg"},{"issue":"1","key":"1303_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0738-081X(94)90254-2","volume":"12","author":"JC Murray","year":"1994","unstructured":"Murray JC (1994) Keloids and hypertrophic scars. Clin Dermatol 12(1):27\u201337","journal-title":"Clin Dermatol"},{"issue":"3","key":"1303_CR3","first-page":"253","volume":"80","author":"G Juckett","year":"2009","unstructured":"Juckett G, Hartman-Adams H (2009) Management of keloids and hypertrophic scars. Am Fam Physician 80(3):253\u2013260","journal-title":"Am Fam Physician"},{"issue":"6","key":"1303_CR4","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1097\/SAP.0b013e31817e9d67","volume":"62","author":"R Ogawa","year":"2009","unstructured":"Ogawa R, Akaishi S, Hyakusoku H (2009) Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg 62(6):660\u2013664","journal-title":"Ann Plast Surg"},{"issue":"1","key":"1303_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/SAP.0b013e3181855172","volume":"62","author":"R Ogawa","year":"2009","unstructured":"Ogawa R, Akaishi S, Izumi M (2009) Histologic analysis of keloids and hypertrophic scars. Ann Plast Surg 62(1):104\u2013105","journal-title":"Ann Plast Surg"},{"issue":"7 Suppl","key":"1303_CR6","doi-asserted-by":"publisher","first-page":"12S","DOI":"10.1097\/01.prs.0000225430.42531.c2","volume":"117","author":"G Broughton 2nd","year":"2006","unstructured":"Broughton G 2nd, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117(7 Suppl):12S\u201334S","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"1303_CR7","first-page":"31","volume":"26","author":"S Enoch","year":"2008","unstructured":"Enoch S, Leaper DJ (2008) Basic science of wound healing. Surgery 26(2):31\u201337","journal-title":"Surgery"},{"issue":"2","key":"1303_CR8","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/bjd.13954","volume":"173","author":"P Martin","year":"2015","unstructured":"Martin P, Nunan R (2015) Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol 173(2):370\u2013378","journal-title":"Br J Dermatol"},{"issue":"1\u20132","key":"1303_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000454919","volume":"58","author":"H Sorg","year":"2017","unstructured":"Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U (2017) Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 58(1\u20132):81\u201394","journal-title":"Eur Surg Res"},{"issue":"7","key":"1303_CR10","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1074\/jbc.R100064200","volume":"277","author":"J McDonald","year":"2002","unstructured":"McDonald J, Hascall VC (2002) Hyaluronan minireview series. J Biol Chem 277(7):4575\u20134579","journal-title":"J Biol Chem"},{"issue":"5","key":"1303_CR11","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0039-6109(16)41631-2","volume":"58","author":"JE Dunphy","year":"1978","unstructured":"Dunphy JE (1978) Wound healing. Surg Clin North Am 58(5):907\u2013916","journal-title":"Surg Clin North Am"},{"issue":"5","key":"1303_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3(5):349\u2013363","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"40","key":"1303_CR13","doi-asserted-by":"publisher","first-page":"41453","DOI":"10.1074\/jbc.M401678200","volume":"279","author":"RH Jenkins","year":"2004","unstructured":"Jenkins RH, Thomas GJ, Williams JD, Steadman R (2004) Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover. J Biol Chem 279(40):41453\u201341460","journal-title":"J Biol Chem"},{"issue":"1","key":"1303_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijpharm.2011.08.031","volume":"420","author":"EL Ferguson","year":"2011","unstructured":"Ferguson EL, Roberts JL, Moseley R, Griffiths PC, Thomas DW (2011) Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. Int J Pharm 420(1):84\u201392","journal-title":"Int J Pharm"},{"issue":"8","key":"1303_CR15","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1038\/jid.2009.9","volume":"129","author":"J Monslow","year":"2009","unstructured":"Monslow J, Sato N, Mack JA, Maytin EV (2009) Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR. J Invest Dermatol 129(8):2046\u20132058","journal-title":"J Invest Dermatol"},{"issue":"5","key":"1303_CR16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1046\/j.1523-1747.2000.00950.x","volume":"114","author":"LJ Meyer","year":"2000","unstructured":"Meyer LJ, Russell SB, Russell JD, Trupin JS, Egbert BM, Shuster S, Stern R (2000) Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts. J Invest Dermatol. 114(5):953\u2013959","journal-title":"J Invest Dermatol."},{"issue":"5","key":"1303_CR17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/exd.12147","volume":"22","author":"GP Sidgwick","year":"2013","unstructured":"Sidgwick GP, Iqbal SA, Bayat A (2013) Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin. Exp Dermatol 22(5):377\u2013379","journal-title":"Exp Dermatol"},{"issue":"7","key":"1303_CR18","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/0007-1226(94)90031-0","volume":"47","author":"U Bertheim","year":"1994","unstructured":"Bertheim U, Hellstr\u00f6m S (1994) The distribution of hyaluronan in human skin and mature, hypertrophic and keloid scars. Br J Plast Surg 47(7):483\u2013489","journal-title":"Br J Plast Surg"},{"issue":"2","key":"1303_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1272\/jnms.78.68","volume":"78","author":"R Ogawa","year":"2011","unstructured":"Ogawa R, Akaishi S, Huang C, Dohi T, Aoki M, Omori Y, Koike S, Kobe K, Akimoto M, Hyakusoku H (2011) Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial\/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction. J Nippon Med Sch 78(2):68\u201376","journal-title":"J Nippon Med Sch"},{"issue":"6","key":"1303_CR20","doi-asserted-by":"publisher","first-page":"e167","DOI":"10.1016\/j.bjps.2014.03.017","volume":"67","author":"M Moio","year":"2014","unstructured":"Moio M, Mataro I, Accardo G, Canta L, Schonauer F (2014) Treatment of hypergranulation tissue with intralesional injection of corticosteroids: preliminary results. J Plast Reconstr Aesthet Surg 67(6):e167\u2013e168","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"3","key":"1303_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/1534734608320786","volume":"7","author":"C Roques","year":"2008","unstructured":"Roques C, T\u00e9ot L (2008) The use of corticosteroids to treat keloids: a review. Int J Low Extrem Wounds 7(3):137\u2013145","journal-title":"Int J Low Extrem Wounds"},{"issue":"5","key":"1303_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.brachy.2014.01.005","volume":"13","author":"L Cicco De","year":"2014","unstructured":"De Cicco L, Vischioni B, Vavassori A, Gherardi F, Jereczek-Fossa BA, Lazzari R, Cattani F, Comi S, De Lorenzi F, Martella S, Orecchia R (2014) Postoperative management of keloids: low-dose-rate and high-dose-rate brachytherapy. Brachytherapy 13(5):508\u2013513","journal-title":"Brachytherapy"},{"issue":"5","key":"1303_CR23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00004630-199509000-00002","volume":"16","author":"P Chang","year":"1995","unstructured":"Chang P, Laubenthal KN, Lewis RW 2nd, Rosenquist MD, Lindley-Smith P, Kealey GP (1995) Prospective, randomized study of the efficacy of pressure garment therapy in patients with burns. J Burn Care Rehabil 16(5):473\u2013475","journal-title":"J Burn Care Rehabil"},{"issue":"5","key":"1303_CR24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.12968\/jowc.2006.15.5.26913","volume":"15","author":"JI Maj\u00e1n","year":"2006","unstructured":"Maj\u00e1n JI (2006) Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars. J Wound Care 15(5):193\u2013196","journal-title":"J Wound Care"},{"issue":"9","key":"1303_CR25","first-page":"1003","volume":"64","author":"MA Khan","year":"2014","unstructured":"Khan MA, Bashir MM, Khan FA (2014) Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. J Pak Med Assoc 64(9):1003\u20131007","journal-title":"J Pak Med Assoc"},{"issue":"2","key":"1303_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1001\/jamafacial.2014.1355","volume":"17","author":"W Carroll","year":"2015","unstructured":"Carroll W, Patel K (2015) Steroids and fluorouracil for keloids and hypertrophic scars. JAMA Facial Plast Surg 17(2):77\u201379","journal-title":"JAMA Facial Plast Surg"},{"issue":"1","key":"1303_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/PRS.0b013e3181904d1b","volume":"123","author":"MJ Haurani","year":"2009","unstructured":"Haurani MJ, Foreman K, Yang JJ, Siddiqui A (2009) 5-Fluorouracil treatment of problematic scars. Plast Reconstr Surg 123(1):139\u2013148","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"1303_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/jocd.12132","volume":"14","author":"K Payapvipapong","year":"2015","unstructured":"Payapvipapong K, Niumpradit N, Piriyanand C, Buranaphalin S, Nakakes A (2015) The treatment of keloids and hypertrophic scars with intralesional bleomycin in skin of color. J Cosmet Dermatol 14(1):83\u201390","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"1303_CR29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/iwj.12455","volume":"13","author":"R Wang","year":"2016","unstructured":"Wang R, Mao Y, Zhang Z, Li Z, Chen J, Cen Y (2016) Role of verapamil in preventing and treating hypertrophic scars and keloids. Int Wound J. 13(4):461\u2013468","journal-title":"Int Wound J."},{"issue":"5","key":"1303_CR30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.burns.2013.12.017","volume":"40","author":"MP Brewin","year":"2014","unstructured":"Brewin MP, Lister TS (2014) Prevention or treatment of hypertrophic burn scarring: a review of when and how to treat with the pulsed dye laser. Burns 40(5):797\u2013804","journal-title":"Burns"},{"issue":"3","key":"1303_CR31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s10103-012-1178-0","volume":"28","author":"G Nicoletti","year":"2013","unstructured":"Nicoletti G, De Francesco F, Mele CM, Cataldo C, Grella R, Brongo S, Accardo M, Ferraro GA, D\u2019Andrea F (2013) Clinical and histologic effects from CO2 laser treatment of keloids. Lasers Med Sci 28(3):957\u2013964","journal-title":"Lasers Med Sci"},{"issue":"5","key":"1303_CR32","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3109\/14764172.2010.514924","volume":"12","author":"L Scrimali","year":"2010","unstructured":"Scrimali L, Lomeo G, Nolfo C, Pompili G, Tamburino S, Catalani A, Sirag\u00f2 P, Perrotta RE (2010) Treatment of hypertrophic scars and keloids with a fractional CO2 laser: a personal experience. J Cosmet Laser Ther 12(5):218\u2013221","journal-title":"J Cosmet Laser Ther"},{"issue":"3","key":"1303_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1590\/abd1806-4841.20131802","volume":"88","author":"FM Camacho-Mart\u00ednez","year":"2013","unstructured":"Camacho-Mart\u00ednez FM, Rey ER, Serrano FC, Wagner A (2013) Results of a combination of bleomycin and triamcinolone acetonide in the treatment of keloids and hypertrophic scars. An Bras Dermatol 88(3):387\u2013394","journal-title":"An Bras Dermatol"},{"issue":"2","key":"1303_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1365-2230.2007.02631.x","volume":"34","author":"A Darougheh","year":"2009","unstructured":"Darougheh A, Asilian A, Shariati F (2009) Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 34(2):219\u2013223","journal-title":"Clin Exp Dermatol"},{"issue":"3","key":"1303_CR35","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3109\/14764172.2013.780448","volume":"15","author":"MS Martin","year":"2013","unstructured":"Martin MS, Collawn SS (2013) Combination treatment of CO2 fractional laser, pulsed dye laser, and triamcinolone acetonide injection for refractory keloid scars on the upper back. J Cosmet Laser Ther 15(3):166\u2013170","journal-title":"J Cosmet Laser Ther"},{"issue":"10","key":"1303_CR36","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1038\/jid.2014.169","volume":"134","author":"S Liu","year":"2014","unstructured":"Liu S, Jiang L, Li H, Shi H, Luo H, Zhang Y, Yu C, Jin Y (2014) Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. J Invest Dermatol 134(10):2648\u20132657","journal-title":"J Invest Dermatol"},{"key":"1303_CR37","doi-asserted-by":"publisher","first-page":"6937976","DOI":"10.1155\/2016\/6937976","volume":"2016","author":"BF Seo","year":"2016","unstructured":"Seo BF, Jung SN (2016) The immunomodulatory effects of mesenchymal stem cells in prevention or treatment of excessive scars. Stem Cells Int 2016:6937976","journal-title":"Stem Cells Int"},{"issue":"3","key":"1303_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/jocd.12212","volume":"15","author":"F Svolacchia","year":"2016","unstructured":"Svolacchia F, De Francesco F, Trovato L, Graziano A, Ferraro GA (2016) An innovative regenerative treatment of scars with dermal micrografts. J Cosmet Dermatol 15(3):245\u2013253","journal-title":"J Cosmet Dermatol"},{"issue":"6","key":"1303_CR39","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s13287-015-0133-y","volume":"18","author":"Q Zhang","year":"2015","unstructured":"Zhang Q, Liu LN, Yong Q, Deng JC, Cao WG (2015) Intralesional injection of adipose-derived stem cells reduces hypertrophic scarring in a rabbit ear model. Stem Cell Res Ther 18(6):145","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"1303_CR40","doi-asserted-by":"publisher","first-page":"374e","DOI":"10.1097\/PRS.0b013e3182590387","volume":"130","author":"S Brongo","year":"2012","unstructured":"Brongo S, Nicoletti GF, La Padula S, Mele CM, D\u02bcAndrea F (2012) Use of lipofilling for the treatment of severe burn outcomes. Plast Reconstr Surg 130(2):374e\u2013376e","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"1303_CR41","first-page":"1377","volume":"23","author":"G Brunelli","year":"2005","unstructured":"Brunelli G, Longinotti C, Bertazzo C, Pavesio A, Pressato D (2005) Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel. J Orthop Res 23(6):1377\u20131382","journal-title":"J Orthop Res"},{"key":"1303_CR42","doi-asserted-by":"publisher","first-page":"783632","DOI":"10.1155\/2014\/783632","volume":"2014","author":"M Abate","year":"2014","unstructured":"Abate M, Schiavone C, Salini V (2014) The use of hyaluronic acid after tendon surgery and in tendinopathies. Biomed Res Int 2014:783632","journal-title":"Biomed Res Int"},{"issue":"4","key":"1303_CR43","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.asj.2004.04.009","volume":"24","author":"SL Matarasso","year":"2004","unstructured":"Matarasso SL (2004) Understanding and using hyaluronic acid. Aesthet Surg J 24(4):361\u2013364","journal-title":"Aesthet Surg J"},{"key":"1303_CR44","doi-asserted-by":"crossref","unstructured":"Tezel A, Fredrickson GH (2008) The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther 10(1):35\u201342. Erratum in: J Cosmet Laser Ther. 2014 16(1):45","DOI":"10.1080\/14764170701774901"},{"issue":"433","key":"1303_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.carres.2016.07.013","volume":"4","author":"S Pluda","year":"2016","unstructured":"Pluda S, Pavan M, Galesso D, Guarise C (2016) Hyaluronic acid auto-crosslinked polymer (ACP): reaction monitoring, process investigation and hyaluronidase stability. Carbohydr Res 4(433):47\u201353","journal-title":"Carbohydr Res"},{"issue":"3","key":"1303_CR46","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/jor.20730","volume":"27","author":"T Wit de","year":"2009","unstructured":"de Wit T, de Putter D, Tra WM, Rakhorst HA, van Osch GJ, Hovius SE, van Neck JW (2009) Auto-crosslinked hyaluronic acid gel accelerates healing of rabbit flexor tendons in vivo. J Orthop Res 27(3):408\u2013415","journal-title":"J Orthop Res"},{"issue":"2","key":"1303_CR47","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1006\/jsre.2001.6248","volume":"100","author":"C Belluco","year":"2001","unstructured":"Belluco C, Meggiolaro F, Pressato D, Pavesio A, Bigon E, Don\u00e0 M, Forlin M, Nitti D, Lise M (2001) Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel. J Surg Res 100(2):217\u2013221","journal-title":"J Surg Res"},{"issue":"6","key":"1303_CR48","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/humrep\/deh238","volume":"19","author":"M Guida","year":"2004","unstructured":"Guida M, Acunzo G, Di Spiezio Sardo A, Bifulco G, Piccoli R, Pellicano M, Cerrota G, Cirillo D, Nappi C (2004) Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod 19(6):1461\u20131464","journal-title":"Hum Reprod"},{"issue":"4","key":"1303_CR49","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3171\/jns.2004.101.4.0648","volume":"101","author":"X Smit","year":"2004","unstructured":"Smit X, van Neck JW, Afoke A, Hovius SE (2004) Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study. J Neurosurg 101(4):648\u2013652","journal-title":"J Neurosurg"},{"issue":"1","key":"1303_CR50","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/micr.20299","volume":"27","author":"A Atzei","year":"2007","unstructured":"Atzei A, Calcagni M, Breda B, Fasolo G, Pajardi G, Cugola L (2007) Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand. Microsurgery 27(1):2\u20137","journal-title":"Microsurgery"},{"issue":"2","key":"1303_CR51","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1177\/1753193409342044","volume":"35","author":"Riccio M, Battiston B, Pajardi G, Corradi M, Passaretti U, Atzei A, Altissimi M, Vaienti L, Catalano F, Del Bene M, Fasolo P, Ceruso M, Luchetti R, Landi A; Study Group on Tendon Adhesion of Italian Society of Hand Surgery","year":"2010","unstructured":"Riccio M, Battiston B, Pajardi G, Corradi M, Passaretti U, Atzei A, Altissimi M, Vaienti L, Catalano F, Del Bene M, Fasolo P, Ceruso M, Luchetti R, Landi A; Study Group on Tendon Adhesion of Italian Society of Hand Surgery (2010) Efficiency of hyaloglide in the prevention of the recurrence of adhesions after tenolysis of flexor tendons in zone II: a randomized, controlled, multicentre clinical trial. J Hand Surg Eur 35(2):130\u2013138","journal-title":"J Hand Surg Eur"},{"issue":"2","key":"1303_CR52","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/01.prs.0000227686.95099.58","volume":"118","author":"A Alessandrini","year":"2006","unstructured":"Alessandrini A, Di Bartolo C, Pavesio A, Pressato D (2006) ACP gel: a new hyaluronic acid-based injectable for facial rejuvenation. Preclinical data in a rabbit model. Plast Reconstr Surg 118(2):341\u2013346","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"1303_CR53","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1007\/s00266-017-1022-9","volume":"42","author":"A Alessandrini","year":"2018","unstructured":"Alessandrini A, Tretyakova K (2018) The rejuvenating effect and tolerability of an auto-cross-linked hyaluronic acid on d\u00e9colletage: a pilot prospective study. Aesthetic Plast Surg 42(2):520\u2013529","journal-title":"Aesthetic Plast Surg"},{"issue":"26","key":"1303_CR54","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.1016\/j.biomaterials.2005.01.053","volume":"26","author":"D Renier","year":"2005","unstructured":"Renier D, Bellato P, Bellini D, Pavesio A, Pressato D, Borrione A (2005) Pharmacokinetic behaviour of ACP gel, an autocrosslinked hyaluronan derivative, after intraperitoneal administration. Biomaterials 26(26):5368\u20135374","journal-title":"Biomaterials"},{"issue":"1","key":"1303_CR55","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/jocd.12024","volume":"12","author":"J Wohlrab","year":"2013","unstructured":"Wohlrab J, Wohlrab D, Neubert RH (2013) Comparison of noncross-linked and cross-linked hyaluronic acid with regard to efficacy of the proliferative activity of cutaneous fibroblasts and keratinocytes in vitro. J Cosmet Dermatol 12(1):36\u201340","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"1303_CR56","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/01.prs.0000172982.43599.d6","volume":"116","author":"AL Kar van de","year":"2005","unstructured":"van de Kar AL, Corion LU, Smeulders MJ, Draaijers LJ, van der Horst CM, van Zuijlen PP (2005) Reliable and feasible evaluation of linear scars by the patient and observer scar assessment scale. Plast Reconstr Surg 116(2):514\u2013522","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"1303_CR57","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1097\/01.PRS.0000122207.28773.56","volume":"113","author":"LJ Draaijers","year":"2004","unstructured":"Draaijers LJ, Tempelman FR, Botman YA, Tuinebreijer WE, Middelkoop E, Kreis RW, van Zuijlen PP (2004) The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg 113(7):1960\u20131965","journal-title":"Plast Reconstr Surg"},{"key":"1303_CR58","unstructured":"R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available from \n                    https:\/\/www.R-project.org\/\n                    \n                  . Accessed 19 December 2017"},{"issue":"3","key":"1303_CR59","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/00004630-198805000-00017","volume":"9","author":"L Bell","year":"1988","unstructured":"Bell L, McAdams T, Morgan R, Parshley PF, Pike RC, Riggs P, Carpenter JE (1988) Pruritus in burns: a descriptive study. J Burn Care Rehabil 9(3):305\u2013308","journal-title":"J Burn Care Rehabil"},{"issue":"3","key":"1303_CR60","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cpr.2012.12.006","volume":"33","author":"A Bakker","year":"2013","unstructured":"Bakker A, Maertens KJ, Van Son MJ, Van Loey NE (2013) Psychological consequences of pediatric burns from a child and family perspective: a review of the empirical literature. Clin Psychol Rev 33(3):361\u2013371","journal-title":"Clin Psychol Rev"},{"key":"1303_CR61","unstructured":"Sund B (2000) New developments in wound care. PJB Publications, London. pp 1\u2013255. (Clinical Report CBS 836.)"},{"issue":"1","key":"1303_CR62","first-page":"95","volume":"158","author":"NE Loey Van","year":"2008","unstructured":"Van Loey NE, Bremer M, Faber AW, Middelkoop E, Nieuwenhuis MK (2008) Itching following burns: epidemiology and predictors. Br J Dermatol 158(1):95\u2013100","journal-title":"Br J Dermatol"},{"issue":"5","key":"1303_CR63","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1524-475X.2009.00533.x","volume":"17","author":"PD Verhaegen","year":"2009","unstructured":"Verhaegen PD, van Zuijlen PP, Pennings NM, van Marle J, Niessen FB, van der Horst CM, Middelkoop E (2009) Differences in collagen architecture between keloid, hypertrophic scar, normotrophic scar, and normal skin: an objective histopathological analysis. Wound Repair Regen 17(5):649\u2013656","journal-title":"Wound Repair Regen"},{"issue":"1","key":"1303_CR64","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/jid.2009.210","volume":"130","author":"C Gebhardt","year":"2010","unstructured":"Gebhardt C, Averbeck M, Diedenhofen N, Willenberg A, Anderegg U, Sleeman JP, Simon JC (2010) Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol 130(1):141\u2013149","journal-title":"J Invest Dermatol"},{"issue":"5","key":"1303_CR65","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/wrr.12214","volume":"22","author":"KL Aya","year":"2014","unstructured":"Aya KL, Stern R (2014) Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regen 22(5):579\u2013593","journal-title":"Wound Repair Regen"},{"issue":"1","key":"1303_CR66","first-page":"76","volume":"109","author":"SR King","year":"1991","unstructured":"King SR, Hickerson WL, Proctor KG (1991) Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 109(1):76\u201384","journal-title":"Surgery"},{"issue":"2","key":"1303_CR67","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jccw.2013.06.001","volume":"4","author":"A Hoffmann","year":"2013","unstructured":"Hoffmann A, Hoing JL, Newman M, Simman R (2013) Role of hyaluronic acid treatment in the prevention of Keloid scarring. J Am Coll Clin Wound Spec. 4(2):23\u201331","journal-title":"J Am Coll Clin Wound Spec."},{"key":"1303_CR68","first-page":"25","volume":"238","author":"C Soranzo","year":"2004","unstructured":"Soranzo C, Renier D, Pavesio A (2004) Synthesis and characterization of hyaluronan-based polymers for tissue engineering. Methods Mol Biol 238:25\u201340","journal-title":"Methods Mol Biol"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-018-01303-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00266-018-01303-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-018-01303-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T19:05:17Z","timestamp":1578510317000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00266-018-01303-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,9]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1303"],"URL":"https:\/\/doi.org\/10.1007\/s00266-018-01303-3","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,9]]},"assertion":[{"value":"4 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All subjects provide their informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}