{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:29:29Z","timestamp":1779316169156,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["10210055"],"award-info":[{"award-number":["10210055"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00266-022-02895-7","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T18:03:41Z","timestamp":1652378621000},"page":"1872-1880","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Effectiveness and Safety of a Botulinum Toxin Monotherapy and a Combination Therapy with Hyaluronic Acid Filler for Improving Glabellar Frown"],"prefix":"10.1007","volume":"46","author":[{"given":"Jun Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-9122","authenticated-orcid":false,"given":"Eun Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Min","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"issue":"3","key":"2895_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1529-8019.2006.00072.x","volume":"19","author":"RC Kiersten","year":"2006","unstructured":"Kiersten RC, Jean C (2006) Combination therapy with BOTOXTM and fillers: the new rejuvenation paradigm. Dermatol Ther 19(3):177\u2013188","journal-title":"Dermatol Ther"},{"issue":"4","key":"2895_CR2","first-page":"1835","volume":"10","author":"AE Samy","year":"2013","unstructured":"Samy AE, Serag MZ (2013) Combination of botulinum toxin type a and hyaluronica acid filler for treatment of moderate to severe glabellar rhytides: results of 1 year follow up. Life Sci J 10(4):1835\u20131840","journal-title":"Life Sci J"},{"issue":"1","key":"2895_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/0019-5154.60343","volume":"55","author":"PK Nigam","year":"2010","unstructured":"Nigam PK, Nigam A (2010) Botulinum toxin. Indian J Dermatol 55(1):8\u201314","journal-title":"Indian J Dermatol"},{"key":"2895_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1533\/9781845693121.147","volume":"2","author":"WYJ Chen","year":"2002","unstructured":"Chen WYJ, Abatangelo G (2002) Functions of hyaluronan in wound repair. Hyaluronan 2:147\u2013156","journal-title":"Hyaluronan"},{"key":"2895_CR5","doi-asserted-by":"publisher","first-page":"107950","DOI":"10.1016\/j.carres.2020.107950","volume":"489","author":"H Alexander","year":"2020","unstructured":"Alexander H, Ronny P (2020) Hyaluronic acid applications in ophthalmology, rheumatology, and dermatology. Carbohyd Res 489:107950","journal-title":"Carbohyd Res"},{"issue":"1","key":"2895_CR6","first-page":"101","volume":"36","author":"H Germain","year":"2019","unstructured":"Germain H, Jean-Yves R, Francois R, Xavier R, Anton G, Veronique R et al (2019) Safety of intra-articular hyaluronic acid injections in osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging 36(1):101\u2013127","journal-title":"Drugs Aging"},{"issue":"03","key":"2895_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1055\/s-0039-1688797","volume":"35","author":"JT Bacos","year":"2019","unstructured":"Bacos JT, Dayan SH (2019) Superficial dermal fillers with hyaluronic acid. Facial Plast Surg 35(03):219\u2013223","journal-title":"Facial Plast Surg"},{"issue":"1","key":"2895_CR8","doi-asserted-by":"publisher","first-page":"32e","DOI":"10.1097\/PRS.0000000000005081","volume":"149","author":"LY Cong","year":"2019","unstructured":"Cong LY, Choi YJ, Hu KS, Tansatit T, Kim HJ (2019) Three-dimensional topography of the emerging point of the ophthalmic artery. Plast Reconstruct Surg 149(1):32e\u201338e","journal-title":"Plast Reconstruct Surg"},{"issue":"1","key":"2895_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/PRS.0000000000005716","volume":"144","author":"W Lee","year":"2019","unstructured":"Lee W, Oh W, Ko HS, Lee SY, Kim KW, Yang EJ (2019) Effectiveness of retrobulbar hyaluronidase injection in an iatrogenic blindness rabbit model using hyaluronic acid filler injection. Plast Reconstruct Surg 144(1):137\u2013143","journal-title":"Plast Reconstruct Surg"},{"issue":"4","key":"2895_CR10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/jocd.12059","volume":"12","author":"D Meghan","year":"2013","unstructured":"Meghan D, Rebecca T, Diana B, Anne MM, Bailey T, Mauricio S, Fabiane MB, Trevor J, Dennis PW, Emily P, Michael N, Murad A (2013) Treatment of forehead\/glabellar rhytide complex with combination botulinum toxin a and hyaluronic acid versus botulinum toxin a injection alone: a split-face, rater-blinded, randomized control trial. J Cosmet Dermatol 12(4):261\u2013266","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"2895_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2165\/11530110-000000000-00000","volume":"11","author":"TC Flynn","year":"2011","unstructured":"Flynn TC (2011) Botulinum toxin: examining duration of effect in facial aesthetic applications. Am J Clin Dermatol 11(3):183\u2013199","journal-title":"Am J Clin Dermatol"},{"issue":"1","key":"2895_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.clindermatol.2003.11.005","volume":"22","author":"SY Paul","year":"2004","unstructured":"Paul SY, Nicholas JL (2004) Botulinum toxin types A and B: comparison of efficacy, duration, and dose-ranging studies for the treatment of facial rhytides and hyperhidrosis. Clin Dermatol 22(1):34\u201339","journal-title":"Clin Dermatol"},{"key":"2895_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fsc.2006.10.001","volume":"15","author":"B Gary","year":"2007","unstructured":"Gary B (2007) Botulinum toxin, immunologic considerations with long-term repeated use, with emphasis on cosmetic applications. Fac Plast Surg Clin N Am 15:11\u201316","journal-title":"Fac Plast Surg Clin N Am"},{"issue":"3","key":"2895_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/01.iio.0000167164.41127.28","volume":"45","author":"AF Jill","year":"2005","unstructured":"Jill AF, Paul LP, Liana HP, Allan EW, Julian DP (2005) Modifying brow position with botulinum toxin. Int Ophthalmol Clin 45(3):123\u2013131","journal-title":"Int Ophthalmol Clin"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-022-02895-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-022-02895-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-022-02895-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T20:44:47Z","timestamp":1664225087000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-022-02895-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["2895"],"URL":"https:\/\/doi.org\/10.1007\/s00266-022-02895-7","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"5 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research board (IRB) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal research"}},{"value":"All participants in this study had written well-informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}