{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:20:17Z","timestamp":1793665217028,"version":"4.5.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00266-021-02596-7","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T02:20:35Z","timestamp":1633486835000},"page":"395-405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Systematic Review And Meta-Analysis: Botulinum Toxin A Effect on Postoperative Facial Scar Prevention"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-3383","authenticated-orcid":false,"given":"Shuai","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"issue":"34","key":"2596_CR1","doi-asserted-by":"crossref","first-page":"e16952","DOI":"10.1097\/MD.0000000000016952","volume":"98","author":"SH Kim","year":"2019","unstructured":"Kim SH, Lee SJ, Lee JW, Jeong HS, Suh IS (2019) Clinical trial to evaluate the efficacy of botulinum toxin type A injection for reducing scars in patients with forehead laceration: a double-blinded, randomized controlled study. Med (Baltimore) 98(34):e16952","journal-title":"Med (Baltimore)"},{"issue":"4","key":"2596_CR2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2648.2004.03123.x","volume":"47","author":"NJ Tebble","year":"2004","unstructured":"Tebble NJ, Thomas DW, Price P (2004) Anxiety and self-consciousness in patients with minor facial lacerations. J Adv Nurs 47(4):417\u2013426","journal-title":"J Adv Nurs"},{"issue":"2","key":"2596_CR3","doi-asserted-by":"crossref","first-page":"171e","DOI":"10.1097\/PRS.0000000000001438","volume":"136","author":"HS Jeong","year":"2015","unstructured":"Jeong HS et al (2015) Effect of botulinum toxin type A on differentiation of fibroblasts derived from scar tissue. Plast Reconstr Surg 136(2):171e\u2013178e","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"2596_CR4","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0030-6665(20)30475-8","volume":"28","author":"DA Sherris","year":"1995","unstructured":"Sherris DA, Larrabee WF Jr, Murakami CS (1995) Management of scar contractures, hypertrophic scars, and keloids. Otolaryngol Clin North Am 28(5):1057\u20131068","journal-title":"Otolaryngol Clin North Am"},{"key":"2596_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14325,July2,2021","author":"B Chowdhury","year":"2021","unstructured":"Chowdhury B et al (2021) Laser in surgical scar clearance: an update review. J Cosmet Dermatol. https:\/\/doi.org\/10.1111\/jocd.14325,July2,2021","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"2596_CR6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00266-009-9334-z","volume":"33","author":"Z Xiao","year":"2009","unstructured":"Xiao Z, Zhang F, Cui Z (2009) Treatment of hypertrophic scars with intralesional botulinum toxin type A injections: a preliminary report. Aesthetic Plast Surg 33(3):409\u2013412","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"2596_CR7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00266-009-9423-z","volume":"34","author":"Z Xiao","year":"2010","unstructured":"Xiao Z, Zhang F, Lin W, Zhang M, Liu Y (2010) Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report. Aesthetic Plast Surg 34(4):424\u2013427","journal-title":"Aesthetic Plast Surg"},{"issue":"4","key":"2596_CR8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.12788\/j.sder.0115","volume":"33","author":"O Ibrahim","year":"2014","unstructured":"Ibrahim O, Keller EC, Arndt KA (2014) Update on botulinum neurotoxin use in aesthetic dermatology. Semin Cutan Med Surg 33(4):152\u2013156","journal-title":"Semin Cutan Med Surg"},{"issue":"12","key":"2596_CR9","first-page":"924","volume":"12","author":"AB Scott","year":"1973","unstructured":"Scott AB, Rosenbaum A, Collins CC (1973) Pharmacologic weakening of extraocular muscles. Invest Ophthalmol 12(12):924\u2013927","journal-title":"Invest Ophthalmol"},{"issue":"1","key":"2596_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.toxicon.2017.08.014","volume":"147","author":"A Cocco","year":"2018","unstructured":"Cocco A, Albanese A (2018) Recent developments in clinical trials of botulinum neurotoxins. Toxicon 147(1):77\u201383","journal-title":"Toxicon"},{"issue":"1","key":"2596_CR11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-2002-19825","volume":"18","author":"DA Sherris","year":"2002","unstructured":"Sherris DA, Gassner HG (2002) Botulinum toxin to minimize facial scarring. Facial Plast Surg 18(1):35\u201339","journal-title":"Facial Plast Surg"},{"issue":"3","key":"2596_CR12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jamcollsurg.2005.03.032","volume":"201","author":"L Lu","year":"2005","unstructured":"Lu L et al (2005) The temporal effects of anti-TGF-\u03b21, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am Coll Surg 201(3):391\u2013397","journal-title":"J Am Coll Surg"},{"issue":"1","key":"2596_CR13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bjps.2005.12.026","volume":"60","author":"RR Reid","year":"2007","unstructured":"Reid RR, Roy N, Mogford JE, Zimmerman H, Lee C, Mustoe TA (2007) Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II. J Plast Reconstr Aesthet Surg 60(1):64\u201372","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"6","key":"2596_CR14","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1097\/00006534-200005000-00005","volume":"105","author":"HG Gassner","year":"2000","unstructured":"Gassner HG, Sherris DA, Otley CC (2000) Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates. Plast Reconstr Surg 105(6):1948\u20131953","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"2596_CR15","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1007\/s00266-018-1187-x","volume":"42","author":"YH Li","year":"2018","unstructured":"Li YH et al (2018) A randomized, placebo-controlled, double-blind, prospective clinical trial of botulinum toxin type A in prevention of hypertrophic scar development in median sternotomy wound. Aesthetic Plast Surg 42(5):1364\u20131369","journal-title":"Aesthetic Plast Surg"},{"issue":"6","key":"2596_CR16","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1007\/s00266-020-01916-7","volume":"44","author":"R Abedini","year":"2020","unstructured":"Abedini R, Mehdizade Rayeni N, Haddady Abianeh S, Rahmati J, Teymourpour A, Nasimi M (2020) Botulinum toxin type A injection for mammoplasty and abdominoplasty scar management: A split-scar double-blinded randomized controlled study. Aesthetic Plast Surg 44(6):2270\u20132276","journal-title":"Aesthetic Plast Surg"},{"issue":"9","key":"2596_CR17","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1111\/jocd.13627","volume":"19","author":"AR Elshahed","year":"2020","unstructured":"Elshahed AR, Elmanzalawy KS, Shehata H, ElSaie ML (2020) Effect of botulinum toxin type A for treating hypertrophic scars: a split-scar, double-blind randomized controlled trial. J Cosmet Dermatol 19(9):2252\u20132258","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"2596_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1","journal-title":"Syst Rev"},{"issue":"3","key":"2596_CR19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/PRS.0000000000000416","volume":"134","author":"CS Chang","year":"2014","unstructured":"Chang CS, Wallace CG, Hsiao YC, Chang CJ, Chen PK (2014) Botulinum toxin to improve results in cleft lip repair. Plast Reconstr Surg 134(3):511\u2013516","journal-title":"Plast Reconstr Surg"},{"issue":"12","key":"2596_CR20","doi-asserted-by":"crossref","first-page":"e115690","DOI":"10.1371\/journal.pone.0115690","volume":"9","author":"CS Chang","year":"2014","unstructured":"Chang CS, Wallace CG, Hsiao YC, Chang CJ, Chen PK (2014) Botulinum toxin to improve results in cleft lip repair: a double-blinded, randomized, vehicle-controlled clinical trial. PLoS ONE 9(12):e115690","journal-title":"PLoS ONE"},{"issue":"8","key":"2596_CR21","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4065\/81.8.1023","volume":"81","author":"HG Gassner","year":"2006","unstructured":"Gassner HG et al (2006) Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study. Mayo Clin Proc 81(8):1023\u20131028","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"2596_CR22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/PRS.0000000000004110","volume":"141","author":"L Hu","year":"2018","unstructured":"Hu L et al (2018) Effects of botulinum toxin on improving facial surgical scars: a prospective, split-scar, double-blind, randomized controlled trial. Plast Reconstr Surg 141(3):646\u2013650","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"2596_CR23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/PRS.0000000000006069","volume":"144","author":"RL Huang","year":"2019","unstructured":"Huang RL, Ho CK, Tremp M, Xie Y, Li Q, Zan T (2019) Early postoperative application of botulinum toxin type a prevents hypertrophic scarring after epicanthoplasty: a split-face, double-blind, randomized trial. Plast Reconstr Surg 144(4):835\u2013844","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"2596_CR24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00266-017-1008-7","volume":"42","author":"SH Lee","year":"2018","unstructured":"Lee SH, Min HJ, Kim YW, Cheon YW (2018) The efficacy and safety of early postoperative botulinum toxin A injection for facial scars. Aesthetic Plast Surg 42(2):530\u2013537","journal-title":"Aesthetic Plast Surg"},{"issue":"3","key":"2596_CR25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00238-018-1488-y","volume":"42","author":"DF Navarro-Barqu\u00edn","year":"2019","unstructured":"Navarro-Barqu\u00edn DF et al (2019) Use of the type A botulinum toxin in patients submitted to cheiloplasty to improve results in scarring in patients with nonsyndromic cleft lip and palate. Eur J Plast Surg 42(3):291\u2013294","journal-title":"Eur J Plast Surg"},{"issue":"5","key":"2596_CR26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/SAP.0000000000000625","volume":"77","author":"J Zelken","year":"2016","unstructured":"Zelken J et al (2016) Donor site aesthetic enhancement with preoperative botulinum toxin in forehead flap nasal reconstruction. Ann Plast Surg 77(5):535\u2013538","journal-title":"Ann Plast Surg"},{"issue":"2","key":"2596_CR27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bjps.2012.09.012","volume":"66","author":"M Ziade","year":"2013","unstructured":"Ziade M et al (2013) Use of botulinum toxin type A to improve treatment of facial wounds: a prospective randomised study. J Plast Reconstr Aesthet Surg 66(2):209\u2013214","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"4","key":"2596_CR28","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3758\/s13428-018-1041-8","volume":"50","author":"YT Sung","year":"2018","unstructured":"Sung YT, Wu JS (2018) The visual analogue scale for rating, ranking and paired-comparison (VAS-RRP): a new technique for psychological measurement. Behav Res Methods 50(4):1694\u20131715","journal-title":"Behav Res Methods"},{"issue":"7","key":"2596_CR29","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.burns.2015.04.018","volume":"41","author":"CM Thompson","year":"2015","unstructured":"Thompson CM, Sood RF, Honari S, Carrougher GJ, Gibran NS (2015) What score on the vancouver scar scale constitutes a hypertrophic scar? results from a survey of north American burn-care providers. Burns 41(7):1442\u20131448","journal-title":"Burns"},{"issue":"5","key":"2596_CR30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1177\/1055665619884455","volume":"57","author":"SM Refahee","year":"2020","unstructured":"Refahee SM et al (2020) Is PRP effective in reducing the scar width of primary cleft lip repair? A randomized controlled clinical study. Cleft Palate Craniofac J 57(5):581\u2013588","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"2596_CR31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/229255031502300402","volume":"23","author":"A Prodromidou","year":"2015","unstructured":"Prodromidou A et al (2015) Botulinum toxin for the prevention and healing of wound scars: a systematic review of the literature. Plast Surg (Oakv) 23(4):260\u2013264","journal-title":"Plast Surg (Oakv)"},{"issue":"1","key":"2596_CR32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0094-1298(02)00074-3","volume":"30","author":"JL Burns","year":"2003","unstructured":"Burns JL, Mancoll JS, Phillips LG (2003) Impairments to wound healing. Clin Plast Surg 30(1):47\u201356","journal-title":"Clin Plast Surg"},{"issue":"3","key":"2596_CR33","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3390\/jcm9030868","volume":"9","author":"DS Bae","year":"2020","unstructured":"Bae DS, Koo DH, Kim JE, Cho JM, Park JO (2020) Effect of botulinum toxin A on scar healing after thyroidectomy: a prospective double-blind randomized controlled trial. J Clin Med 9(3):868","journal-title":"J Clin Med"},{"issue":"9","key":"2596_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins11090491","volume":"11","author":"S Bellows","year":"2019","unstructured":"Bellows S, Jankovic J (2019) Immunogenicity associated with botulinum toxin treatment. Toxins (Basel) 11(9):1\u201322","journal-title":"Toxins (Basel)"},{"issue":"12","key":"2596_CR35","first-page":"cd003633","volume":"12","author":"M Castel\u00e3o","year":"2017","unstructured":"Castel\u00e3o M et al (2017) Botulinum toxin type A therapy for cervical dystonia. Cochrane Database Syst Rev 12(12):cd003633","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2596_CR36","first-page":"168","volume":"90","author":"R Small","year":"2014","unstructured":"Small R (2014) Botulinum toxin injection for facial wrinkles. Am Fam Physician 90(3):168\u2013175","journal-title":"Am Fam Physician"},{"issue":"2","key":"2596_CR37","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3390\/molecules17022169","volume":"17","author":"Z Xiao","year":"2012","unstructured":"Xiao Z, Qu G (2012) Effects of botulinum toxin type a on collagen deposition in hypertrophic scars. Molecules 17(2):2169\u20132177","journal-title":"Molecules"},{"issue":"5","key":"2596_CR38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/wrr.12215","volume":"22","author":"E Suarez","year":"2014","unstructured":"Suarez E, Syed F, Rasgado TA, Walmsley A, Mandal P, Bayat A (2014) Skin equivalent tensional force alters keloid fibroblast behavior and phenotype. Wound Repair Regen 22(5):557\u2013568","journal-title":"Wound Repair Regen"},{"issue":"2","key":"2596_CR39","doi-asserted-by":"crossref","first-page":"158e","DOI":"10.1097\/PRS.0b013e3182789b2b","volume":"131","author":"E Suarez","year":"2013","unstructured":"Suarez E, Syed F, Alonso-Rasgado T, Mandal P, Bayat A (2013) Up-regulation of tension-related proteins in keloids: knockdown of Hsp27, \u03b12\u03b21-integrin, and PAI-2 shows convincing reduction of extracellular matrix production. Plast Reconstr Surg 131(2):158e\u2013173e","journal-title":"Plast Reconstr Surg"},{"key":"2596_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02196-5,March5,2021","author":"Z Qiao","year":"2021","unstructured":"Qiao Z, Yang H, Jin L, Li S, Wang X (2021) The efficacy and safety of botulinum toxin injections in preventing postoperative scars and improving scar quality: a systematic review and meta-analysis. Aesthetic Plast Surg. https:\/\/doi.org\/10.1007\/s00266-021-02196-5,March5,2021","journal-title":"Aesthetic Plast Surg"},{"issue":"1","key":"2596_CR41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3342\/ceo.2009.2.1.20","volume":"2","author":"BJ Lee","year":"2009","unstructured":"Lee BJ, Jeong JH, Wang SG, Lee JC, Goh EK, Kim HW (2009) Effect of botulinum toxin type a on a rat surgical wound model. Clin Exp Otorhinolaryngol 2(1):20\u201327","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"1","key":"2596_CR42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/jidsymp.2008.7","volume":"13","author":"JP Ortonne","year":"2008","unstructured":"Ortonne JP, Bissett DL (2008) Latest insights into skin hyperpigmentation. J Investig Dermatol Symp Proc 13(1):10\u201314","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"25","key":"2596_CR43","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3109\/09638280902874196a","volume":"31","author":"S Vercelli","year":"2009","unstructured":"Vercelli S, Ferriero G, Sartorio F, Stissi V, Franchignoni F (2009) How to assess postsurgical scars: a review of outcome measures. Disabil Rehabil 31(25):2055\u20132063","journal-title":"Disabil Rehabil"},{"issue":"4","key":"2596_CR44","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/01.prs.0000232378.88776.b0","volume":"118","author":"JAL Duncan","year":"2006","unstructured":"Duncan JAL et al (2006) Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality? Plast Reconstr Surg 118(4):909\u2013918","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"2596_CR45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5999\/aps.2014.41.2.111","volume":"41","author":"SH Bae","year":"2014","unstructured":"Bae SH, Bae YC (2014) Analysis of frequency of use of different scar assessment scales based on the scar condition and treatment method. Arch Plast Surg 41(2):111\u2013115","journal-title":"Arch Plast Surg"},{"issue":"3","key":"2596_CR46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.12968\/jowc.2008.17.3.28666","volume":"17","author":"DQ Nguyen","year":"2008","unstructured":"Nguyen DQ, Potokar T, Price P (2008) A review of current objective and subjective scar assessment tools. J Wound Care 17(3):101\u2013106","journal-title":"J Wound Care"},{"issue":"4","key":"2596_CR47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.12968\/jowc.2009.18.4.41610","volume":"18","author":"D Stavrou","year":"2009","unstructured":"Stavrou D, Haik J, Weissman O, Goldan O, Tessone A, Winkler E (2009) Patient and observer scar assessment scale: how good is it? J Wound Care 18(4):171\u2013176","journal-title":"J Wound Care"},{"issue":"7","key":"2596_CR48","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1097\/01.prs.0000287275.15511.10","volume":"120","author":"AJ Singer","year":"2007","unstructured":"Singer AJ, Arora B, Dagum A, Valentine S, Hollander JE (2007) Development and validation of a novel scar evaluation scale. Plast Reconstr Surg 120(7):1892\u20131897","journal-title":"Plast Reconstr Surg"},{"key":"2596_CR49","doi-asserted-by":"publisher","DOI":"10.7916\/D88W3C1M,August2,2021","author":"MA Brodsky","year":"2021","unstructured":"Brodsky MA, Swope DM, Grimes D (2021) Diffusion of botulinum toxins. Tremor Other Hyperkinet Mov. https:\/\/doi.org\/10.7916\/D88W3C1M,August2,2021","journal-title":"Tremor Other Hyperkinet Mov"},{"issue":"1","key":"2596_CR50","doi-asserted-by":"crossref","first-page":"13670","DOI":"10.1038\/s41598-021-93203-x","volume":"11","author":"Z Chen","year":"2021","unstructured":"Chen Z et al (2021) The effect of botulinum toxin injection dose on the appearance of surgical scar. Sci Rep 11(1):13670","journal-title":"Sci Rep"},{"issue":"8","key":"2596_CR51","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1097\/GOX.0000000000000852","volume":"4","author":"A Gugerell","year":"2016","unstructured":"Gugerell A, Kober J, Schmid M, Buchberger E, Kamola LP, Keck M (2016) Botulinum toxin A: dose-dependent effect on reepithelialization and angiogenesis. Plast Reconstr Surg Glob Open 4(8):e837","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"5","key":"2596_CR52","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/wrr.12204","volume":"22","author":"YS Kim","year":"2014","unstructured":"Kim YS, Lee HJ, Cho SH, Lee JD, Kim HS (2014) Early postoperative treatment of thyroidectomy scars using botulinum toxin: A split-scar, double-blind randomized controlled trial. Wound Repair Regen 22(5):605\u2013612","journal-title":"Wound Repair Regen"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-021-02596-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-021-02596-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-021-02596-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T18:14:46Z","timestamp":1644516886000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-021-02596-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["2596"],"URL":"https:\/\/doi.org\/10.1007\/s00266-021-02596-7","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"assertion":[{"value":"30 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"For this type of study informed consent is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}