{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:51:05Z","timestamp":1788918665500,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00266-021-02650-4","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:02:49Z","timestamp":1637704969000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical Management of Complications Following Filler Injection"],"prefix":"10.1007","volume":"46","author":[{"given":"Sara","family":"Carella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9211-1231","authenticated-orcid":false,"given":"Giulia","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"La Russa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpietro","family":"Volonnino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Frati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giuseppina","family":"Onesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"2650_CR1","unstructured":"www.plasticsurgery.org\/documents\/News\/Statistics\/2020\/plastic-surgery-statistics-full-report-2020.pdf"},{"key":"2650_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s00266-017-1063-0","volume":"42","author":"F Urdiales-G\u00e1lvez","year":"2018","unstructured":"Urdiales-G\u00e1lvez F et al (2018) Treatment of soft tissue filler complications: expert consensus recommendations. Aesthetic Plast Surg 42:498\u2013510","journal-title":"Aesthetic Plast Surg"},{"key":"2650_CR3","doi-asserted-by":"crossref","unstructured":"Graivier, M. H. et al. Differentiating nonpermanent injectable fillers: prevention and treatment of filler complications. Aesthetic Surg. J.38, S29\u2013S40 (2018).","DOI":"10.1093\/asj\/sjy032"},{"key":"2650_CR4","doi-asserted-by":"publisher","first-page":"120S","DOI":"10.1097\/PRS.0000000000001770","volume":"136","author":"J Carruthers","year":"2015","unstructured":"Carruthers J, Carruthers A, Humphrey S (2015) Introduction to fillers. Plast Reconstr Surg 136:120S-131S","journal-title":"Plast Reconstr Surg"},{"key":"2650_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.det.2009.08.003","volume":"27","author":"DH Jones","year":"2009","unstructured":"Jones DH (2009) Semipermanent and permanent injectable fillers. Dermatol Clin 27:433\u2013444","journal-title":"Dermatol Clin"},{"key":"2650_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/s-0039-1688843","volume":"35","author":"MH Liu","year":"2019","unstructured":"Liu MH, Beynet DP, Gharavi NM (2019) Overview of deep dermal fillers. Facial Plast Surg 35:224\u2013229","journal-title":"Facial Plast Surg"},{"key":"2650_CR7","doi-asserted-by":"crossref","unstructured":"Mercer N (2011) Re: a retrospective study on liquid injectable silicone for lip augmentation: long term results and patient satisfaction. J Plast Reconstr Aesthetic Surg 64:831","DOI":"10.1016\/j.bjps.2010.10.017"},{"key":"2650_CR8","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1016\/j.bjps.2009.10.013","volume":"63","author":"RA Moscona","year":"2010","unstructured":"Moscona RA, Fodor L (2010) A retrospective study on liquid injectable silicone for lip augmentation: long-term results and patient satisfaction. J Plast Reconstr Aesthetic Surg 63:1694\u20131698","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"2650_CR9","first-page":"295","volume":"6","author":"D Funt","year":"2013","unstructured":"Funt D, Pavicic T (2013) Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol 6:295\u2013316","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2650_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jdv.13977","volume":"31","author":"YZ Chiang","year":"2017","unstructured":"Chiang YZ, Pierone G, Al-Niaimi F (2017) Dermal fillers: pathophysiology, prevention and treatment of complications. J Eur Acad Dermatol Venereol 31:405\u2013413","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"2650_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/0748806817729024","volume":"34","author":"EJ Nuveen","year":"2017","unstructured":"Nuveen EJ, Smith I, Leflar L (2017) What is our obligation to inform our patients of being cosmetic surgeons? Am J Cosmet Surg 34(4):167\u2013170","journal-title":"Am J Cosmet Surg"},{"issue":"1","key":"2650_CR12","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1515\/med-2016-0044","volume":"11","author":"M Piras","year":"2016","unstructured":"Piras M et al (2016) Cosmetic surgery: medicolegal considerations. Open Med 11(1):327\u2013329","journal-title":"Open Med"},{"issue":"1","key":"2650_CR13","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s00266-011-9768-y","volume":"36","author":"A Marchesi","year":"2012","unstructured":"Marchesi A et al (2012) Mammaplasties and medicolegal issues: 50 cases of litigation in aesthetic surgery of the breast. Aesthetic Plast Surg 36(1):122\u2013127","journal-title":"Aesthetic Plast Surg"},{"key":"2650_CR14","doi-asserted-by":"crossref","unstructured":"Vasalos E, Dermengiu D, Salem A, Hostiuc S (2010) Liability in plastic surgery. A Romanian forensic perspective. Roman J Legal Med 18(3):213\u2212216","DOI":"10.4323\/rjlm.2010.213"},{"issue":"3","key":"2650_CR15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.4103\/0974-2077.146655","volume":"7","author":"N Khunger","year":"2014","unstructured":"Khunger N (2014) Risk assessment and prevention of complications in aesthetic surgery. J Cutan Aesthet Surg 7(3):141","journal-title":"J Cutan Aesthet Surg"},{"key":"2650_CR16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4103\/0974-2077.63221","volume":"3","author":"M Vedamurthy","year":"2010","unstructured":"Vedamurthy M, Vedamurthy A, Nischal K (2010) Dermal fillers: do\u2032s and dont\u2032s. J Cutan Aesthet Surg 3:11","journal-title":"J Cutan Aesthet Surg"},{"key":"2650_CR17","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/j.1600-0560.2007.00853.x","volume":"35","author":"OE Dadzie","year":"2008","unstructured":"Dadzie OE et al (2008) Adverse cutaneous reactions to soft tissue fillers - A review of the histological features. J Cutan Pathol 35:536\u2013548","journal-title":"J Cutan Pathol"},{"key":"2650_CR18","doi-asserted-by":"crossref","unstructured":"Chayangsu O et al. (2020) Legal vs. illegal injectable fillers: the adverse effects comparison study. J Cosmet Dermatol 19:1580\u20131586","DOI":"10.1111\/jocd.13492"},{"key":"2650_CR19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/dth.12298","volume":"29","author":"J Seok","year":"2016","unstructured":"Seok J et al (2016) Delayed immunologic complications due to injectable fillers by unlicensed practitioners: our experiences and a review of the literature. Dermatol Ther 29:41\u201344","journal-title":"Dermatol Ther"},{"key":"2650_CR20","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Villarreal, AA et al. (2017) A case series and a review of the literature on foreign modelling agent reaction: an emerging problem. Int Wound J 14:546\u2013554","DOI":"10.1111\/iwj.12643"},{"key":"2650_CR21","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1007\/s00266-013-0212-3","volume":"37","author":"S Carella","year":"2013","unstructured":"Carella S, Romanzi A, Ciotti M, Onesti MG (2013) Skin ulcer: a long-term complication after massive liquid silicone oil infiltration. Aesthetic Plast Surg 37:1220\u20131224","journal-title":"Aesthetic Plast Surg"},{"issue":"Suppl 1","key":"2650_CR22","first-page":"S115","volume":"34","author":"M Alam","year":"2008","unstructured":"Alam M, Gladstone H, Kramer EM et al (2008) ASDS guidelines of care: injectable fillers. Dermatol Surg 34(Suppl 1):S115\u2013S148","journal-title":"Dermatol Surg"},{"key":"2650_CR23","doi-asserted-by":"publisher","first-page":"232","DOI":"10.5999\/aps.2015.42.2.232","volume":"42","author":"JM Lee","year":"2015","unstructured":"Lee JM, Kim YJ (2015) Foreign body granulomas after the use of dermal fillers: Pathophysiology, clinical appearance, histologic features, and treatment. Arch Plast Surg 42:232\u2013239","journal-title":"Arch Plast Surg"},{"issue":"6","key":"2650_CR24","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1177\/1090820X13493638","volume":"33","author":"CN Ozturk","year":"2013","unstructured":"Ozturk CN, Li Y, Tung R, Parker L, Piliang MP, Zins JE (2013) Complications following injection of soft-tissue fillers. Aesthet Surg J 33(6):862\u2013877","journal-title":"Aesthet Surg J"},{"key":"2650_CR25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1468-3083.2011.04047.x","volume":"26","author":"X Wortsman","year":"2012","unstructured":"Wortsman X et al (2012) Ultrasound detection and identification of cosmetic fillers in the skin. J Eur Acad Dermatol Venereol 26:292\u2013301","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2650_CR26","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3109\/14764172.2014.946048","volume":"16","author":"FR Grippaudo","year":"2014","unstructured":"Grippaudo FR, Di Girolamo M, Mattei M, Pucci E, Grippaudo C (2014) Diagnosis and management of dermal filler complications in the perioral region. J Cosmet Laser Ther 16:246\u2013252","journal-title":"J Cosmet Laser Ther"},{"key":"2650_CR27","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.7863\/ultra.34.7.1163","volume":"34","author":"X Wortsman","year":"2015","unstructured":"Wortsman X (2015) Identification and complications of cosmetic fillers: Sonography first. J Ultrasound Med 34:1163\u20131172","journal-title":"J Ultrasound Med"},{"key":"2650_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.032","author":"LW Schelke","year":"2019","unstructured":"Schelke LW, Velthuis P, Kadouch J, Swift A (2019) Early ultrasound for diagnosis and treatment of vascular adverse events with hyaluronic acid fillers. J Am Acad Dermatol. https:\/\/doi.org\/10.1016\/j.jaad.2019.07.032","journal-title":"J Am Acad Dermatol"},{"key":"2650_CR29","doi-asserted-by":"crossref","unstructured":"Kadouch JA et al. (2014) Complications after facial injections with permanent fillers: important limitations and considerations of MRI evaluation. Aesthetic Surg J 34:913\u2013923","DOI":"10.1177\/1090820X14539504"},{"key":"2650_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13005-016-0124-y","volume":"12","author":"S Tal","year":"2016","unstructured":"Tal S et al (2016) MRI in detecting facial cosmetic injectable fillers. Head Face Med 12:1\u20137","journal-title":"Head Face Med"},{"key":"2650_CR31","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s00330-014-3513-2","volume":"25","author":"M Di Girolamo","year":"2015","unstructured":"Di Girolamo M, Mattei M, Signore A, Grippaudo FR (2015) MRI in the evaluation of facial dermal fillers in normal and complicated cases. Eur Radiol 25:1431\u20131442","journal-title":"Eur Radiol"},{"key":"2650_CR32","doi-asserted-by":"crossref","unstructured":"Grippaudo FR, Spalvieri C, Rossi A, Giuseppina Onesti M Scuderi N (2004) Ultrasound-assisted liposuction for the removal of siliconomas. Scand J Plast Reconstr Surg Hand Surg 38:21\u201326","DOI":"10.1080\/02844310310004686"},{"key":"2650_CR33","doi-asserted-by":"crossref","unstructured":"Salgado CJ, Sinha VR, Desai U (2014) Liposuction and lipofilling for treatment of symptomatic silicone toxicosis of the gluteal region. Aesthetic Surg J 34:571\u2013577","DOI":"10.1177\/1090820X14527107"},{"key":"2650_CR34","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s00266-011-9778-9","volume":"36","author":"F Bassetto","year":"2012","unstructured":"Bassetto F, Abatangelo S, Masetto L, Vindigni V (2012) Ultrasound-assisted liposuction as a safe and effective method for the removal of siliconomas. Aesthetic Plast Surg 36:220\u2013222","journal-title":"Aesthetic Plast Surg"},{"issue":"6","key":"2650_CR35","first-page":"E65","volume":"12","author":"G Sito","year":"2019","unstructured":"Sito G, Manzoni V, Sommariva R (2019) Vascular Complications after Facial Filler Injection: A Literature Review and Meta-analysis. J Clin Aesthet Dermatol. 12(6):E65\u2013E72","journal-title":"J Clin Aesthet Dermatol."},{"issue":"Suppl 2","key":"2650_CR36","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1111\/j.1524-4725.2009.01346.x","volume":"35","author":"AP Sclafani","year":"2009","unstructured":"Sclafani AP, Fagien S (2009) Treatment of injectable soft tissue filler complications. Dermatol Surg 35(Suppl 2):1672\u20131680","journal-title":"Dermatol Surg"},{"issue":"4","key":"2650_CR37","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1177\/1090820X14525035","volume":"34","author":"C DeLorenzi","year":"2014","unstructured":"DeLorenzi C (2014) Complications of injectable fillers, part 2: vascular complications. Aesthet Surg J 34(4):584\u2013600","journal-title":"Aesthet Surg J"},{"key":"2650_CR38","unstructured":"King M, Convery C, Davies E (2018) This month's guideline: the use of hyaluronidase in aesthetic practice (v2.4). J Clin Aesthet Dermatol 11(6):E61-E68. Epub 2018 Jun 1. PMID: 29942426; PMCID: PMC6011868."}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-021-02650-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-021-02650-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-021-02650-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T15:16:48Z","timestamp":1652195808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-021-02650-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["2650"],"URL":"https:\/\/doi.org\/10.1007\/s00266-021-02650-4","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"16 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}