{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:44:24Z","timestamp":1776203064019,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s00266-024-04000-6","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T15:01:46Z","timestamp":1711724506000},"page":"2965-2974","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Smart Use of Skin Biopsy Punch in Treating Keloids: A Single-Center Retrospective Study"],"prefix":"10.1007","volume":"48","author":[{"given":"Yixin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-2096","authenticated-orcid":false,"given":"Renliang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"issue":"2","key":"4000_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","volume":"35","author":"D Wolfram","year":"2009","unstructured":"Wolfram D, Tzankov A, Pulzl P et al (2009) Hypertrophic scars and keloids\u2014a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35(2):171\u2013181","journal-title":"Dermatol Surg"},{"issue":"1\u20132","key":"4000_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2119\/molmed.2009.00153","volume":"17","author":"GG Gauglitz","year":"2011","unstructured":"Gauglitz GG, Korting HC, Pavicic T et al (2011) Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 17(1\u20132):113\u2013125","journal-title":"Mol Med"},{"issue":"1","key":"4000_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clindermatol.2006.09.009","volume":"25","author":"DT Robles","year":"2007","unstructured":"Robles DT, Berg D (2007) Abnormal wound healing: keloids. Clin Dermatol 25(1):26\u201332","journal-title":"Clin Dermatol"},{"issue":"6","key":"4000_CR4","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","volume":"17","author":"CK Sen","year":"2009","unstructured":"Sen CK, Gordillo GM, Roy S et al (2009) Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen 17(6):763\u2013771","journal-title":"Wound Repair Regen"},{"issue":"2","key":"4000_CR5","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1524-4725.1996.tb00493.x","volume":"22","author":"B Berman","year":"1996","unstructured":"Berman B, Bieley HC (1996) Adjunct therapies to surgical management of keloids. Dermatol Surg 22(2):126\u2013130","journal-title":"Dermatol Surg"},{"issue":"8","key":"4000_CR6","first-page":"825","volume":"40","author":"MH Gold","year":"2014","unstructured":"Gold MH, McGuire M, Mustoe TA et al (2014) Updated international clinical recommendations on scar management: part 2\u2013algorithms for scar prevention and treatment. Dermatol Surg 40(8):825\u2013831","journal-title":"Dermatol Surg"},{"key":"4000_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2147\/CCID.S133672","volume":"11","author":"M Morelli Coppola","year":"2018","unstructured":"Morelli Coppola M, Salzillo R, Segreto F, Persichetti P (2018) Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol 11:387\u2013396","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"6","key":"4000_CR8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1001\/archfaci.8.6.362","volume":"8","author":"D Leventhal","year":"2006","unstructured":"Leventhal D, Furr M, Reiter D (2006) Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch Facial Plast Surg 8(6):362\u2013368","journal-title":"Arch Facial Plast Surg"},{"key":"4000_CR9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.actbio.2015.12.031","volume":"32","author":"MH Kural","year":"2016","unstructured":"Kural MH, Billiar KL (2016) Myofibroblast persistence with real-time changes in boundary stiffness. Acta Biomater 32:223\u2013230","journal-title":"Acta Biomater"},{"issue":"12","key":"4000_CR10","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1111\/dsu.12346","volume":"39","author":"JA Ledon","year":"2013","unstructured":"Ledon JA, Savas J, Franca K et al (2013) Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg 39(12):1745\u20131757","journal-title":"Dermatol Surg"},{"issue":"2","key":"4000_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/229255031302100208","volume":"21","author":"AM Wilson","year":"2013","unstructured":"Wilson AM (2013) Eradication of keloids: Surgical excision followed by a single injection of intralesional 5-fluorouracil and botulinum toxin. Can J Plast Surg 21(2):87\u201391","journal-title":"Can J Plast Surg"},{"issue":"1","key":"4000_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5021\/ad.2015.27.1.53","volume":"27","author":"SY Lee","year":"2015","unstructured":"Lee SY, Park J (2015) Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence. Ann Dermatol 27(1):53\u201358","journal-title":"Ann Dermatol"},{"issue":"6","key":"4000_CR13","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1097\/DSS.0000000000001695","volume":"45","author":"YI Lee","year":"2019","unstructured":"Lee YI, Kim J, Yang CE et al (2019) Combined therapeutic strategies for keloid treatment. Dermatol Surg 45(6):802\u2013810","journal-title":"Dermatol Surg"},{"issue":"6","key":"4000_CR14","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.bjps.2018.01.033","volume":"71","author":"E Bijlard","year":"2018","unstructured":"Bijlard E, Timman R, Verduijn GM et al (2018) Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: randomised controlled trials. J Plast Reconstr Aesthet Surg 71(6):847\u2013856","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"4","key":"4000_CR15","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.jamcollsurg.2007.12.001","volume":"206","author":"PD Butler","year":"2008","unstructured":"Butler PD, Longaker MT, Yang GP (2008) Current progress in keloid research and treatment. J Am Coll Surg 206(4):731\u2013741","journal-title":"J Am Coll Surg"},{"issue":"5","key":"4000_CR16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/DSS.0000000000002438","volume":"47","author":"H Wang","year":"2021","unstructured":"Wang H, Zhao W, Xu M et al (2021) Treatment of keloids by surgical excision combined with 5-fluorouracil and betamethasone injection. Dermatol Surg 47(5):740\u2013741","journal-title":"Dermatol Surg"},{"issue":"3","key":"4000_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/ced.14920","volume":"47","author":"PP Naik","year":"2022","unstructured":"Naik PP (2022) Novel targets and therapies for keloid. Clin Exp Dermatol 47(3):507\u2013515","journal-title":"Clin Exp Dermatol"},{"key":"4000_CR18","doi-asserted-by":"publisher","first-page":"205951312092662","DOI":"10.1177\/2059513120926628","volume":"6","author":"C Sohrabi","year":"2020","unstructured":"Sohrabi C, Goutos I (2020) The use of botulinum toxin in keloid scar management: a literature review. Scars Burn Heal 6:2059513120926628","journal-title":"Scars Burn Heal"},{"issue":"6","key":"4000_CR19","doi-asserted-by":"publisher","first-page":"np567","DOI":"10.1093\/asj\/sjaa357","volume":"41","author":"P Wang","year":"2021","unstructured":"Wang P, Gu L, Bi H et al (2021) Comparing the Efficacy and Safety of Intralesional verapamil with Intralesional triamcinolone Acetonide in treatment of hypertrophic scars and keloids: a meta-analysis of randomized controlled trials. Aesthet Surg J 41(6):np567\u2013np575","journal-title":"Aesthet Surg J"},{"issue":"1","key":"4000_CR20","doi-asserted-by":"publisher","first-page":"e12769","DOI":"10.1111\/dth.12769","volume":"32","author":"E Hussein Ali","year":"2019","unstructured":"Hussein Ali E, Adnan SS (2019) Effect of collagenase ointment versus moist exposed burn ointment on healing of full-thickness burns in mice by removing of necrotic tissue. Dermatol Ther 32(1):e12769","journal-title":"Dermatol Ther"},{"issue":"5","key":"4000_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/00004630-199509000-00013","volume":"16","author":"MJ Baryza","year":"1995","unstructured":"Baryza MJ, Baryza GA (1995) The Vancouver scar scale: an administration tool and its interrater reliability. J Burn Care Rehabil 16(5):535\u2013538","journal-title":"J Burn Care Rehabil"},{"issue":"3","key":"4000_CR22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/jcph.250","volume":"54","author":"MD Reed","year":"2014","unstructured":"Reed MD, Van Nostran W (2014) Assessing pain intensity with the visual analog scale: a plea for uniformity. J Clin Pharmacol 54(3):241\u2013244","journal-title":"J Clin Pharmacol"},{"issue":"1","key":"4000_CR23","doi-asserted-by":"publisher","first-page":"79e","DOI":"10.1097\/PRS.0000000000008667","volume":"149","author":"R Ogawa","year":"2022","unstructured":"Ogawa R (2022) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg 149(1):79e\u201394e","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"4000_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/SLA.0b013e318220b159","volume":"254","author":"GC Gurtner","year":"2011","unstructured":"Gurtner GC, Dauskardt RH, Wong VW et al (2011) Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann Surg 254(2):217\u2013225","journal-title":"Ann Surg"},{"issue":"3","key":"4000_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.diff.2013.02.003","volume":"86","author":"KC Rustad","year":"2013","unstructured":"Rustad KC, Wong VW, Gurtner GC (2013) The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation. Differentiation 86(3):87\u201391","journal-title":"Differentiation"},{"issue":"8","key":"4000_CR26","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1001\/jamadermatol.2022.2207","volume":"158","author":"M Artz","year":"2022","unstructured":"Artz M, Trimaille A, Labouche A et al (2022) Outcomes associated with combination shaving and cryosurgery treatment in patients with keloid scars. JAMA Dermatol 158(8):956\u2013958","journal-title":"JAMA Dermatol"},{"issue":"3","key":"4000_CR27","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/jocd.12552","volume":"17","author":"EZ Azzam","year":"2018","unstructured":"Azzam EZ, Omar SS (2018) Treatment of auricular keloids by triple combination therapy: surgical excision, platelet-rich plasma, and cryosurgery. J Cosmet Dermatol 17(3):502\u2013510","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"4000_CR28","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/PRS.0000000000000911","volume":"135","author":"MCE van Leeuwen","year":"2015","unstructured":"van Leeuwen MCE, van der Wal MBA, Bulstra AJ et al (2015) Intralesional cryotherapy for treatment of keloid scars: a prospective study. Plast Reconstr Surg 135(2):580\u2013589","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"4000_CR29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/exd.13460","volume":"28","author":"HI Harn","year":"2019","unstructured":"Harn HI, Ogawa R, Hsu CK et al (2019) The tension biology of wound healing. Exp Dermatol 28(4):464\u2013471","journal-title":"Exp Dermatol"},{"issue":"7","key":"4000_CR30","doi-asserted-by":"publisher","first-page":"150e","DOI":"10.1097\/01.prs.0000191977.51206.43","volume":"116","author":"A Burd","year":"2005","unstructured":"Burd A, Huang L (2005) Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg 116(7):150e\u2013157e","journal-title":"Plast Reconstr Surg"},{"issue":"11","key":"4000_CR31","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1111\/jocd.13383","volume":"19","author":"YJ Choi","year":"2020","unstructured":"Choi YJ, Lee YH, Lee HJ et al (2020) Auricular keloid management in Asian skin: clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection. J Cosmet Dermatol 19(11):3041\u20133047","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"4000_CR32","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1097\/PRS.0000000000000962","volume":"135","author":"R Ogawa","year":"2015","unstructured":"Ogawa R, Akaishi S, Dohi T et al (2015) Analysis of the surgical treatments of 63 keloids on the cartilaginous part of the auricle: effectiveness of the core excision method. Plast Reconstr Surg 135(3):868\u2013875","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"4000_CR33","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3181\/00379727-163-40750","volume":"163","author":"BJ McCoy","year":"1980","unstructured":"McCoy BJ, Diegelmann RF, Cohen IK (1980) In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med 163(2):216\u2013222","journal-title":"Proc Soc Exp Biol Med"},{"key":"4000_CR34","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.3389\/fimmu.2019.01810","volume":"10","author":"S Tan","year":"2019","unstructured":"Tan S, Khumalo N, Bayat A (2019) Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies. Front Immunol 10:1810","journal-title":"Front Immunol"},{"issue":"1","key":"4000_CR35","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/01.prs.0000195073.73580.46","volume":"117","author":"A Al-Attar","year":"2006","unstructured":"Al-Attar A, Mess S, Thomassen JM et al (2006) Keloid pathogenesis and treatment. Plast Reconstr Surg 117(1):286\u2013300","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"4000_CR36","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/SAP.0000000000000989","volume":"78","author":"P Mankowski","year":"2017","unstructured":"Mankowski P, Kanevsky J, Tomlinson J et al (2017) Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 78(4):403\u2013411","journal-title":"Ann Plast Surg"},{"issue":"5","key":"4000_CR37","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.jaad.2020.06.023","volume":"83","author":"Y Son","year":"2020","unstructured":"Son Y, Phillips EON, Price KM et al (2020) Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: an in vitro and in vivo study. J Am Acad Dermatol 83(5):1304\u20131314","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"4000_CR38","first-page":"778","volume":"95","author":"E Bijlard","year":"2015","unstructured":"Bijlard E, Steltenpool S, Niessen FB (2015) Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol 95(7):778\u2013782","journal-title":"Acta Derm Venereol"},{"issue":"Suppl 12","key":"4000_CR39","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1097\/DSS.0000000000000207","volume":"40","author":"AM Erlendsson","year":"2014","unstructured":"Erlendsson AM, Anderson RR, Manstein D et al (2014) Developing technology: ablative fractional lasers enhance topical drug delivery. Dermatol Surg 40(Suppl 12):S142\u2013S146","journal-title":"Dermatol Surg"},{"issue":"2","key":"4000_CR40","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/j.jaad.2019.01.041","volume":"88","author":"R Dhurat","year":"2019","unstructured":"Dhurat R, Daruwalla SB, Sharma A (2019) Fractionated de-volumizing Keloid tissue\u2014the \u201cpop\u201d method\u2014a novel technique to facilitate administration of intralesional corticosteroid in difficult keloids. J Am Acad Dermatol 88(2):e75\u2013e77","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"4000_CR41","doi-asserted-by":"publisher","first-page":"970e","DOI":"10.1097\/PRS.0000000000010137","volume":"151","author":"P Wang","year":"2023","unstructured":"Wang P, Wang Q, Yang X et al (2023) Targeting the glycolytic enzyme pgk1 to inhibit the Warburg effect: a new strategy for keloid therapy. Plast Reconstr Surg 151(6):970e\u2013980e","journal-title":"Plast Reconstr Surg"}],"updated-by":[{"DOI":"10.1007\/s00266-025-04931-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000}}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-024-04000-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-024-04000-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-024-04000-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T21:02:09Z","timestamp":1747688529000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-024-04000-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":41,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["4000"],"URL":"https:\/\/doi.org\/10.1007\/s00266-024-04000-6","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,29]]},"assertion":[{"value":"4 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00266-025-04931-8","URL":"https:\/\/doi.org\/10.1007\/s00266-025-04931-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Dermatology Hospital of Southern Medical University (Approved number: 2021003).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}},{"value":"Patient provided informed consent to participate in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}