{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:56:14Z","timestamp":1793271374595,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00266-018-1250-7","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T16:46:53Z","timestamp":1539017213000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Managing Periocular Filler-Related Syndrome Prior to Lower Blepharoplasty"],"prefix":"10.1007","volume":"43","author":[{"given":"Christopher I.","family":"Zoumalan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"1250_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0037-1598189","volume":"31","author":"S Lee","year":"2017","unstructured":"Lee S, Yen MT (2017) Nonsurgical rejuvenation of the eyelids with hyaluronic acid gel injections. Semin Plast Surg 31:17\u201321","journal-title":"Semin Plast Surg"},{"key":"1250_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/01.iop.0000235820.00633.61","volume":"22","author":"RA Goldberg","year":"2006","unstructured":"Goldberg RA, Fiaschetti D (2006) Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections. Ophthalmic Plast Reconstr Surg 22:335\u2013341","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"1250_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12452","author":"H Mustak","year":"2017","unstructured":"Mustak H, Fiaschetti D, Goldberg RA (2017) Filling the periorbital hollows with hyaluronic acid gel: long-term review of outcomes and complications. J Cosmet Dermatol. \n                    https:\/\/doi.org\/10.1111\/jocd.12452","journal-title":"J Cosmet Dermatol"},{"key":"1250_CR4","unstructured":"American Society of Plastic Surgeons (2017) Plastic surgery statistics report. \n                    https:\/\/www.plasticsurgery.org\/documents\/News\/Statistics\/2017\/plastic-surgery-statistics-report-2017.pdf\n                    \n                   Accessed May 2018"},{"key":"1250_CR5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1055\/s-0029-1243081","volume":"25","author":"MJ Weinberg","year":"2009","unstructured":"Weinberg MJ, Solish N (2009) Complications of hyaluronic acid fillers. Facial Plast Surg 25:324\u2013328","journal-title":"Facial Plast Surg"},{"key":"1250_CR6","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.bjps.2011.01.008","volume":"64","author":"TH Park","year":"2011","unstructured":"Park TH, Seo SW, Kim JK, Chang CH (2011) Clinical experience with hyaluronic acid-filler complications. J Plast Reconstr Aesthet Surg 64:892\u2013896","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"1250_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1473-2165.2012.00622.x","volume":"11","author":"SH Dayan","year":"2012","unstructured":"Dayan SH, Arkins JP, Somenek M (2012) Restylane persisting in lower eyelids for 5 years. J Cosmet Dermatol 11:237\u2013238","journal-title":"J Cosmet Dermatol"},{"key":"1250_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/IOP.0000000000000368","volume":"31","author":"DR Jordan","year":"2015","unstructured":"Jordan DR, Stoica B (2015) Filler migration: a number of mechanisms to consider. Ophthal Plast Reconstr Surg 31:257\u2013262","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"1250_CR9","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1097\/IOP.0000000000000487","volume":"33","author":"AA Teo","year":"2017","unstructured":"Teo AA, Mokhtarzadeh A, Cameron JD, Harrison AR (2017) Late presentation of enlarging lower eyelid mass and muscle degeneration secondary to hyaluronic acid filler. Ophthal Plast Reconstr Surg 33:S9\u2013S11","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"1250_CR10","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1097\/DSS.0000000000000442","volume":"41","author":"TT Khan","year":"2015","unstructured":"Khan TT, Woodward JA (2015) Retained dermal filler in the upper eyelid masquerading as periorbital edema. Dermatol Surg 41:1182\u20131184","journal-title":"Dermatol Surg"},{"key":"1250_CR11","doi-asserted-by":"publisher","first-page":"196e","DOI":"10.1097\/PRS.0000000000001906","volume":"137","author":"CI Zoumalan","year":"2016","unstructured":"Zoumalan CI, Roostaeian J (2016) Simplifying blepharoplasty. Plast Reconstr Surg 137:196e\u2013213e","journal-title":"Plast Reconstr Surg"},{"key":"1250_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/0748806816687605","volume":"34","author":"MR Taban","year":"2017","unstructured":"Taban MR (2017) Lower eyelid blepharoplasty in eyelids previously injected with hyaluronic acid gel filler. Am J Cosmetic Surg 34:103\u2013106","journal-title":"Am J Cosmetic Surg"},{"key":"1250_CR13","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/S0886-3350(01)01070-7","volume":"27","author":"JC Hagan 3rd","year":"2001","unstructured":"Hagan JC 3rd, Hill WE (2001) Use of a compounding pharmacy hyaluronidase for ophthalmic injection anesthesia. J Cataract Refract Surg 27:1712\u20131714","journal-title":"J Cataract Refract Surg"},{"key":"1250_CR14","first-page":"600","volume":"15","author":"P Micheels","year":"2016","unstructured":"Micheels P, Sarazin D, Tran C, Salomon D (2016) Effect of different crosslinking technologies on hyaluronic acid behavior: a visual and microscopic study of seven hyaluronic acid gels. J Drugs Dermatol 15:600\u2013606","journal-title":"J Drugs Dermatol"},{"key":"1250_CR15","doi-asserted-by":"publisher","first-page":"5S","DOI":"10.1097\/PRS.0b013e31829d1d40","volume":"132","author":"H Sundaram","year":"2013","unstructured":"Sundaram H, Cassuto D (2013) Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. Plast Reconstr Surg 132:5S\u201321S","journal-title":"Plast Reconstr Surg"},{"key":"1250_CR16","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/PRS.0000000000001638","volume":"136","author":"H Sundaram","year":"2015","unstructured":"Sundaram H, Rohrich RJ, Liew S et al (2015) Cohesivity of hyaluronic acid fillers: development and clinical implications of a novel assay, pilot validation with a five-point grading scale, and evaluation of six U.S. Food and Drug Administration-approved fillers. Plast Reconstr Surg 136:678\u2013686","journal-title":"Plast Reconstr Surg"},{"key":"1250_CR17","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1097\/IOP.0000000000000871","volume":"33","author":"JTS Yu","year":"2017","unstructured":"Yu JTS, Peng L, Ataullah S (2017) Chronic eyelid edema following periocular hyaluronic acid filler treatment. Ophthal Plast Reconstr Surg 33:e139\u2013e140","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"1250_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/01676830.2017.1337203","volume":"36","author":"SM Iverson","year":"2017","unstructured":"Iverson SM, Patel RM (2017) Dermal filler-associated malar edema: treatment of a persistent adverse effect. Orbit 36:473\u2013475","journal-title":"Orbit"},{"key":"1250_CR19","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1177\/1090820X13511970","volume":"33","author":"M Cavallini","year":"2013","unstructured":"Cavallini M, Gazzola R, Metalla M, Vaienti L (2013) The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. Aesthet Surg J 33:1167\u20131174","journal-title":"Aesthet Surg J"},{"key":"1250_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/2047-783X-19-30","volume":"19","author":"S Hilton","year":"2014","unstructured":"Hilton S, Schrumpf H, Buhren BA et al (2014) Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients. Eur J Med Res 19:30","journal-title":"Eur J Med Res"},{"key":"1250_CR21","doi-asserted-by":"publisher","first-page":"e416","DOI":"10.1016\/j.bjps.2010.01.005","volume":"63","author":"H Menon","year":"2010","unstructured":"Menon H, Thomas M, D silva J (2010) Low dose of Hyaluronidase to treat over correction by HA filler\u2013a case report. J Plast Reconstr Aesthet Surg 63:e416\u2013e417","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"1250_CR22","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1473-2165.2007.00332.x","volume":"6","author":"A Pierre","year":"2007","unstructured":"Pierre A, Levy PM (2007) Hyaluronidase offers an efficacious treatment for inaesthetic hyaluronic acid overcorrection. J Cosmet Dermatol 6:159\u2013162","journal-title":"J Cosmet Dermatol"},{"key":"1250_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/01.PRS.0000127250.35248.56","volume":"114","author":"V Lambros","year":"2004","unstructured":"Lambros V (2004) The use of hyaluronidase to reverse the effects of hyaluronic acid filler. Plast Reconstr Surg 114:277","journal-title":"Plast Reconstr Surg"},{"key":"1250_CR24","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1177\/1090820X13484492","volume":"33","author":"C DeLorenzi","year":"2013","unstructured":"DeLorenzi C (2013) Complications of injectable fillers, part I. Aesthet Surg J 33:561\u2013575","journal-title":"Aesthet Surg J"},{"key":"1250_CR25","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/DSS.0000000000001084","volume":"43","author":"MLW Juh\u00e1sz","year":"2017","unstructured":"Juh\u00e1sz MLW, Levin MK, Marmur ES (2017) The kinetics of reversible hyaluronic acid filler injection treated with hyaluronidase. Dermatol Surg 43:841\u2013847","journal-title":"Dermatol Surg"},{"key":"1250_CR26","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001562","author":"G Casabona","year":"2018","unstructured":"Casabona G, Marchese PB, Montes JR, Hornfeldt CS (2018) Durability, behavior, and tolerability of 5 hyaluronidase products. Dermatol Surg. \n                    https:\/\/doi.org\/10.1097\/DSS.0000000000001562","journal-title":"Dermatol Surg"},{"key":"1250_CR27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.det.2009.08.009","volume":"27","author":"LA Brightman","year":"2009","unstructured":"Brightman LA, Brauer JA, Anolik R et al (2009) Ablative and fractional ablative lasers. Dermatol Clin 27:479\u2013489","journal-title":"Dermatol Clin"},{"key":"1250_CR28","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/j.1365-4632.2010.04712.x","volume":"50","author":"SH Han","year":"2011","unstructured":"Han SH, Kim HJ, Kim SY et al (2011) Skin rejuvenating effects of chemical peeling: a study in photoaged hairless mice. Int J Dermatol 50:1075\u20131082","journal-title":"Int J Dermatol"},{"key":"1250_CR29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/DSS.0000000000001248","volume":"44","author":"TS Alster","year":"2018","unstructured":"Alster TS, Graham PM (2018) Microneedling: a review and practical guide. Dermatol Surg 44:397\u2013404","journal-title":"Dermatol Surg"},{"key":"1250_CR30","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/PL00007466","volume":"293","author":"Y Kitano","year":"2001","unstructured":"Kitano Y, Yoshimura K, Uchida G et al (2001) Pretreatment with topical all-trans-retinoic acid is beneficial for wound healing in genetically diabetic mice. Arch Dermatol Res 293:515\u2013521","journal-title":"Arch Dermatol Res"},{"key":"1250_CR31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/wrr.12417","volume":"24","author":"Peseto D Campos de","year":"2016","unstructured":"de Campos Peseto D, Carmona EV, Silva KC et al (2016) Effects of tretinoin on wound healing in aged skin. Wound Repair Regen 24:411\u2013417","journal-title":"Wound Repair Regen"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00266-018-1250-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-018-1250-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-018-1250-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T23:10:23Z","timestamp":1570489823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00266-018-1250-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1250"],"URL":"https:\/\/doi.org\/10.1007\/s00266-018-1250-7","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]},"assertion":[{"value":"14 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Christopher I. Zoumalan, MD, FACS, is a consultant for Allergan, Irvine, CA, and owns stock and is the scientific advisor for MD Medical Designs, Inc., Los Angeles, CA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}