{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:07:23Z","timestamp":1778954843984,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100005648","name":"American Association of Orthodontists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00266-019-01494-3","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T22:03:42Z","timestamp":1573164222000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhance Mandibular Symphyseal Surface Bone Growth with Autologous Mesenchymal Stem Cell Sheets: An Animal Study"],"prefix":"10.1007","volume":"44","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boon Ching","family":"Tee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leighann","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-3662","authenticated-orcid":false,"given":"Zongyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"1494_CR1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00266-015-0518-4","volume":"39","author":"D Bertossi","year":"2015","unstructured":"Bertossi D, Galzignato PF, Albanese M, Botti C, Botti G, Nocini PF (2015) Chin microgenia: a clinical comparative study. Aesthetic Plast Surg 39:651\u2013658","journal-title":"Aesthetic Plast Surg"},{"key":"1494_CR2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/asj\/sjw082","volume":"36","author":"CS Chang","year":"2016","unstructured":"Chang CS, Kang GCW (2016) Achieving ideal lower face aesthetic contours: combination of tridimensional fat grafting to the chin with masseter botulinum toxin injection. Aesthetic Surg J 36:1093\u20131100","journal-title":"Aesthetic Surg J"},{"key":"1494_CR3","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1097\/PRS.0000000000001279","volume":"135","author":"SJ Aston","year":"2015","unstructured":"Aston SJ, Smith DM (2015) Taking it on the chin: recognizing and accounting for lower face asymmetry in chin augmentation and genioplasty. Plast Reconstr Surg 135:1591\u20131595","journal-title":"Plast Reconstr Surg"},{"key":"1494_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0094-1298(20)31936-2","volume":"9","author":"RM Ricketts","year":"1982","unstructured":"Ricketts RM (1982) Divine proportion in facial esthetics. Clin Plast Surg 9:401\u2013422","journal-title":"Clin Plast Surg"},{"key":"1494_CR5","volume-title":"Essentials of facial growth","author":"DH Enlow","year":"1996","unstructured":"Enlow DH (1996) Essentials of facial growth. Saunders, Philadelphia"},{"key":"1494_CR6","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/ar.20588","volume":"290","author":"P Ochareon","year":"2007","unstructured":"Ochareon P, Herring SW (2007) Growing the mandible: role of the periosteum and its cells. Anat Rec Hoboken 290:1366\u20131376","journal-title":"Anat Rec Hoboken"},{"key":"1494_CR7","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1177\/1090820X11415516","volume":"31","author":"JB White","year":"2011","unstructured":"White JB, Dufresne CR (2011) Management and avoidance of complications in chin augmentation. Aesthet Surg J 31:634\u2013642","journal-title":"Aesthet Surg J"},{"key":"1494_CR8","first-page":"1616","volume":"31","author":"NJ Lowe","year":"2005","unstructured":"Lowe NJ, Maxwell CA, Patnaik R (2005) Adverse reactions to dermal fillers: review. Dermatol Surg 31:1616\u20131625","journal-title":"Dermatol Surg"},{"key":"1494_CR9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/0278-2391(92)90097-J","volume":"50","author":"JE Van Sickels","year":"1992","unstructured":"Van Sickels JE, Tiner BD (1992) Cost of a genioplasty under deep intravenous sedation in a private office versus general anesthesia in an outpatient surgical center. J Oral Maxillofac Surg 50:687\u2013690","journal-title":"J Oral Maxillofac Surg"},{"key":"1494_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","volume":"180","author":"A Ho-Shui-Ling","year":"2018","unstructured":"Ho-Shui-Ling A, Bolander J, Rustom LE, Johnson AW, Luyten FP, Picart C (2018) Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials 180:143\u2013162","journal-title":"Biomaterials"},{"key":"1494_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/01.SAP.0000054180.78960.15","volume":"51","author":"T Ueno","year":"2003","unstructured":"Ueno T, Kagawa T, Fukunaga J, Mizukawa N, Kanou M, Fujii T, Sugahara T, Yamamoto T (2003) Regeneration of the mandibular head from grafted periosteum. Ann Plast Surg 51:77\u201383","journal-title":"Ann Plast Surg"},{"key":"1494_CR12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1054\/jcms.2001.0226","volume":"29","author":"T Ueno","year":"2001","unstructured":"Ueno T, Kagawa T, Ishida N, Fukunaga J, Mizukawa N, Sugahara T, Yamamoto T (2001) Prefabricated bone graft induced from grafted periosteum for the repair of jaw defects: an experimental study in rabbits. J Cranio-Maxillofac Surg 29:219\u2013223","journal-title":"J Cranio-Maxillofac Surg"},{"key":"1494_CR13","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.joca.2008.10.011","volume":"17","author":"GG Reinholz","year":"2009","unstructured":"Reinholz GG, Fitzsimmons JS, Casper ME, Ruesink TJ, Chung HW, Schagemann JC, Odriscoll SW (2009) Rejuvenation of periosteal chondrogenesis using local growth factor injection. Osteoarthr Cartil 17:723\u2013734","journal-title":"Osteoarthr Cartil"},{"key":"1494_CR14","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1002\/jcp.22698","volume":"226","author":"AS Patil","year":"2011","unstructured":"Patil AS, Sable RB, Kothari RM (2011) An update on transforming growth factor-\u03b2 (TGF-\u03b2): sources, types, functions and clinical applicability for cartilage\/bone healing. J Cell Physiol 226:3094\u20133103","journal-title":"J Cell Physiol"},{"key":"1494_CR15","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1089\/ten.tea.2008.0446","volume":"15","author":"B Schonmeyr","year":"2009","unstructured":"Schonmeyr B, Clavin N, Avraham T, Longo V, Mehrara BJ (2009) Synthesis of a tissue-engineered periosteum with acellular dermal matrix and cultured mesenchymal stem cells. Tissue Eng Part A 15:1833\u20131841","journal-title":"Tissue Eng Part A"},{"key":"1494_CR16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1089\/ten.2006.0182","volume":"13","author":"C Xie","year":"2007","unstructured":"Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, Okeefe RJ, Zhang X (2007) Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng 13:435\u2013445","journal-title":"Tissue Eng"},{"key":"1494_CR17","doi-asserted-by":"publisher","first-page":"74672","DOI":"10.1371\/journal.pone.0074672","volume":"8","author":"Z Sun","year":"2013","unstructured":"Sun Z, Tee BC, Kennedy KS, Kennedy PM, Kim DG, Mallery SR, Fields HW (2013) Scaffold-based delivery of autologous mesenchymal stem cells for mandibular distraction osteogenesis: preliminary studies in a porcine model. PLoS ONE 8:74672","journal-title":"PLoS ONE"},{"key":"1494_CR18","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1089\/scd.2010.0348","volume":"20","author":"D Ma","year":"2011","unstructured":"Ma D, Zhong C, Yao H, Liu Y, Chen F, Li J, Zhao J, Mao T, Ren L (2011) Engineering injectable bone using bone marrow stromal cell aggregates. Stem Cells Dev 20:989\u2013999","journal-title":"Stem Cells Dev"},{"key":"1494_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1746-6148-10-36","volume":"10","author":"MBC Fernandes","year":"2014","unstructured":"Fernandes MBC, Guimar\u00e3es JA, Casado P, Ados Cavalcanti, Gon\u00e7alves NN, Ambr\u00f3sio CE, Rodrigues F, Pinto ACF, Miglino M, Duarte MEL (2014) The effect of bone allografts combined with bone marrow stromal cells on the healing of segmental bone defects in a sheep model. BMC Vet Res 10:36","journal-title":"BMC Vet Res"},{"key":"1494_CR20","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.bone.2004.06.013","volume":"35","author":"H Kitoh","year":"2004","unstructured":"Kitoh H, Kitakoji T, Tsuchiya H, Mitsuyama H, Nakamura H, Katoh M, Ishiguro N (2004) Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis\u2014a preliminary result of three cases. Bone 35:892\u2013898","journal-title":"Bone"},{"key":"1494_CR21","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1056\/NEJMoa040455","volume":"351","author":"K Nishida","year":"2004","unstructured":"Nishida K, Yamato M, Hayashida Y, Watanabe K, Yamamoto K, Adachi E, Nagai S, Kikuchi A, Maeda N, Watanabe H, Okano T, Tano Y (2004) Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med 351:1187\u20131196","journal-title":"N Engl J Med"},{"key":"1494_CR22","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1053\/j.gastro.2012.04.050","volume":"143","author":"T Ohki","year":"2012","unstructured":"Ohki T, Yamato M, Ota M, Takagi R, Murakami D, Kondo M, Sasaki R, Namiki H, Okano T, Yamamoto M (2012) Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets. Gastroenterology 143:582\u2013588","journal-title":"Gastroenterology"},{"key":"1494_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00595-011-0106-4","volume":"42","author":"Y Sawa","year":"2012","unstructured":"Sawa Y, Miyagawa S, Sakaguchi T, Fujita T, Matsuyama A, Saito A, Shimizu T, Okano T (2012) Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case. Surg Today 42:181\u2013184","journal-title":"Surg Today"},{"key":"1494_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/term.1785","volume":"9","author":"T Iwata","year":"2015","unstructured":"Iwata T, Washio K, Yoshida T, Ishikawa I, Ando T, Yamato M, Okano T (2015) Cell sheet engineering and its application for periodontal regeneration. J Tissue Eng Regen Med 9:343\u2013356","journal-title":"J Tissue Eng Regen Med"},{"key":"1494_CR25","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/jre.12541","volume":"53","author":"S Mu","year":"2018","unstructured":"Mu S, Tee BC, Emam H, Zhou Y, Sun Z (2018) Culture-expanded mesenchymal stem cell sheets enhance extraction-site alveolar bone growth: an animal study. J Periodontal Res 53:514\u2013524","journal-title":"J Periodontal Res"},{"key":"1494_CR26","doi-asserted-by":"publisher","first-page":"28126","DOI":"10.1038\/srep28126","volume":"6","author":"Z-S Wang","year":"2016","unstructured":"Wang Z-S, Feng Z-H, Wu G-F, Bai S-Z, Dong Y, Chen F-M, Zhao Y-M (2016) The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering. Sci Rep 6:28126","journal-title":"Sci Rep"},{"key":"1494_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.archoralbio.2016.04.007","volume":"68","author":"Y Liang","year":"2016","unstructured":"Liang Y, Wen L, Shang F, Wu J, Sui K, Ding Y (2016) Endothelial progenitors enhanced the osteogenic capacities of mesenchymal stem cells in vitro and in a rat alveolar bone defect model. Arch Oral Biol 68:123\u2013130","journal-title":"Arch Oral Biol"},{"key":"1494_CR28","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.bone.2011.05.025","volume":"49","author":"M Yu","year":"2011","unstructured":"Yu M, Zhou W, Song Y, Yu F, Li D, Na S, Zou G, Zhai M, Xie C (2011) Development of mesenchymal stem cell-implant complexes by cultured cells sheet enhances osseointegration in type 2 diabetic rat model. Bone 49:387\u2013394","journal-title":"Bone"},{"key":"1494_CR29","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.archoralbio.2016.08.017","volume":"72","author":"Y Ueyama","year":"2016","unstructured":"Ueyama Y, Yagyuu T, Maeda M, Imada M, Akahane M, Kawate K, Tanaka Y, Kirita T (2016) Maxillofacial bone regeneration with osteogenic matrix cell sheets: an experimental study in rats. Arch Oral Biol 72:138\u2013145","journal-title":"Arch Oral Biol"},{"key":"1494_CR30","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/0003-9969(86)90009-9","volume":"31","author":"D Strom","year":"1986","unstructured":"Strom D, Holm S, Clemensson E, Haraldson T, Carlsson GE (1986) Gross anatomy of the mandibular joint and masticatory muscles in the domestic pig (Sus scrofa). Arch Oral Biol 31:763\u2013768","journal-title":"Arch Oral Biol"},{"key":"1494_CR31","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/ocr.12101","volume":"18","author":"J Price","year":"2015","unstructured":"Price J, Tee BC, Vig K, Shanker S, Kennedy K, Sun Z (2015) Growth characteristics underlying the lack of a chin in pigs: a histomorphometric study. Orthod Craniofac Res 18:232\u2013241","journal-title":"Orthod Craniofac Res"},{"key":"1494_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archoralbio.2017.01.012","volume":"77","author":"B Lloyd","year":"2017","unstructured":"Lloyd B, Tee BC, Headley C, Emam H, Mallery S, Sun Z (2017) Similarities and differences between porcine mandibular and limb bone marrow mesenchymal stem cells. Arch Oral Biol 77:1\u201311","journal-title":"Arch Oral Biol"},{"key":"1494_CR33","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1161\/CIRCULATIONAHA.112.000293","volume":"128","author":"Y Shudo","year":"2013","unstructured":"Shudo Y, Cohen JE, Macarthur JW, Atluri P, Hsiao PF, Yang EC, Fairman AS, Trubelja A, Patel J, Miyagawa S, Sawa Y, Woo YJ (2013) Spatially oriented, temporally sequential smooth muscle cell-endothelial progenitor cell bi-level cell sheet neovascularizes ischemic myocardium. Circulation 128:S59\u2013S68","journal-title":"Circulation"},{"key":"1494_CR34","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3727\/096368912X652968","volume":"22","author":"D Kaigler","year":"2013","unstructured":"Kaigler D, Pagni G, Park CH, Braun TM, Holman LA, Yi E, Tarle SA, Bartel RL, Giannobile WV (2013) Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Cell Transpl 22:767\u2013777","journal-title":"Cell Transpl"},{"key":"1494_CR35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jbm.b.31627","volume":"94","author":"J Xie","year":"2010","unstructured":"Xie J, Han Z, Naito M, Maeyama A, Kim SH, Kim YH, Matsuda T (2010) Articular cartilage tissue engineering based on a mechano-active scaffold made of poly(L-lactide-co-\u03b5-caprolactone): in vivo performance in adult rabbits. J Biomed Mater Res Part B Appl Biomater 94:80\u201388","journal-title":"J Biomed Mater Res Part B Appl Biomater"},{"key":"1494_CR36","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1177\/0022034510378427","volume":"89","author":"TL Aghaloo","year":"2010","unstructured":"Aghaloo TL, Chaichanasakul T, Bezouglaia O, Kang B, Franco R, Dry SM, Atti E, Tetradis S (2010) Osteogenic potential of mandibular vs long-bone marrow stromal cells. J Dent Res 89:1293\u20131298","journal-title":"J Dent Res"},{"key":"1494_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00441-014-1927-4","volume":"358","author":"W Dong","year":"2014","unstructured":"Dong W, Ge J, Zhang P, Fu Y, Zhang Z, Cheng J, Jiang H (2014) Phenotypic characterization of craniofacial bone marrow stromal cells: unique properties of enhanced osteogenesis, cell recruitment, autophagy, and apoptosis resistance. Cell Tissue Res 358:165\u2013175","journal-title":"Cell Tissue Res"},{"key":"1494_CR38","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.bone.2005.10.027","volume":"38","author":"SO Akintoye","year":"2006","unstructured":"Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG (2006) Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone 38:758\u2013768","journal-title":"Bone"},{"issue":"1","key":"1494_CR39","first-page":"0857","volume":"98","author":"J Jenkins","year":"2019","unstructured":"Jenkins J, Shi L, Tee BC, Emam H, Larsen P, Sun Z (2019) Impact of bone marrow withdrawal on local corticotomy healing. J Dent Res 98(1):0857","journal-title":"J Dent Res"},{"key":"1494_CR40","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.11607\/jomi.3036","volume":"28","author":"W Katagiri","year":"2013","unstructured":"Katagiri W, Osugi M, Kawai T, Ueda M (2013) Novel cell-free regeneration of bone using stem cell-derived growth factors. Int J Oral Maxillofac Implants 28:1009\u20131016","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1494_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13005-016-0101-5","volume":"12","author":"W Katagiri","year":"2016","unstructured":"Katagiri W, Osugi M, Kawai T, Hibi H (2016) First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells. Head Face Med 12:5","journal-title":"Head Face Med"},{"key":"1494_CR42","first-page":"3","volume":"31","author":"HM Frost","year":"1983","unstructured":"Frost HM (1983) The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J 31:3\u20139","journal-title":"Henry Ford Hosp Med J"},{"key":"1494_CR43","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/jbm.a.31087","volume":"81","author":"RD Bloebaum","year":"2007","unstructured":"Bloebaum RD, Willie BM, Mitchell BS, Hofmann AA (2007) Relationship between bone ingrowth, mineral apposition rate, and osteoblast activity. J Biomed Mater Res A 81:505\u2013514","journal-title":"J Biomed Mater Res A"},{"key":"1494_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ajodo.2016.11.026","volume":"152","author":"KM Owen","year":"2017","unstructured":"Owen KM, Campbell PM, Feng JQ, Dechow PC, Buschang PH (2017) Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement. Am J Orthod Dentofacial Orthop 152:49\u201357","journal-title":"Am J Orthod Dentofacial Orthop"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-019-01494-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-019-01494-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-019-01494-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:03:36Z","timestamp":1721999016000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-019-01494-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1494"],"URL":"https:\/\/doi.org\/10.1007\/s00266-019-01494-3","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"5 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable institutional and national guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"For this type of study, informed consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}