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The patients underwent a cycle of 6 sessions, with biweekly treatments, without the addition of any active ingredient. Direct infiltration of pharmacologically active SAP solutions into the adipose tissue with a long needle, very similar to the needles used for spinal anesthesia, was performed. This procedure is quick and painless (does not require any anesthesia) with moderate infiltration speed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the patients treated showed good results with good satisfaction of the circumferential reductions. Before treatment: Waist (cm) 78.8\u2009\u00b1\u200910.6 and hip 93.6\u2009\u00b1\u20099.0 with WHR 0.84\u2009\u00b1\u20090.07. After treatment: Waist (cm) 70.8\u2009\u00b1\u20099.6 and hip 92.6\u2009\u00b1\u20098.0 with WHR 0.76\u2009\u00b1\u20090.06. Indeed, signs of adipocyte apoptosis were observed in subcutaneous skin after injection of SAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results showed in the present study suggest that the SAP utilized induces apoptosis of adipocytes and could be of use as a safe and effective method with which to eliminate subcutaneous abdominal fat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence IV<\/jats:title><jats:p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.springer.com\/00266\">www.springer.com\/00266<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00266-020-01865-1","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T17:03:10Z","timestamp":1597424590000},"page":"1604-1612","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-6146","authenticated-orcid":false,"given":"Antonio","family":"Scarano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sbarbati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio Luigi","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Amuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"1865_CR1","unstructured":"WHO World Health Statistics Report 2020, Obesity and overweight. 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