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The present study aimed to assess the efficacy of a mixture of low molecular weight hyaluronic acid and six amino acids when applied with a specific intradermal injection technique known as intra-mural fluid technique. A clinical study was carried out in 32 patients (with a dropout rate by 9.4%) with striae distensae alba (SA) in one or more of the following anatomical areas: breast, abdomen, inner thigh, trochanteric area, gluteal area, posterior supra-iliac area, and lumbar area. Product efficacy was assessed by the investigator using the Global Aesthetic Improvement Scale, while a Likert scale was used to evaluate to score the treatment tolerability and a QoL stretch marks questionnaire was used to investigate the patients\u2019 self-body image. The treatment was effective in improving the appearance of SA fifteen days after the second treatment and 6 months after the first treatment (and after a total of 4 treatments). The product efficacy and tolerability were also perceived by the patients during each treatment session. Our results suggest that the test treatment is a valid treatment option to decrease the appearance of SA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of Evidence IV<\/jats:title>\n                <jats:p> This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors  <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.springer.com\/00266\">https:\/\/www.springer.com\/00266<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00266-024-03911-8","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T17:01:30Z","timestamp":1711990890000},"page":"2475-2483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low Molecular Weight Hyaluronic Acid Added to Six Specific Amino Acids in the Treatment of Striae Alba (SA): An Observational Study"],"prefix":"10.1007","volume":"48","author":[{"given":"Elena","family":"Fasola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-302X","authenticated-orcid":false,"given":"Vincenzo","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"3911_CR1","volume-title":"Stretch marks","author":"AM Oakley","year":"2023","unstructured":"Oakley AM, Patel BC (2023) Stretch marks. 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