{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:46:23Z","timestamp":1773391583707,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Health Bureau of Zhejiang Province","award":["2015KYB244"],"award-info":[{"award-number":["2015KYB244"]}]},{"name":"the most important subject of higher education in Education Department of Zhejiang Province","award":["2008-255"],"award-info":[{"award-number":["2008-255"]}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["LY17H160052"],"award-info":[{"award-number":["LY17H160052"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00266-020-01727-w","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T16:04:08Z","timestamp":1588176248000},"page":"749-757","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars"],"prefix":"10.1007","volume":"45","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Long","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"issue":"7","key":"1727_CR1","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.burns.2015.03.014","volume":"41","author":"J Tan","year":"2015","unstructured":"Tan J, He W, Luo G, Wu J (2015) Involvement of impaired desmosome related proteins in hypertrophic scar intraepidermal blister formation. Burns 41(7):1517\u20131523. https:\/\/doi.org\/10.1016\/j.burns.2015.03.014","journal-title":"Burns"},{"issue":"2","key":"1727_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jss.2015.10.040","volume":"201","author":"S Tejiram","year":"2016","unstructured":"Tejiram S, Zhang J, Travis TE, Carney BC, Alkhalil A, Moffatt LT, Johnson LS, Shupp JW (2016) Compression therapy affects collagen type balance in hypertrophic scar. J Surg Res 201(2):299\u2013305. https:\/\/doi.org\/10.1016\/j.jss.2015.10.040","journal-title":"J Surg Res"},{"issue":"4","key":"1727_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","volume":"7","author":"Z Zhu","year":"2013","unstructured":"Zhu Z, Ding J, Shankowsky HA, Tredget EE (2013) The molecular mechanism of hypertrophic scar. J Cell Commun Signal 7(4):239\u2013252. https:\/\/doi.org\/10.1007\/s12079-013-0195-5","journal-title":"J Cell Commun Signal"},{"issue":"3","key":"1727_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ijms19030711","volume":"19","author":"HJ Lee","year":"2018","unstructured":"Lee HJ, Jang YJ (2018) Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci 19(3):711. https:\/\/doi.org\/10.3390\/ijms19030711","journal-title":"Int J Mol Sci"},{"key":"1727_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2174\/1874312901206010130","volume":"6","author":"S Vettori","year":"2012","unstructured":"Vettori S, Gay S, Distler O (2012) Role of microRNAs in fibrosis. Open Rheumatol J 6:130\u2013139","journal-title":"Open Rheumatol J"},{"issue":"2","key":"1727_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/MAJ.0b013e318267680d","volume":"346","author":"J Cheng","year":"2013","unstructured":"Cheng J, Wang Y, Wang D, Wu Y (2013) Identification of collagen 1 as a post-transcriptional target of miR-29b in skin fibroblasts: therapeutic implication for scar reduction. Am J Med Sci 346(2):98\u2013103. https:\/\/doi.org\/10.1097\/MAJ.0b013e318267680d","journal-title":"Am J Med Sci"},{"issue":"2","key":"1727_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00296-010-1615-y","volume":"32","author":"H Li","year":"2012","unstructured":"Li H, Yang R, Fan X, Gu T, Zhao Z, Chang D, Wang W (2012) MicroRNAs array analysis of microRNAs related to systemic scleroderma. Rheumatol Int 32(2):307\u2013313. https:\/\/doi.org\/10.1007\/s00296-010-1615-y","journal-title":"Rheumatol Int"},{"issue":"9","key":"1727_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00403-013-1410-1","volume":"305","author":"O Babalola","year":"2013","unstructured":"Babalola O, Mamalis A, Lev-Tov H et al (2013) The role of microRNAs in skin fibrosis. Arch Dermatol Res. 305(9):763\u2013776","journal-title":"Arch Dermatol Res."},{"issue":"8","key":"1727_CR9","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1093\/abbs\/gmt057","volume":"45","author":"C Li","year":"2013","unstructured":"Li C, Bai Y, Liu H (2013) Comparative study of microRNAs profiling in keloid fibroblast and annotation of differential expressed microRNAs. Acta Biochim Biophys Sin 45(8):692\u2013699. https:\/\/doi.org\/10.1093\/abbs\/gmt057","journal-title":"Acta Biochim Biophys Sin"},{"issue":"15","key":"1727_CR10","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.3748\/wjg.v22.i15.3907","volume":"21, 22","author":"S Fiorino","year":"2016","unstructured":"Fiorino S, Bacchi-Reggiani ML, Visani M, Acquaviva G, Fornelli A, Masetti M, Tura A, Grizzi F, Zanello M, Mastrangelo L, Lombardi R, Di Tommaso L, Bondi A, Sabbatani S, Domanico A, Fabbri C, Leandri P, Pession A, Jovine E, de Biase D (2016) MicroRNAs as possible biomarkers for diagnosis and prognosisof hepatitis B- and C-related-hepatocellular-carcinoma. World J Gastroenterol 21, 22(15):3907\u20133936. https:\/\/doi.org\/10.3748\/wjg.v22.i15.3907","journal-title":"World J Gastroenterol"},{"issue":"7","key":"1727_CR11","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.molonc.2015.03.013","volume":"9","author":"MA Ihle","year":"2015","unstructured":"Ihle MA, Trautmann M, Kuenstlinger H, Huss S, Heydt C, Fassunke J, Wardelmann E, Bauer S, Schildhaus HU, Buettner R, Merkelbach-Bruse S (2015) miRNA-221 and miRNA-222 induce apoptosis via the KIT\/AKT signalling pathway in gastrointestinal stromal tumours. Mol Oncol 9(7):1421\u20131433. https:\/\/doi.org\/10.1016\/j.molonc.2015.03.013","journal-title":"Mol Oncol"},{"issue":"2","key":"1727_CR12","doi-asserted-by":"publisher","first-page":"242","DOI":"10.18632\/oncotarget.820","volume":"4","author":"MT Di Martino","year":"2013","unstructured":"Di Martino MT, Gull\u00e0 A, Cantafio ME, Lionetti M, Leone E, Amodio N, Guzzi PH, Foresta U, Conforti F, Cannataro M, Neri A, Giordano A, Tagliaferri P, Tassone P (2013) In vitro and in vivoantitumor activity of miR-221\/222 inhibitors in multiple myeloma. Oncotarget 4(2):242\u2013255. https:\/\/doi.org\/10.18632\/oncotarget.820","journal-title":"Oncotarget"},{"key":"1727_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13075-016-0929-x","volume":"18","author":"S O'Reilly","year":"2016","unstructured":"O'Reilly S (2016) MicroRNAs in fibrosis: opportunities and challenges. Arthritis Res Ther 18:11. https:\/\/doi.org\/10.1186\/s13075-016-0929-x","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"1727_CR14","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1093\/abbs\/gmt057","volume":"45","author":"C Li","year":"2013","unstructured":"Li C, Bai Y, Liu H, Zuo X, Yao H, Xu Y, Cao M (2013) Comparative study of microRNAs profiling in keloid fibroblast and annotation of differential expressed microRNAs. Acta Biochim Biophys Sin 45(8):692\u2013699. https:\/\/doi.org\/10.1093\/abbs\/gmt057","journal-title":"Acta Biochim Biophys Sin"},{"issue":"15","key":"1727_CR15","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.3748\/wjg.v22.i15.3907","volume":"22","author":"S Fiorino","year":"2016","unstructured":"Fiorino S, Bacchi-Reggiani ML, Visani M et al (2016) MicroRNAs as possible biomarkers for diagnosis and prognosisof hepatitis B-and C-related-hepatocellular-carcinoma. World J Gastroenterol 22(15):3907\u20133936","journal-title":"World J Gastroenterol"},{"issue":"2","key":"1727_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3892\/ijmm.2016.2653","volume":"38","author":"ST Aherne","year":"2016","unstructured":"Aherne ST, Smyth P, Freeley M, Smith L, Spillane C, O'Leary J, Sheils O (2016) Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells and impacts on MEK and TRAIL protein expression. Int J Mol Med 38(2):433\u2013445. https:\/\/doi.org\/10.3892\/ijmm.2016.2653","journal-title":"Int J Mol Med"},{"issue":"1","key":"1727_CR17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.4143\/crt.2015.462","volume":"49","author":"B Choi","year":"2017","unstructured":"Choi B, Yu J, Han TS, Kim YK, Hur K, Kang BC, Kim WH, Kim DY, Lee HJ, Kim VN, Yang HK (2017) Gastric carcinogenesis in the miR-222\/221 transgenic mouse model. Cancer Res Treat 49(1):150\u2013160. https:\/\/doi.org\/10.4143\/crt.2015.462","journal-title":"Cancer Res Treat"},{"issue":"29","key":"1727_CR18","doi-asserted-by":"publisher","first-page":"45462","DOI":"10.18632\/oncotarget.9990","volume":"7","author":"KA Lloyd","year":"2016","unstructured":"Lloyd KA, Moore AR, Parsons BN, O'Hara A, Boyce M, Dockray GJ, Varro A, Pritchard DM (2016) Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1. Oncotarget 7(29):45462\u201345478","journal-title":"Oncotarget"},{"issue":"28","key":"1727_CR19","doi-asserted-by":"publisher","first-page":"43076","DOI":"10.18632\/oncotarget.9246","volume":"7","author":"X Ying","year":"2016","unstructured":"Ying X, Wu Q, Wu X, Zhu Q, Wang X, Jiang L, Chen X, Wang X (2016) Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages. Oncotarget 7(28):43076\u201343087. https:\/\/doi.org\/10.18632\/oncotarget.9246","journal-title":"Oncotarget"},{"issue":"6","key":"1727_CR20","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1001\/jamafacial.2013.1211","volume":"15","author":"H Li","year":"2013","unstructured":"Li H, Nahas Z, Feng F, Elisseeff JH, Boahene K (2013) Tissue engineering for in vitro analysis of matrix metalloproteinases in the pathogenesis of keloid lesions. JAMA Facial Plast Surg 15(6):448\u2013456. https:\/\/doi.org\/10.1001\/jamafacial.2013.1211","journal-title":"JAMA Facial Plast Surg"},{"issue":"4","key":"1727_CR21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.exphem.2013.12.009","volume":"42","author":"H Nakasone","year":"2014","unstructured":"Nakasone H, Terasako-Saito K, Yamazaki R, Sato M, Tanaka Y, Sakamoto K, Kurita M, Yamasaki R, Wada H, Ishihara Y, Kawamura K, Machishima T, Ashizawa M, Kimura S, Kikuchi M, Tanihara A, Kanda J, Kako S, Nishida J, Yamada S, Kanda Y (2014) Impact of high-\/middle-molecular-weight adiponectin on the synthesis and regulation of extracellular matrix in dermal fibroblasts. Exp Hematol 42(4):261\u2013273. https:\/\/doi.org\/10.1016\/j.exphem.2013.12.009","journal-title":"Exp Hematol"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-020-01727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-020-01727-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-020-01727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T01:29:20Z","timestamp":1619659760000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-020-01727-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1727"],"URL":"https:\/\/doi.org\/10.1007\/s00266-020-01727-w","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"10 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the First Affiliated Hospital of Wenzhou Medical University research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All participants gave their informed consent in writing prior to inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}