{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:54:17Z","timestamp":1790812457601,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["2023A1515030103"],"award-info":[{"award-number":["2023A1515030103"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aesth Plast Surg"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00266-024-04062-6","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T18:02:12Z","timestamp":1716400932000},"page":"4014-4023","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human Adipose-Derived Microvessel Fragments: A Natural Vascularization Units for Ischemic Diseases"],"prefix":"10.1007","volume":"48","author":[{"given":"Xin","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiDan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JianHua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"issue":"9","key":"4062_CR1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.tibtech.2016.03.002","volume":"34","author":"J Rouwkema","year":"2016","unstructured":"Rouwkema J, Khademhosseini A (2016) Vascularization and angiogenesis in tissue engineering: beyond creating static networks. Trends Biotechnol 34(9):733\u2013745","journal-title":"Trends Biotechnol"},{"issue":"2","key":"4062_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.scr.2010.11.003","volume":"6","author":"V Cervelli","year":"2010","unstructured":"Cervelli V, Gentile P, De Angelis B et al (2010) Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Stem Cell Res 6(2):103\u2013111","journal-title":"Stem Cell Res"},{"key":"4062_CR3","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1136\/annrheumdis-2014-205681","volume":"74","author":"B Granel","year":"2015","unstructured":"Granel B, Daumas A, Jouve E et al (2015) Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial. Ann Rheum Dis 74:2175\u20132179","journal-title":"Ann Rheum Dis"},{"key":"4062_CR4","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","volume":"17","author":"EY Lee","year":"2009","unstructured":"Lee EY, Xia Y, Kim WS et al (2009) Hypoxia-enhanced wound-healing function of adipose derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen 17:540\u2013545","journal-title":"Wound Repair Regen"},{"issue":"11","key":"4062_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080364","volume":"8","author":"Z Dong","year":"2013","unstructured":"Dong Z, Peng Z, Chang Q, Lu F (2013) The survival condition and immunoregulatory function of adipose stromal vascular fraction (SVF) in the early stage of nonvascularized adipose transplantation. PLoS ONE 8(11):e80364","journal-title":"PLoS ONE"},{"issue":"5","key":"4062_CR6","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3727\/096368911X623862","volume":"21","author":"M Mazo","year":"2012","unstructured":"Mazo M, Cemborain A, Gavira JJ et al (2012) Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity. Cell Transplant 21(5):1023\u20131037","journal-title":"Cell Transplant"},{"key":"4062_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biomaterials.2013.09.083","volume":"35","author":"M Ara\u00f1a","year":"2014","unstructured":"Ara\u00f1a M, Gavira JJ, Pe\u00f1a E et al (2014) Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction. Biomaterials 35:143\u2013151","journal-title":"Biomaterials"},{"key":"4062_CR8","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.biomaterials.2011.11.049","volume":"33","author":"NC Cheng","year":"2012","unstructured":"Cheng NC, Wang S, Young TH (2012) The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials 33:1748\u20131758","journal-title":"Biomaterials"},{"key":"4062_CR9","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1016\/j.biomaterials.2014.07.061","volume":"35","author":"IS Park","year":"2014","unstructured":"Park IS, Chung PS, Ahn JC (2014) Enhanced angiogenic effect of adipose-derived stromal cell spheroid with low-level light therapy in hind limb ischemia mice. Biomaterials 35:9280\u20139289","journal-title":"Biomaterials"},{"key":"4062_CR10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s10456-015-9461-x","volume":"18","author":"U Utzinger","year":"2015","unstructured":"Utzinger U, Baggett B, Weiss JA et al (2015) Large-scale time series microscopy of neovessel growth during angiogenesis. Angiogenesis 18:219\u2013232","journal-title":"Angiogenesis"},{"key":"4062_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.22203\/eCM.v024a19","volume":"24","author":"MW Laschke","year":"2012","unstructured":"Laschke MW, Kleer S, Scheuer C et al (2012) Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments. Eur Cell Mater 24:266\u2013277","journal-title":"Eur Cell Mater"},{"key":"4062_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.22203\/eCM.v028a02","volume":"28","author":"M Pilia","year":"2014","unstructured":"Pilia M, McDaniel JS, Guda T et al (2014) Transplantation and perfusion of microvascular fragments in a rodent model of volumetric muscle loss injury. Eur Cell Mater 28:11\u201323","journal-title":"Eur Cell Mater"},{"issue":"1","key":"4062_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mvr.2009.10.001","volume":"79","author":"SS Nunes","year":"2010","unstructured":"Nunes SS, Greer KA, Stiening CM et al (2010) Implanted microvessels progress through distinct neovascularization phenotypes. Microvasc Res 79(1):10\u201320","journal-title":"Microvasc Res"},{"key":"4062_CR14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jid.2016.08.010","volume":"137","author":"FS Frueh","year":"2017","unstructured":"Frueh FS, Spater T, Lindenblatt N et al (2017) Adipose tissue-derived microvascular fragments improve vascularization, lymphangiogenesis, and integration of dermal skin substitutes. J Invest Dermatol 137:217\u2013227","journal-title":"J Invest Dermatol"},{"key":"4062_CR15","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1089\/ten.2007.0025","volume":"13","author":"BR Shepherd","year":"2007","unstructured":"Shepherd BR, Hoying JB, Williams SK (2007) Microvascular transplantation after acute myocardial infarction. Tissue Eng 13:2871\u20132879","journal-title":"Tissue Eng"},{"key":"4062_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1089\/tea.2007.0099","volume":"14","author":"AM Hiscox","year":"2008","unstructured":"Hiscox AM, Stone AL, Limesand S et al (2008) An islet-stabilizing implant constructed using apreformed vasculature. Tissue Eng Part A 14:433\u2013440","journal-title":"Tissue Eng Part A"},{"key":"4062_CR17","doi-asserted-by":"publisher","first-page":"10977","DOI":"10.1038\/s41598-018-29252-6","volume":"8","author":"FS Frueh","year":"2018","unstructured":"Frueh FS, Spater T, Korbel C et al (2018) Prevascularization of dermal substitutes with adipose tissuederived microvascular fragments enhances early skin grafting. Sci Rep 8:10977","journal-title":"Sci Rep"},{"issue":"8","key":"4062_CR18","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.tibtech.2015.06.001","volume":"33","author":"MW Laschke","year":"2015","unstructured":"Laschke MW, Menger MD (2015) Adipose tissue-derived microvascular fragments: natural vascularization units for regenerative medicine. Trends Biotechnol 33(8):442\u2013448","journal-title":"Trends Biotechnol"},{"issue":"11","key":"4062_CR19","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1073\/pnas.69.11.3175","volume":"69","author":"RC Wagner","year":"1972","unstructured":"Wagner RC, Kreiner P, Barrnett RJ, Bitensky MW (1972) Biochemical characterization and cytochemical localization of a catecholamine-sensitive adenylate cyclase in isolated capillary endothelium. Proc Natl Acad Sci USA 69(11):3175\u20133179","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"4062_CR20","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/01.ATV.0000124103.86943.1e","volume":"24","author":"BR Shepherd","year":"2004","unstructured":"Shepherd BR, Chen HY, Smith CM, Gruionu G, Williams SK, Hoying JB (2004) Rapid perfusion and network remodeling in a microvascular construct after implantation. Arterioscler Thromb Vasc Biol 24(5):898\u2013904","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"4062_CR21","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.joen.2021.04.012","volume":"47","author":"X Xu","year":"2021","unstructured":"Xu X, Liang C, Gao X et al (2021) Adipose tissue-derived microvascular fragments as vascularization units for dental pulp regeneration. J Endod 47(7):1092\u20131100","journal-title":"J Endod"},{"issue":"1","key":"4062_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s13770-021-00391-8","volume":"19","author":"T Sp\u00e4ter","year":"2022","unstructured":"Sp\u00e4ter T, Marschall JE, Br\u00fccker LK et al (2022) Vascularization of microvascular fragment isolates from visceral and subcutaneous adipose tissue of mice. Tissue Eng Regen Med 19(1):161\u2013175","journal-title":"Tissue Eng Regen Med"},{"issue":"3","key":"4062_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","volume":"3","author":"M Crisan","year":"2008","unstructured":"Crisan M, Yap S, Casteilla L et al (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301\u2013313","journal-title":"Cell Stem Cell"},{"issue":"6","key":"4062_CR24","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/01913123.2019.1673863","volume":"43","author":"E Pasanisi","year":"2019","unstructured":"Pasanisi E, Ciavarella C, Valente S, Ricci F, Pasquinelli G (2019) Differentiation and plasticity of human vascular wall mesenchymal stem cells, dermal fibroblasts and myofibroblasts: a critical comparison including ultrastructural evaluation of osteogenic potential. Ultrastruct Pathol 43(6):261\u2013272","journal-title":"Ultrastruct Pathol"},{"issue":"1","key":"4062_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jid.2016.08.010","volume":"137","author":"FS Frueh","year":"2017","unstructured":"Frueh FS, Sp\u00e4ter T, Lindenblatt N et al (2017) Adipose tissue-derived microvascular fragments improve vascularization, lymphangiogenesis, and integration of dermal skin substitutes. J Invest Dermatol 137(1):217\u2013227","journal-title":"J Invest Dermatol"},{"key":"4062_CR26","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.actbio.2020.03.018","volume":"108","author":"T Sp\u00e4ter","year":"2020","unstructured":"Sp\u00e4ter T, Tobias AL, Menger MM, Nickels RM, Menger MD, Laschke MW (2020) Biological coating with platelet-rich plasma and adipose tissue-derived microvascular fragments improves the vascularization, biocompatibility and tissue incorporation of porous polyethylene. Acta Biomater 108:194\u2013206","journal-title":"Acta Biomater"},{"key":"4062_CR27","doi-asserted-by":"crossref","unstructured":"Nakano M, Nakajima Y, Tsuchida Y, Kudo S, Nakamura H, Fukuda O (1997) Direct evidence of a connection between autotransplanted microvessel fragments and the host microvascular system. Int J Microcirc 17(4):159\u2013163","DOI":"10.1159\/000179224"},{"issue":"8","key":"4062_CR28","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.305368","volume":"116","author":"PJ Psaltis","year":"2015","unstructured":"Psaltis PJ, Simari RD (2015) Vascular wall progenitor cells in health and disease. Circ Res 116(8):1392\u20131412","journal-title":"Circ Res"}],"container-title":["Aesthetic Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-024-04062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00266-024-04062-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00266-024-04062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T14:03:21Z","timestamp":1730901801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00266-024-04062-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":28,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4062"],"URL":"https:\/\/doi.org\/10.1007\/s00266-024-04062-6","relation":{},"ISSN":["0364-216X","1432-5241"],"issn-type":[{"value":"0364-216X","type":"print"},{"value":"1432-5241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"6 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial interest to declare in relation to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was compliant with the Declaration of Helsinki and its further amendments. The protocol was approved by the Institutional Review Board of our Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All patients included in this study have signed informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}