{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:24:33Z","timestamp":1781364273523,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.461654\/2019-01"],"award-info":[{"award-number":["88882.461654\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"bioplastia brasil","award":["01\/2017"],"award-info":[{"award-number":["01\/2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00266-022-03179-w","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T16:24:06Z","timestamp":1669307046000},"page":"1205-1216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tissue Remodeling After Implantation with Polymethylmethacrylate: An Experimental Study in Mice"],"prefix":"10.1007","volume":"47","author":[{"given":"An\u00e1lia Cirqueira","family":"Milhomem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Mendes","family":"de Souza Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"dos Santos Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Dias","family":"Tom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Luiz","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Clare","family":"Vinaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathas Xavier","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy","family":"de Souza Lino J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"3179_CR1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1080\/15583724.2015.1031377","volume":"55","author":"U Ali","year":"2015","unstructured":"Ali U, Karim KJBA, Buang NA (2015) A review of the properties and applications of poly (Methylmethacrylate) (PMMA). Polym Rev 55:678\u2013705","journal-title":"Polym Rev"},{"key":"3179_CR2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1590\/S1678-77572011000400021","volume":"19","author":"RCC Abdo Filho","year":"2011","unstructured":"Abdo Filho RCC, Oliveira TM, Louren\u00e7o Neto N et al (2011) Reconstruction of bony facial contour deficiencies with polymethylmethacrylate implants: case report. J Appl Oral Sci 19:426\u2013430","journal-title":"J Appl Oral Sci"},{"key":"3179_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/app7030276","volume":"7","author":"J Kwarcinski","year":"2017","unstructured":"Kwarcinski J, Boughton P, Ruys A et al (2017) Cranioplasty and craniofacial reconstruction: a review of implant material, manufacturing method and infection risk. Appl Sci 7:276","journal-title":"Appl Sci"},{"key":"3179_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/asjof\/ojaa002","volume":"2","author":"AC Milhomem","year":"2020","unstructured":"Milhomem AC, de Jorge IMS, da Costa EL et al (2020) Polymethylmethacrylate (PMMA) in the treatment of a case of hemifacial microsomia. Aesthetic Surg J Open Forum 2:1\u20135","journal-title":"Aesthetic Surg J Open Forum"},{"key":"3179_CR5","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.2310\/6350.2005.31237","volume":"31","author":"D Jones","year":"2005","unstructured":"Jones D (2005) HIV facial lipoatrophy: causes and treatment options. Dermatol Surg 31:1519\u20131529","journal-title":"Dermatol Surg"},{"key":"3179_CR6","first-page":"1019","volume":"48","author":"HL Sun","year":"2016","unstructured":"Sun HL, Li CD, Yang ZC et al (2016) Polymethylmethacrylate augmentation of bone cement-injectable cannulated pedicle screws for the treatment of degenerative lumbar diseases with osteoporosis. Beijing Da Xue Xue Bao 48:1019\u20131025","journal-title":"Beijing Da Xue Xue Bao"},{"key":"3179_CR7","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1039\/C6PY01957A","volume":"8","author":"X Xu","year":"2017","unstructured":"Xu X, He L, Zhu B et al (2017) Advances in polymeric materials for dental applications. Polym Chem 8:807\u2013823","journal-title":"Polym Chem"},{"key":"3179_CR8","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00417-017-3740-8","volume":"255","author":"A Grzybowski","year":"2017","unstructured":"Grzybowski A, Wasinska-Borowiec W, Alio JL et al (2017) Intraocular lenses in age-related macular degeneration. Graefe\u2019s Arch Clin Exp Ophthalmol 255:1687\u20131696","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"3179_CR9","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1016\/j.jsxm.2016.06.008","volume":"13","author":"L Casavantes","year":"2016","unstructured":"Casavantes L, Lemperle G, Morales P (2016) Penile girth enhancement with Polymethylmethacrylate-based soft tissue fillers. J Sex Med 13:1414\u20131422","journal-title":"J Sex Med"},{"key":"3179_CR10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/bju.15145","volume":"127","author":"J Romero-Otero","year":"2021","unstructured":"Romero-Otero J, Manfredi C, Ralph D et al (2021) Non-invasive and surgical penile enhancement interventions for aesthetic or therapeutic purposes: a systematic review. BJU Int 127:269\u2013291","journal-title":"BJU Int"},{"key":"3179_CR11","first-page":"e7","volume":"10","author":"CM McCarthy","year":"2010","unstructured":"McCarthy CM, VanLaeken N, Lennox P et al (2010) The efficacy of Artecoll injections for the augmentation of nipple projection in breast reconstruction. Eplasty 10:e7","journal-title":"Eplasty"},{"key":"3179_CR12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s00266-009-9413-1","volume":"34","author":"G Lemperle","year":"2010","unstructured":"Lemperle G, Knapp TR, Sadick NS et al (2010) ArteFill\u00ae permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques. Aesthetic Plast Surg 34:264\u2013272","journal-title":"Aesthetic Plast Surg"},{"key":"3179_CR13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00266-009-9414-0","volume":"34","author":"G Lemperle","year":"2010","unstructured":"Lemperle G, Knapp TR, Sadick NS et al (2010) ArteFill\u00ae permanent injectable for soft tissue augmentation: II. Indications and applications. Aesthetic Plast Surg 34:273\u2013286","journal-title":"Aesthetic Plast Surg"},{"key":"3179_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/229255031202000110","volume":"20","author":"P Solomon","year":"2012","unstructured":"Solomon P, Sklar M, Zener R (2012) Facial soft tissue augmentation with Artecoll\u00ae: a review of eight years of clinical experience in 153 patients. Can J Plast Surg 20:28\u201332","journal-title":"Can J Plast Surg"},{"key":"3179_CR15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1055\/s-0037-1605599","volume":"33","author":"D Li","year":"2017","unstructured":"Li D, Luo S-K, Wang Y-C et al (2017) Facial volume restoration with permanent dermal filler (Artecoll-4) in Chinese women. Facial Plast Surg 33:537\u2013544","journal-title":"Facial Plast Surg"},{"key":"3179_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/2292550320933675","volume":"29","author":"P Solomon","year":"2021","unstructured":"Solomon P, Ng CL, Kerzner J et al (2021) Facial soft tissue augmentation with bellafill: a review of 4 years of clinical experience in 212 patients. Plast Surg (Oakv) 29:98\u2013102","journal-title":"Plast Surg (Oakv)"},{"key":"3179_CR17","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jbm.a.35958","volume":"105","author":"R Klopfleisch","year":"2017","unstructured":"Klopfleisch R, Jung F (2017) The pathology of the foreign body reaction against biomaterials. J Biomed Mater Res Part A 105:927\u2013940","journal-title":"J Biomed Mater Res Part A"},{"key":"3179_CR18","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.addr.2019.08.010","volume":"144","author":"O Veiseh","year":"2019","unstructured":"Veiseh O, Vegas AJ (2019) Domesticating the foreign body response: recent advances and applications. Adv Drug Deliv Rev 144:148\u2013161","journal-title":"Adv Drug Deliv Rev"},{"key":"3179_CR19","doi-asserted-by":"publisher","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","volume":"32","author":"S Franz","year":"2011","unstructured":"Franz S, Rammelt S, Scharnweber D et al (2011) Immune responses to implants\u2014a review of the implications for the design of immunomodulatory biomaterials. Biomaterials 32:6692\u20136709","journal-title":"Biomaterials"},{"key":"3179_CR20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2147\/CCID.S80446","volume":"8","author":"K De Boulle","year":"2015","unstructured":"De Boulle K, Heydenrych I (2015) Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol 8:205\u2013214","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"3179_CR21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.toxrep.2021.01.011","volume":"8","author":"G Montealegre","year":"2021","unstructured":"Montealegre G, Uribe R, Mart\u00ednez-Ceballos MA et al (2021) ASIA syndrome symptoms induced by gluteal biopolymer injections: case-series and narrative review. Toxicol Rep 8:303\u2013314","journal-title":"Toxicol Rep"},{"key":"3179_CR22","first-page":"2296","volume":"2","author":"G Lemperle","year":"2018","unstructured":"Lemperle G (2018) Biocompatibility of injectable microspheres. Biomed J Sci Tech Res 2:2296\u20132306","journal-title":"Biomed J Sci Tech Res"},{"key":"3179_CR23","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1097\/PRS.0b013e31818236d7","volume":"123","author":"G Lemperle","year":"2009","unstructured":"Lemperle G, Gauthier-Hazan N, Wolters M et al (2009) Foreign body granulomas after all injectable dermal fillers: part 1. Possible causes. Plast Reconstr Surg 123:1842\u20131863","journal-title":"Plast Reconstr Surg"},{"key":"3179_CR24","doi-asserted-by":"publisher","first-page":"e244","DOI":"10.4317\/jced.50868","volume":"4","author":"L Carlos-Fabuel","year":"2012","unstructured":"Carlos-Fabuel L, Marzal-Gamarra C, Mart\u00ed-\u00c1lamo S et al (2012) Foreign body granulomatous reactions to cosmetic fillers. J Clin Exp Dent 4:e244","journal-title":"J Clin Exp Dent"},{"key":"3179_CR25","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00266-019-01522-2","volume":"44","author":"BP Paulucci","year":"2020","unstructured":"Paulucci BP (2020) PMMA safety for facial filling: review of rates of granuloma occurrence and treatment methods. Aesthetic Plast Surg 44:148\u2013159","journal-title":"Aesthetic Plast Surg"},{"key":"3179_CR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1177\/1090820X13484492","volume":"33","author":"C DeLorenzi","year":"2013","unstructured":"DeLorenzi C (2013) Complications of injectable fillers Part I. Aesthetic Surg J 33:561\u2013575","journal-title":"Aesthetic Surg J"},{"key":"3179_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12016-012-8348-5","volume":"45","author":"J Alijotas-Reig","year":"2013","unstructured":"Alijotas-Reig J, Fern\u00e1ndez-Figueras MT, Puig L (2013) Late-onset inflammatory adverse reactions related to soft tissue filler injections. Clin Rev Allergy Immunol 45:97\u2013108","journal-title":"Clin Rev Allergy Immunol"},{"key":"3179_CR28","first-page":"295","volume":"6","author":"D Funt","year":"2013","unstructured":"Funt D, Pavicic T (2013) Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin Cosmet Investig Dermatol 6:295\u2013316","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"3179_CR29","doi-asserted-by":"publisher","first-page":"e12676","DOI":"10.1111\/dth.12676","volume":"32","author":"E Haneke","year":"2019","unstructured":"Haneke E (2019) Adverse effects of fillers. Dermatol Ther 32:e12676","journal-title":"Dermatol Ther"},{"key":"3179_CR30","first-page":"400","volume":"52","author":"EL Costa","year":"2016","unstructured":"Costa EL, Milhomem AC, De Moura Filho RM et al (2016) Polymethyl methacrylate (Linnea Safe) causes local inflammatory response after intramuscular implant in BALB\/c mice but it is not observed in distant organs. J Bras Patol e Med Lab 52:400\u2013406","journal-title":"J Bras Patol e Med Lab"},{"key":"3179_CR31","first-page":"1","volume":"2012","author":"NR d\u2019E\u00e7a","year":"2012","unstructured":"d\u2019E\u00e7a NR, Herdt MA, Wohlgemuth FB et al (2012) Possible migration and histopathological analysis of injections of Polymethylmethacrylate in Wistar rats. ISRN Dermatol 2012:1\u20139","journal-title":"ISRN Dermatol"},{"key":"3179_CR32","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1097\/01.PRS.0000112764.22839.7A","volume":"113","author":"G Lemperle","year":"2004","unstructured":"Lemperle G, Morhenn VB, Pestonjamasp V et al (2004) Migration studies and histology of injectable microspheres of different sizes in mice. Plast Reconstr Surg 113:1380\u20131390","journal-title":"Plast Reconstr Surg"},{"key":"3179_CR33","doi-asserted-by":"publisher","first-page":"e0137550","DOI":"10.1371\/journal.pone.0137550","volume":"10","author":"S Jhunjhunwala","year":"2015","unstructured":"Jhunjhunwala S, Aresta-DaSilva S, Tang K et al (2015) Neutrophil responses to sterile implant materials. PLoS ONE 10:e0137550","journal-title":"PLoS ONE"},{"key":"3179_CR34","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2147\/CCID.S81467","volume":"8","author":"LH Jesus","year":"2015","unstructured":"Jesus LH, Hildebrand LC, Martins MD et al (2015) Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects: an experimental and histopathologic study. Clin Cosmet Investig Dermatol 8:431\u2013436","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"3179_CR35","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.ijom.2012.04.007","volume":"41","author":"SP Moure","year":"2012","unstructured":"Moure SP, De Vargas KF, Borghetti RL et al (2012) Clinical and pathological characteristics of polymethylmethacrylate and hyaluronic acid in the rat tongue. Int J Oral Maxillofac Surg 41:1296\u20131303","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"10","key":"3179_CR36","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3390\/ani9100754","volume":"9","author":"RC Hubrecht","year":"2019","unstructured":"Hubrecht RC, Carter E (2019) The 3Rs and humane experimental technique: implementing change. Animals (Basel) 9(10):754. https:\/\/doi.org\/10.3390\/ani9100754","journal-title":"Animals (Basel)"},{"key":"3179_CR37","doi-asserted-by":"publisher","first-page":"342604","DOI":"10.1155\/2015\/342304","volume":"2015","author":"SN Christo","year":"2015","unstructured":"Christo SN, Diener KR, Bachhuka A et al (2015) Innate immunity and biomaterials at the nexus: friends or foes. Biomed Res Int 2015:342604","journal-title":"Biomed Res Int"},{"key":"3179_CR38","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.ajpath.2019.02.006","volume":"189","author":"PJ Brooks","year":"2019","unstructured":"Brooks PJ, Glogauer M, McCulloch CA (2019) An overview of the derivation and function of multinucleated giant cells and their role in pathologic processes. Am J Pathol 189:1145\u20131158","journal-title":"Am J Pathol"},{"key":"3179_CR39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/ten.teb.2017.0242","volume":"24","author":"RJ Miron","year":"2018","unstructured":"Miron RJ, Bosshardt DD (2018) Multinucleated giant cells: good guys or bad guys? Tissue Eng Part B Rev 24:53\u201365","journal-title":"Tissue Eng Part B Rev"},{"key":"3179_CR40","doi-asserted-by":"publisher","first-page":"0007","DOI":"10.1038\/s41551-016-0007","volume":"1","author":"E Dondossola","year":"2016","unstructured":"Dondossola E, Holzapfel BM, Alexander S et al (2016) Examination of the foreign body response to biomaterials by nonlinear intravital microscopy. Nat Biomed Eng 1:0007","journal-title":"Nat Biomed Eng"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-022-03179-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-022-03179-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-022-03179-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T19:02:56Z","timestamp":1685473376000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-022-03179-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3179"],"URL":"https:\/\/doi.org\/10.1007\/s00266-022-03179-w","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"29 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Animal rights were completely respected and this study followed the regulations of the ethical committee in animal use, approval protocol number 027\/2017 (CEUA\/UFG).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"For this type of study, informed consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}